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Patent Searching and Data


Matches 901 - 950 out of 6,139

Document Document Title
WO/2002/064549A1
PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certan plasma lipid levels, including high density liporprotein-cholesterol and to lower certain other plasma lipid lev...  
WO/2002/064130A1
PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipo-protein-cholesterol and to lower certain plasma lipid levels, ...  
WO/2002/062763A2
This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.  
WO/2002/062762A2
Compounds of formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.  
WO2002002518A3
The present invention is disubstituted amines of formula (I) and disbustituted amines of formula (II) useful in treating Alzheimer's disease and other similar diseases.  
WO2002006189A3
The present invention relates to compounds of formula (I) and pharmaceutically acceptable salt and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associa...  
WO/2002/059077A1
It is intended to provide drugs which have cholesteryl ester transfer protein inhibitory effect and are useful as blood lipid lowering agent, etc. Namely, compounds represented by the following general formula (I), salts thereof, and med...  
WO/2002/059080A2
The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins, and to pharmaceutical compositions comprising one or more of the said compounds. The invent...  
WO2002002505A3
The present invention is substituted amines of formula (X) useful in treating Alzheimer's disease and other similar diseases.  
WO/2002/059102A2
The invention concerns novel products of formula (I) wherein: Y represents oxygen or sulphur; Z represents C=CH2, CH-CH3 or CH2; R1 represents hydrogen, morpholinyl or the radical (II) wherein the two nitrogen atoms are linear or form a ...  
WO/2002/059081A2
Urea and amide derivatives inhibit cell function of the chemokine receptor CCR-3. These compounds offer an effective means for treating a range of diseases thought to be mediated by the CCR-3 receptor. A variety of useful area and amide ...  
WO/2002/057242A2
Novel antagonists of &agr 4β1 integrin and/or &agr 4β7 integrin of the general Formula (I): wherein R1, R2, R5, L1, L2, Rb, W and Z are as defined in any one of claims 1 to 13, A represents -CH- or a nitrogen atom, and p is from 0 to 4.  
WO/2002/057233A1
The present invention related to compounds of the formula (I) or a pharmaceutically acceptable addition salt and/or hydrate thereof, or where applicable, a geometric or optical isomer or racemic mixture thereof; which are useful for the ...  
WO2002030874A3
The present invention relates to compounds of the general formula (I), (I)processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatme...  
WO2001040188A9
The present invention is directed to curcumin analogs (I), wherein Y is OH, halogen, or CF3; Z is H, OH, OR1, halogen, or CF3; X1 and X2 are independently C or N; and A is as defined in the application; exhibiting anti-tumor and anti-ang...  
WO/2002/053523A1
A tropolone derivative represented by the formula (I) which has retinoid activity and is useful as an active ingredient for medicines [R?1¿ to R?4¿ each represents hydrogen, alkyl, or alkoxy; ring Ar represents an aryl ring or heteroar...  
WO2000064911A9
The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates...  
WO/2002/053534A1
Compounds represented by the general formula (I) or salts thereof, and medicines containing the same: (I) [wherein W is W?A¿-A?1¿-W?B¿- (wherein W?A¿ is optionally substituted aryl or the like; A?1¿ is -NR?1¿-, a single bond, -C(O)...  
WO2000073263A9
A composition is provided comprising a novel cationic lipid compound having hydrophobic tails and two quaternary ammonium headgroups bridged by a linker. The composition is useful as a cytofectin for facilitating delivery and transfectio...  
WO/2002/051810A2
The invention relates to novel compounds, to the use thereof as the ligands of integrin receptors, especially for the use as the ligands of the $g(a)¿v?$g(b)¿3? integrin receptor, as well as to pharmaceutical preparations that contain ...  
WO2002022627A3
The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates...  
WO/2002/051799A1
Biphenyl derivatives represented by the general formula (1) or salts thereof; and ACAT inhibitors or medicines containing the same as the active ingredient: (1) [wherein R?1¿ is C¿5-7? alkyl; R?2¿ is optionally substituted aromatic hy...  
WO2001092213A3
Compounds of the formula (I) in which: R<1> is (CH2)nY; n is 1 or 2; Y is NHSO2R<2> or X<1>-W-X<2>-R<3>; X<1> is O or NH; W is C=O, C=S, C=NH, or SO2; X<2> is O or NH, provided that X<1> and X<2> are not both O; R<2> is C1-10 alkyl; C2-1...  
WO/2002/050052A1
The invention relates to compounds of formula (I), wherein R¿1? is aryl unsubstituted or mono- to penta-substituted by R¿7? or is heteroaryl unsubstituted or mono- to tetra-substituted by R¿7? it being possible for the substituents in...  
WO2002018323A3
Compound of formula (I) or therapeutically acceptable salts thereof, are protein tyrosine kinase PTP1B inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are dis...  
WO/2002/050019A2
The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.  
WO2002022592A3
Compounds represented by structural formula (I) including its N-oxides wherein Y is (a) or (b); R<1> is H or (C1-C6)alkyl; R<2> is H,(C1-C6)alkyl,(C3-C9)cycloalkyl or (C3-C7)cycloalkyl(C1-C6)alkyl; R<3> is (c), (d), (e), (f), (g), (h) or...  
WO2002024613A3
The present invention relates to certain resorcinol derivatives and their use as skin lightening agents.  
WO2002012243A3
A novel process for the preparation of (R)-3-(4-Bromobenzyl)-1-(3,5-dichlorophenyl)-5-iodo-3-methyl -1-H-imidazo[1,2-a]imidazol-2-one (1). This compound is useful as an intermediate in the preparation of certain small molecules that are ...  
WO/2002/048099A1
The invention relates to compounds of formula (I), wherein the variables have the following meanings: D means a phenyl or a pyridyl which is unsubstituted or is mono- or polysubstituted by Hal, A, OR?2¿, N(R?2¿)¿2?, NO¿2?, CN, COOR2 ...  
WO/2002/046141A2
The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for...  
WO1999059957A9
Compounds of formula (I) wherein the groups are as defined in the description are disclosed. The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine palmitoyl-transferase and are useful in the preparatio...  
WO/2002/046172A2
The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for...  
WO/2002/046181A2
The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for...  
WO/2002/046146A1
Novel substituted carboxylic acid derivatives which bind to human peroxisome proliferator-activated receptor a (PPARa) as a ligand thereof and activate the same to thereby exert a lipid-lowering effect, an arteriosclerosis-preventing eff...  
WO2001085681A3
1-(3-methoxybenzyl)-3-substituted thiourea antioxidant compounds and improved lipids compositions which are supplemented with amounts of such antioxidant compounds effective for augmenting oxidative stability of the base lipid are provid...  
WO2002004406A3
The present invention pertains, at least in part, to novel 9- substituted minocycline compounds. These minocyline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms...  
WO/2002/044126A2
The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins. In the compounds of this invention, at least two carbo-or heterocyclic groups are attached ...  
WO2001021160B1
The present invention relates to the use of carboxamide compounds as selective inhibitors of pathogens, particularly viruses and, more particularly, herpesviridae. Surprisingly, these compounds show reduced side effects in comparison wit...  
WO/2002/042248A2
The present invention relates to naphthalene derivatives of formula (I), wherein X is S, S(O), S(O)¿2?, S(O)¿2?NH, P(O)OCH¿3?, P(O)OH, NH, N(CH¿3?), NHC(O)NH, C(O), C(O)O, NHC(O), CH(OH), CH=N, CH=CH, CH¿2?NH, C(=NH); R?1¿ is aryl ...  
WO2002014264A3
Novel (hydroxyethyl)ureas are described. These compounds are effective inhibitors of certain aspartyl proteases, notably secretases involved in the enzymatic cleavage of amyloid precursor protein (APP) to yield amyloid- beta peptide. Met...  
WO/2002/042257A1
The invention relates to substituted cyclohexane derivates of formula (I), a method for the production thereof and the use thereof in medicaments, particularly for preventing and/or treating cardiovascular diseases, diseases of the uroge...  
WO2001098235A3
The invention relates to 3,4-dihydroxybenzyl-substituted carbonic acid derivatives, to their production, and to their use as antioxidants or free-radical scavengers, especially in cosmetic and pharmaceutical preparations and in foodstuff...  
WO/2002/040446A1
A novel class of compounds of the general formula (I): wherein Z is arylene or a divalent radical derived from a 5 or 6 membered heteroaromatic ring E is which act to antagonize the action of the glucagon hormone on the glucagon receptor...  
WO/2002/040444A1
Novel compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any di...  
WO/2002/040445A1
A novel class of compounds of the general formula (I): wherein B is (1), (2), (3) or (4), Z is arylene or a divalent radical derived from a 5 or 6 membered heteroaromaic ring containing 1 or 2 heteroatoms selected from nitrogen, oxygen a...  
WO/2002/039967A1
Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of the formula (1): wherein X is selected from halogen and R?5¿SO¿4?, R, R?1¿, R?2¿ and R?5¿ are each individually selected from C¿1? to C¿22? alky...  
WO/2002/038534A2
The invention relates to novel compounds which are substituted alkyldiamino derivatives of formula (I). The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions con...  
WO/2002/036553A2
The invention is directed to physiologically active compounds of general formula (1): wherein:- A?1¿ represents (i) a saturated 3 to 6 membered carbocycle, optionally substituted by one or more alkyl groups, (ii) indanyl or (iii) a satu...  
WO2001081298A3
The present invention relates to compounds of general formula (I), processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatment of i...  

Matches 901 - 950 out of 6,139