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WO/2004/060854A1 |
The present invention relates to a process for the minimization of volatile organic sulphur byproducts in dimethyl sulfate quaternization of amines made with hypophosphorous acid, which leads to the formation of an odor stable product.
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WO/2004/058982A2 |
Processes for the preparation of compounds having a chiral carbon substituted with an amine are disclosed. The processes include admixing a ketone with an amine in the presence of a catalyst having a chiral phosphine ligand and an acid. ...
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WO/2004/037767A1 |
The invention relates to an improved method for producing levosalbutamol or the pharmacologically acceptable salts thereof on an industrial scale by using asymmetric hydration as a key step and, optionally, a special sequence of successi...
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WO/2004/035534A2 |
The invention relates to novel compounds of 4-[2-(4-arylpiperazin-1-yl)-ethoxy]benzo-1,2-diamine I, to the derivatives thereof in the form of benzoimidazole-2-thiones, benzoimidazoles and benzotriazoles, to the use of the pharmacological...
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WO/2004/029004A1 |
The invention relates to the use of an ionic liquid as a matrix liquid for organic synthesis in a homogeneous phase on a soluble medium, said ionic liquid being present in the form of a liquid or solid at room temperature, having formula...
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WO/2004/026807A1 |
Intermediates represented by the following general formula (I), etc. which are useful in producing phenoxyacetic acid derivatives represented by the following general formula (X) or pharmaceutically acceptable salts thereof having an eff...
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WO/2004/024672A1 |
The invention relates to (1S)-1-isobutoxymethyl-3- methylbutylamine useful as an intermediate in the synthesis of sodium (2S, 3S)-3-[[(1S)-1-isobutoxymethyl-3-methylbutyl]- carbamoyl]oxirane-2-carboxylate and a process for production the...
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WO/2004/024671A1 |
The invention relates to a method for producing dialkyl amino ethers by reacting dialkyl amino alcohol compounds with acetylene, followed by hydrogenation.
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WO/2004/022521A1 |
An optically active 1-(fluoro-, trifluoromethyl- or trifluoromethoxy-substituted phenyl)alkylamine N-monoalkyl derivative represented by the formula [4] is produced by a process including (a) reacting an optically active secondary amine,...
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WO/2004/022522A1 |
The invention relates to a method for the production of optically active 2-amino-, 2 chloro-, 2-hydroxy- or 2-alkoxy-1-alkanoles by catalytic hydrogenation of corresponding optically active 2-amino-, -chloro-, 2-hydroxy- and 2-alkoxy car...
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WO/2004/020390A1 |
The invention relates to a method for the production of 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol with high stereoselectivity and in high yield.
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WO/2004/020389A1 |
The invention relates to methods for the enantioselective production of amino alcohols of formula (I), wherein R1, R2 and n have the meaning cited in the description.
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WO/2004/016579A1 |
The invention relates to a method for producing 3-amino-4,4,4-trifluorocrotonic acid esters of formula (I) or their E/Z isomers or tautomeric forms, whereby R1 and R2, independent of one another, represent hydrogen, an optionally substit...
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WO/2004/014551A2 |
An immobilised nitrogen-containing ligand is described comprising the reaction product of a compound of formula (I) wherein R5, R6, R7 and R8 are independently hydrogen, a saturated or unsaturated C1-C10 alkyl group, an aryl group, a ure...
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WO/2004/013081A1 |
Process for the preparation of primary amines of formula (I): on enclosed where R3 represents an alkyl, cycloalkyl or aralkyl group, by reaction of a triazolium salt of formula (II): (formula see on enclosed paper version) where R1 and R...
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WO/2004/013083A1 |
Nolomirole hydrochloride in a highly purified crystalline polymorphic form I, the process for its preparation and pharmaceutical preparations thereof for the treatment of patients suffering of cardiovascular diseases such as congestive h...
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WO/2004/013082A2 |
The invention relates to methods for producing 4-[aminoalkoxy]benzylamines of general formula (I) by means of catalytic hydrogenation of 4-[aminoalkoxy]benzonitriles of general formula (II). In the compounds of general formulae (I) and (...
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WO/2004/011416A1 |
The invention provides a crystalline salt form of a novel β2 adrenergic receptor agonist. The invention also provides pharmaceutical compositions comprising the crystalline form, formulations containing the pharmaceutical compositions, ...
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WO/2004/009529A1 |
Disclosed herein is a process for the reductive alkylation of primary amines to form secondary amines, by high pressure reaction of the primary amine with an alkylating agent and hydrogen in the presence of a catalyst which comprises met...
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WO/2004/007407A2 |
The present invention includes methods and compositions for increasing the fluorous nature of an organic compound by reacting it with at least one fluorous compound to produce a fluorous tagged organic compound. The increased fluorous na...
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WO/2004/005239A1 |
The invention relates to a process for the synthesis of N-monosubstituted β-amino alcohols of formula (I) and/or an addition salt of a proton acid, wherein R1 and R2 independently represent alkyl, cycloalkyl, aryl or aralkyl, each being...
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WO/2004/005251A1 |
Novel phenol derivatives represented by the formula (1) [wherein the carbon atom indicated by (S) is of the S configuration and Z represents the group represented by the formula (2) or the formula (3) (wherein the carbon atom indicated b...
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WO/2004/002939A2 |
The present invention relates to a compound formula [I]: Y is bond, -0-(CH2)n- (in which n is 1, 2, 3 or 4), etc., Z is cyano, tetrazolyl, etc., R1 is hydrogen, lower alkyl, etc., R2 is hydrogen or an amino protective group, R3 is hydrog...
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WO/2004/000782A1 |
The present invention relates to a preparation method of valienamine from acarbose and/or acarbose derivatives using organic acid TFA(trifluoroacetic acid). By using the method of the present invention, valienamine, the core precursor of...
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WO/2003/104186A1 |
A process for easily producing, from an easily available inexpensive starting material, an optically active ß-amino alcohol useful as an intermediate for medicines. An easily available &agr -substituted ketone is reacted with an optical...
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WO/2003/101931A2 |
The invention disclosed in this application relates to an improved process for the preparation of compounds of formula (I): R1R2NCH2CH2CH2CH(OR3)2; wherein, R1 = R2 = C1-C16 alkyl; C3-C7 cycloalkyl; R1 = C1-C16 alkyl; R2 = C3-C7 cycloalk...
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WO/2003/101932A2 |
A compound of Formula (IA) or Formula (IB) wherein R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, R¿6?, R¿7?, and R¿8? are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds,...
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WO/2003/096989A2 |
Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the treatment of infectious diseases are provided....
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WO/2003/095416A1 |
The present invention relates to a method for preparing 2-Alkoxyphenoxyethanamines and more particularly relates to the preparation of the new chemical entity 2-Alkoxyphenoxyethylacetamides, in particular as intermediates in said method....
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WO/2003/093218A1 |
The invention concerns a method for making dimethylaminoethyl acrylate by transesterification from dimethylaminoethanol and ethyl acrylate in the presence of a transesterification catalyst and at least one polymerisation inhibitor, the a...
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WO/2003/092667A1 |
A composition and a kit for treating cancer comprising N, N-dimethylphytosphingosine. The composition represses the activity of sphingosine kinase, and therefore, intercepts various mechanisms which sphingosine kinase induces. For exampl...
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WO/2003/093219A1 |
The invention provides compounds of formula (I) and their medicinal salts: In which, R1 is H, CI or Br; R2 is selected from electron-withdrawing group of -CF3, -CN, -F, -COSO3H, -CF3SO3 and -NO2; R3 is C1-10 linear or branched alkyl, C2-...
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WO/2003/091199A1 |
The invention relates to a method for converting a tertiary OH group of an organic compound into a tertiary CI group of said organic compound using a solvent selected from the group containing toluene, o-xylene, m-xylene, p-xylene and mi...
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WO/2003/091198A1 |
Either an ionic liquid which is liquid at 25°C or an organic solution containing one or more ionic compounds is contacted with an electrode in an atmosphere having a dew point of -40°C or lower or at a reduced pressure of 76 Torr or lo...
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WO/2003/087081A1 |
The antidepressant drug Escitalopram is prepared from 5-bromophthalide via the diol intermediate (4-bromo-2-(hydroxymethyl)phenyl)-(4-fluorophenyl)methanol. The racemic diol intermediate is converted to an enantiomerically enriched form ...
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WO/2003/087033A1 |
Process for the preparation of enantiomerically enriched amino aldehydes and amino alcohols, wherein a corresponding enantiomerically enriched amino nitrile is subjected to hydrogenation in the presence of hydrogen, a hydrogenation catal...
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WO/2003/084919A2 |
The invention concerns novel methods for preparing combretastatins by Wittig condensation between nitromethoxy-benzaldehyde and a trimethoxybenzyl phosphonium salt or inversely a nitromethoxybenzyl phosphonium salt with trimethoxybenzyla...
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WO/2003/082835A1 |
Processes for the preparation of a compound of formula (IIIA)(I), or a salt thereof; wherein; Z represents a bond, CO, SO2, CR10R7(CH2)n, (CH2)nCR10R7, CHR7(CH2)nO, CHR7(CH2)nS, CHR7(CH2)nOCO, CHR7(CH2)nCO, COCHR7(CH2)n or SO2CHR7(CH2)n;...
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WO/2003/080556A1 |
The present invention relates to an amine derivative of formula I, its isomer, racemate or optical isomer, pharmaceutical salt, its amide or ester, a medicinal composition containing these, and the preparation of the same. The invention ...
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WO/2003/080557A1 |
The invention relates to substituted 4-aminocyclohexanols, to methods for producing them, to drugs containing said compounds and to the use of substituted 4-aminocyclohexanols in the production of drugs for the treatment of various indic...
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WO/2003/080560A1 |
A process for the preparation of hydroxy (cycloalkane/cyclokene) phenylethyl amine of the general formula (III) comprising alkylation of its precursor amine of general formula (II) which is in turn produced by an effective reduction proc...
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WO/2003/080561A1 |
The invention provides a process by which voglibose can be safely and easily prepared at a low cost&semi intermediates favorably usable in the process&semi and a process for preparation of the intermediates, specifically, inositol deriva...
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WO/2003/078380A2 |
A process is described for the preparation of (RR,SS˜2-dimethylaminomethyl-1-(3-methoxyphenyl) cyclohexanol hydrochloride (hereinafter 'tramadol hydrochloride'), which process comprises reacting a mixture of (RR,SS)- and (RS,SR)-2-dimet...
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WO/2003/076386A2 |
Disclosed are catalysts, the catalytically active mass of which contains 22 to 40 percent by weight of oxygen-containing compounds of zirconium, calculated as ZrO2, 1 to 30 percent by weight of oxygen-containing compounds of copper, calc...
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WO/2003/072246A2 |
A catalyst which comprises a carrier and silver deposited on the carrier, which carrier has a surface area of at least 1 m2/g, and a pore size distribution such that pores with diameters in the range of from 0.2 to 10 µm represent at le...
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WO/2003/066570A1 |
The present invention relates to a process for the preparation of N-aryl amine and N- aryl amide compounds. Generally, the process of the present invention involves reacting a compound having a primary or secondary amino or amido group w...
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WO/2003/055599A1 |
One aspect of the invention relates to a catalyst composite containing an extruded catalyst support containing an extruded activated carbonaceous material having specifically a defined pore structure. For example, the extruded activated ...
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WO/2003/055849A1 |
The invention relates to a method for the production of solutions a quaternary cation and an anion from a deprotonated hydroxy aromatic in an organic solvent by a reactive extraction of a quaternary salt in the presence of an aqueous hyd...
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WO/2003/055474A1 |
1R,2S-Methoxamine may be used topically for effective treatment of faecal incontinence at low doses without local or systemic side effects, for example, without affecting blood pressure. 1R,2S-Methoxamine may be used to treat other distu...
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WO/2003/051819A1 |
The invention relates to substituted 1,5-diaminopentan-3-ol compounds, methods for production and use thereof for the production of medicaments and medicaments comprising the same.
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