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WO/1994/027946A1 |
The compounds of formula (I), wherein the symbol X denotes a -CHO group or an acetal group of formula (a), the symbols R', taken alone, each denote a straight or branched, saturated or unsaturated C1 - C4 hydrocarbon radical or, taken to...
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WO/1994/027942A1 |
The invention discloses a process for the preparation of a halogenated alcohol of the formula (I): CF3-CXC1-CH(OH)-CH=C(CH3)2 wherein X is bromo or chloro which comprises reacting a compound of the formula (II): CF3CHXC1 with 3-methylbut...
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WO/1994/026687A1 |
Compounds of formula (I) wherein m is 1-4; R1-R4 independdently are hydrogen, lower alkyl of 1 to 6 carbons, Cl, Br, or I; R5 is hydrogen, lower alkyl of 1 to 6 carbons, Cl, Br, I, lower alkoxy or lower thioalkoxy of 1-6 carbons; R6 is h...
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WO/1994/025431A1 |
The present invention is concerned with novel hydroxamic acid derivatives of formula (I) and their use in medical therapy, particularly in the prophylaxis or treatment of clinical conditions for which an inhibitor of the lipoxygenase or ...
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WO/1994/022802A1 |
A protecting group of the formula (I): Ar - L - Y -, where Ar represents a substantially plane, fused ring system containing at least 4 aromatic rings; L represents a linker group containing at least one carbon atom which is capable of b...
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WO/1994/020442A1 |
A fluorinated aromatic compound represented by formula (I), utilizable for preparing a magnetic fluid having a wide heat-resistant temperature range and a high water resistance. In said formula, X represents H, F, Cl, C1-C20 alkyl or C1-...
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WO/1994/020456A1 |
A compound with a 12-lipoxygenase inhibitor activity, represented by general formula (I), a precursor therefor, and a medicine containing the same, wherein R1 represents hydrogen or hydroxy; one of R2 and R3 represents hydrogen, while th...
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WO/1994/018148A1 |
Hexanol derivatives have general formula (I) in which, independently, the residue R1 denotes hydrogen or a methyl group, the residues R2 and R3 are hydrogen or an alkyl group with 1 to 3 C atoms and the residues R4 and R5 are hydrogen or...
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WO/1994/017796A1 |
Process of treatment of mammals, including humans to treat diseases or conditions of the type which are normally treated with retinoid-like compounds is disclosed, with pharmaceutical compositions containing an active compound which is a...
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WO/1994/018147A1 |
A method comprising a hydrodimerising reaction of 1,3-butadiene with water in the presence of a transition metal in the form of a metal or compound thereof, a tertiary or quaternary water-soluble phosphorus compound and at least a nitrog...
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WO/1994/014807A1 |
Substituted triols of Formula D-R wherein R represents the group of Formulae (a), (b), (c) or (d), can be used as active substances in drugs against hyperproteinemia.
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WO/1994/014436A1 |
A retroviral protease inhibiting compound of formula (A) is disclosed.
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WO/1994/012457A1 |
Processes for synthesizing tertiary alkynols by reacting carbonyl-group-containing compounds with alkynes in the presence of a basic catalyst are disclosed. Preferred products are 6,10,14-trimethyl-4-pentadecyn-6-ol compounds having stru...
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WO/1994/011343A1 |
New long chain fatty alcohol derivatives, characterized by general formulas (I) or (II) whose linear hydrocarbon side chain has from 7 to 25 carbon atoms, is saturated or has a double bond with a configuration cis or trans at beta of the...
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WO/1994/008028A1 |
The invention relates to a method for enzymatically preparing aromas, particularly C6 to C10 aldehydes, by contacting at least one source of lipoxygenase and hydroperoxyde-lyase with a source of unsaturated fatty acids, the reaction taki...
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WO/1994/006737A1 |
A process for preparing felbamate and a key intermediate, 2-phenyl-1, 3-propanediol (PPD) is disclosed. PPD can be prepared by contacting (i) the enolate salt of formyl phenyl acid ester (VIII), (ii) an E-enol (X), a Z-enol (XII) or form...
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WO/1993/025530A2 |
A process and pharmaceutical compositions for treating several diseases and conditions which are normally treatable with retinoid-like compounds are disclosed where the compounds used for the treatment are substantially non-teratogenic a...
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WO/1993/023408A1 |
The borane reduction of prochiral ketones to optically pure alcohols is effectively achieved by the utilization of catalytic amounts of the new and valuable oxazaborolidine catalysts of formula (I).
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WO/1993/021142A1 |
The invention concerns pentene derivatives of the general formula (I), in which, independently of each other, R?1¿ is hydrogen or a methyl group, R?2¿ and R?3¿ are hydrogen or an alkyl group with 1 to 5 C-atoms, R?4¿ is hydrogen or a...
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WO/1993/016975A1 |
The invention provides a process for preparing aryl ethanols from aryl methyl ketones. The process involves a novel oxidation of the ketone to a dialkylacetal derivative of an aryl glyoxal, which is then hydrolyzed to an aryl glyoxal. Th...
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WO/1993/017150A1 |
A process is disclosed in wich optically active glycols are produced through an electrolytic asymmetric dihydroxylation (ADH) reaction involving olefins as substrates. The ADH reaction is mediated by a catalytically active amount of osmi...
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WO/1993/016022A1 |
An alkylative cycloaddition method is provided that is particularly useful for the synthesis of many of the Vitamin D analogues with differing side chains. Thus, a preferred synthesis is of Vitamin D analogues having a side chain R1 wher...
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WO/1993/015090A1 |
Described are racemic optically active phosphorus compounds of formula (I), in which R is a hydroxy or protected hydroxy group, R1 is a hydroxy or protected hydroxy group or a lower alkoxy group and R2 is a lower alkyl, cycloalkyl or ary...
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WO/1993/015091A1 |
Described are racemic optically active phosphorus compounds of the formula (I), in which R is a lower alkyl or lower alkoxy group and R1 is a lower alkyl, cycloalkyl or substituted phenyl group. The compounds of the formula (I) act, in t...
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WO/1993/013046A1 |
The present invention relates to a stereospecific chemical synthesis of optically pure enantiomers of 2-aryl-alkanoic acids, especially those of the biologically active (S)-aryl-propionic acids, in good chemical yields, useful for prepar...
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WO/1993/011094A1 |
The invention relates to novel odorants derived from formylpinane. In particular, these are compounds of general formula (I), in which R represents H or C¿1?-C¿4? alkyl, for example methyl, ethyl, propyl, butyl etc., preferably methyl ...
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WO/1993/009777A1 |
The present invention relates to novel tocotrienols and tocotrienol-like compounds displaying biological activity. The tocotrienols and tocotrienol-like compounds of this invention may be conveniently obtained from biological sources or ...
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WO/1993/010068A1 |
The invention concerns butenol derivatives of general formula (I), in which R?1¿ is hydrogen or an alkyl group with 1 to 4 C-atoms and R?2¿ is an alkyl group with 1 to 4 C-atoms, with the provision that R?2¿ is not a methyl group if R...
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WO/1993/008799A1 |
Novel indane and indene derivatives are described which are endothelin receptor antagonists.
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WO/1993/008195A1 |
Compounds of general formula (I), pharmaceutically acceptable salts thereof or stereoisomeric forms thereof, wherein 1 = 1, 2 or 3, n is an integer from 1-6, where X is independently selected from H, =O, =CH¿2?, aryl, COR, OR, COOR or X...
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WO/1993/008148A1 |
A process is disclosed for preparing a mixture of 8E,10E-dodecadienol (Ia), 8E,10Z-dodecadienol (Ib), 8Z,10E-dodecadienol (Ic) and 8Z,10Z-dodecadienol (Id), H¿3?C-CH=CH-CH=CH-(CH¿2?)¿6?-CH¿2?-OH, (8E,10E = Ia), (8E,10Z = Ib), (8Z,10E...
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WO/1993/007142A1 |
Osmium-catalyzed methods of addition to an olefin are discussed. In the method of asymmetric dihydroxylation of the present invention, an olefin, a chiral ligand, an organic solvent, an aqueous solution, a base, a ferricyanide salt and a...
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WO/1993/007128A1 |
This invention relates to substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors, to pharmaceutical compositions comprising such compounds, and to methods of using these compounds for treating viral...
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WO/1993/005004A1 |
A compound represented by general formula (I) and a separating agent comprising the same. In formula (I), Ar and Ar' represent each an aromatic group and two substituents on the central benzene ring may be positioned ortho, meta or para ...
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WO/1993/005003A1 |
Unsaturated fatty alcohols with 6 to 22 C atoms can be produced by directly hydrating deacidified and/or non-deacidified glyceride oils containing monounsaturated and/or polyunsaturated, straight chain and/or branched-chain fatty acids h...
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WO/1993/004022A1 |
A method of recovering and reusing a solvent and an optical isomer, characterized by providing a packed bed, which is disposed in the passage for circulating a solvent and packed with a packing material for optical resolution, with a por...
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WO/1993/003839A1 |
This invention relates to asymmetric syntheses in which a prochiral or chiral compound is contacted in the presence of an optically active metal-ligand complex catalyst to produce an optically active product.
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WO/1993/002998A1 |
Disclosed are bicyclic compounds of general formula (I), in which R is: (a) -CH=CR?1¿-CH(OH)-CH¿2?R?2¿, (b) -CH=CR?1¿-CO-CH¿2?R?2¿, (c), (d), (e) a cyclohexyl group which may be substituted in any of various positions with an OH an...
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WO/1993/002030A1 |
A novel method for preparing 2-phenyl substituted-1,3-propanediols, useful intermediates in the synthesis of pharmaceutical preparations is disclosed.
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WO/1993/000347A1 |
The novel organoboron reagent of the present invention is useful in the preparation of unsubstituted propargylic alcohols. This compound reacts with aldehydes and ketones cleanly to afford propargylic alcohols in excellent yields. Unsubs...
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WO/1993/000318A1 |
Formaldehyde and acetylene are usually converted into butynediol in the presence of a suspension catalyst in a cascade of reactors. The catalyst is separated from the product solution after the last reactor in the cascade and fed back in...
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WO/1992/022518A1 |
The present invention relates to the field of perfumery. It concerns in particular a hydroxylated compound derived from alpha-campholene aldehyde, namely of formula (I), or 3,3-dimethyl-5-(2',2',3'-trimethyl-3'-cyclopenten-1'-yl)-pen
tan...
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WO/1992/021643A1 |
Novel azulenic retinoid compounds and therapeutic compositions are disclosed, along with method for their production and use as anti-cancer and cancer-prevention agents. The compositions of the present invention will also find use in tre...
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WO/1992/020677A1 |
Osmium-catalyzed methods of addition to an olefin are discussed. In the method of asymmetric dihydroxylation of the present invention, an olefin, a chiral ligand, an organic solvent, water, an oxidant and an osmium-containing compound ar...
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WO/1992/019748A1 |
In addition to virions, herpesvirus-infected cells produce non-infectious particles, termed L-particles, which consist of tegument surrounded by envelope but lack the nucleocapsid. L-particles of a herpesvirus can be prepared substantial...
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WO/1992/017176A1 |
Compounds are disclosed which are retroviral protease inhibitors. Also disclosed are methods of using the compounds and compositions for inhibiting a retroviral protease and for treating an HIV infection.
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WO/1992/016504A1 |
The invention discloses new leukotriene B4 derivatives of formula (I), wherein R?1� stands for CH�2?OH, CH�3?, CF�3?, COOR?5�, CONR?6�R?7�, or R?1� together with R?2� stands for a carbonyl group, R?2� and R?3� are t...
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WO/1992/012167A1 |
The protection group has the following formula (I): Ar-L- where Ar represents a substantially flat system of fused rings containing at least 4 aromatic rings, and L represents a group containing at least one carbon atom capable of bondin...
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WO/1992/006065A1 |
The invention relates to compounds of formula (I) wherein Hal1 and Hal2, the same or different from each other, are a halogen atom, X is a hydrogen atom, an alkyl, alkenyl or alkynyl radical having up to 4 carbon atoms or a cyano radical...
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WO/1992/006061A1 |
An iridoide derivative synthesized from genipin, an aglycon of geniposide, which is useful as an antihyperlipemic agent and chologogue.
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