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WO/1999/029645A1 |
A compound of formula (II), wherein R¿1? is chlorine, fluorine or trifluoromethyl; R¿2? is hydrogen, chloride, fluorine or trifluoromethyl; and R is hydrogen or a protective group of the hydroxy moiety useful as intermediate for the sy...
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WO/1999/028034A1 |
The invention relates to a method for preparing a catalyst through activation of a catalytic material comprising a) at least one metal from the first or second side group or one compound thereof and b) optionally a carrier. This catalyst...
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WO/1999/026938A1 |
A compound having formula (I) wherein R is fluorine, hydrogen, an unsubstituted or substituted aliphatic or unsubstituted or substituted aromatic radical; R¿1? is an unsubstituted or substituted aliphatic radical, or unsubstituted or su...
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WO/1999/025674A1 |
Unsaturated coconut and/or palm oil fatty alcohols with an iodine number in a range of 65 to 85 contain substantially unsaturated fatty alcohols and mixtures of saturated fatty alcohols of formula (I): R?1¿OH, in which R?1¿ stands for ...
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WO/1999/025673A1 |
Unsaturated palm oil fatty alcohols with an iodine number in a range of 65 to 85 contain substantially unsaturated fatty alcohols and mixtures of saturated fatty alcohols of formula (I) R?1¿OH, in which R?1¿ stands for a saturated or u...
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WO/1999/024410A1 |
The invention is drawn to novel transition metal catalysts for the pratical synthesis of important chiral molecules. The transition metal catalysts comprise chiral ligands based on chiral amine oxazolinyl ligands. The invention includes ...
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WO/1999/024443A2 |
This invention is to develop novel transition metal catalysts for the pratical synthesis of important chiral molecules. The invention emphasizes asymmetric catalysis based on chiral bidentate phosphine ligands with cyclic ring structures...
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WO1999001124A9 |
The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same...
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WO/1999/021813A1 |
The novel compound 2-(cyclododecadienyl)propan-1-ol exhibits an odor of amber and so finds use in perfumes and in perfumed products.
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WO/1999/021817A1 |
Lewis acid-catalysed reaction of alkenes (including cycloalkenes) with an epoxide is a novel reaction useful for synthesis of various fragrance materials (known and novel) and their intermediates.
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WO/1999/015487A1 |
The invention relates to benzyl-biphenyls and analogous compounds thereof which are produced first by reacting $g(a) and $g(b)-unsaturated ketones to form corresponding substituted and conjugated dienes, and afterwards said dienes are cy...
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WO/1999/012877A1 |
The invention concerns a method for the enantioselective reduction of prochiral ketones into chiral alcohol's comprising the following steps: a) reacting a prochiral ketone with a silane agent, present in stoichimetric amount, in the pre...
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WO/1999/007668A1 |
Novel non-steroidal ligands for the estrogen receptor which possess tissue-dependent estrogenic and antiestrogenic activity as well as methods for making the same and their applications in treating a variety of disease states.
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WO/1999/002526A1 |
New tropane analogs that bind to monoamine transporters are described, particularly, 8-aza, 8-carbo and 8-oxy tropanes having 6- or 7-substituents. The compounds of the present invention can be racemic, pure $i(R)-enantiomers, or pure $i...
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WO/1998/058935A1 |
This invention describes a process for covalently coupling organic compounds which comprises reacting an olefinic compound having a halogen or halogen-like substituent at a coupling position with a diboron derivative in the presence of a...
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WO/1998/058735A1 |
The present method provides a method of transferring oxygen to at least one oxidizable site on a target compound. The method includes the steps of selectively oxidizing an oxidizable site on a target compound by reacting in solution: the...
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WO/1998/056743A1 |
The invention relates to a continuous method for producing primary or secondary alcohols by reducing the corresponding aldehydes or ketones with a secondary aliphatic alcohol as the hydrogen donor, in the presence of a catalyst. The redu...
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WO/1998/052912A2 |
The invention relates to leukotriene B�4? antagonists of formula (I), a method for the production and the pharmaceutical use thereof.
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WO/1998/042676A1 |
The invention relates to a process for preparing a compound of formula (I), comprising reacting a bromo-substituted pyridine with an amine of the formula NHR?5�R?6�, reacting the resulting amide with an iodo-halomethyl-substituted co...
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WO/1998/042643A1 |
A catalytic transfer hydrogenation process is provided. The catalyst employed in the process is a metal cyclopentadienyl complex which is coordinated to defined bidentate ligands. Preferred metals include rhodium, ruthenium and iridium. ...
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WO/1998/040345A1 |
Methods for preparing 3-methyl-2-buten-1-ol (prenyl alcohol) from 2-methyl-1,3-butadiene (isoprene) and carboxylic acids are disclosed. Carboxylic acids which can be used in the process have a K�a? (relative to water) greater than 10?-...
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WO/1998/034895A1 |
The invention relates to novel 5-hydroxyalkyl substituted phenyls, which are produced either by reacting corresponding benzaldehydes with Grignard compounds and then reduces the remaining functional groups, or by reducing corresponding b...
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WO/1998/028306A1 |
A process for the preparation of an aromatic organozinc compound is provided. The process comprises reacting a zinc chloride, bromide or iodide and an organometallic compoud of another metal comprising an aromatic moiety, producing a rea...
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WO/1998/028273A1 |
The invention concerns a method for preparing 1-[2-(2-naphthyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-
tetrahydropyridin of formula (I) and its pharmaceutically acceptable salts by reacting 2-(2-bromoethyl)naphthalene with 4-(3-trifl...
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WO/1998/025599A1 |
The present invention provides an oil composition for parenteral administration comprising a dihydropolyprenol of formula (I) and a pharmaceutically acceptable oil, wherein n is an integer of 5 to 7.
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WO/1998/022415A1 |
Disclosed is a method of enantioselective catalytic reduction of ketones to chiral alcohols. So far, this reaction was made in batches. Expanding the catalysator by means of a polymer allows for a substantially continuous reaction to be ...
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WO/1998/017613A1 |
The invention concerns an improved process for preparing 2-methyl-4-(2,2,3-trimethyl-cyclopent-3-en-1-yl)-but-2-en-1-
ol (A), in which first campholene aldehyde and propionaldehyde are reacted with one another in a conventional manner in...
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WO/1998/017612A1 |
The invention concerns a process for preparing oxidation products from cyclohexane by catalytic oxidation with oxygenous gases in the liquid phase. In a reaction zone the gases are brought substantially uniformly into contact with the ox...
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WO/1998/011085A1 |
The invention relates to processes for preparing a compound of formula (X) and the enantiomer of said compound, wherein the benzoic acid moiety is attached at position 6 or 7 of the chroman ring, and R?1�, R?2�, and R?3� are as def...
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WO/1998/009932A1 |
The invention concerns a process for preparing alkyne diols or mixtures of alkyne diols with alkyne monools by reacting acetylene with more than equimolar amounts of ketones and/or aldehydes in the presence of an alkaline compound, the a...
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WO/1998/009931A1 |
An improved process for decomposing alkyl or aromatic hydroperoxides to form a decomposition reaction mixture containing the corresponding alcohol and ketone. The improvement relates to decomposing the hydroperoxide by contacting the hyd...
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WO/1998/008794A1 |
The invention concerns a process for telomerizing dienes, according to which the diene is reacted with a compound containing an active hydrogen atom in the presence of a palladium compound, a water-soluble phosphine ligand and a base, th...
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WO/1998/006686A1 |
This invention relates to a process for the isomerization of a vinyl glycol to an unsaturated diol in the presence of a rhenium-based catalyst; and to a catalyst for said isomerization. More specifically, this invention relates to the is...
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WO/1998/004528A2 |
Substituted pyridines of formula (IA) are produced by reaction of suitably substituted pyridylaldehydes with Grignard or Witting reagents, and the resulting products are appropriately reduced. The pyridines of formula (IA) are suitable a...
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WO/1998/003456A1 |
According to the invention, alcohols and/or aldehydes are prepared from olefins by the crossed metathesis of olefins with alcohols which comprise at least one double bond in the molecule and in which at least one hydroxy group is in the ...
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WO/1998/002404A1 |
This invention pertains firstly to the use of mixtures of hydriodic acid and organic solvent soluble iodide salts as catalysts for the hydration of gamma, delta-epoxyalkenes to form a mixture of the corresponding 2-alkene-1,4-diol and 3-...
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WO/1998/002405A1 |
This invention provides a catalyst recovery process whereby a liquid/liquid extraction is used to separate mixtures of 2-alkene-1,4-diols and 3-alkene-1,2-diols, formed by the hydration of gamma,delta-epoxyalkenes using mixtures of hydri...
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WO/1998/002428A1 |
The invention concerns a method for the biosynthesis of natural diol -1,3 derivatives of general formula (I) in which Z is the pentyl or pent-2-enyl (Z) or (E), preferably (Z) grouping, which consists in converting a natural precursor of...
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WO/1997/047575A1 |
The present invention relates to process of halogenating an alkynol having 3 to 20 carbon atoms to produce a compound having the formula: R-C(C-CH2)x-OH, wherein R is F, C1, Br or I and x is 1 to 18. In particular, this invention provide...
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WO/1997/047633A1 |
The present invention relates to rigid chiral ligands useful in making catalysts for asymmetric synthesis. More particularly, the present invention relates to new monodentate and bidentate cyclic chiral phosphine ligands which are formed...
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WO/1997/046534A1 |
The invention relates to a process for producing substituted aryl pyrazoles of general formula (I) in which R1, R2, R3 and R4 have the meanings given in the description, and novel intermediate products for producing said aryl pyrazoles.
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WO/1997/045391A1 |
A process for preparing optically active alcoholic compounds wherein a carbonyl compound is asymmetrically reduced in an economical and practical manner. The process comprises treating a prochiral carbonyl compound represented by general...
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WO/1997/043242A1 |
A process is described for the production of at least one C4 compound selected from butane-1,4-diol, 'gamma'-butyrolactone and tetrahydrofuran, which includes the step of hydrogenation in the vapour phase of a di-(C1 to C4 alkyl) maleate...
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WO/1997/043272A2 |
A compound of formula (I), wherein R1 and R2 which may be the same or different represent H, C1-6 alkyl, C3-7 cycloalkyl or aryl; R3, and R4 which may be the same or different represent H, halogen, C1-6 alkyl; or substituted aryl; R5 rep...
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WO/1997/042152A1 |
The invention relates to vitamin D analogs of general formula (I) wherein: R1 is a hydrogen atom or a substituent selected from the group consisting of hydroxy, CH2OH, CH2CH2OH, CH2CH2CH2OH, OCH3, OCH2OH, OCH2CH2OH and OCH2CH2CH2OH; R2 i...
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WO/1997/039997A1 |
This invention relates in part to processes for producing one or more substituted or unsubstituted 1,6-hexanediols which comprise subjecting one or more substituted or unsubtituted penten-1-ols to reductive hydroformylation in the presen...
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WO/1997/034589A1 |
The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation. The active compounds are substituted ...
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WO/1997/034857A1 |
This invention discloses an improved method for the [2 + 2 + 2] cyclotrimerization reaction in aqueous solutions using a water soluble transition metal catalyst.
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WO/1997/034852A1 |
The invention concerns cycloalkyl derivatives of formula (I), where n is 0 to 4 and the other variables have the meaning given in claim 1. It also concerns a method for producing said derivatives and their use for producing compounds of ...
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WO/1997/033856A1 |
Novel diaromatic propynyl or dienyl compounds having general formula (I), and the use thereof in pharmaceutical compositions useful in human or veterinary medicine (in particular for the treatment of dermatological, rheumatic, respirator...
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