NOVEL ARYL ETHER SUBSTITUTED HETEROCYCLIC COMPOUND AS GLP1R AGONIST

Title:

NOVEL ARYL ETHER SUBSTITUTED HETEROCYCLIC COMPOUND AS GLP1R AGONIST

Document Type and Number:

WIPO Patent Application WO/2023/029380

Kind Code:

A1

Abstract:

The present invention relates to a novel aryl ether substituted heterocyclic compound having GLP1R agonist activity. Specifically, disclosed are a compound as a GLP1R agonist represented by formula (I), or a pharmaceutically acceptable salt, solvate, hydrate, isotope substituent or isomer thereof.

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Inventors:

ZHANG LONG (CN)
NIU ZHANGMING (CN)
TANG BOWEN (CN)

Application Number:

PCT/CN2022/075295

Publication Date:

March 09, 2023

Filing Date:

January 31, 2022

Export Citation:

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Assignee:

MINDRANK AI LTD (CN)

International Classes:

C07D401/14; A61K31/496; A61K31/506; A61P3/00; C07D405/06; C07D405/14; C07D409/14; C07D471/04

Domestic Patent References:

WO2021096284A1	2021-05-20
WO2020207474A1	2020-10-15
WO2021112538A1	2021-06-10

Foreign References:

TW202128658A	2021-08-01
US20210171499A1	2021-06-10
US20200325121A1	2020-10-15
CN202111017657A	2021-08-30
CN202111168512A	2021-09-29

Other References:

MEIER ET AL., BIODRUGS, vol. 17, no. 2, 2003, pages 93 - 102
BERGE ET AL.: "Pharmaceutical Salts", JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 66, 1977, pages 1 - 19, XP002675560, DOI: 10.1002/jps.2600660104
MAEHR, J. CHEM. ED, vol. 62, 1985, pages 114 - 120
"Remington: The Science and Practice of Pharmacy", 2005, LIPPINCOTT, WILLIAMS & WILKINS

Attorney, Agent or Firm:

BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)

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