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WO/1994/023771A1 |
An aqueous coating process is disclosed for preparing polymer-coated medical and laboratory devices which are characterized by their biocompatibility and resistance to nonspecific protein adsorption. The process involves placing a prepol...
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WO/1994/023770A1 |
A packaged endo-osteal material to be used in surgery for sterile and biocompatibility promoting storage comprising the endo-osteal material treated with a solution of a bisphosphonate of formula (I) wherein X is H, OH, Cl, F or a methyl...
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WO/1994/022885A1 |
A series of sulfated disaccharides having blocked anomeric centers have been shown to exhibit blood anticoagulant properties specific to inhibition of factor IXa, and can be used in vivo to inhibit clotting, extracorporeally, or in vitro...
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WO/1994/022437A2 |
Therapeutic compounds and methods for inhibiting amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is inhibited by the administration to a subject of an effective amount of a therapeutic co...
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WO/1994/017904A1 |
A membrane for medical purposes treated with a low pressure plasma is modified so that its complement activation capacity and thrombogenicity are reduced with respect to non-modified dialysis membranes. The membrane is characterized in t...
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WO/1994/016750A1 |
A solid substrate, the surface of which has been modified to introduce reactive groups of a hydrophilic nature thereon, the modification being provided by a primer comprising a first polysaccharide containing as reactive groups amino and...
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WO/1994/016749A1 |
The present invention provides materials which comprise a surface having pendant zwitterionic groups Z comprising, as anion, a phosphate, sulphonate, carboxylate or phosphate-ester group or a phosphate ester group in which one or more of...
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WO/1994/016748A1 |
The present invention relates to materials which comprise a surface having pendant groups of formula (I), in which the groups -B- are the same or different, preferably the same, and each is -CH2- or -C( = O)-, preferably -CH2-, R1 is hyd...
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WO/1994/015581A1 |
Articles of manufacture which are adapted for use in contact with one or more biologically active agents are coated with a glassy carbohydrate film. The glassy film provides a reduced surface energy coating which exhibits a reduced degre...
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WO/1994/014897A1 |
The biocompatibility of various polymers are improved by blending with them a polymer including a zwitterionic groups. The zwitterionic group is usually an ammonium phosphate ester zwitterionic group and the polymer containing it may be ...
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WO/1994/011118A1 |
The surface of a substrate material may be permanently modified so as to develop a microscopically smooth, biocompatible surface thereon. A biocompatible polymeric material may be covalently grafted to the surface of the substrate materi...
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WO/1994/011411A1 |
Triblock polymers comprised of polysaccharide, such as heparin or dextran, and a hydrocarbon chain, have been prepared. The triblock polymer adsorbs strongly on the surface of hydrophobic polymer substrates such as polyethylene, through ...
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WO/1994/010938A1 |
The present invention provides a method for surface modifying a substrate, such as an implant, to provide the substrate with anticoagulant activity and resistance to the deposition of plasma proteins; and the resulting substrate. The sur...
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WO/1994/007432A2 |
Novel implant materials having porosity are provided by the present invention. Novel methods for treating a synthetic or naturally occurring implant, such as a vascular graft, intended for implantation in a human patient are also provide...
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WO/1994/003544A1 |
A protein-compatible polymer blend made from a water-soluble polymer and a matrix polymer. The glass transition temperature of either the water-soluble polymer or the matrix polymer is greater than the application temperature, i.e., the ...
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WO/1994/002083A1 |
The invention provides hard, wear resistant, biocompatible and blood compatible coatings for components of ventricular assist (Figs. 5A-5B), external mechanical heart and blood flow assist devices and total heart implants (Figs. 1-4B) th...
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WO/1994/001481A1 |
Synthetic biomaterials are provided with irreversibly bound amino diphosphonate, polyphosphonate, or other anticalcification agent to prevent in vivo calcification. Such biomaterials include biocompatible elastomers such as polyurethane ...
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WO/1993/025587A1 |
A process for the functionalisation of polymers is disclosed. Functionalisation takes place by reacting a polymer with a peroxidant, preferably the peroxydisulphate or monosulphate or sodium or potassium in an aqueous medium. The hydroxy...
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WO/1993/025594A1 |
Supports having azlactone-functional surfaces, adduct supports prepared from such azlactone-functional supports, and methods of preparing both are disclosed. Azlactone functionality is introduced to surfaces of a pre-existing support in ...
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WO/1993/025255A2 |
A tubular sheath is disclosed which is slidably disposed over a tubular medical device which tubular medical device is positioned at a body tissue access site. The sheath is deposited within a patient to assist in sealing the incision ca...
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WO/1993/025247A1 |
This invention pertains to a method for immobilizing polyethylene oxide (PEO) star molecules in the form of hydrogel layers. The PEO star molecules are biocompatible and demonstrate non-thrombogenic properties. As such, the PEO star mole...
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WO/1993/023997A1 |
Fixed-dried human blood platelets and processes for preparing the same are disclosed. The platelets, upon reconstitution: adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change (spreading) upon ...
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WO/1993/023090A1 |
Artificial blood vessels having significantly improved anticlot characteristic and function, particularly for small-diameter artificial blood vessels. The artificial blood vessels, made of polyester, polyacrylonitrile or polyurethane, ha...
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WO/1993/021858A1 |
A device for preventing adhesions or binding of tissue to tissue or of tissue to bone which comprises a composite of a first layer and a second layer, each of which comprises a biodegradable polymer. The first layer is selected from the ...
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WO/1993/021860A1 |
The invention provides vascular prostheses (10) free of any substance that counteracts an anti-coagulant comprising a base material having inner (16) and outer (14) surfaces, wherein the outer surface has a layer of a material capable of...
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WO/1993/022320A1 |
Compounds of formula (I), in which the groups R are hydrogen or C1-4 alkyl, n is from 2 to 4, X is alkylene, poly(ethoxy) or an aryl-containing group, Y is a valence bond or a divalent functional or heterocyclic group or a trivalent alky...
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WO/1993/021970A1 |
A method of reducing the extent to which microorganisms, particularly bacteria, will adhere to a surface, which comprises providing a surface having pendant groups of formula (I), in which each group R is the same or different and is alk...
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WO/1993/022360A1 |
The present invention relates to a biocompatible, hydrophilic, segmented block polyurethane copolymer which comprises 5 to 45 wt% of a hard segment, preferably a reaction product of an organic diisocyanate, a diamine and a polyol, and 95...
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WO/1993/021971A1 |
Surfaces of polymeric materials are coated with a layer of thermally denatured fibrinogen. The fibrinogen may be treated with thrombin to produce fibrin, and additional fibrinogen and factor XIII added to produce a cross-linked fibrin co...
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WO/1993/021257A1 |
Polymeric polyetheramidoamine hydrogel materials, which are capable of complexing heparin in physiological conditions are herein described. Said materials are useful in the manufacturing of medical devices.
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WO/1993/015775A1 |
A method of producing a material bearing zwitterionic groups, such as phosphoryl choline groups, which comprises treating at least the surface of a substrate with a solution or dispersion of a polymer grafted with zwitterionic groups, an...
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WO/1993/016112A1 |
A mixture of sulphated oligosaccharides which are components of heparin. At least 70 % has a molar mass of 5400-7800 daltons, and at least 5 % has a molar mass of over 6900 daltons.
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WO/1993/016117A1 |
A water-soluble cellulose derivative which is produced by grafting 2-methacryloyloxyethylphosphorylcholine onto water-soluble cellulose and has a structural unit represented by formula (I); and a biocompatible material containing the sam...
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WO/1993/016176A1 |
A method of immobilizing a chemical specie in a three-dimensional, crosslinked matrix. The method involves bringing together in covalent bonding proximity a desired chemical specie and a polymeric coupling compound having at least two la...
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WO/1993/011152A1 |
The invention relates to new competitive inhibitors of thrombin, their synthesis, pharmaceutical compositions containing the compounds as active ingredients, and the use of the compounds as anticoagulants for prophylaxis and treatment of...
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WO/1993/009718A1 |
The interior surface of a container (10), such as a bloodbag, is primed and subsequently coated with a time-releasable viricide (11) against HIV absorbed in a hydrogel polymer (14). The viricides of this invention are derivatives of urea...
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WO/1993/009807A1 |
The present invention contemplates various methods of preventing and treating thrombosis via increasing circulating endogenous blood activated protein C levels and via upregulating the plasma level or generation of activated protein C. T...
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WO/1993/009790A1 |
Polyionic derivatives of cyclodextrins and methods for preparing these derivatives are provided in which a polyionic derivative of cyclodextrin is combined with a growth factor, preferably a heparin binding growth factor. These compositi...
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WO/1993/007217A1 |
An antithrombotic resin comprising polyurethane or polyurethaneurea prepared by using at least one polyetherdiol selected among polyols containing a polyoxyethylene group represented by general formula (I), wherein n represents a number-...
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WO/1993/005825A1 |
Processes for reducing the thrombogenicity of biomaterials are disclosed. These processes include coating biomaterials or medical devices with heparin and then exposing the coated biomaterials to ionizing radiation to chemically bind the...
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WO/1993/005793A1 |
The invention relates to a substantially water-soluble biologically active conjugate comprising a substantially straight-chained organic polymer having a number of functional groups distributed along the polymer backbone chain, via which...
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WO/1993/005081A1 |
A graft polymer obtainable by grafting a polymer substrate with a compound of formula (I), in which the groups R are the same or different and each is a straight or branched C1-C4 alkyl group; X is an aryl group or a straight or branched...
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WO/1993/003776A1 |
A minus power anterior chamber ocular implant for placement in the anterior chamber of a phakic eye having an anatomic lens in situ comprises a negative artificial refracting lens having at least one concave surface, a surface coating wh...
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WO/1993/001221A1 |
Polymers of one or more radical polymerisable monomers which polymer has pendant groups bearing a centre of permanent positive charge and other pendant groups capable of stably binding the polymer to a surface are useful in the treatment...
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WO/1993/000407A1 |
Disclosed is a treated material including a base material such as an extrudate, a woven fabric, or unwoven fibers, a disperse dye-type molecule such as a dye or antibiotic dispersed within and non-covalently adhered to the base material,...
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WO/1992/021386A1 |
A process for coating a surface comprising applying to the surface a solution or suspension, in an organic solvent of a polymer and removing the solvent, wherein the polymer is obtainable by polymerising a phospholipid of formula (I), wh...
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WO/1992/021387A1 |
A composition for coating medical blood contacting surfaces comprises a mixture of an anticoagulant and a defoaming agent. The coating composition is applied by either dipping the device into a solution containing the mixture or by spray...
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WO/1992/018320A1 |
The invention relates to a method for modifying at least a part of the surface of a fluorine-containing plastic, which comprises making the surface hydrophobic by: i) ion-etching the plastic surface; and ii) subsequently cleaning the tre...
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WO/1992/017218A1 |
An artificial blood vessel comprising a tube made from a porous synthetic polymer and, covalently bonded to the surface of the tube via a hydroxyl, carboxyl, epoxy or amino group, a protein or peptide having an activity of cell adhesion ...
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WO/1992/015342A1 |
A stent comprising a cylindrical/tubular body knitted of polymer filaments which is capable of being absorbed by an organism and is constituted of polylactic acid, polyglycolic acid, or copolymer of said acids. This cylindrical/tubular b...
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