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WO/2005/082835A1 |
Severely sterically hindered secondary aminoether alcohols are prepared by reacting organic carboxylic, organic carboxylic acid halides, acid anhydrides or a ketene with an alkyl, alkaryl or alkylhalo sulfonate to yield a sulfonic. Carbo...
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WO/2005/082837A1 |
Severely sterically hindered secondary aminoether alcohols are prepared by reacting acid anhydrides or organic carboxylic acid halides with S03 to yield a sulfonic carboxylic anhydride compound which is then reacted with a dioxane to cle...
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WO/2005/082838A1 |
À process for the preparation of optically active substituted alpha-indanyl amide derivatives of formula (I), which comprise*: - an asymmetric hydrogenation reaction of an en-amide derivative óf formula (III) in presence of hydrogen ...
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WO/2005/082836A1 |
Severely sterically hindered secondary aminoether alcohols are prepared by a process comprising reacting a ketene with sulfuric acid to produce an anhydride which is then reacted with, to cleave the ring of, a dioxane to yield a cleavage...
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WO/2005/080370A1 |
Provided is a process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols, particularly of (S)-(-)- and (R)-(+)-3-N-methylamino-l-(2-thienyl)-1-propanol, by asymmetrically hydrogenating salts of a carboxylic acids ...
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WO/2005/077870A1 |
The invention concerns a method for producing optically active hydroxy-, alkoxy-, amino-, alkyl-, aryl- or chlorine-substituted alcohols or hydroxycarboxylic acids having 3 to 25 carbon atoms or their acid derivatives or cyclization prod...
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WO/2005/077871A1 |
The invention concerns a method for producing optically active hydroxy-, alkoxy-, amino-, alkyl-, aryl- or chlorine-substituted alcohols or hydroxycarboxylic acids having 3 to 25 carbon atoms or their acid derivatives or cyclization prod...
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WO/2005/077863A1 |
The invention relates to a method for establishing carbon-carbon bonds by reacting electropohilic substrates that have a solvolysis rate kEtOH (25°C) > 10-6 s-1 and &pgr compounds. The method is characterized by generating the intermedi...
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WO/2005/069930A2 |
A process for preparing a non-racemic aminoalcohol is provided. The process includes the step of contacting a chiral alpha-amino carbonyl compound and hydrogen, in the presence of a non-racemic hydrogenation catalyst, at a temperature, p...
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WO/2005/070871A2 |
The application relates to novel amino alcohols of general formula (I) where R, R1, R2, R3, R4, R5, X1 and X2 each have the definitions illustrated in detail in the description, to a process for their preparation and to the use of these ...
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WO/2005/070869A1 |
The present invention describes an improved catalyst and process for the selective hydrogenation of nitro aromatics, nitrosoaromatics and aromatic hydroxyl amines to their corresponding amines using gaseous hydrogen, in the presence of s...
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WO/2005/070870A2 |
The application relates to novel amino alcohols of the general formula (I) where R, R1, R2, R3, R4, R5 and R6 each have the definitions illustrated in detail in the description, to a process for their preparation and to the use of these ...
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WO/2005/068403A2 |
A method for the selective reduction of an aromatic compound. The present invention provides a method for preventing the reduction of at least one halogen substituted aromatic ring of an aromatic compound, while allowing the reduction of...
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WO/2005/063680A1 |
The present invention provides a process for the preparation of arylamines comprises reacting aryl halide and aryl amine/heterocyclic amine. The said process is carried out in the presence of a solvent, catalyst and a base.
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WO/2005/063682A1 |
The invention relates to an improved method for producing chiral or enantiomer-enriched beta amino acids, -aldehydes, -ketones and gamma-amino alcohols, during which an allyl amine of formula (I), in which: R1 represents an alkyl radical...
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WO/2005/061432A1 |
Racemic tolterodine free base in crystalline form, tolterodine with improved purity, compositions and uses thereof, and processes of preparing the same.
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WO/2005/061431A1 |
The invention relates to a method of obtaining tolterodine. The inventive method consists in: reacting a compound having formula (II), wherein R is a hydroxyl protective group and the asterisk indicates an asymmetric carbon atom, with di...
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WO/2005/058794A1 |
This application discloses an improved process for the preparation of N-methyl-N-(1-naphthylmethyl)-6,6-dimethyl-2-hydroxyheptan-4
-ynyl-1-amine, a key intermediate used in the synthesis of terbinafine ((E)-N-(6,6-dimethyl-2-hepten-4-yny...
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WO/2005/058795A1 |
The invention relates to a process for the treatment of an alkanolamine, e.g. triethanolamine, having an improved colour stability over time. The process comprises contacting the alkanolamine with hydrogen in the presence of a supported ...
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WO/2005/058796A2 |
A process for preparing venlafaxine in a high yield as well as processes for producing venlafaxine hydrochloride of form I having a very high polymorphic purity are described.
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WO/2005/056514A2 |
There is provided a process for the preparation of substituted amino alcohols HO-(CH2)n-NR1R2 from haloalcohols HO-(CH2)n-X, where X is Cl, Br or I, bz reaction with an amine HNR1R2, in water as solvent at a temperature range of about 20...
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WO/2005/049549A1 |
A process for the synthesis of lipid cations having general formula (6) in which: R1 represents a lipophilic chain; R2, R3, R4, which are identical or different from one another, represent C1-C10 alkyl, C1-C10 alkenyl, or C1-C10 alkynyl ...
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WO/2005/049560A2 |
A process for the preparation of anti-depressant, compound of formula (I) or its pharmaceutically acceptable salts said process comprising reducing compound of formula (IIa) (wherein R is CONMe2) with sodium bis(2-methoxyethoxy) aluminiu...
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WO/2005/049547A1 |
Provided herein are processes for the preparation of 1,2,3,4-cyclohexanetetrol derivatives, which are useful intermediates for the synthesis of voglibose; processes for the preparation of substituted 2,3,4,5-tetrahydroxycyclohexanone; an...
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WO/2005/046568A2 |
Metoprolol manufacturing process with optimized reaction temperatures and reactant molar ratios, to avoid the manufacture of excessive epoxide intermediates, thus avoiding the need for purification of epoxide intermediates, thus achievin...
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WO/2005/037769A1 |
Disclosed is a method for the distillative separation of mixtures containing ethyleneamines, the separation process being carried out in one or several fractionation columns. The ethyleneamines particularly represent ethylenediamine (EDA...
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WO/2005/035481A2 |
The invention relates to a method for distillative separation of triethanolamin from a substance mixture consisting of mono- di-, and triethanolamin, ethanolamin-ether and water obtainable by an ammonia and ethylene oxide reaction in a l...
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WO/2005/030698A1 |
The invention relates to processes for the preparation of pure voglibose. The invention also relates to the preparation of acid addition salts of voglibose. More particularly, it relates to the preparation of crystalline hydrochloride sa...
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WO/2005/023754A1 |
The invention relates to the preparation of (meth)acrylate di-ammonium salts responding to formula (I) wherein R1 represents hydrogen or methyl, each R2 , independently, represents an alkyl comprising from 1 to 4 carbon atoms, each R3, i...
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WO/2005/019164A2 |
The present invention relates to a novel process for the preparation of phenethanolamine derivatives, which process comprises the step of reacting a compound of formula RO(CH2)nBRaRb with a compound of formula (II).
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WO/2005/012227A2 |
The present invention relates to processes for preparation of 2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethyl-phenol
of Formula I, which is a metabolite of tolterodine.
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WO/2005/009928A2 |
The present disclosure provides methods of synthesizing alkylating agents and methods of use.
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WO/2005/005356A2 |
Method of preparing an enantiomerically enriched compound of formula (II) comprising enantioselective hydrogenation of a compound of general formula (I): where W, X and Z have the meanings indicated in the description, to give a compound...
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WO/2005/000788A1 |
The invention relates to a method for dehydrating substituted 4-dimethylamino-2-aryl-butan-2-ol compounds and to methods for producing substituted dimethyl-(3-aryl-butyl)-amine compounds by means of heterogeneous catalysis.
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WO/2004/113268A1 |
The present invention relates to a process for preparing an ethanolamine having an improved colour quality. The process comprises contacting ethanolamine with an activated carbon free of one or more metals chosen from Re, Ru, Rh, Pd, Os,...
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WO/2004/108657A1 |
Disclosed is a preparation method of valienamine using solid catalysts. The valienamine, which has strong inhibiting activity, is prepared by selective hydrolysis of acarbose and acarbose derivatives, validamycin and validamycin derivati...
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WO/2004/106278A1 |
The invention provides a process for producing N-alkylaminoalkyl (meth)acrylates reduced in the content of low-boiling components, particularly raw material components without troublesome operation and special equipment, that is, a proce...
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WO/2004/103990A1 |
A process for producing an optically active N-monoalkyl3-oxo-3-arylpropylamine compound represented by the formula (3): (wherein symbol * indicates an asymmetric carbon atom and R1 represents optionally substituted C1-5 alkyl), charact...
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WO/2004/101492A1 |
The invention relates to a method for isolating toremifene from a mixture of toremifene and its corresponding E isomer. The method comprises contacting the isomer mixture with a first solvent comprising methanol, allowing toremifene to c...
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WO/2004/101581A2 |
The present invention relates to novel nitrogen-containing monodentate phosphane ligands of formula (I) and to their use in catalytic reactions, especially in the improvement of haloaromatic compounds.
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WO/2004/096740A2 |
A process for preparing (+)-p-mentha-2,8-diene-1-ol comprising reacting (+)-limonene oxide with at least one amine in the presence of at least one Lewis acid to form amine adduct intermediates. The amine adduct is then oxidized to form a...
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WO/2004/089871A1 |
A method for producing trans-2-[(&agr -methylbenzyl)amino] cyclopentanol being highly pure as a diastereoisomer, which comprises reacting a mixture of two diastereoisomers of trans-2-[(&agr -methylbenzyl)amino]cyclopentanol represented b...
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WO/2004/089872A1 |
The invention relates to a compound of general formula (I) wherein A represents deuterium or hydrogen, R represents a group selected from C1-6 alkyl, C3-10 cycloalkyl or phenyl, which can be substituted by C1-3 alkoxy, fluorine, chlorine...
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WO/2004/087628A1 |
This invention relates to a process of asymmerically alkynating ketones or ketoimines by asymmerical addition of terminal alkynes to trifluoromethyl ketones or trifluoromethyl ketoimines in the presence of copper or zinc salt and a kind ...
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WO/2004/080934A2 |
A process for the preparation of a compound of formula (I), wherein R1, and R2 are ortho or para substituents, independently selected from the group consisting of hydrogen, hydroxyl, C1-C6 alkyl, C1-C6 alkoxy, C7-C9 aralkoxy, C2-C7 alkan...
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WO/2004/078700A1 |
The invention relates to 3,3-diarylpropylamines derivatives and processes for producing them. More particularly, it relates to the preparation of pure tolterodine or a pharmaceutically acceptable salt thereof and pharmaceutical compositi...
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WO/2004/078701A1 |
Compounds capable of giving novel materials which are excellent in heat resistance, mechanical characteristics, electrical characteristics, physical characteristics and so on and useful as interlayer dielectrics or protection films of se...
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WO/2004/072088A2 |
Palladum-phosphine complexes obtained by reacting a 5 compound of formula (1) below with a palladium compound: (wherein R1 is a hydrogen atom, an alkyl group, a cycloalkyl group or a phenyl group which may be substituted; R2 and R3 are e...
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WO/2004/072028A2 |
A process is disclosed for preparing ortho substituted phenylamines comprising contacting phenylhydroxylamine, optionally substituted with at least one inert substituent, with a nucleophilic reagent in the presence of a manganese oxide a...
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WO/2004/063175A1 |
The invention disclosed in this application relates to an improved process for the preparation of the oxazolidinone of formula (I) It comprises (i) Preparing the 4-nitro-(S)-phenylalaninol of formula (IV) by conventional methods. (ii) Re...
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