| Document |
Document Title |
|
WO/2001/092210A1 |
This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, their use in treating human or animal disorders. The compounds of the invention are useful as modulators of th...
|
|
WO/2001/092229A1 |
The invention provides TNF-$g(a) production inhibitors useful as remedies for autoimmune diseases such as rheumatoid arthritis. Novel compounds of the general formula [1] or salts thereof exhibit excellent TNF-a production inhibiting act...
|
|
WO/2001/092218A2 |
Novel 'bispolyamine' inhibitor compounds of polyamine transport are disclosed. These compounds are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine transport or other polyamine binding proteins,...
|
|
WO/2001/090051A1 |
The invention is concerned with novel N-(4-carbamimidoyl-phenyl)-glycine derivatives of the formula (I) wherein X and R?1¿ to R?5¿ are as defined in the description and in the claims, as well as hydrates or solvates and/or physiologica...
|
|
WO/2001/087840A1 |
Novel propanoic acid derivatives are integrin receptor antagonists or inhibitors, in particular of the avb3 integrin receptor. The compounds of the invention are for instance useful for the treatment of solid tumors by inhibition of angi...
|
|
WO2000056681A9 |
This invention provides combinatorial chemistry libraries containing thiourea and urea compounds of formula (I), in which X is S or O; R and R1 are individually (CHR) -Ar; and the other variables are as defined in the claims. In addition...
|
|
WO/2001/085681A2 |
1-(3-methoxybenzyl)-3-substituted thiourea antioxidant compounds and improved lipids compositions which are supplemented with amounts of such antioxidant compounds effective for augmenting oxidative stability of the base lipid are provid...
|
|
WO/2001/085706A1 |
Compounds of formula (I) wherein X is oxygen or sulfonyl, R is a ring, R?1¿ is cycloalkyl, y and z are 0 or 1, and R?2¿ is -CO-NHR?3¿ or a heteroaromatic ring having a ring nitrogen atom adjacent to the connecting ring carbon atom, ar...
|
|
WO/2001/083429A1 |
Compounds represented by the formular (A), tautomers thereof, or medicinally acceptable salts of both exhibit an NOS-inhibitory activity and are useful as drugs in the treatment of various diseases.
|
|
WO/2001/083427A1 |
To provide PPAR$g(g) modulators seemingly usable in remedies for involutional osteoporosis which inhibit the accelerated differentiation of adipocytes and promote the formation and differentiation of osteoblasts from stem cells, or remed...
|
|
WO/2001/081298A2 |
The present invention relates to compounds of general formula (I), processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatment of i...
|
|
WO/2001/077077A1 |
Compounds of formula (I) wherein R¿1?, L, L', alk, W and Z have the meanings as defined hereinbefore; and pharmaceutically acceptable salts thereof; are useful as inhibitors of microcosmal triglyceride transfer protein (MTP) and of apol...
|
|
WO/2001/074761A1 |
Substituted tetracycline compounds, methods of synthesis, and methods of use are discussed. Tetracyclines useful for treating tetracycline related disorders are also discussed. Intermediates useful for synthesizing other tetracycline com...
|
|
WO/2001/070675A2 |
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell pr...
|
|
WO/2001/070684A2 |
One aspect of the present invention relates to novel peptidomimetic compounds. A second aspect of the present invention relates to the use of the novel peptidomimetic compounds as ligands - agonists or antagonists - for various cellular ...
|
|
WO2000071506A9 |
Compounds of formula (I), wherein R<1> and R<2> are substituents on the A rings and are, independently, -SO2NR<7>2, -C(O)NR<7>2, -NR<7>SO2R<7>, -NR<7>C(O)R<7>, -SO2OR<7>, -C(O)OR<7>, -OSO2R<7>, or -OC(O)R<7>, R<3> and R<4> are, independe...
|
|
WO/2001/066515A1 |
A urea-urethane compound represented by the following formula; a process for producing the compound; a color developer comprising the urea-urethane compound; and a color former containing a colorless or light-colored leuco dye. (In the f...
|
|
WO/2001/058854A1 |
Compound (2-hydroxy-2-methyl-N-(4-X-3-(trifluoromethyl)phenyl)-3-(2,2
,2-perfluoroacylamino)propionamide) applied topically, specifically inhibits and/or eliminates cutaneous androgen receptors and thus finds cosmetic use in skin afflict...
|
|
WO/2001/058859A1 |
The invention generally relates to a novel kind of arginine mimetics which are inhibitors of the factor X¿a?. The invention also relates to pharmaceutical compositions that contain said mimetics and to the use of said arginine mimetics ...
|
|
WO/2001/056988A1 |
Compounds having an Rho kinase inhibitory activity. These compounds include the compound of general formula (I): Het-X-Z, pharmaceutically acceptable salts thereof and solvates of the same, wherein Het represents a monocyclic or dicyclic...
|
|
WO/2001/056978A1 |
The invention relates to positional isomer diethyloctandioldicarbamates and diethyloctandioldiallophanates, to a method for the production thereof and to the use thereof as synthetic building blocks and constituents of adhesives, luting ...
|
|
WO/2001/056975A1 |
The invention concerns novel substituted imide derivatives of general formula (I), wherein R?1¿ represents optionally substituted cycloalkyl; R?2¿ represents optionally substituted alkyl or optionally substituted cycloalkyl; R?3¿ repr...
|
|
WO/2001/057105A1 |
The invention concerns a novel aqueous composition that can be hardened physically, thermally and/or with actinic radiation, containing a compound of general formula (I): X[NH-C(=O)-NH-Y-NH-C(=O)-OR]¿2? having at least one urea and uret...
|
|
WO/2001/055146A1 |
The present invention relates to a compound with aryl-amidines, particularly amidinoaryl-cyclopropanes, amidinoarylmethyl-pyrroles, amidinoaryl-benzenes, amidinoaryl-pyridines, or amindonoaryl-alanines, represented by formula (1), a phar...
|
|
WO/2001/055081A2 |
Esters derived from fatty acids and juvenoid alcohols of the general formula (I), in which X means the oxygen atom or the NH group, Y means the NH group or the oxygen atom, R means methyl, ethyl, 1-propyl, 2-methylethyl or propargyl and ...
|
|
WO/2001/055095A1 |
The present invention refers to new classes of polymerisable monomers, to molecularly imprinted polymers obtainable by polymerisation of at least one of the monomers and a crosslinking monomer in the presence of a template molecule. The ...
|
|
WO/2001/053279A1 |
A compound of formula (I) where D is a VLA-4 specificity determinant which does not impart significant IIB/IIIa activity; R?41¿ is a group of the formula (V): U - (CH¿2?)¿d? - V - T wherein U is selected from oxygen, sulphur, a direct...
|
|
WO/2001/052900A2 |
Polyazacarboxylates and their peptide conjugates which are useful for imaging, diagnosis and therapy are disclosed. Particularly, this invention relates to compositions of two or more peptides that are conjugated to a molecule of polyaza...
|
|
WO/2001/051487A1 |
There is disclosed a genus of non-peptidyl compounds, wherein said compounds are VLA-4 inhibitors useful in treating inflammatory, autoimmune, and respiratory diseases, and wherein said compounds comprise a compound of formula (1.0.0) an...
|
|
WO/2001/051456A2 |
Hydroxyamidines and related compounds are provided which are suitable as antibacterial agents.
|
|
WO/2001/047875A1 |
The present invention is directed to a series of novel substituted aminoalkylamide derivatives, pharmaceutical compositions containing them and their use in the treatment of reproductive disorders and affective conditions. Further, the c...
|
|
WO/2001/045678A2 |
The invention relates to a composition which comprises as its constituents (a) a local anaesthetic and (b) an anti-inflammatory compound and/or an immunostimulant compound and/or a compound which acts as a supporting material for the loc...
|
|
WO/2001/046124A1 |
Aromatic diamide derivatives of general formula (I) or salts thereof; chemicals for agricultural or horticultural use; and usage thereof [wherein A?1¿ is optionally substituted C¿1-8? alkylene, C¿3-8? alkenylene, or the like; B is O- ...
|
|
WO1999063937A9 |
Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptogramins, tetracycline and/or other compounds which bind to bacterial ribosomal RNA and/or to one or more prot...
|
|
WO/2001/044216A1 |
2,3-Di-substituted trans olefinic N-heteroaromatic or urido proprionamides of formula (I) with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a cycloalkyl ring, said proprionamides being ...
|
|
WO/2001/044223A1 |
A method of inhibiting interleukin 5 gene expression in a mammal comprising administering to a mammal in need of such treatment a pharmaceutically effective amount of one or more compounds selected from formula (I) and/or from formula (II).
|
|
WO/2001/042192A2 |
Compounds of formula (I) wherein Ar is carbocyclic or heterocyclic aryl, or biaryl; Q is O, S or N-C$m(Z)N; X is arylene; V is NH, O, NHOH, CH¿2? or a direct bond; W is NH, O, NHOH, CH¿2? or a direct bond; Alk is C¿2?-C¿7?-alkylene o...
|
|
WO2001030749B1 |
The present invention relates to novel compounds, pharmaceutical compositions containing the same as well as a method for treatment of parasitic disorders, wherein said compounds are administered. The present compounds are especially wel...
|
|
WO/2001/038322A1 |
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell pr...
|
|
WO/2001/036381A1 |
Hydrazone compounds represented by general formula (1) or salts thereof and novel agricultural chemicals (in particular, insecticides and miticides) containing these compounds as the active ingredient formulae (1), G-1, G-2, G-3, wherein...
|
|
WO/2001/036376A1 |
Phenylalanine derivatives represented by general formula (1) or pharmaceutically acceptable salts thereof: wherein x represents an interatomic bond, -O-, etc.; Y and Z represent each -C(=O)-, etc.; A represents a specific substituted phe...
|
|
WO/2001/036375A1 |
This invention relates to new aminoalcohol derivatives or salts thereof represented by formula (I): wherein each symbol is as defined in the specification or salts thereof which have gut selective sympathomimetic, anti-ulcerous, anti-pan...
|
|
WO/2001/036403A1 |
Disclosed are novel aromatic compounds of formula (I) wherein G, X, Ar, L and Q are defined herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chr...
|
|
WO/2001/034141A1 |
This invention relates to novel compounds and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
|
|
WO/2001/032604A1 |
Use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in the activation of soluble guanylate cyclase, wherein: R¿1? and R¿2? are the same or different and each repre...
|
|
WO/2001/032610A1 |
A urea derivative represented by the general formula (I) or a salt thereof: wherein R?1¿ is hydrogen, alkyl, etc.; X is hydrogen, halogeno, alkyl, aryl, arylamide, etc.; Y is oxygen or sulfur; and Z is a hydrocarbon or heterocyclic grou...
|
|
WO/2001/030333A2 |
The invention includes tissue factor (TF) blocking compounds and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such compounds. Compounds of the invention are particularly useful for treating...
|
|
WO/2001/028498A2 |
Novel retro-anandamides are presented which have high affinities for the cannabinoid CB1 and/or CB2 receptor sites. Further, most of the analogs exhibit greater metabolic stability than arachidonylethanolamide. The improved receptor affi...
|
|
WO/2001/028987A1 |
The present application describes modulators of CCR3 of formula (I) or pharmaceutically acceptable salt forms thereof, useful for the prevention of inflammatory diseases such as asthma and other allergic diseases.
|
|
WO/2001/025190A1 |
Diarylamide derivatives represented by general formula (1) or salts thereof, and pharmaceutical compositions containing the derivatives or the salts as the active ingredient, wherein A and B are each an aromatic ring such as benzene ring...
|
