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Patent Searching and Data


Matches 651 - 700 out of 6,128

Document Document Title
WO/2004/065356A1
The invention relates to compounds of formula (I) wherein the radicals have the cited meaning, in addition to the physiologically compatible salts thereof. The compounds, for example, can be used as medicaments for preventing and treatin...  
WO/2004/064730A2
Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.  
WO/2004/065351A1
Compounds of the formula (I) provide pharmacological agents which lower intracellular glucocorticoid concentrations in mammals, in particular, intracellular cortisol levels in humans. Therefore, the compounds of the instant invention imp...  
WO2004046091A3
The invention relates to novel biaromatic compounds which correspond to the general formula (I), and also to a process for preparing them and to their use in pharmaceutical compositions intended for use in human or veterinary medicine (i...  
WO/2004/063181A1
The present invention provides compositions and their use in the treatment of inflammatory diseases caused by T-cell proliferation such as sepsis, inflammatory bowel diseases, autoimmune encephalomyelitis, or lupus. The compositions comp...  
WO/2004/063147A1
The invention provides salts and solvated of glucagon antagonists.  
WO2004033422A3
Fatty acid amide hydrolase inhibitors of the Formula (I) are provided, wherein X is NH, CH2, O, or S; Q is O or S; Z is O or N; R is an aromatic moiety selected from the group consisting of substituted or unsubstituted aryl; substituted ...  
WO/2004/062601A2
Antibacterial compounds of formula (I) are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infectio...  
WO2003014296A3
Compounds containing a specific saturated or unsaturated branched chain terminal group; a polar leading group; and a long-chain aliphatic, non-cyclic, saturated or unsaturated, substituted or unsubstituted, hydrocarbon group linking them...  
WO/2004/058747A1
The present invention provides compounds capable of binding to an Fc receptor and modulating Fc receptor activity comprising a core lipophilic group in the form of an Aryl ring substituted with a group rich in p-electrons. The invention ...  
WO/2004/058683A2
Compounds which have utility in the treatment of conditions associated with altered mitochondrial function. The compounds having structure (I), including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein X, ...  
WO/2004/058164A2
Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/...  
WO/2004/058686A1
The present invention relates to compounds of formula (I); useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta­secretase enzyme that are useful in the treatment of Alzheimer'...  
WO/2004/058145A2
Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds...  
WO/2004/058690A1
The invention relates to agents for dyeing keratin fibres, especially human hair, said agents containing at least one p-phenylenediamine derivative of formula (I) in a cosmetically acceptable medium, as a developing constituent. In said ...  
WO/2004/056763A2
Novel compounds that act to antagonize the action of the glucagon peptide hormone on the glucagon receptor. More particularly, it relates to glucagon antagonists or inverse agonists.  
WO/2004/052838A1
The present invention describes compounds of general formula (I), a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutical agents. The compounds according ...  
WO/2004/052845A1
This invention relates to tetrahydro-naphthalene derivatives and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have an excellent acti...  
WO/2004/052846A1
This invention relates to tetrahydro-naphthalene derivatives and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have an excellent acti...  
WO/2004/052847A2
The present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation comprising administering to a patient in need thereof an effective amount of a compound of the formula...  
WO/2004/052840A1
The invention relates to novel compounds that correspond to the general formula (I) below and to a method for preparing them, and to their use in pharmaceutical compositions intended for use in human or veterinary medicine (in dermatolog...  
WO2003051841A3
Carbamates and related compounds of formula R1 R2NCO-Y or R1 R2NCS-Y wherein R1 and R2 are hydrogen, alkyl, aryl, heteroaryl or may together form a piperidine, piperazine, morpholine or other heterocyclic ring, are inhibitors of hormone ...  
WO/2004/050609A1
The invention provides compounds of formula I: useful in treating Alzheimer’s disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer’s disease...  
WO/2004/048319A1
Novel compounds of Formula I which modulate MCH activity are disclosed, in which A is a linker, Ar, is an aryl or heteroaryl group; R1 is hydrogen or a lower alkoxy group; Q together with the carbonyl forms an amide group, which is furth...  
WO/2004/046162A2
ABSTRACT Potent non-steroidal farnesoid X receptor (FXR) agonists are N-aryl-N-arylmethyl amido and ureido compounds having the chemical structure represented by the following formula (I): INSERT FORMULA wherein E1 is (C1-C8)alkyl, cyclo...  
WO2003051842A3
Carbamates and related compounds of formula R1R2NCO-Y or R1R2NCS-Y wherein R1 and R2 may form a ring, are inhibitors of hormone sensitive lipase and are useful for the treatment of any disorder where it is desirable to modulate the plasm...  
WO/2004/046091A2
The invention relates to novel biaromatic compounds which correspond to the general formula (I), and also to a process for preparing them and to their use in pharmaceutical compositions intended for use in human or veterinary medicine (i...  
WO/2004/046090A2
This invention relates to novel aryl ureido benzoic acid derivatives useful as selective and non-competitive antagonists of the ionotropic GluR5 receptor. Due to their biological activity, the aryl ureido derivatives of the invention are...  
WO/2004/043899A1
The invention concerns 4-aminomethyl-1-aryl-cyclohexylamine derivatives, methods for producing same, medicines containing said compounds and the use of 4-aminomethyl-1-aryl-cyclohexylamine derivatives for producing medicines.  
WO/2004/043909A1
The invention relates to cyclohexylurea derivatives, methods for the production thereof, medicaments containing said compounds, and the use of cyclohexylurea derivatives for producing medicaments.  
WO/2004/041211A2
One aspect of the present invention relates to urea-containing compounds. In certain embodiments, the urea-containing compounds of the present invention comprise a heteroaromatic moiety. Another aspect of the present invention relates to...  
WO2004022528A3
The present invention relates to compounds of Formula (I), and salts solvates and hydrates thereof. The invention further relates to pharmaceutical compositions containing said compounds and methods of treating neurological, neuropsychia...  
WO/2004/039865A1
The invention relates to a process wherein one or more polyamines, each with one or more -NH2 functions and one or more second amine functions, said second amine functions having a lower lactone reactivity than said -NH2 functions, is re...  
WO/2004/039764A1
The invention relates to amide compounds of general formula (I), in which the groups and residues A, B, b, W, X, Y, Z, R1, R2 and R3 have the meanings given in claim 1. The invention further relates to medicaments comprising at least one...  
WO2004033416A3
The invention concerns carboxyalkoxy-substituted acyl-carboxyphenyl-urea derivatives of formula (I) wherein the groups are such as defined in the description and their physiologically acceptable salts and their physiologically functional...  
WO/2004/039766A1
The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of...  
WO2004022529A3
The present invention relates to novel diarylurea derivatives represented by general formula (I) useful as chloride channel blockers. In other aspects the invention relates to the use of these compounds in a method for therapy, such as f...  
WO/2004/039762A1
The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of...  
WO/2004/037777A1
The invention features tetralin and indane compounds of Formula I, compositions containing them, and methods of using them as PPAR alpha modulators to treat or inhibit the progression of, for example, diabetes.  
WO/2004/037778A1
The invention features tetralin and indane compounds, compositions containing them, and methods of using them as PPAR alpha modulators to treat or inhibit the progression of, for example, dyslipidemia.  
WO/2004/035533A1
The present invention relates to novel n-hydroxythiourea, urea and amide compounds as a potent vanilloid receptor antagonist and the pharmaceutical compositions comprising the same. The inventive compound can be useful for analgesics to ...  
WO/2004/033416A2
The invention concerns carboxyalkoxy-substituted acyl-carboxyphenyl-urea derivatives of formula (I) wherein the groups are such as defined in the description and their physiologically acceptable salts and their physiologically functional...  
WO/2004/033422A2
Fatty acid amide hydrolase inhibitors of the Formula (I) are provided, wherein X is NH, CH2, O, or S; Q is O or S; Z is O or N; R is an aromatic moiety selected from the group consisting of substituted or unsubstituted aryl; substituted ...  
WO2004009558A3
The invention encompasses ureido substituted benzoic acid compounds of structure (I), compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these...  
WO2003080554A3
A compound represented by the following general formula (IA) or a salt thereof: wherein Ar>1< represents hydrogen atom or an aryl group having at least one iodine atom as a substituent; Ar>2< represents an aryl group having at least one ...  
WO/2004/028538A1
Small organic molecules capable of effecting a 'pharmacological trabeculocanalotomy' in an eye by means of reducing juxtacanalicular meshwork as a barrier to outflow of aqueous. The small organic molecules increase Gelatinase A activity ...  
WO2003051276B1
Compounds of formula (I) or (II) wherein R1 , R2 , R3 , R4 , W, Q, G, X and Y are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are usefu...  
WO2003027064B1
The present invention is related to new vanilloid analogues containing resiniferatoxin pharmacophores, pharmaceutical compositions comprising such analogues, and their uses as vanilloid receptor agonistsand potent analgesics.The present ...  
WO2002076402A3
The invention provides conjugates of fatty amines and pharmaceutical agents useful in treating cancers, viruses, psychiatric disorders. Compositions, pharmaceutical preparations, and methods of preparations of the fatty amine-pharmaceuti...  
WO2004005478A3
This invention relates to a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA cons...  

Matches 651 - 700 out of 6,128