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Matches 801 - 850 out of 6,167

Document Document Title
WO/2003/076397A1
The present invention relates to a compound formula [I] wherein R1 and R5 are each independently hydrogen, halogen, lower alkyl, etc., R2 is hydrogen or an amino protective group, x is bond,-o-o,-O-CH2-, etc., y is in which Z is bond, -0...  
WO/2003/075857A2
Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.  
WO/2003/075853A2
The present application describes modulators of MCP-1 of formula (I) or pharmaceutically acceptable salt forms thereof, useful for the prevention of rheumatoid arthritis, multiple sclerosis, atherosclerosis, asthma, restinosis, organ tra...  
WO/2003/072537A2
Compounds of formula (I), or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of disorders using the ...  
WO/2003/072539A1
The present invention relates to novel compounds of formula (I),to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of ...  
WO/2003/070692A1
A compound represented by the following formula (1): (1) (wherein R1 represents C1-12 alkyl, phenyl, 1-naphthyl, etc.; R2 represents C2-12 alkyl; (R3)b represent zero to four substituents, e.g., halogeno; R4 represents lower alkyl; R5 re...  
WO2002072534A3
The invention relates novel butane acid derivatives containing a cyanide group, pharmaceutical compositions containing butane acid derivatives and the use of said butane acid derivatives in the production of pharmaceutical compositions f...  
WO2002002512A3
The present invention is substituted amines of formula (X) useful in treating Alzheimer's disease and other similar diseases.  
WO/2003/066579A2
The present invention is directed to certain bicyclic hydroxamate derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical c...  
WO/2003/066581A1
The present invention is directed to compounds of the structural formula (I), and pharmaceutically acceptable salts, solvates and hydrates thereof: Formula I (a) R1, R2 and R6 are each independently selected from the group consisting of ...  
WO/2003/066889A2
This invention is directed to a continuous method for measuring the activity of an enzyme that catalyzes the addition of an acetyl group to a residue capable of being acetylated or an enzyme that catalyzes the removal of an acetyl group ...  
WO2003024955A3
The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein A, B, D, E, G, J, n, and R1 are as described generally and in classes and subclasses herein, and additionally provi...  
WO2002062762A3
Compounds of formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.  
WO/2003/062192A1
Cycloalkyl ketoamide derivatives, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such cycloalkyl ketoamide derivatives as well as methods of using the same in the ...  
WO/2003/060523A1
The present invention relates to compounds particularly asymmetric urea compounds which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors which express NA...  
WO/2003/057169A2
The present invention pertains, at least in part, to novel substituted 4-dedimethylamino tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infect...  
WO/2003/055848A2
This invention relates to urea derivatives of the formula (I), its tautomeric or stereoisomeric form, or a salt thereof: (I) wherein Y is R1- R6 and X have the same meanings given in the description, which is useful as an active ingredie...  
WO2001096297A3
Compounds of the formula (I), where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions ...  
WO/2003/051841A2
Carbamates and related compounds of formula R1 R2NCO-Y or R1 R2NCS-Y wherein R1 and R2 are hydrogen, alkyl, aryl, heteroaryl or may together form a piperidine, piperazine, morpholine or other heterocyclic ring, are inhibitors of hormone ...  
WO/2003/051842A2
Carbamates and related compounds of formula R1R2NCO-Y or R1R2NCS-Y wherein R1 and R2 may form a ring, are inhibitors of hormone sensitive lipase and are useful for the treatment of any disorder where it is desirable to modulate the plasm...  
WO/2003/051276A2
Compounds of formula (I) or (II) wherein R1 , R2 , R3 , R4 , W, Q, G, X and Y are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are usefu...  
WO/2003/050066A1
This invention is directed to functionalized higher diamondoids having at least one functional group. These derivatives have a higher diamondoid nucleus and up to six independently selected functional groups. The functionalized higher di...  
WO/2003/048115A1
Compounds of formula (I) are antibacterial agents: wherein: Z is −N(OH)CH(=O) or −C(=O)NH(OH)&semi R1 represents hydrogen, methyl or trifluoromethyl or, except when Z is a radical of formula −N(OH)CH(=O), a hydroxy, halo or amino g...  
WO2002017712A3
Compounds of formula (I): wherein A, B, D, and R are as defined herein and their agriculturally acceptable salts are disclosed as effective insecticides. In addition, compositions comprising an insecticidally effective amount of a compou...  
WO/2003/048108A2
Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine−mediated inflammatory response in cultured cells, in ameliorating bone destruction, in an animal mode...  
WO/2003/047568A1
The present invention discloses compounds of the formula I which, are novel antagonists for melanin−concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceut...  
WO2000037429A3
The present invention relates to small molecules according to formula (I) which are potent inhibitors of a alpha 4 beta 1 mediated adhesion to either VCAM or CS-1 and which can be used for treating or preventing alpha 4 beta 1 adhesion m...  
WO2003005965A3
The present invention relates to compounds which can be used as inhibitors of mitochondrial ceramidase, in particular human mitochondrial ceramidase. The invention also relates to methods of designing and making the compounds, as well as...  
WO2002100836A3
Methods and compositions useful in the treatment of amyloidosis and conditions and diseases associated therewith, such as Alzheimer's disease; are provided. The methods involve administering to a subject in need thereof a pharmaceutical ...  
WO/2003/037865A1
The present invention relates to compounds of formula (I): (I) their pharmacologically acceptable salts, or solvates and hydrates, and their prodrugs, respectively, and to pharmaceutical compositions containing the same as active ingredi...  
WO/2003/034989A2
Acylated $g(a)-hydroxyarylbutanamines and related sulfonamides, ureas and carbamates that inhibit aspartyl protease are disclosed, as are methods of treating diseases, particularly HIV, using these compounds. The compounds have the formu...  
WO2003011223A3
The present invention is directed to novel compounds that function as immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases, to novel adjuvant formulations which include at least one...  
WO2002026701A3
Ionic compounds with a freezing point of up to 100 DEG C are formed by the reaction of an one amine salt of formula (I) R<1> R<2> R<3> R<4> N<+> X<->, such as choline chloride with an organic compound (II) capable of forming a hydrogen b...  
WO1998003518A3
Bis-platinum(II) complexes with polymethylene derivatives, the method of making the complexes, and the use of the complexes for the treatment of tumors in mammals, are disclosed. The method of making the polymethylene derivatives, is als...  
WO/2003/030889A1
The present invention relates to compounds of the general formula (I), their preparation and use as pharmaceutical compositions asintegrin antagonists, especially as $g(a)¿4?$g(b) and/or $g(a)¿4?$g(b)¿7 ?and/or $g(a)¿9?$g(b)¿1? inte...  
WO2000037430A3
Substituted phenylalanines are provided comprising an hydantoin, urea or 2-hydroxyl, 2-methylpropionyl group, dimers thereof and alkyl, polyfluoroamido and haloarylamino derivatives thereof, as well as radiolabeled derivatives thereof. T...  
WO/2003/029199A1
Novel benzene derivatives represented by the general formula (&Verbar ), which exhibit vanilloid receptor agonism and are useful as preventive and therapeutic drugs for pollakisuria and urinary incontinence, analgesic, or the like: (&Ver...  
WO/2003/029198A1
The invention relates to the use of compounds having general formula X-(A)¿n?-Y, wherein: n varies between 6 and 20; X denotes a hydrogen atom, an R¿a?CO, R¿a?OCO, R¿a?NHCO or R¿a?SO¿2? group, R¿a? being an alkyl, alkenyl, alkynyl...  
WO/2003/027064A1
The present invention is related to new vanilloid analogues containing resiniferatoxin pharmacophores, pharmaceutical compositions comprising such analogues, and their uses as vanilloid receptor agonistsand potent analgesics.The present ...  
WO/2003/024448A2
The invention relates to the inhibition of histone deacetylase. The invention provides compounds e.g. (1) and methods for inhibiting deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell p...  
WO/2003/024920A1
The current invention provide novel compounds, methods of treating preventing emphysema, cancer and dermatological disorders, pharmaceutical compositions suitable for the treatment or prevention of emphysema, cancer and dermatological di...  
WO2002030915A3
A new family of compounds, particularly aryl-indane compounds, is disclosed. The compounds may be used as inhibitors of P-glycoprotein-mediated transport. Use of the compounds to enhance bioavailability and to modulate multi-drug resista...  
WO2001092218A3
Novel "bispolyamine" inhibitor compounds of polyamine transport are disclosed. These compounds are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine transport or other polyamine binding proteins,...  
WO2002014261A3
Compounds of general formula (I), in which: X represents a bond, O, S, SO or SO2; and R<1> represents a (1-10C)alkyl, (2-10C)alkenyl, (2-10C)alkynyl, (4-10C)alkadienyl, carboxamido(1-8C)alkyl or aminocarbonyl(1-8C)alkyl group which is un...  
WO/2003/024921A1
The current invention provides compounds of the general formula (I), methods of treating or preventing emphysema, cancer and dermatological disorders, pharmaceutical compositions suitable for the treatment or prevention of emphysema, can...  
WO/2003/024955A2
The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein A, B, D, E, G, J, n, and R1 are as described generally and in classes and subclasses herein, and additionally provi...  
WO/2003/024439A1
The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of...  
WO2002051810A3
The invention relates to novel compounds, to the use thereof as the ligands of integrin receptors, especially for the use as the ligands of the alpha v beta 3 integrin receptor, as well as to pharmaceutical preparations that contain said...  
WO/2003/022799A1
The present invention relates to 1,2-diaminocyclopentane derivatives of Formula (I), wherein R¿1? - R¿4? are as defined in the specification. The compounds are useful as CCR-3 receptor antagonists, and therefore, may be used for the tr...  
WO2002100836A8
Methods and compositions useful in the treatment of amyloidosis and conditions and diseases associated therewith, such as Alzheimer's disease; are provided. The methods involve administering to a subject in need thereof a pharmaceutical ...  

Matches 801 - 850 out of 6,167