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Matches 301 - 350 out of 5,963

Document Document Title
WO/2012/027570
Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.  
WO/2012/026575
[Problem] The purpose of the present invention is to provide a muscle-enhancing agent. The purpose of the present invention is also to provide food having a muscle-enhancing effect. [Solution] The inventors focused on the effects that Wa...  
WO/2012/024242
There are disclosed selective myostatin antagonists (including antibodies), nucleic acids encoding them, and methods of making and using them. Neutralizing antibodies recognizing the conformational epitope near position 21 to 31 and posi...  
WO/2012/019002
A population of somatic stem cells and a method of preparing same. Also disclosed are two subpopulations thereof and their various uses.  
WO/2012/019071
The present invention provides methods and compositions useful for the treatment and/or prevention of sarcopenia. The compositions include one or more of the following benzothiazepine, benzoxazepine, benzodiazepine or benzazepine compoun...  
WO/2012/019002
A population of somatic stem cells and a method of preparing same. Also disclosed are two subpopulations thereof and their various uses.  
WO/2012/016930
The present invention relates to the compound of formula (I) for use in the treatment of a nonsense-mutation-mediated genetic disease.  
WO/2012/018257
The invention relates to means and methods for removing a proteolytic cleavage site from a protein comprising providing a cell that expresses pre-m RNA encoding said protein with an anti-sense oligonucleotide that induces skipping of the...  
WO/2012/012843
The present invention provides novel compounds of the Formula (1), pharmaceutical compositions comprising such compounds and methods for using such compounds as tools for biological studies or as agents or drugs for modulating Protease A...  
WO/2012/014890
Provided are: a nucleic acid molecule capable of binding to c-Met, which is a substance that can be used for analysis of the mechanism of development, diagnosis and treatment of diseases that are induced by c-Met; and use of the nucleic ...  
WO/2012/014994
Provided is a compound which can regulate a VCP activity. Specifically provided is a compound represented by formula (I) (wherein R is as defined in the description) or an oxide, ester, prodrug, pharmaceutically acceptable salt or solvat...  
WO/2012/012300
Provided herein are methods for ameliorating an adverse effect of systemic administration of a PEG hyaluronan degrading enzyme to a subject. The methods involve systemically administering a PEGylated hyaluronan degrading enzyme, particul...  
WO/2012/011673
The present invention relates to a promoter of muscle cell differentiation or renewal, to a pharmaceutical composition for treating or preventing muscular impairment, and to a food composition for alleviating or preventing muscular impai...  
WO/2012/011673
The present invention relates to a promoter of muscle cell differentiation or renewal, to a pharmaceutical composition for treating or preventing muscular impairment, and to a food composition for alleviating or preventing muscular impai...  
WO/2012/011548
The present invention provides a nitrogen-containing heterocyclic derivative which has ASK1-inhibitory activity and is useful as a prophylactic and/or therapeutic agent for ALS and so on, or a pharmaceutically acceptable salt thereof. Th...  
WO/2012/012300
Provided herein are methods for ameliorating an adverse effect of systemic administration of a PEG hyaluronan degrading enzyme to a subject. The methods involve systemically administering a PEGylated hyaluronan degrading enzyme, particul...  
WO/2012/011572
It has been discovered that carnitine, a derivative thereof or a pharmaceutically acceptable salt thereof is useful as an active ingredient of a prophylactic or therapeutic agent for diastolic heart failure. The present invention is capa...  
WO/2012/011591
Disclosed is a compound that has excellent pharmacological activity, physicochemical qualities, and the like, and is useful in the prevention/treatment of eicosanoid-related conditions including arteriosclerosis, diabetes, obesity, ather...  
WO/2012/008457
The present invention provides a composition for external application, which contains a vitamin A, a heparin analogue and an antioxidant. The present invention also provides a composition for external application for improving rough skin...  
WO/2012/006864
Disclosed are a series of pentacyclic triterpenoid compounds, preparation methods and uses thereof. The compounds have anti-inflammatory, anti-tumor, anti-bacterial and antiviral activities, and they can be used for treating urinary inco...  
WO/2012/009474
The present invention relates to compositions and methods for treating sialic acid deficiencies comprising extended release formulations.  
WO/2012/008549
Disclosed is a compound which has an activity of regulating the differentiation of a muscle cell or an adipocyte, is effective for the prevention or treatment of diseases including diabetes, obesity and dyslipidemia, and has excellent ph...  
WO/2012/007688
The present invention relates to a monoclonal antibody to tetanus toxin, characterised in that it bonds to a protein fragment of tetanus toxin.  
WO/2012/004291
A pharmaceutical active ingredient for cell differentiation to alleviate cell and cell-related deficiencies in mammals comprising porous silica containing a releasable agent capable of contributing to a cell environment conducive for ste...  
WO/2012/005582
The invention relates to the use of an anabolic amino acid derivative stimulus acting in combination with vitamin D for the manufacture of a medicament or nutritional composition for the prevention and/or treatment of a loss of any one o...  
WO/2012/004966
Disclosed is a drug effective in the treatment of fibromyalgia. Basically, the disclosed therapeutic agent was created on the basis of experiments showing improvement in symptoms when etanercept was administered to patients suffering fro...  
WO/2012/005568
The invention relates to the use of an anabolic amino acid derivative stimulus acting in combination with vitamin D for the manufacture of a medicament or nutritional composition for the prevention and/or treatment of a loss of any one o...  
WO/2012/005227
As a pharmaceutical product useful for patients with urine evacuation disorders for whom conventional drugs are ineffective, a drug is disclosed having inhibitory activity on ENPP2, which is a target different from that of already existi...  
WO/2012/002773
A novel phenylcarbamate compound and a pharmaceutical composition containing the same are provided. More specifically, a novel phenylcarbamate compound, a composition for muscle relaxation containing the phenylcarbamate compound as an ac...  
WO/2012/002773
A novel phenylcarbamate compound and a pharmaceutical composition containing the same are provided. More specifically, a novel phenylcarbamate compound, a composition for muscle relaxation containing the phenylcarbamate compound as an ac...  
WO/2012/001121
The present invention relates to a composition comprising a calpain-3 inhibitor for treating cardiomyopathies and muscular dystrophies, in particular tibial muscular dystrophy (TMD).  
WO/2012/001941
Disclosed is a prophylactic or ameliorating agent for a genetic disease which is induced by the mutation of an exon in a gene and in which an exon that contains the mutation is skipped so as to produce a functional truncated protein. Spe...  
WO/2011/162320
Disclosed is a medicament characterized by the combination of: epigallocatechin gallate, methylated epigallocatechin gallate, or a pharmacologically permitted salt thereof; and a phosphodiesterase inhibitor.  
WO/2011/160826
A method for treating a disease or condition caused by or associated with hyperactivity of muscles or exocrine glands in a patient, the method comprising administering a composition comprising an effective amount of Clostridium botulinum...  
WO/2011/161427
The invention provides formulations and methods for ameliorating symptoms associated with metabolic disorders, such as cachexia, hypoglycemia, obesity, diabetes, and the like by administering Zn-α2-glycoproteins or a functional fragment...  
WO/2011/157059
Isoacteoside or a pharmaceutically acceptable saltthereof which is used as an inhibitor of production, accumulation or aggregation of amyloid βpeptide has effect on preventing or treating diseases or symptoms associated with amyloid βp...  
WO/2011/152618
The present invention relates to a method for purifying non-diffusive botulinum toxin causing local muscle paralysis, and non-diffusive botulinum toxin purified thereby, and more specifically, to a method for purifying non-diffusive botu...  
WO/2011/153277
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, re...  
WO/2011/151632
The present invention relates to the field of nutritional support for individuals and reducing the effects of muscle conditions caused by high levels of physical activity. In particular, the invention provides dietary formulations, compo...  
WO/2011/152618
The present invention relates to a method for purifying non-diffusive botulinum toxin causing local muscle paralysis, and non-diffusive botulinum toxin purified thereby, and more specifically, to a method for purifying non-diffusive botu...  
WO/2011/150457
The present invention generally relates to compounds that inhibit haematopoietic-prostaglandin D2 synthase (H-PGDS), to compositions containing them and to their use in treating or preventing conditions and diseases associated with H-PGD...  
WO/2011/152618
The present invention relates to a method for purifying non-diffusive botulinum toxin causing local muscle paralysis, and non-diffusive botulinum toxin purified thereby, and more specifically, to a method for purifying non-diffusive botu...  
WO/2011/152618
The present invention relates to a method for purifying non-diffusive botulinum toxin causing local muscle paralysis, and non-diffusive botulinum toxin purified thereby, and more specifically, to a method for purifying non-diffusive botu...  
WO/2011/152524
The disclosed cell growth-promoting agent contains as active ingredient, an artificially synthesized peptide comprising (A) an amino acid sequence that configures a membrane-penetrating peptide and (B) an amino acid sequence that configu...  
WO/2011/151432
The present invention relates to humanised antigen binding proteins, such as antibodies, which bind to myostatin, polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding protein...  
WO/2011/153277
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, re...  
WO/2011/147967
The present invention relates to a therapeutic substance and/or medicament and methods relating to the use of said substance and/or medicament for skeletal muscle regeneration using mesenchymal stem cells (MSCs) which can be applied dire...  
WO/2011/150008
The present invention provides isolated human or humanized antibodies or antigen- binding fragments thereof which specifically bind to Growth and Differentiation Factor-8 (GDF8) and block GDF8 activity. The antibodies and antibody fragme...  
WO/2011/147086
Microvesicles containing small interfering RNAs, preparation methods and uses thereof are provided. Pharmaceutical compositions and kits comprising the microvesicles containing small interfering RNAs are also provided. Microvesicles cont...  
WO/2011/145909
The present invention relates to the novel use of panduratin derivatives or an extract of Boesenbergia pandurata for promoting muscle mass growth, fighting fatigue, and enhancing exercise performance capability. More particularly, the pr...  

Matches 301 - 350 out of 5,963