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WO/2003/050062A2 |
Methods for production of chirally pure $g(a)-amino acids and N-sulfonyl $g(a)-amino acids are described. An aldehyde and a cyanide salt are reacted with an $g(a)-methylbenzylamine to afford a product. The product reacts with a strong ac...
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WO/2003/050074A1 |
The present invention discloses process for the preparation of (∓)-1-[2-(dimethylamino)-1-(4-methoxyphenyl)-ethyl] cyclohexanol hydrochloride (Venlafaxine hydrochloride) and its novel crystalline polymorphs designated as Form -I, Form ...
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WO/2003/050075A1 |
This invention relates to a highly thermally stable novel anhydrous crystalline polymorphic form of venlafaxine hydrochloride, methods for the preparation thereof, and its use.
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WO/2003/050063A2 |
A process is provided for preparing chirally pure S-enantiomers of $g(a)-amino acids comprising the steps of: a) preparing an organometallic reagent from an alkyl halide of the Formula (R)¿2?CH(CH¿2?)¿n?CH¿2?X; b) adding the organome...
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WO/2003/050076A1 |
This invention relates to novel crystalline polymorphic form of venlafaxine hydrochloride which exists in hydrated form (e.g., as a monohydrate), methods for the preparation thereof, and its use.
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WO/2003/048105A1 |
The present invention relates to a process for decolourising triethanolamine (TEA) characterized in that a coloured TEA is exposed to electromagnetic radiation of wavelength chosen within the range from 100 to 1200 nanometres (nm), for a...
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WO/2003/048104A1 |
The present invention provides an efficient method of making O-desmethylvenlafaxine by demethylating venlafaxine with a thiolate a nion.
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WO/2003/048082A2 |
The present invention relates to novel essentially pure venlafaxine and the process of preparation thereof. The present invention also relates to novel solvate forms of venlafaxine hydrochloride and the process of preparation thereof. Fu...
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WO/2003/046197A1 |
The invention relates to simple and efficient preparation of optically active 7−substituted−2−aminotetralins with industrial advantage. A process for preparation of optically active 7− substituted−2−aminotetralins or salts th...
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WO/2003/042166A2 |
The invention concerns a novel process for the preparation of 2-phenyl-2-hydroxy-N-[2-(3-alkoxy-4-hydroxyphenyl)-ethyl]-ac
etamides of the formula (I), wherein R1 is alkyl, R2 and R3 are each independently hydrogen or alkyl, and R4 is op...
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WO/2003/042161A1 |
The invention relates to new crystalline forms I, II and III (±)-1-[2-dimethylamino-1-(4-methoxy-phenyl)-ethyl]-cyclohex
anol-hydrochloride of the Formula (I) and hydrates thereof. The new polymorphs are of uniform morphology and can be...
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WO/2003/042134A2 |
Disclosed is a method for preparing tertiary amine compounds from primary amines and nitriles in the presence of hydrogen gas and a metal catalyst, or metal-containing catalyst composition, at a temperature from about 50 °C to about 200...
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WO/2003/037831A2 |
Disclosed is a method for preparing a 4-nitroso-substituted aromatic amine that includes contacting an amide compound with a nitroaromatic compound in the presence of a base and a solvent to directly prepare 4-nitroso-substituted aromati...
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WO/2003/035600A1 |
A process for producing an optically active benzocycloheptene derivative (X) which comprises reacting a compound (III) with an optically active compound (IV), reducing the resultant reaction product to obtain an optically active benzocyc...
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WO/2003/033455A1 |
Oligoamine compounds with anti-cancer and anti-proliferative activity are provided, as well as methods for making and using the compounds. The compounds are shown to be active against prostate cancer cell lines and against prostate cance...
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WO/2003/029236A1 |
The present invention provides a novel process for the preparation of Citalopram, a known antidepressant.
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WO/2003/029186A1 |
Compositions comprising (±)-2-((dimethylamino)methyl)cyclohexanone, a transition-metal salt, and an organic solvent and methods ofpreparing (±)-cis-2-((dimethylamino)methyl)-l-(aryl)cyclohexanols, in particular (±)-cis-2-((dimethylami...
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WO/2003/029208A2 |
The invention relates to a method for producing vanillylamine or one of the salts thereof, whereby a) vanillin is reacted with hydroxylamine or the salts of the same in the presence of an organic salt which can optionally be produced in ...
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WO/2003/024439A1 |
The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of...
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WO/2003/022796A1 |
The invention relates to a method for transesterifying methyl methacrylate involving catalysis, particularly zirconium acetylacetonate catalysis. The obtained esters of formula (I) are characterized by having an extremely low content of ...
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WO/2003/020686A2 |
The invention relates to a method for producing 4-amino-1-naphthol ethers which is characterized in that naphthol ethers are firstly produced from 1-naphthols, are subsequently transformed into corresponding 4-acetamino-1-naphthol ethers...
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WO/2003/018531A1 |
A method for the preparation of a compound of formula (VI): in which R¿2? is an optionally substituted C1-C6 alkyl; R¿4? is H, OH, an optionally substituted C1-C6 alkyl or an optionally substituted C1-C6 alkoxy; R¿5? is an optionally ...
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WO/2003/014060A1 |
The present invention relates to a cost effective and industrially advantageous process for the preparation of tolterodine and pharmaceutically acceptable salts thereof.
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WO/2003/014061A1 |
The invention relates to the production of amines by the reaction of aldehydes or ketones with ammonia or primary or secondary amines in the presence of a hydrogen-donor and the presence of homogeneous metal catalysts of the eighth sub-g...
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WO/2003/008370A1 |
The invention relates to substituted 4-aminocyclohexanols, methods for the production thereof, pharmaceuticals containing said compounds, and the use of substituted 4-aminocyclohexanols for producing pharmaceuticals for treating various ...
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WO/2003/006628A2 |
Disclosed are compounds that inhibit the microbial NAD synthetase enzyme. For example, disclosed are compounds of the formula Ar¿1?-X-Ar¿2?-Y-L-Z-Q, wherein Q is Q¿1?Ar¿3? or Ar¿3?Q¿1?; Ar¿1?, Ar¿2?, and Ar¿3? are independently ...
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WO/2003/006420A1 |
The present invention is directed to a method of converting an aryl compound to an aniline compound, comprising the steps of (1)providing an aryl compound containing a halide group or a sulfur-containing group; (2) reacting the aryl comp...
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WO/2003/004454A1 |
The invention relates to compounds of the following formula (I). In these compounds, R¿1?, R¿2?, R¿3? and R¿4? are each independently a substituted or unsubstituted cyclitol with a ring comprising six carbon atoms, or hydrogen, subst...
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WO/2003/003115A1 |
A process for purifying p-phenylenediamine color developers in their free-base form. The process includes subjecting a solution containing p-phenylenediamine-type free base color developer to short path distillation which includes at lea...
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WO/2003/000645A1 |
A specific aminostilbene derivative or a salt thereof such as (Z)−3,4,4',5−tetramethoxy−3'−aminostilbene, which is important as an active component of an anticancer drug or an intermediate for the production of the component, can...
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WO/2002/100817A2 |
The invention relates to a method for producing basic (meth)acrylic acid esters IV by means of transesterification of (meth)acrylic acid alkyl esters I in the presence of a catalyst and by reprocessing the reaction mixture by distillatio...
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WO/2002/100814A1 |
The invention relates to a method for producing (meth)acrylic acid esters IV by means of transesterification of a (meth)acrylic acid ester I with an alcohol R?2¿OH comprising at least one more carbon atom than the alcohol constituents (...
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WO/2002/100813A2 |
Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, -CH¿2?-or-CH¿2?CH¿2?-; W is a substituted or unsubstituted alkylene or a substituted or unsubsti...
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WO/2002/100815A1 |
The invention relates to a method for producing higher-molecular (meth)acrylic acid esters IV by the transesterification of a lower-molecular (meth)acrylic acid ester I with a higher-molecular alcohol R?2¿OH in the presence of a stabili...
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WO2001047866A9 |
The invention relates to substituted 1 and 2 naphthol Mannich bases, a method for the production thereof, medicaments containing said compounds and the use of said compounds in the production of medicaments.
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WO/2002/085877A2 |
Disclosed are intermediates and processes for preparing epoxides of the formula (1): where R and PROT are defined herein. These epoxides are useful as intermediates in the production of biologically active compounds, i.e., in the product...
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WO/2002/086037A1 |
The invention relates to a method for purifying a phenol derivative that is selected from among alkyl phenols with an average molecular weight of from 200 to 4000 and the Mannich adducts thereof. The inventive method is characterized by ...
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WO/2002/085838A1 |
The present invention relaters to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the ...
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WO/2002/076927A2 |
The invention relates to a method for the production of carboxylic acid amides, especially peptides, from an acid component in the form of a compound having at least one carboxy group and an amine component in the form of a compound havi...
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WO/2002/072542A2 |
NMDA receptor blockers, including pH-sensitive NMDA receptor blockers, are provided as neuroprotective drugs that are useful in stroke, traumatic brain injury, epilepsy, and other neurologic events that involve acidification of brain or ...
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WO/2002/072540A2 |
The present invention pertains to methods for preparing a compound of Formula (I), wherein A is O or N-L; each L is independently H or an acyl group; K is, together with the two contiguous linking carbon atoms, a phenyl ring, a 5- or 6-m...
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WO/2002/068504A1 |
The invention relates to addition compounds of formula (1) in which: n is a number from 1 to 10; Z represents a group -CH¿2?-CH¿2?-, -CH¿2?-CH(CH¿3?)-, -CH(CH¿3?)-CH¿2?- or a combination thereof; s is number from 1 to 200; B repres...
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WO/2002/066414A1 |
The invention relates to a method for isolating and purifying (1RS,2RS)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-cycl
ohexanol as a saccharinate from a mixture of the diastereomers (1SR,2RS)-2-[(dimethylamino)methyl]-1-(3-methoxyphe...
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WO1999064055A9 |
Disclosed are multibinding compounds which are agonists, partial agonists, inverse agonists or antagonists of the 5HT4 receptors, which are involved in gastrointestinal disorders. The multibinding compounds of this invention containing f...
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WO/2002/064544A1 |
A process for industrially producing in a high yield 1,3-bis(3-aminophenoxy)benzene, which is effective as, e.g., a material for polyimides having high heat resistance, which comprises reacting 1,3-difluorobenzene with an alkali metal sa...
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WO/2002/062308A2 |
Primary intermediates for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): where R¿1?, and R¿2? are each individually selected from a hydrogen atom, a C¿1? to C¿3? alkyl group, a C¿...
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WO/2002/060857A1 |
The present invention relates to novel pharmaceutical formulations and methods of using Form A of fluoxetine hydrochloride.
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WO/2002/058632A2 |
Primary intermediates for hair coloring compositions for oxidative of hair are compounds of the formula (1): where R¿1? and R¿2? are each individually selected from a hydrogen atom, a C¿1? to C¿3? alkyl group, a C¿1? to C¿5? mono o...
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WO/2002/058630A2 |
Primary intermediate for hair coloring compositions for oxidative dyeing of hair is 4-amino-2-(1-hydroxy-ethyl)-phenol.
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WO/2002/058653A1 |
Primary intermediates for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): wherein R¿1? and R¿2? are aech independently selected from hydrogen atoms, a C¿1? to C¿5? alkyl or hydroxyalkyl group...
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