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WO/2024/084406A1 |
The invention relates to a process for synthesising acyl derivatives of glutathione and cysteine which involves considerable environmental advantages, because said compounds can be synthesised effectively without the use of environmental...
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WO/2024/079348A1 |
The present invention relates to compounds of formula (I). The invention also extends to micro- or nanoparticles comprising a compound of formula (I). For instance, compounds of formula (I) can be used to produce stable lipid nanoparticl...
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WO/2024/080383A1 |
A polythiol composition containing polythiol compound A, which is 4-mercaptomethyl-1,8-dimercapto-3,6-dithiaoctane, and compound B1 which shows a retention time of 65-75 minutes in a high-performance liquid chromatography measurement und...
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WO/2023/240156A9 |
Provided are ionizable cationic lipids and lipid nanoparticles for the delivery of nucleic acids to cells (e.g., immune cells), and methods of making and using such lipids and targeted lipid nanoparticles.
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WO/2024/072908A1 |
Provided herein are compounds having one or more cleavable disulfide moieties and one or more hydrophobic tail moieties (HTM) for delivery of one or more therapeutic or diagnostic agents. In some embodiments, the one or more therapeutic ...
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WO/2024/065042A1 |
Provided are novel sulfur-containing lipids and nanoparticles containing such lipids and a cargo molecule, such as a nucleic acid, methods to formulate said lipids with nucleic acids to produce lipid nanoparticles and chemical routes for...
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WO/2024/065043A1 |
Provided are lipids and nanoparticles containing such lipids and a cargo molecule, such as nucleic acid, methods to formulate said lipids with nucleic acids to produce lipid nanoparticles and chemical routes for making the lipids. The li...
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WO/2024/065041A1 |
The present disclosure relates to a sulfur-containing ionizable lipid or a pharmaceutically acceptable salt thereof that incorporates a dithioacetal or dithioketal moiety in one or more of its lipophilic chains. Further provided is a del...
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WO/2024/061348A1 |
The present invention provides a 1,3-cyclohexanedione compound shown in formula I, and a stereoisomer and an agrochemically acceptable salt thereof, wherein R1, R2, R3, and R4 are as defined in the description. Also disclosed are a prepa...
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WO/2024/061218A1 |
An organic polysulfide and preparation method and use thereof. The preparation method comprises the following steps: S1: adding metal hydroxide solution into a reactor, adding sulfur to react, and lowering the temperature at the end of t...
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WO/2024/043020A1 |
A compound represented by formula (1). [In formula (1): Ar is an arylene group; R1 is a monovalent group represented by formula (2); and R2 is a monovalent group represented by formula (3). In formula (2): R3 is a hydrogen atom or an opt...
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WO/2024/035783A2 |
Lipid nanoparticle compositions (LNPs), methods for preparing the LNPs, methods of using the same, including, but not limited to, for treatment of certain diseases and disorders, including, but not limited to liver disorders, kits for th...
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WO/2024/031242A1 |
A method for synthesizing an aryl benzyl thioether compound using photocatalysis. By using the iron (III) complex [HIMXy Me][FeBr 4]([HIMXy Me]=l,3-bis(4-methoxy-2,6-dimethylphenyl)-4,5-dimethylimidaz
olium cation) as a catalyst, fac-Ir(...
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WO/2024/027789A1 |
Disclosed are a cationic lipid compound as represented by formula (I) and composition for nucleic acid delivery, and a use. Also disclosed are a use of nano-lipid particles using said compound as a key component in the aspect of nucleic ...
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WO/2024/026200A1 |
The present inventive concept provides methods for treating or preventing ulcerative colitis, systemic lupus erythematosus (SLE), sepsis, or post-sepsis syndrome including administering a therapeutically effective amount of dihydro-lipoi...
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WO/2024/018286A2 |
A lipophilic anchor includes a conjugation domain linked via a linker domain to an anchor domain having a plurality of hydrophobic tails. This lipophilic anchor allows deposition of at least one lipophilic target molecule with affinity f...
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WO/2023/115221A9 |
Ionizable lipids with a disulfide moiety and lipid nanoparticles comprising said lipids are disclosed. In select preferred embodiments, the ionizable lipids have a structure of formulae 11-15. The lipid nanoparticles formed from the ioni...
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WO/2024/011415A1 |
Disclosed in the present invention is a method for preparing an o-iodophenyl compound, wherein an iodobenzene compound and an amide compound as raw materials are reacted in the presence of sodium hydride or n-butyllithium and a solvent t...
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WO/2024/007862A1 |
Provided are a para-substituted biphenyl thioether compound, a composition, and use thereof. The compound has a structure represented by formula (I): , the definitions of the groups in the formula are provided in the description. The par...
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WO/2024/009998A1 |
Provided is a method for producing a fluorinated organic compound by fluorinating an organic compound in the presence of a fluorination composition which contains IF5, iodine and an amine and in which the iodine is contained at a quantit...
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WO/2024/004755A1 |
A compound according to the present invention is represented by general formula (1). General formula (1): (In formula (1), A represents an n-valent organic group that contains a sulfur atom; n represents an integer of 3 or more; S repr...
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WO/2024/005030A1 |
A diphenylethene-based compound according to the present invention is represented by formula (I).
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WO/2024/004619A1 |
An embodiment of the present invention provides: a curable composition containing a radical polymerization initiator represented by formula (1) and a radically polymerizable compound; a method for producing a cured product; a film; an op...
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WO/2024/000062A1 |
The present technology relates to thiol functionalized conductors which can be grafted onto polymers and methods for making same. In certain embodiments, the thiol functionalized conductors can be grafted onto polymers with low Tg to syn...
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WO/2023/246074A1 |
Provided in the present invention are a cationic lipid compound used for nucleic acid delivery, a composition and a use. The compound is as shown in the following formula (I). Further provided in the present invention are the use of the ...
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WO/2023/246747A1 |
Provided in the present invention are a cationic lipid compound and a composition for delivery of a nucleic acid, and the use. The compound is represented by the following formula (I). Further provided in the present invention are the us...
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WO/2023/241087A1 |
The present invention provides a thiodiglycolic acid extraction agent, and a preparation method therefor and use thereof, in the technical field of extraction separation in the fields of extraction agent synthesis and hydrometallurgy. Th...
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WO/2023/242103A1 |
The present invention relates to the use of compounds of formula (I) as RAS inhibitors and as a medicament, in particular for use in treating proliferative disorders, inflammatory diseases and/or genetic disorders. The present invention ...
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WO/2023/242020A1 |
The invention provides a process for obtaining mixtures containing methionine and potassium hydrogencarbonate from aqueous solutions or suspensions containing titratable potassium in the form of potassium hydrogencarbonate and/or potassi...
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WO/2023/240057A1 |
Disclosed are compositions comprising a first component comprising an isocyanate, a second component comprising a first polyol comprising a phosphorous, a second polyol comprising a sulfur or a combination of the first polyol and the sec...
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WO/2023/238762A1 |
This method for producing a blue cured film includes: a step for forming, on a substrate, a coating film of a blue photosensitive composition that contains a colorant, an alkali-soluble resin, a photopolymerizable compound, and a photoin...
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WO/2023/240156A1 |
Provided are ionizable cationic lipids and lipid nanoparticles for the delivery of nucleic acids to cells (e.g., immune cells), and methods of making and using such lipids and targeted lipid nanoparticles.
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WO/2023/222870A1 |
The present invention generally relates to the field of ionizable (also termed cationic) lipids,and in particular provides a novel type of such lipids as represented by any of the formulae disclosed herein. The present invention further ...
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WO/2023/222589A1 |
Compounds of the formula (I), (I), wherein the substituents are as defined in claim 1, useful as a pesticides, especially as herbicides.
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WO/2023/215989A1 |
Provided herein are novel sulfur-containing lipids having a structure of Formula A or a salt thereof. The compounds may be formulated in a lipid nanoparticle for use in the delivery of charged cargo such as nucleic acids for use in the t...
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WO/2023/218702A1 |
The present invention provides: a curing agent containing a thiol compound represented by chemical formula (I); and a use thereof. Specifically, provided are: a curing agent containing a thiol compound represented by chemical formula (I)...
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WO/2023/216232A1 |
Provided are a lipid compound and a composition thereof. The lipid compound comprises: a lipid compound represented by general formula (I) and/or (II), or a pharmaceutically acceptable salt of the lipid compound, or a solvate of the lipi...
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WO/2023/219521A1 |
The invention relates to novel 2-(diethylamino)-4,6-diphenylbenzene-1,3-carbonitrile derivatives of general formula (1) in which R1 stands for: one of the following groups, where the dashed line indicates a bond that is, the compounds se...
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WO/2023/218862A1 |
The present invention provides a novel thiol compound and uses thereof. Specifically, the present invention provides: a novel thiol compound; a curing agent containing said thiol compound; a resin composition containing this curing agent...
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WO/2023/213922A1 |
The present invention primarily relates to compounds of formula (I) as defined herein. It also relates to fragrance substance mixtures as defined herein and methods for producing the same and to perfumed products as defined herein and me...
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WO/2023/209028A1 |
The invention relates to sulphonyl benzene derivatives, in particular to fluorinated sulphonyl benzene derivatives. It is provided a compound of formula (I) or general formula (IA) wherein X is fluorine; A is either O or NH; B is an amin...
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WO/2023/203254A2 |
The present invention relates to compounds inhibiting the toxic activity of extrasynaptic NMDA receptors, in particular by inhibiting the formation of NMDA receptor/TRPM4 complexes. In particular, the present invention relates to diamine...
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WO/2023/204627A1 |
Provided is a compound comprising: a binding part comprising a dithio C1-C16 alkyl moiety (a dithio C1-C16 alkyl moiety); a hydrophilic linking part comprising oxygen; and a terminal part comprising an unsubstituted C6-C40 aryl group, an...
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WO/2023/203473A1 |
The object of the present invention is a novel class of compounds and the pharmaceutical compositions containing them as active ingredients. The compounds according to the invention are effective in the prevention or treatment of disorde...
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WO/2023/202554A1 |
Disclosed are a chiral aryl propionic acid derivative and a pharmaceutical composition thereof, and a use. The chiral aryl propionic acid derivative is as shown in formula (I), and the definition of each group is given in the description...
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WO/2023/184031A1 |
Methods and uses for the treatment or prevention of stroke in a mammal including in a human, including administering a therapeutically effective amount of bucillamine or a pharmaceutically acceptable salt or solvate thereof to a mammal i...
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WO/2023/190166A1 |
The present invention provides: a cationic lipid that can be used as a nucleic acid delivery carrier having excellent intercellular behavior; a lipid membrane structure including the same; a nucleic acid introduction agent and a pharmace...
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WO/2023/190767A1 |
[Problem] The present invention provides: a polyether ether ketone decomposition method which efficiently decomposes a polyether ether ketone; and a novel compound which is synthesized using a starting material that is a decomposition pr...
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WO/2023/186149A1 |
The present invention relates to the technical field of biomedicines, and particularly disclosed are a lipid compound, a composition containing the same, and use thereof. The lipid compound has a structure represented by formula (I) or f...
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WO/2023/180824A1 |
A thiol-containing compound having at least two terminal groups of formula -NH-CO-CO-NH-R1 -SH where R1 is an alkylene, reaction mixtures containing the thiol-containing compound and an epoxy resin, and compositions containing a polymeri...
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