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WO/2024/082416A1 |
The present invention relates to a collagenous fiber composite membrane for repairing nerve injuries. The collagenous fiber composite membrane comprises: an anti-adhesion layer, an elastic connection layer chemically cross-linked with th...
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WO/2024/084040A1 |
The disclosure relates to an aqueous bioink solution for use in light-based bioprinting applications, comprising: (a) 0.5-95 wt % water-soluble prepolymer; (b) 0.001-5 wt % biocompatible metal acylphosphinate photoinitiator; (c) 0.001-10...
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WO/2024/084686A1 |
Artificial skin containing photochromic material that changes color when irradiated with ultraviolet light.
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WO/2024/086171A1 |
The present invention provides a bone graft such as an allograft and a method for releasing growth factors from tissues (e.g., bone marrow, bone matrix, periosteum, and/or endosteum) having native living cells. Also provided are a compos...
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WO/2024/082029A1 |
A melt electrowritten soft tissue scaffold, comprising: a first region having one or more sets of fibres and a second region having one or more sets of fibres; and an interface region joining the first region and the second region, the i...
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WO/2024/086253A1 |
Liquid compositions containing at least one S-nitrosothiol (RSNO), such as S-nitroso-N- acetylpenicillamine (SNAP) and S -nitrosoglutathione (GSNO), and at least one alkanediol or alkanediol oligomer/polymer are provided. To modulate the...
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WO/2024/084416A1 |
A medical device (1) for repairing a lesion (200) in a spinal cord (2) or in a peripheral nerve comprises a biocompatible flexible support (10) made of expanded polytetrafluoroethylene (ePTFE). Stem cells (20) suitable for being oriented...
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WO/2024/085257A1 |
The present invention addresses the problem of providing a three-dimensional tissue culture and a method for producing the same. The problem is solved by this method for producing a three-dimensional tissue culture, the method comprising...
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WO/2024/082070A1 |
There is provide the use of a specific magnesium phosphate xerogel as a coating for bone implants; a coating for a bone implant comprising the xerogel as well as a bone implant, wherein a surface of the implant is covered by such a coati...
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WO/2024/080482A1 |
The present invention relates to a composition for endometrial regeneration containing a uterus derived decellularized extracellular matrix (UdECM) and a manufacturing method therefor. Characterized by containing uterus derived decellula...
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WO/2024/080382A1 |
The zirconia ceramic according to an embodiment has a crystal structure comprising zirconium, silver, and oxygen ions. The method for producing a zirconia ceramic according to an embodiment includes a sediment formation step (S1) and a f...
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WO/2024/078355A1 |
Provided are a biological mesh, a preparation method therefor a use thereof. The biological mesh comprises a matrix having an active group, the matrix being modified with a phosphorylcholine compound, and the phosphorylcholine compound b...
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WO/2024/080737A1 |
The present invention relates to a bone graft material and a bone formation method using same and, more specifically, to a bone graft material and a bone formation method using same, wherein the bone graft material is designed such that,...
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WO/2024/081310A1 |
Described herein are engineered mammalian cells comprising a reduction in the level or function of one or more of a major histocompatibility complex (MHC) class I protein complex component, optionally, a MHC class II protein complex comp...
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WO/2024/078253A1 |
An anti-calcification method for a bioprosthetic tissue, and a bioprosthetic tissue. The anti-calcification method for a bioprosthetic tissue comprises: putting a bioprosthetic tissue at least partially fixed in a cross-linking manner in...
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WO/2024/081153A1 |
An alternating vacuum and pressure system for decellularizing a bone matrix includes piping having a first end open to atmospheric pressure and a second end open to atmospheric pressure, and a subset of piping that forms a loop, a chambe...
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WO/2024/081898A1 |
The present disclosure provides compositions, systems, and methods related to cellular transduction. In particular, the present disclosure provides compositions, systems, and methods pertaining to implantable macroporous scaffolds that f...
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WO/2024/081656A1 |
Described herein are methods of using bone sialoprotein (BSP) to promote alveolar bone healing, for example, to improve bone preservation following tooth extraction, in preparation for a dental implant or other restorative device. Also d...
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WO/2024/081452A1 |
A composition comprising a hydrogel includes a polymer of formula (1), at least one repeating unit of which comprises BO2H2. Methods of making such hydrogels and methods of encapsulating cells using such hydrogels are also disclosed herein.
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WO/2024/022079A9 |
A use of a human mesenchymal stem cell sheet in the preparation of a drug for treating uterine scars, and a use of a human mesenchymal stem cell sheet in the preparation of a composition for treating a uterine scar in a subject. The huma...
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WO/2024/080661A1 |
The present invention relates to vMSC, which is a stem cell that is newly identified and has angiogenic properties. vMSCs cultured under specific culture conditions and identified, according to the present invention, are novel MSCs that ...
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WO/2024/081309A1 |
Described herein are engineered mammalian cells comprising a reduction in the level or function of a major histocompatibility complex (MHC) class I protein complex component, and, optionally, a MHC class II protein complex component and/...
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WO/2024/074119A1 |
A recombinant collagen and the use thereof in cartilage repair matrix. The recombinant collagen comprises a sequence as shown in SEQ ID No.1; the amino acid sequence of the recombinant collagen comprises N basic repeating units, and the ...
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WO/2024/075118A1 |
The invention provides a dental or subperiosteal implant having a porous polymeric structure and uses thereof in the method of treatment of periodontal diseases, conditions and symptoms.
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WO/2024/076771A1 |
Magneto-responsive properties are traditionally imparted to scaffold systems via integration of iron oxide-based magnetic nanoparticles (MNPs), yet poor understanding of long-term MNP toxicity presents a significant translational chall...
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WO/2024/074120A1 |
The present invention provides a transdermal photocuring forming hydrogel with biological activity, and a preparation method therefor and use thereof. The hydrogel can release a recombinant collagen with biological activity. The recombin...
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WO/2024/074944A1 |
An ocular implant includes an endothelial patch constructed of a clear, transparent, biologically compatible material, and which has a property-modified region that has different properties than other portions of the endothelial patch.
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WO/2024/076303A1 |
Disclosed is a composition for supporting survival and differentiation of neural precursor cells (NPCs) grafted into a neurological injury or disease site, the composition comprising: (a) a gel forming molecule; and (b) a chemokine recep...
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WO/2024/076900A1 |
A drug delivery implant may include an implant body and a core comprising a pharmaceutical agent. The core can be located within the implant body that extends longitudinally and circumferentially around the core. The implant body can als...
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WO/2024/077130A1 |
The present disclosure relates to compositions and methods for treating bladder cancer. In some embodiments the compositions and methods involve using antisense (AS) nucleic acids directed against Insulin-like Growth Factor 1 Receptor (I...
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WO/2024/077032A1 |
A bioprinting robotic system comprises a robotic manipulator, a bioprinting instrument configured as an end effector of the robotic manipulator further configured to print bioink, a head mounted display (HMD), an optical tracking system,...
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WO/2024/077231A1 |
A method of fabricating a surgical implant (e.g., a bioabsorbable surgical breast implant) includes forming an open framework body from a bioabsorbable material. The method further includes treating the open framework body with a solutio...
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WO/2024/075124A1 |
Compositions that comprise a solvent (e.g., an aqueous solvent) and a plurality of aromatic peptides that are soluble in the solvent, and non-crystalline materials formed thereof, which can be glassy and/or adhesive materials, are provid...
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WO/2024/076329A1 |
The invention relates to an exosome-based biocompatible implant obtained by spraying exosomes obtained from stem cells onto implant materials consisting of different materials. Said exosomes are attached to the implant material at a leve...
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WO/2024/076708A1 |
The present disclosure provides biomaterials and methods for preventing and minimizing progression of cartilage and/or connective tissue damage. Also provided herein are biomaterials and methods for alleviating and/or reducing the risk f...
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WO/2024/067485A1 |
Provided herein are magnesium oxychloride cement compositions having a micro-/macro-two-tier porous structure derived from a Pickering foam form of the compositions. The compositions include magnesium oxide, magnesium chloride, water, an...
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WO/2024/071510A1 |
The present invention relates to a medical tube and, more specifically, to a medical tube that is made of a novel material in which ceramic nanoparticles are dispersed in a metal that is radiopaque and biodegradable, and thus can solve p...
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WO/2024/066843A1 |
Disclosed in the present invention are a polycaprolactone microsphere pre-dispersion composition and a polycaprolactone injectable gel prepared from same. In the polycaprolactone microsphere pre-dispersion composition, polycaprolactone m...
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WO/2024/071513A1 |
The present invention relates to a bio-implantable piezoelectric composite material and a manufacturing method therefor, wherein the bio-implantable piezoelectric composite material comprises: a ceramic-based piezoelectric body; and a me...
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WO/2024/069605A1 |
Method of manufacturing a silver dendrite platform for biomedical applications, comprising the steps of providing a silicon wafer (10) stripped of its native surface silicon oxide layer and immersing said silicon wafer in a solution of s...
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WO/2024/073155A1 |
A composition comprising a hydrogel includes a polymer of formula (1), at least one repeating unit of which comprises norbomene. Methods of treating wounds and methods of encapsulating drugs and/or cells using such hydrogels are also dis...
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WO/2024/073359A1 |
The present disclosure provides hydrophobically-modified biopolymers, including hydrophobically-modified chitosans, which comprise benzenediol groups, optionally where a portion are oxidized to the corresponding quinone. The biopolymers ...
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WO/2024/073130A1 |
A Mg-Zn-Ca-Mn alloy for use in the treatment of a malignant tumor, use of a Mg-Zn-Ca-Mn alloy in the manufacture of a medicament as a treatment for a malignant tumor, and a method of treating a malignant tumor comprising administering to...
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WO/2024/069629A1 |
A 3D-printing support medium is provided herein, comprising hybrid calcium-alginate hydrogel particles and a dispersion medium, formulated by combining calcium-alginate and a soluble polymer distinct from alginate, and the dispersion med...
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WO/2024/073758A1 |
Provided herein, inter alia, are hydrogel composite, its compositions, and use thereof for treatment of undesired adhesion formation and treatment of peripheral nerves, e.g., by preventing scarring and adhesion of peripheral nerves.
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WO/2024/066040A1 |
A zinc oxide/zinc phosphate nanorod composite antibacterial coating and a preparation method therefor and use thereof. The preparation method comprises preparing a zinc oxide nanorod coating on the surface of a medical material and then ...
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WO/2024/073386A1 |
An implantable medical device is provided. The implantable medical device includes a core having an antisense oligonucleotide (ASO) dispersed within a core polymer matrix. The core polymer matrix includes an ethylene vinyl acetate copoly...
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WO/2023/183953A9 |
Provided are compositions that include single cell suspensions of pancreatic islet cells, pancreatic islet-like cells derived from iPS cells, or combinations thereof, wherein the cells are present within a MAP scaffold and/or are encapsu...
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WO/2024/062325A1 |
An apparatus for generating a force at a tissue site is described. The apparatus can include a closure device formed from a super-elastic material. The closure device can have a first side, a second side, a perimeter portion, and a cente...
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WO/2024/063737A1 |
Although this invention is primarily designed for various types of bone defects in dentistry, it can also be used in the medical field for various types of bone defects. It can be used in maxillary sinus augmentations, various intraosseo...
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