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WO/2001/025185A1 |
A process for the preparation of a piperazine derivative of formula (V), which comprises reacting 1-methyl -3-phenylpiperazine with 2-chloro-3-cyanopyridine in the presence of a base and an alkali metal halide in an aprotic polar organic...
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WO/2001/025294A1 |
The invention relates to a method for producing Mannich adducts that contain polyisobutylene phenol by: a) alkylating a phenol with highly-reactive polyisobutylene at a temperature lower than approximately 50 °C and in the presence of a...
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WO/2001/023345A1 |
A process for the preparation of a piperazine derivative represented by formula (V) which comprises reacting 1-methyl-3-phenylpiperazine with 2-chloro-3-cyanopyridine in the presence of a base and an alkali metal halide in an aprotic pol...
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WO/2001/021601A1 |
The invention concerns an oxazolin-2 compound of formula (I) wherein: R represents a phenyl group; R1 represents an ethyl group; and R2 represents an alkyl or aryl group; and its use for preparing trimebutine. More particularly, the inve...
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WO/2001/017944A1 |
An industrially advantageous process for producing optically active 4-amino-2-methylbutan-1-ol which is useful as an intermediate in synthesizing optically active medicines and pesticides. Racemic 4-amino-2-methylbutan-1-ol is treated wi...
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WO/2001/017945A1 |
Disclosed are cationic alkyl alkoxylate derivatives having formula (IV): wherein at least one of R?1¿, R?2¿, R?3¿ or R?4¿ is independently an alkyl alkoxylate group having the following formula: -(R?5¿-O)¿m?-R?6¿ wherein R?5¿ is ...
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WO/2001/018005A1 |
The invention provides an industrially advantageous process for the preparation of antimicrobial drugs and industrially advantageous processes for the preparation of intermediates of antimicrobial drugs. Specifically, a process for prepa...
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WO/2001/017946A1 |
Disclosed are tertiary alkyl alkoxylate derivatives having formula (I) wherein at least one of R?1¿, R?2¿, or R?3¿ is independently an alkyl alkoxylate group having formula (II)-((R?5¿-O)¿m?-R?6¿, wherein R?5¿ is independently a l...
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WO/2001/014299A1 |
Chiral ligands and transition metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The chiral ligands include phospholanes, P, N ligands, N, N ligands, biphenols, and chelating phosphines. The ferroc...
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WO/2001/014313A1 |
A process for making a tertiary amine ester of formula (I), the process comprising: (a) reacting a ketone or an aldehyde having formula (III) with a glycol to form a ketal or an acetal; (b) reacting the ketal or the acetal with acrylonit...
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WO/2001/012583A1 |
This invention relates to an improved industrial scale production method for adrenaline or an addition salt thereof employing an asymmetric hydrogenation reaction as the key reaction step and a special sequence of subsequent steps, where...
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WO/2001/010816A2 |
The invention relates to substituted 2-dialkylaminoalkylbiphenyl derivatives, a method for the preparation thereof, drugs containing them and the use thereof for the production of drugs.
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WO/2001/009081A1 |
Described is method for preparing tertiary amines comprising sequential, exhaustive alkylation of a hydroxylamine derivative and cleavage of the O-N bond using the following steps: (a) reacting the hydroxylamine derivative with an alkyla...
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WO/2001/009082A1 |
The invention relates to a process for preparing an esterquat composition comprising (a) reacting a tertiary amine according to formula (I) wherein R?1¿ represents a C¿3?-C¿6? hydrocarbon group, R?2¿ represents a C¿3?-C¿6? hydrocar...
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WO/2001/007397A1 |
Process for producing venlafaxine and/or physiologically acceptable addition salts thereof, consisting in reacting a compound having the general formula (II) wherein R is a C¿1?-C¿10? alkyl group, aryl group, aralkyl group or cycloalky...
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WO/2001/005741A1 |
The invention relates to the production of amines, including chiral amines, by reacting aldehydes or ketones with ammonia or primary or secondary amines in the presence of hydrogen and in the presence of homogeneous metal catalysts, unde...
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WO/2001/005743A1 |
The invention relates to substituted 3-amino-2-benzyl-1-phenyl-propane derivatives, to methods for producing them, to medicaments containing these compounds and to the use of these substances for producing medicaments.
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WO/2001/002334A1 |
The objective bicyclic amino alcohol (IV) is produced by reacting nopinone (I) (starting material) with XCH¿2?COOR?1¿ (wherein X is halogeno; and R?1¿ is alkyl) in the presence of an additive and a base to form a compound (II), conver...
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WO/2001/000564A1 |
The invention relates to a method for producing amines by reacting aldehydes with ammonia in the presence of hydrogen and of a hydrogenating catalyst while adding disodium tetraborate.
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WO/2001/000565A1 |
Disclosed are methods of producing of alkoxy arylamine compounds which find particular use in the syntheses of pharmaceutical drug. The alkoxy arylamine compounds generally have the formula: H¿2?N-Ar-OR wherein Ar is an unsubstituted or...
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WO/2000/078898A1 |
This invention relates to a composition, comprising: (I) an aromatic Mannich compound derived from: (A) a hydroxy containing aromatic compound having formula (A-1) wherein in Formula (A-1): Ar is an aromatic group; m is 1, 2 or 3; n is a...
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WO/2000/078705A1 |
The invention relates to a method for separating the diastereomer bases of 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-cyclohexanol, whereby the separation of said diastereomer bases takes place by the formation of a base hydrate.
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WO/2000/076953A1 |
The invention concerns compounds of formula (I) wherein A, X, Y, n, R¿1?, R¿2? and R¿3? are as defined in Claim 1. Said compounds are specifically binding to sigma receptors particularly those of the peripheral nervous system.
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WO/2000/069806A1 |
The invention relates to amines of general formula (I) or to the mirror image thereof, wherein R?1¿ means hydrogen, C¿1-6?-alkyl, aryl-C¿1-4?-alkyl or acyl. The inventive amines are produced by means of steteroselective hydrogenation ...
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WO/2000/069807A1 |
A process for the removal of primary and secondary amine and alkanolamine impurities from aqueous tertiary amine and alkanolamine solutions without affecting the tertiary amine and/or alkanolamine by treating these solutions with a monoa...
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WO/2000/068182A1 |
The present invention relates to processes for crystallizing (R)-fluoxetine hydrochloride.
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WO/2000/068238A1 |
Synthetic methods for convenient large scale preparation of D-erythro sphingosines and ceramides of high isomeric purity are described.
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WO/2000/068181A2 |
The invention relates to a process for preparing (1R,2S,4R) -(-)-2-[(2'- {N,N-dimethylamino} -ethoxy)] -2-[phenyl] -1,7,7-tri- [methyl] -bicyclo [2.2.1] heptane and pharmaceutically acceptable acid addition salts thereof with higher yiel...
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WO/2000/068183A2 |
The invention relates to high purity (1R,2S,4R)-(-)-2- [(2'-{N,N- dimethylamino} -ethoxy)] -2-[phenyl] -1,7,7-tri-[methyl] -bicyclo[2.2.1] heptane and pharmaceutically acceptable acid addition salts thereof containing not more than 0.2 %...
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WO/2000/066538A1 |
A process for the alkoxylation of a polyetheramine to form an etheramine alkoxylate. In the process, a polyetheramine is reacted with an alkylene oxide in the presence of an alcohol to form the etheramine alkoxylate. The alcohol serves a...
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WO/2000/064855A1 |
The present invention provides a process for epimerizing the isomers of fluoxetine to the racemate.
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WO/2000/061540A1 |
The present invention provides processes for the preparation of 3-aryloxy-3-arylpropylamines and intermediates thereof using an nucleophilic aromatic displacement in 1,3-dimethyl-2-imidazolidinone or N-methylpyrrolidinone.
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WO/2000/061708A1 |
The invention relates to polyalkene alcohol polyetheramines of formula R?1¿-(CH¿2?)¿n?-(O-A)¿m?-NR?2¿R?3¿, wherein R?1¿ represents a polyalkene radical derived from C¿2?- to C¿30?-alkenes with a number average molecular weight o...
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WO/2000/059883A2 |
The invention relates to a method for producing N-aryl-aza-heterocycles of general formula (I) in which: R1, R2, R3, R4 and R5 are the same or different and represent a hydrogen atom, a nitro group, a cyano group, an alkoxycarbonyl group...
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WO/2000/058262A1 |
The present invention provides stereospecific processes for the preparation of tomoxetine using a nucleophilic aromatic displacement, processes to intermediates thereof, and intermediates thereof.
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WO/2000/053571A1 |
Processes for preparing $g(a)-amino halomethyl ketones or N-protected $g(a)-amino halomethyl ketones from specific 3-oxazolidin-5-one derivatives through 5-halomethyl-5-hydroxy-3-oxazolidine derivatives. The processes are suitable for in...
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WO/2000/053570A1 |
Esterquats, their intermediates, a process to make the esterquats, and their use as a fabric softener wherein said esterquats are of the formula: R¿4?[R¿5?R¿6?N?+¿Z]¿n? X?-¿, wherein Z is covalently bonded to the nitrogen atom and ...
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WO/2000/053567A1 |
Disclosed is a method for preparing serinol (2-amino-1,3-proanediol). From nitromethane, para-formaldehyde and sodium hydroxide, 1-nitro-1,3-propanediol sodium salt is prepared as a medical intermediate. In a fixed bed, this intermediate...
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WO/2000/051546A2 |
Methods and compositions are disclosed which utilize metabolites of bupropion for treating disorders ameliorated by inhibition of neuronal monoamine reuptake. Such disorders include, but are not limited to, erectile dysfunction, affectiv...
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WO/2000/050379A1 |
The invention relates to a process for the preparation of (1R,2S,4R) -(-) -2- (2-dimethylaminoethoxy) -2 -phenyl -1,7,7- trimethylbicyclo [2.2.1] heptane of Formula (I) and pharmaceutically acceptable acid addition salts thereof starting...
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WO/2000/050377A1 |
A method for selective mono-N-alkylation of primary amines to produce secondary amines that are substantially free of overalkylated tertiary amines and quaternary ammonium salts, under mild reaction conditions without the necessity of pr...
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WO/2000/050378A2 |
The present invention relates to a method of preparing a 1-nitro-3-substituted-3-amino-2-propanol diastereomer represented by Structural Formula (I): In Structural Formula (I), R is an amine protecting group, and R?1¿ is an amino acid s...
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WO2000002887B1 |
One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and car...
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WO/2000/048987A1 |
The invention relates to novel substituted 3-phenoxy or 3-phenylalkyloxy-2-phenyl-propylamines of general formula (1), to methods for producing them and to their use as medicaments.
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WO/2000/048986A2 |
A low-odor choline salt purified to an extent wherein the equilibrium concentration of trimethylamine in the atmosphere above the choline salt is less than 0.2 parts per billion.
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WO/2000/047546A1 |
The invention relates to a method for the racemization of optically active amines by reacting the optically active amine in the presence of hydrogen and of a hydrogenation or dehydrogenation catalyst at an elevated temperature. According...
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WO/2000/047545A1 |
The invention relates to a method for producing racemic amines of formula (I), in which R?1¿ and R?2¿ are not the same and R?1¿, R?2¿, R?3¿ are alkyl-, cycloalkyl-, arylalkyl-, aryl-, heteroaryl rests and heterocyclic rests and R?3Â...
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WO1999063936A9 |
Novel multi-binding compounds (agents) which bind endothelin receptors are used to treat disorders affecting the cardiovascular, renal, endocrine and nervous systems in mammals that are mediated by the endothelin receptors, such as conge...
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WO/2000/046179A1 |
A process for producing an aromatic primary amine, characterized by hydrogenating an aromatic nitrile at a low partial pressure of hydrogen in a heterogeneous system comprising a nonreducing polar solvent and a supported nickel catalyst ...
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WO/2000/044701A1 |
Norbornadienyl derivatives represented by general formula (1) (wherein R?1¿ and R?2¿ are the same or different and each is either an aromatic group containing a heteroatom or a phenyl group having one to three substituents selected fro...
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