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Matches 701 - 750 out of 6,197

Document Document Title
WO/2004/052847A2
The present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation comprising administering to a patient in need thereof an effective amount of a compound of the formula...  
WO/2004/052840A1
The invention relates to novel compounds that correspond to the general formula (I) below and to a method for preparing them, and to their use in pharmaceutical compositions intended for use in human or veterinary medicine (in dermatolog...  
WO2003051841A3
Carbamates and related compounds of formula R1 R2NCO-Y or R1 R2NCS-Y wherein R1 and R2 are hydrogen, alkyl, aryl, heteroaryl or may together form a piperidine, piperazine, morpholine or other heterocyclic ring, are inhibitors of hormone ...  
WO/2004/050609A1
The invention provides compounds of formula I: useful in treating Alzheimer’s disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer’s disease...  
WO/2004/048319A1
Novel compounds of Formula I which modulate MCH activity are disclosed, in which A is a linker, Ar, is an aryl or heteroaryl group; R1 is hydrogen or a lower alkoxy group; Q together with the carbonyl forms an amide group, which is furth...  
WO/2004/046162A2
ABSTRACT Potent non-steroidal farnesoid X receptor (FXR) agonists are N-aryl-N-arylmethyl amido and ureido compounds having the chemical structure represented by the following formula (I): INSERT FORMULA wherein E1 is (C1-C8)alkyl, cyclo...  
WO2003051842A3
Carbamates and related compounds of formula R1R2NCO-Y or R1R2NCS-Y wherein R1 and R2 may form a ring, are inhibitors of hormone sensitive lipase and are useful for the treatment of any disorder where it is desirable to modulate the plasm...  
WO/2004/046091A2
The invention relates to novel biaromatic compounds which correspond to the general formula (I), and also to a process for preparing them and to their use in pharmaceutical compositions intended for use in human or veterinary medicine (i...  
WO/2004/046090A2
This invention relates to novel aryl ureido benzoic acid derivatives useful as selective and non-competitive antagonists of the ionotropic GluR5 receptor. Due to their biological activity, the aryl ureido derivatives of the invention are...  
WO/2004/043899A1
The invention concerns 4-aminomethyl-1-aryl-cyclohexylamine derivatives, methods for producing same, medicines containing said compounds and the use of 4-aminomethyl-1-aryl-cyclohexylamine derivatives for producing medicines.  
WO/2004/043909A1
The invention relates to cyclohexylurea derivatives, methods for the production thereof, medicaments containing said compounds, and the use of cyclohexylurea derivatives for producing medicaments.  
WO/2004/041211A2
One aspect of the present invention relates to urea-containing compounds. In certain embodiments, the urea-containing compounds of the present invention comprise a heteroaromatic moiety. Another aspect of the present invention relates to...  
WO2004022528A3
The present invention relates to compounds of Formula (I), and salts solvates and hydrates thereof. The invention further relates to pharmaceutical compositions containing said compounds and methods of treating neurological, neuropsychia...  
WO/2004/039865A1
The invention relates to a process wherein one or more polyamines, each with one or more -NH2 functions and one or more second amine functions, said second amine functions having a lower lactone reactivity than said -NH2 functions, is re...  
WO/2004/039764A1
The invention relates to amide compounds of general formula (I), in which the groups and residues A, B, b, W, X, Y, Z, R1, R2 and R3 have the meanings given in claim 1. The invention further relates to medicaments comprising at least one...  
WO2004033416A3
The invention concerns carboxyalkoxy-substituted acyl-carboxyphenyl-urea derivatives of formula (I) wherein the groups are such as defined in the description and their physiologically acceptable salts and their physiologically functional...  
WO/2004/039766A1
The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of...  
WO2004022529A3
The present invention relates to novel diarylurea derivatives represented by general formula (I) useful as chloride channel blockers. In other aspects the invention relates to the use of these compounds in a method for therapy, such as f...  
WO/2004/039762A1
The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of...  
WO/2004/037777A1
The invention features tetralin and indane compounds of Formula I, compositions containing them, and methods of using them as PPAR alpha modulators to treat or inhibit the progression of, for example, diabetes.  
WO/2004/037778A1
The invention features tetralin and indane compounds, compositions containing them, and methods of using them as PPAR alpha modulators to treat or inhibit the progression of, for example, dyslipidemia.  
WO/2004/035533A1
The present invention relates to novel n-hydroxythiourea, urea and amide compounds as a potent vanilloid receptor antagonist and the pharmaceutical compositions comprising the same. The inventive compound can be useful for analgesics to ...  
WO/2004/033416A2
The invention concerns carboxyalkoxy-substituted acyl-carboxyphenyl-urea derivatives of formula (I) wherein the groups are such as defined in the description and their physiologically acceptable salts and their physiologically functional...  
WO/2004/033422A2
Fatty acid amide hydrolase inhibitors of the Formula (I) are provided, wherein X is NH, CH2, O, or S; Q is O or S; Z is O or N; R is an aromatic moiety selected from the group consisting of substituted or unsubstituted aryl; substituted ...  
WO2004009558A3
The invention encompasses ureido substituted benzoic acid compounds of structure (I), compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these...  
WO2003080554A3
A compound represented by the following general formula (IA) or a salt thereof: wherein Ar>1< represents hydrogen atom or an aryl group having at least one iodine atom as a substituent; Ar>2< represents an aryl group having at least one ...  
WO/2004/028538A1
Small organic molecules capable of effecting a 'pharmacological trabeculocanalotomy' in an eye by means of reducing juxtacanalicular meshwork as a barrier to outflow of aqueous. The small organic molecules increase Gelatinase A activity ...  
WO2003051276B1
Compounds of formula (I) or (II) wherein R1 , R2 , R3 , R4 , W, Q, G, X and Y are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are usefu...  
WO2003027064B1
The present invention is related to new vanilloid analogues containing resiniferatoxin pharmacophores, pharmaceutical compositions comprising such analogues, and their uses as vanilloid receptor agonistsand potent analgesics.The present ...  
WO2002076402A3
The invention provides conjugates of fatty amines and pharmaceutical agents useful in treating cancers, viruses, psychiatric disorders. Compositions, pharmaceutical preparations, and methods of preparations of the fatty amine-pharmaceuti...  
WO2004005478A3
This invention relates to a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA cons...  
WO2003082777A3
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as glucocorticoid receptor modulators. The compounds of the instant invention are ligands for glucocorticoid receptors and as such may be ...  
WO/2004/026815A2
The present invention is related to a compound of the formula (I), (II), (III), (IV), (V): wherein Z1, Z2, Z3 and Z4 are each and independently selected from the group comprising C(O)-, -C(S)-, -C(O)-NR10-, -C(S)-NR11-, -C(N-CN)-NR12-, -...  
WO2003075853A3
The present application describes modulators of MCP-1 of formula (I) or pharmaceutically acceptable salt forms thereof, useful for the prevention of rheumatoid arthritis, multiple sclerosis, atherosclerosis, asthma, restinosis, organ tra...  
WO2003102044A3
Low-cure powder coating compositions are disclosed. The compositions comprise a polyepoxide and a material having the structure: formula (I) wherein R1 is an organic radical having 6 to 25 carbon atoms; R2 is an organic radical having 1 ...  
WO/2004/022528A2
The present invention relates to compounds of Formula (I), and salts solvates and hydrates thereof. The invention further relates to pharmaceutical compositions containing said compounds and methods of treating neurological, neuropsychia...  
WO2003018535A3
The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating patients comprising administering said compo...  
WO/2004/022530A1
The invention provides a compound containing a head group based on urea, glycerol or glycerate and a tail selected from the group consisting of a branched alkyl chain, a branched alkyloxy chain or an alkenyl chain. The compounds may be u...  
WO2004007459A3
This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to naphthol, quinoline and isoquinoline-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatme...  
WO/2004/022529A2
The present invention relates to novel diarylurea derivatives represented by general formula (I) useful as chloride channel blockers. In other aspects the invention relates to the use of these compounds in a method for therapy, such as f...  
WO2003097587A3
The invention relates to a novel class of gelling agents, to a process of preparing said agents, to the use of said agents to prepare gels, and to the gels thus obtained. A gelling agent or thickener according to the invention comprises ...  
WO2003002524A3
The present invention relates to compounds of the formula I, in which R<1>, R<2>, R<4>, R<5>, D1, D2, X1, X2, X3, A and B have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active com...  
WO2003089615A3
Methods for evaluating the antiviral activity of test compounds are provided. Further aspects of the methods involve the retroviral capsid protein of HIV-1. In another aspect, methods of reducing mortality associated with AIDS with a com...  
WO2003088915A3
The present invention is directed to novel phenytoin derivative compounds and the use of such compounds as sodium channel blockers. Such compositions have utility as anti-cancer agents and can be used to limit or prevent PCa growth and/o...  
WO/2004/020400A1
This invention pertains to certain enzyme (CPG2) activated self-immolative nitrogen mustard prodrugs, which are useful in enzyme prodrug therapy (EPT), such as ADEPT and GDEPT, for the treatment of proliferative conditions, such as cance...  
WO/2004/013089A1
Fluorinated urethane compounds represented by the general formula (1) can impart high water- and oil-repellency: [Rf-A1-(X1(OH))-(Y1)a-OC(=O)NH-]m I [-NHC(=O)O-Y2]n [-NHC(=O)O-((ClCH2-)X2O)b-R1]k (1) wherein I is a group derived from a p...  
WO2003075857A3
Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.  
WO/2004/009558A2
The invention encompasses ureido substituted benzoic acid compounds of structure (I), compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these...  
WO/2004/007437A1
The invention relates to urea-substituted and urethane-substituted acylureas, to physiologically compatible salts thereof and to their physiologically functional derivatives. The invention thus relates to compounds of formula (I), wherei...  
WO/2004/007459A2
This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to naphthol, quinoline and isoquinoline-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatme...  

Matches 701 - 750 out of 6,197