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WO/2000/006531A2 |
Nitric acid esters and nitrate salts with medicines active in the respiratory system pathology treatment.
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WO/2000/006679A1 |
The present invention relates to a method for preparing a cationic surfactant in which physical chemical characteristics such as softness, antistatic properties, etc. as well as biodegradability are quite excellent due to having an ester...
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WO/2000/006527A1 |
The 3- and 4-methylcatechols are converted to the corresponding benzaldehyde by first alkylating the hydroxyl groups to form an alkylated methylcatechol. The methyl group is then converted to a methyl dibromide group using 1,3-dibromo-5,...
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WO/2000/005199A1 |
The present invention provides a process for the preparation of a wide range of primary arylamines. The arylamines are prepared in two efficient, straightforward transformations: 1) an activated aryl group and an imine group are combined...
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WO/2000/000459A1 |
A process for the preparation of optically active cyclohexylamine compounds useful as intermediates for the preparation of 1-phenyl-2-(3-phenylcyclohexyl-amino)ethanol compounds exhibiting a selective $g(b)¿3?-adreneric receptor stimula...
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WO/1999/067198A1 |
The ($i(R, R)) -, ($i(S, S)) -, ($i(R, S)) -, ($I(R, S)) - isomers of 3 - amino- 4- hydroxy-$g(a)- [[[2- (4- methoxyphenyl)- 1-methylethyl]amino]methyl] -benzenemethanol (D) are disclosed, as well as an efficient method for their stereos...
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WO/1999/067196A1 |
A synthesis of fluoxetine is disclosed. The process begins with a lower alkyl ester of 3-benzoylpropionic acid, which is reduced in the presence of a chiral ligand to produce the corresponding $g(g)-hydroxy ester, and the ester is cleave...
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WO/1999/064042A1 |
Disclosed are novel multi-binding compounds (agents) which bind alpha-1A adrenergic receptors. The compounds of this invention comprise a plurality of ligands each of which can bind to such receptors thereby modulating the biological pro...
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WO/1999/063996A1 |
Disclosed are multibinding compounds which are agonists, partial agonists, inverse agonists or antagonists of the 5HT¿2? receptors, which are involved in neurological disorders. The multibinding compounds of this invention containing fr...
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WO/1999/064052A1 |
This invention relates to novel multibinding compounds that bind to leukotriene receptors and inhibit their activity. In particular, cysteinal leukotriene receptor antagonists and, most particularly leukotriene D¿4? receptor antagonist ...
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WO/1999/063944A2 |
Disclosed are novel multi-binding compounds (agents) which bind estrogen receptors. The compounds of this invention comprise a plurality of ligands each of which can bind to such receptors thereby modulating the biological processes/func...
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WO/1999/063993A1 |
Disclosed are multibinding compounds which are agonists, partial agonists, inverse agonists or antagonists of the D¿1? receptors, preferably, agonists of the D¿1? receptors, which are involved in neurological disorders. The multibindin...
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WO/1999/063999A1 |
This invention relates to novel multibinding compounds (agents) that are H1-histamine receptor antagonists and pharmaceutical compositions comprising such compounds. Accordingly, the multibinding compounds and pharmaceutical compositions...
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WO/1999/063930A2 |
This invention relates to novel multibinding compounds that bind to angiotensin (AT) receptors and modulate their activity. The compounds of this invention comprise 2-10 AT receptor ligands covalently connected by a linker or linkers, wh...
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WO/1999/064053A1 |
The present invention is directed to multibinding compounds which are $g(b)3-adrenergic receptor agonists and are therefore useful in the treatment and prevention of metabolic disorders such as obesity, diabetes, and the like.
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WO/1999/062854A1 |
This invention relates to a process for producing a plurality of olefin compounds of formula (I). The method is ideal for generating libraries of compounds for high throughput screening. The invention also provides a library of above com...
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WO/1999/062871A1 |
Novel 3-aryl proprionic acid derivatives and analogs, having general formula (I) and stereo- and optical isomers and racemates thereof as well as pharmaceutically acceptable salts, solvates and crystalline forms thereof, process for thei...
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WO/1999/062861A1 |
A process for producing protected 3-amino-1,2-dihydroxypropane acetal, particularly in chiral forms, for use as an intermediate in the preparation of various 3-carbon compounds which are chiral. In particular, the present invention relat...
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WO/1999/062863A1 |
A process for the preparation of protected dihydroxypropyl trialkylammonium salts, particularly in chiral form is described. In particular, a process for the preparation of (2,2-dimethyl-1,3-dioxolan-4-ylmethyl) trialkylammonium salts, p...
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WO/1999/061405A1 |
(R*,R*)-2-[ (dimethylamino) methyl]-1-( 3-methoxyphenyl) cyclohexanol (Tramadol) is synthesized in a Grignard reaction in the presence of an additive resulting in a higher trans:cis ratio of product than is obtained in the absence of the...
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WO/1999/058478A1 |
The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the inv...
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WO/1999/058492A1 |
The invention relates to quaternary ester compounds which have an ethoxylated hydroxycarboxylic acid as their basic framework. These cationic tensides are suitable for the production of water-white formulations, such as in particular hai...
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WO/1999/054297A1 |
A process for preparing compounds represented by general formula (X), comprising the steps of: saponifying a (2S,3R)-4-hydroxy-2,3-epoxybutanoic acid derivative; regioselectively opening the epoxy ring of the resultant derivative to obta...
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WO/1999/052855A1 |
The present invention relates to a process for preparing chiral (S)-2,3-disubstituted-1-propylamine derivatives and more particularly, to the process for preparing chiral (S)-2,3-disubstituted-1-propylamine derivatives expressed in formu...
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WO/1999/052521A1 |
Investigation of the activity of extracts of the clam $i(Spisula polynyma) has led to antitumour long-chain, straight-chain alkane or alkene compounds which have a 2-amino group and a 3-hydroxy group.
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WO/1999/051564A1 |
This invention relates to new propanolamine derivatives or salts thereof represented by general formula (I), wherein each symbol is as defined in the specification or salts thereof which are $g(b)¿3? adrergenic receptor agonists and the...
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WO/1999/050226A1 |
A process for producing N-cyclopropylanilines usable as important intermediates for the production of quinolonecarboxylic acids having a cyclopropyl group at the 1-position, a fluorine atom at the 6-position, and an alkyl group, an alkox...
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WO/1999/050224A1 |
The instant invention is directed to a method for recovering surface active amines from an emulsion comprising the salt of the amine comprising: (a) contacting an emulsion layer or phase containing surface active amine salt with an acid ...
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WO/1999/050261A1 |
A process for producing compounds having PGD¿2? antagonism represented by formula (I), pharmaceutically acceptable salts thereof or hydrates of the same characterized by reacting an amino alcohol of formula (II) or its salt with a compo...
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WO/1999/050217A1 |
Disclosed is the compound valiolone, which has formula (I), a method of preparing valiolone, and a method of using valiolone to prepare acarbose and voglibose.
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WO/1999/046234A1 |
The invention concerns methods for the preparation of an N-bis-[2-(1,2-dicarboxy-ethoxy)-ethyl]-amine derivative, products of said methods as well as uses of the products. According to the invention said derivative is prepared by reactin...
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WO/1999/042434A2 |
The invention relates to a method for producing an aqueous hydroxylamine solution which is substantially free of metal ions. According to said method the hydroxylamine solution is subjected to at least one treatment with an acid cation e...
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WO1998022435A9 |
The invention concerns a reagent and a family of compounds. The reagent contains by successive or simultaneous addition: a material of formula RfH, a silicophilic base, a trivalent nitrogenous derivative containing no hydrogen and at lea...
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WO/1999/038838A1 |
The invention relates to an especially advantageous method for producing optically active amino alcohols from optically active amino acids by means of reduction in the presence of catalysts containing ruthenium, acids being added in the ...
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WO/1999/038613A1 |
The invention relates to a method for obtaining advantageous catalysts, especially for hydrogenation. According to said method, a suspension of a ruthenium compound with a specific surface area of 50 to 300 m?2¿/g is brought together wi...
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WO/1999/037601A1 |
A process for producing 4,6-diaminoresorcinol or its salt which comprises reducing by hydrogenation in the presence of a metallic catalyst 4,6-bis(substituted)phenylazoresorcinol represented by general formula (1) (for example, 4,6-bisph...
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WO/1999/036380A1 |
Anxiolytic agents containing as the active ingredient biphenyl derivatives represented by general formula (I), wherein R¿1? and R¿2? represent each hydroxy, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, lower alkenyloxy, ary...
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WO/1999/036390A1 |
A process for the preparation of Tramadol according to a Grignard reaction of 2(dimethylaminomethyl)cyclo-hexanone with the reagent 3-methoxyphenylMgX, where X is a halogen, to obtain the crude base which is then introduced to a solvent,...
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WO/1999/036389A1 |
A process for the preparation of Tramadol according to a Grignard reaction of 2-(dimethylaminomethyl)cyclo-hexanone with the reagent 3-methoxyphenylMgX, where X is a halogen, to obtain the crude base which is then introduced to a solvent...
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WO/1999/036388A1 |
The invention relates to a method for producing a N-alkylated aniline of formula (I) Ar-N(R?1¿)¿2-n?(CHR?2¿CHR?3¿Ar')¿n? by reacting an aromatic olefin of formula (II) Ar'CR?3¿=CHR?2¿ with an aniline of formula (III) Ar-N(R?1¿)¿...
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WO/1999/033783A1 |
The invention relates to a method for producing oxalkylated amines or alcohols, whereby a reaction mixture containing an amine or an alcohol or a mixture of two or more amines and/or alcohols and an alkylene oxide or a mixture of two or ...
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WO/1999/033938A1 |
The invention concerns an additive for motive fuel additive, in particular with low sulphur content not more than 500 ppm, consisting for the most part of a combination comprising 5 to 95 wt. % of a glycerol monoester R¿1?-C(O)-O-CH¿2?...
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WO/1999/032431A1 |
The present invention relates to a novel monophosphate salt of isopropyl-methyl-[2-(3-n-propoxyphenoxy)ethyl]amine. Moreover, the present invention also relates to a process for the preparation of the monophosphate salt of isopropyl-meth...
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WO/1999/032430A1 |
The present invention relates to a novel process for the synthesis of isopropyl-methyl-[2-(3-n-propoxyphenoxy)ethyl]amine. Moreover, the present invention also relates to a novel intermediate and an optional purification step in the nove...
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WO/1999/028034A1 |
The invention relates to a method for preparing a catalyst through activation of a catalytic material comprising a) at least one metal from the first or second side group or one compound thereof and b) optionally a carrier. This catalyst...
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WO/1999/026928A1 |
Disclosed in a three step synthesis of 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepines from a 2-aminobenzophenone represented by structural formula (II) and a starting material represented by structural formula (III). Phenyl Ring A, Phenyl R...
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WO/1999/024393A1 |
The present invention includes a number of novel intermediates such as the (S)-secondary alcohol of formula (VIIIA) X¿2?-CH¿2?-C*H(OH)-CH¿2?-NH-CO-R¿N? and processes for production of pharmacologically useful oxazolidinones.
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WO/1999/021821A1 |
A process for the purification of an aqueous alkanolamine which process comprises subjecting the alkanolamine to a distillation process carried out in one or more film-type evaporators and comprising at least two steps, wherein in the fi...
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WO/1999/021811A1 |
A method of separating optical isomers which permits optical resolution of compounds which have been incapable of satisfactory optical resolution under the conventional reversed-phase conditions. Specifically a method of separating optic...
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WO/1999/020667A1 |
A novel high-performance polymer which is usable as a polymeric coagulant in centrifugal drying, belt-press drying, or the like and can attain a satisfactory dewatering rate. The polymer is a water-soluble vinyl polymer (A) which contain...
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