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WO/2002/040445A1 |
A novel class of compounds of the general formula (I): wherein B is (1), (2), (3) or (4), Z is arylene or a divalent radical derived from a 5 or 6 membered heteroaromaic ring containing 1 or 2 heteroatoms selected from nitrogen, oxygen a...
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WO/2002/039967A1 |
Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): wherein X is selected from halogen and R?5¿SO¿4?, R, R?1¿, R?2¿ and R?5¿ are each individually selected from C¿1? to C¿22? alky...
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WO/2002/038534A2 |
The invention relates to novel compounds which are substituted alkyldiamino derivatives of formula (I). The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions con...
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WO/2002/036553A2 |
The invention is directed to physiologically active compounds of general formula (1): wherein:- A?1¿ represents (i) a saturated 3 to 6 membered carbocycle, optionally substituted by one or more alkyl groups, (ii) indanyl or (iii) a satu...
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WO/2002/030876A2 |
The present invention relates to compounds of the general formula (I), process for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatment of...
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WO/2002/030915A2 |
A new family of compounds, particularly aryl-indane compounds, is disclosed. The compounds may be used as inhibitors of P-glycoprotein-mediated transport. Use of the compounds to enhance bioavailability and to modulate multi-drug resista...
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WO/2002/030875A1 |
The present invention relates to compounds of the general formula (I), processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatment ...
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WO/2002/030874A2 |
The present invention relates to compounds of the general formula (I), (I)processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatme...
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WO/2002/028820A1 |
The present invention relates to a compound of formula (I) in which X, A, T, Y, G and R are as defined in Claim (1).
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WO/2002/028824A1 |
The present invention relates to compounds named Citrullimycines which are obtainable by cultivation of Streptomyces sp. ST 101396(DSM 13309), and to their pharmaceutically acceptable salts. The present invention further relates to a pro...
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WO/2002/026701A2 |
Ionic compounds with a freezing point of up to 100 °C are formed by the reaction of an one amine salt of formula (I) R?1¿ R?2¿ R?3¿ R?4¿ N?+¿ X?-¿, such as choline chloride with an organic compound (II) capable of forming a hydrog...
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WO/2002/024635A2 |
The present invention relates to a compound formula (I) wherein X¿1? is bond or -O-CH¿2?-, (II) or (III) R?1¿ is hydrogen or an amino protective group, a is phenyl, indolyl or carbazolyl, each of which may be substituted with one or t...
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WO/2002/024613A2 |
The present invention relates to certain resorcinol derivatives and their use as skin lightening agents.
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WO/2002/022563A1 |
A novel urea derivative and a medicinal application thereof, especially as an adhesive-molecule inhibitor useful for the treatment of inflammatory diseases. The urea derivative, for example, has the chemical structure represented by the ...
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WO/2002/022592A2 |
Compounds represented by structural formula (I) including its N-oxides wherein Y is (a) or (b); R?1¿ is H or (C¿1?-C¿6?)alkyl; R?2¿ is H,(C¿1?-C¿6?)alkyl,(C¿3?-C¿9?)cycloalkyl or (C¿3?-C¿7?)cycloalkyl(C¿1?-C¿6?)alkyl; R?3¿ i...
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WO/2002/022844A1 |
(R)-N-(aminocarbonyl)fluorophenylalanine; and a process for producing (R)-N-(aminocarbonyl)fluorophenylalanine, characterized by treating 5-(fluorobenzyl)hydantoin with either an enzyme having the ability to selectively hydrolyze the (R)...
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WO/2002/022627A2 |
The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates...
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WO/2002/020472A1 |
The invention relates to substituted phenylcyclohexane carboxylic acid amides of formula (I), a method for the production thereof and the use thereof in medicaments, especially in the prevention and/or treatment of cardiovascular diseases.
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WO/2002/018326A1 |
Propenohydroxamic acid derivatives represented by the following general formula (1) or salts thereof and drugs containing the same: (1) wherein R?1¿ represents hydrogen, alkyl or halogeno; R?2 ¿represents cycloalkyl, aryl, heteroaryl, ...
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WO/2002/018323A2 |
Compound of formula (I) or therapeutically acceptable salts thereof, are protein tyrosine kinase PTP1B inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are dis...
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WO/2002/017712A2 |
Compounds of formula (I): wherein A, B, D, and R are as defined herein and their agriculturally acceptable salts are disclosed as effective insecticides. In addition, compositions comprising an insecticidally effective amount of a compou...
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WO/2002/016318A1 |
The present invention relates to novel thiourea derivatives as a modulator for vanilloid receptor (VR) and the pharmaceutical compositions containing the same. As diseases associated with the activity of vanilloid receptor, pain acute pa...
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WO/2002/014265A1 |
Urea derivatives represented by the following general formula (1) or pharmaceutically acceptable salts thereof: (1) wherein each symbol is as defined in the description. Because of having a C5a receptor antagonism, these compounds are us...
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WO/2002/014261A2 |
Compounds of general formula (I), in which: X represents a bond, O, S, SO or SO¿2?; and R?1¿ represents a (1-10C)alkyl, (2-10C)alkenyl, (2-10C)alkynyl, (4-10C)alkadienyl, carboxamido(1-8C)alkyl or aminocarbonyl(1-8C)alkyl group which i...
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WO/2002/014267A1 |
The present invention relates to compounds of formula (I) wherein U, V, W, A?1¿, A?2¿, A?3¿, A?4¿, A?5¿, A?6¿, m and n are as defined in the description and claims and pharmaceutically acceptable salts and/or pharmaceutically accep...
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WO/2002/014264A2 |
Novel (hydroxyethyl)ureas are described. These compounds are effective inhibitors of certain aspartyl proteases, notably secretases involved in the enzymatic cleavage of amyloid precursor protein (APP) to yield amyloid-$g(b) peptide. Met...
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WO/2002/012169A1 |
The invention relates to novel amino diphenyl ethers and amido diphenyl ethers, to methods for the production thereof, and to their use in medicaments, especially for the indications of arteriosclerosis and hypercholesterolemia.
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WO/2002/012168A1 |
A compound having general formula (I) and methods of using such compounds for the treatment of diseases and pharmaceutical composition comprising such compounds.
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WO/2002/012534A2 |
The present invention relates to compounds made by a subset of modules from one or more polyketide synthase ('PKS') genes that are used as starting material in the chemical synthesis of novel molecules, particularly naturally occurring p...
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WO/2002/012243A2 |
A novel process for the preparation of (R)-3-(4-Bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl
-1-H-imidazo[1,2-a]imidazol-2-one (1). This compound is useful as an intermediate in the preparation of certain small molecules that are ...
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WO/2002/008209A1 |
Compounds fo the formula (I) wherein R?1¿ and R?2¿ are independently hydrogen or substituents; R?3¿ is lower alkyl having from 2 to 4 carbon atoms or a 5 to 7-membered ring which is cycloalkyl, cycloalkenyl, or heterocycloalkyl having...
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WO/2002/008174A1 |
Novel mono- and dihydroxy phenylethylamine derivatives useful in treating melanoma are provided having the formulae (Ia, Ib or Ic). In the above formulae, R?a¿ is hydrogen or -COOR?b¿, R?b¿ is hydrogen or C¿1-6? alkyl; R?e¿ and R?eÂ...
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WO/2002/006189A2 |
The present invention relates to compounds of formula (I) and pharmaceutically acceptable salt and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associa...
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WO/2002/003995A2 |
The present invention relates to the use of neutral endopeptidase inhibitors (NEPi) and a combination of NEPi and phosphodiesterase type (PDE5) inhibitor for the treatment of male sexual dysfunction, in particular MED.
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WO/2002/004406A2 |
The present invention pertains, at least in part, to novel 9- substituted minocycline compounds. These minocyline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms...
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WO/2002/004407A2 |
The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplas...
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WO/2002/002520A2 |
The present invention is disubstituted amines of formula (I) and disubstituted amines of formula (II) useful in treating Alzheimer's disease and other similar diseases.
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WO/2002/002506A2 |
The present invention is substituted amines of formula (XV) useful in treating Alzheimer's disease and other similar diseases.
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WO/2002/002518A2 |
The present invention is disubstituted amines of formula (I) and disbustituted amines of formula (II) useful in treating Alzheimer's disease and other similar diseases.
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WO/2002/002512A2 |
The present invention is substituted amines of formula (X) useful in treating Alzheimer's disease and other similar diseases.
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WO/2002/002505A2 |
The present invention is substituted amines of formula (X) useful in treating Alzheimer's disease and other similar diseases.
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WO/2002/002513A1 |
The invention provides compounds of formula I wherein R?1¿ is optionally substituted C¿1?-¿6?alkyl, optionally substituted C¿3-7? cycloalkyl, optionally substituted aryl or optionally substituted heterocyclyl; n is 0, 1 or 2; and Y i...
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WO/2002/000612A1 |
A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or preventio...
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WO/2001/098256A1 |
This invention relates to compounds of the formula (I) which are thyroid receptor ligands, and are preferably selective for the thyroid hormone receptor $g(b), to methods of preparing such compounds and to methods for using such compound...
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WO/2001/098235A2 |
The invention relates to 3,4-dihydroxybenzyl-substituted carbonic acid derivatives, to their production, and to their use as antioxidants or free-radical scavengers, especially in cosmetic and pharmaceutical preparations and in foodstuff...
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WO/2001/096297A2 |
Compounds of the formula (I), where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions ...
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WO/2001/094301A2 |
The present invention relates to compounds of formula (I), in which R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, A, X, m and n have the meanings indicated in the claims. The compounds of the formula (I) are valuable pharmacologically active...
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WO/2001/094300A1 |
The invention relates to acylphenyl urea derivatives and the physiologically compatible salts and physiologically functional derivatives thereof. Such compounds correspond to the formula (I) wherein the radicals have the cited meanings. ...
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WO/2001/094357A1 |
New spisulosine derivatives of use in treating tumors are of the formula (I) wherein: each X is the same or different, and represents H, OH, OR', SH, SR', SOR', SO¿2?R', NO¿2?, NH¿2?, NHR', N(R')¿2?, CN, halogen, C(=O)H, C(=O)CH¿3?,...
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WO/2001/092213A2 |
Compounds of the formula (I) in which: R?1¿ is (CH¿2?)¿n?Y; n is 1 or 2; Y is NHSO¿2?R?2¿ or X?1¿-W-X?2¿-R?3¿; X?1¿ is O or NH; W is C=O, C=S, C=NH, or SO¿2?; X?2¿ is O or NH, provided that X?1¿ and X?2¿ are not both O; R?2Â...
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