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Matches 851 - 900 out of 6,170

Document Document Title
WO2002050019A3
The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.  
WO/2003/020688A1
Compounds of formula (I) or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of disorders using the c...  
WO2002036553A3
The invention is directed to physiologically active compounds of general formula (1): wherein:- A<1> represents (i) a saturated 3 to 6 membered carbocycle, optionally substituted by one or more alkyl groups, (ii) indanyl or (iii) a satur...  
WO/2003/018535A2
The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating patients comprising administering said compo...  
WO/2003/018536A1
The invention provides 1,2-substituted cyclic compounds useful for treatment of diseases or disorders arising from abnormal or inappropriate cell proliferation, such as tumour growth, tumour metastasis and associated angiogenesis, as wel...  
WO2002096884A3
The invention relates to novel substituted benzoylketones of formula (I), in which Q = O (oxygen) or S (sulphur), R<1> - R<5> and Z have the meaning given in the description and several methods for production thereof and use thereof as h...  
WO2002024635A3
The present invention relates to a compound formula (I) wherein X1 is bond or -O-CH2-, (II) or (III) R<1> is hydrogen or an amino protective group, a is phenyl, indolyl or carbazolyl, each of which may be substituted with one or two subs...  
WO/2003/014064A1
Naphthylurea and naphthylacetamide derivatives of formula (I) which have vanilloid receptor 1 (VR1) antagonistic activity are disclosed, formula (I) wherein Y represents formula (II) and formula (III) and the variables Q, X, R6, R7, R8, ...  
WO/2003/014296A2
Compounds containing a specific saturated or unsaturated branched chain terminal group; a polar leading group; and a long-chain aliphatic, non-cyclic, saturated or unsaturated, substituted or unsubstituted, hydrocarbon group linking them...  
WO/2003/011223A2
The present invention is directed to novel compounds that function as immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases, to novel adjuvant formulations which include at least one...  
WO/2003/010135A1
Phenylpropionic acid derivatives represented by the general formula (1): (1) (2−1) [wherein A is a group represented by the general formula (2−1) or the like&semi R10 to R13 are each hydrogen or the like&semi Arm is a benzene ring or...  
WO2002046172A3
The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for...  
WO2002046141A3
The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for...  
WO/2003/006422A1
Compounds having general formula (I): wherein: -R represents a hydrogen atom, a C¿1?-C¿8? alkyl or haloalkyl group, a C¿2?-C¿8? alkoxyalkyl or haloalkoxyalkyl group, a C¿2?-C¿8? alkenyl or haloalkenyl group, a C¿2?-C¿8? alkinyl o...  
WO/2003/005965A2
The present invention relates to compounds which can be used as inhibitors of mitochondrial ceramidase, in particular human mitochondrial ceramidase. The invention also relates to methods of designing and making the compounds, as well as...  
WO2002076930A3
Substituted diarylureas, pharmaceutical compositions containing them, and their use for stimulating Fas-mediated apoptosis. The compounds, as single stereoisomers or mixtures of stereoisomers, their pharmaceutically acceptable salts, and...  
WO/2003/004458A1
The present invention relates to 2-(benzoylamino)benzoic acid derivatives of the formula (I), wherein the variants Ar, X and R are described in the specification. The said compounds modulate the activity of peroxisome proliferator-activa...  
WO/2003/004460A2
The present invention relates to compounds of the general formula (I), processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatment ...  
WO2002070467B1
The invention relates to new diphenylurea having the formula (I) or a salt thereof, where Y is CO=O, C=S, C=NH, (C=O)2 or SO2; and to processes for the preparation of these compounds and to their use in the treatment of protozoal disease...  
WO/2003/005025A1
The present invention relates to a method for identifying compounds capable of binding the ligand binding domain of peroxisome proliferator-activated receptor gamma (PPAR$g(g)), and selectively modulating the activity of PPAR$g(g). The s...  
WO2002072536A8
The invention relates to novel compounds having Vanilloid Receptor (VR1) antagonist activity, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders.  
WO/2003/002524A2
The present invention relates to compounds of the formula I, in which R?1¿, R?2¿, R?4¿, R?5¿, D¿1?, D¿2?, X¿1?, X¿2?, X¿3?, A and B have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacol...  
WO/2003/002519A1
The invention relates to novel phenol derivatives, a method for the production of said derivatives and their use in medicaments.  
WO2002059102A3
The invention concerns novel products of formula (I) wherein: Y represents oxygen or sulphur; Z represents C=CH2, CH-CH3 or CH2; R1 represents hydrogen, morpholinyl or the radical (II) wherein the two nitrogen atoms are linear or form a ...  
WO2002059081A3
Urea and amide derivatives inhibit cell function of the chemokine receptor CCR-3. These compounds offer an effective means for treating a range of diseases thought to be mediated by the CCR-3 receptor. A variety of useful area and amide ...  
WO/2003/000653A1
The invention relates to novel substituted N-acyl aniline derivatives of general formula (I), where R?1¿ to R?5¿, A, X, Y and Z are as defined in claim 1, the tautomers, stereoisomers, mixtures, prodrugs, derivatives with a group, nega...  
WO2002046181A3
The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for...  
WO/2002/100836A2
Methods and compositions useful in the treatment of amyloidosis and conditions and diseases associated therewith, such as Alzheimer's disease; are provided. The methods involve administering to a subject in need thereof a pharmaceutical ...  
WO2002059080A3
The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins, and to pharmaceutical compositions comprising one or more of the said compounds. The invent...  
WO2002042248A3
The present invention relates to naphthalene derivatives of formula (I), wherein X is S, S(O), S(O)2, S(O)2NH, P(O)OCH3, P(O)OH, NH, N(CH3), NHC(O)NH, C(O), C(O)O, NHC(O), CH(OH), CH=N, CH=CH, CH2NH, C(=NH); R<1> is aryl or heteroaryl; R...  
WO/2002/098849A2
Disclosed are compounds of formula X, where R¿n?, R¿20?, R¿1?, R¿2?, R¿3?, and R¿c? are defined herein. These compounds are useful in treating Alzheimer's disease and other similar diseases. Pharmaceutical compositions comprising c...  
WO/2002/096864A1
The invention relates to carboxamide-substituted phenylurea derivatives and method for production thereof as medicaments, physiologically-acceptable salts and physiologically-functional derivatives thereof. Compounds of formula (I), in w...  
WO/2002/096884A2
The invention relates to novel substituted benzoylketones of formula (I), in which Q = O (oxygen) or S (sulphur), R?1¿ - R?5¿ and Z have the meaning given in the description and several methods for production thereof and use thereof as...  
WO/2002/096863A1
The present invention relates to certain phenalkyloxy-phenyl derivatives of formula (I) and analogs, to a process for preparing such compounds, having the utility in clinical conditions associated with insulin resistance, to methods for ...  
WO/2002/096876A1
Disclosed are novel aromatic compounds of the formula (I) described herein, wherein G, E, W, Ar, X, Y and Z are disclosed herein. The compounds are useful for treating cytokine mediated diseases or conditions such as chronic inflammatory...  
WO/2002/092574A1
The invention relates to novel substituted benzoylcyclohexenones of formula (I), in which Q, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, Y and Z are defined as per the description. The invention also relates to a method for their production and t...  
WO2002038534A3
The invention relates to novel compounds which are substituted alkyldiamino derivatives of formula (I). The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions con...  
WO/2002/090336A1
The invention relates to novel arylketones of formula (I) wherein A?1¿, A?2¿, Q, R?1¿, R?2¿, X, Y and Z have the meaning cited in the description, the use thereof as herbicides and to methods and intermediate products for the product...  
WO/2002/085838A1
The present invention relaters to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the ...  
WO/2002/085829A1
A process for production of dimers of aromatic monohydroxyl compounds, characterized by conducting the oxidative coupling of an aromatic compound represented by the general formula [I]: Ar-OH [I] (wherein Ar is an optionally substituted ...  
WO/2002/085836A1
A binaphtol derivative represented by the following general formula [1]: [1] and a salt of the derivative.  
WO2001070675A3
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell pr...  
WO2001058855A9
Substituted phenylalanines are provided comprising an hydantoin, urea or 2-hydroxyl, 2-methylpropionyl group, dimers thereof and alkyl, polyfluoroamido and haloarylamino derivatives thereof, as well as radiolabeled derivatives thereof. T...  
WO/2002/083627A2
The invention relates to the novel biphenyl derivatives of the general formula (I), wherein R1, R1', R1'', R2 and n are defined as in claim 1. The invention also relates to the stereoisomers and the physiologically acceptable salts or so...  
WO2002062763A3
This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.  
WO/2002/078686A1
The invention relates to the use of retinyl carbonates of formula (I), wherein R represents an optionally substituted C¿1?-C¿12? alkyl, C¿6?-C¿12? aryl, C¿7?-C¿13? aralkyl or a group of formula (II), for the cosmetic treatment of t...  
WO/2002/076402A2
The invention provides conjugates of fatty amines and pharmaceutical agents useful in treating cancers, viruses, psychiatric disorders. Compositions, pharmaceutical preparations, and methods of preparations of the fatty amine-pharmaceuti...  
WO/2002/076930A2
Substituted diarylureas, pharmaceutical compositions containing them, and their use for stimulating Fas-mediated apoptosis. The compounds, as single stereoisomers or mixtures of stereoisomers, their pharmaceutically acceptable salts, and...  
WO/2002/076929A1
In one embodiment, this invention provides a novel class of compounds as antagonists of the MCH receptor, methods of preparing such compounds, pharmaceutical compositions containing one or more of the compounds, methods of preparing phar...  
WO2002044126A3
The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins. In the compounds of this invention, at least two carbo-or heterocyclic groups are attached ...  

Matches 851 - 900 out of 6,170