Heterocyclic Compounds

Matches 651 - 700 out of 1,290	< 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 >

Document	Document Title
JP4222833B2	Use of aryl and heteroarylurea Chk1 inhibitors as radiosensitizers and chemical sensitizers Aryl- and heteroaryl-substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, f...
JP2009007341A	MEDICINAL COMPOSITION To provide a CCR4 function control agent useful for preventing and treating diseases such as bronchial asthma and atopic dermatitis.This CCR4 function control agent comprises a compound represented by formula (1) [wherein, the ring A rep...
JP2009004374A	PROTON CONDUCTOR OF LIQUID FORM To provide a proton conductor which has a melting point lower than room temperature and a low vapor pressure and a similar conductivity with what can be obtained in an aqueous medium.The proton conductor of a liquid form contains a mixtu...
JP2008545622A	Substitution 4,5-dihydro-1,2,4-triazine-6-ones, 1,2,4-triazine-6-ones and their use as fungicides This invention relates to substituted dihydrotriazinones, triazinones and related compounds, compositions comprising such compounds and an agronomically acceptable carrier, and the use thereof as broad spectrum fungicides. This invention...
JP4199315B2	Fluoroalkyl- and Fluoralkoxy-Substituted Heterocyclic Bradykinin Antagonists, Their Production Methods and Their Use Fluoroalkyl- and fluoroalkoxy-substituted benzyloxy-azaheterocyclic compounds of formula (I) and their salts are new: X1-X3 = N or CR<5>; R<1>, R<2> = H or halo; R<3>, R<4> = H, halo, 1-5C alkyl or 2-5C alkenyl; R<5> = 2-5C alkenediyl, h...
JP4199309B2	New acetamide derivatives and protease inhibitors The present invention relates to novel acetamide derivatives having a substituted heterocyclic group and consecutive dicarbonyl structures, for example 1-pyrimidinylacetamide compounds, 1-pyrazinylacetamide compounds, 1-triazinylacetamid...
JP4194539B2	Azolotriazines and azolopyrimidines
JP2008543775A	Methods and compositions for treating eye disorders The invention provides methods and compositions for the delivery of lipophilic drugs that are useful for the treatment of various ophthalmological diseases, disorders, and pathologies, including the treatment of age-related macular degen...
JP4181291B2	Retrovirus protease inhibitor compound A compound comprising a substituent of the formula (II) is disclosed as an HIV protease inhibitor. Intermediates for making such compounds and processes for making such intermediates are also disclosed.
JP4172895B2	Heterodiadinone derivative
JP2008530072A	Anthranilic acid derivatives and their use in the treatment of diseases of lipid metabolism, especially abnormal lipidemia Therapeutically active anthranilic acid derivatives of Formula (I) wherein R1, R2, W, Y and Z are as defined in the specification, processes for the preparation of said derivatives, pharmaceutical formulations containing the active compo...
JP2008530074A	Anthranilic acid derivative as an HM74A receptor agonist Therapeutically active anthranilic acid derivatives of Formula (I) wherein R1, R2 and W, are as defined in the specification, processes for the preparation of said derivatives, pharmaceutical formulations containing the active compounds ...
JP2008530241A	A compound that inhibits the aggregation of superoxide dismutase-1 The invention is directed to methods of inhibiting the rate at which superoxide dismutse-1 (SOD) aggregates using compounds that stabilize SOD dimers. The methods are useful in the study and therapy of amyotrophic lateral sclerosis. The ...
JP4129993B2	Conformatation-Restricting Aromatic Inhibitors and Methods for Microsome Triglyceride Transfer Proteins Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure (I) or (IA) or (IB) including pharmaceutically acceptable sa...
JP2008528679A	Heterocyclic triazine as a hypoxic selective protein kinase inhibitor The invention relates to novel heterocyclic N-oxides which are useful as hypoxic selective cytotoxic agents that mediate and/or inhibit cell proliferation, for example, through the activity of protein kinases. The invention is further re...
JP4125803B2	Heterocyclic bradykinin antagonists containing sulfur, how to make them and their use Sulphur-containing bradykinin antagonist compounds of formula (I) and their salts are claimed: one of X1-X3 = COR<2>, and the other X1-X4 = N, CR<1>; R<1>,R<3> = H, halo, 1-6C alkyl, OR<6>, SR<6>, NHR<6>, 6-12C aryl, (6-12C aryl)(1-3C al...
JP4124487B2	Five-membered ring anion salts or tetraazapentalene derivatives and their use as ionic conductive materials Battery has an electrolyte comprising a solvent and a salt (I) comprising a hydroxonium, nitrosonium, ammonium, metal, organic or organometallic cation and a 5-membered (hetero)cyclic anion. Battery has an electrolyte comprising a solven...
JP4115518B2	New 3,5-dioxo- (2H, 4H) -1,2,4-triazine derivatives, their preparation and use as a drug PCT No. PCT/FR95/01589 Sec. 371 Date May 30, 1997 Sec. 102(e) Date May 30, 1997 PCT Filed Dec. 1, 1995 PCT Pub. No. WO96/16949 PCT Pub. Date Jun. 6, 1996Novel 3,5-dioxo-(2H,4H-triazine derivatives of general formula (I): wherein R1 is hy...
JP4109271B2	Substituted arylacylthiourea and related compounds; Inhibitor of viral replication The invention provides compounds and pharmaceutically acceptable salts of Formula I wherein the variables A1, A2, R1, R2, V, W, X, Y, and Z are defined herein. Certain compounds of Formula I described herein which possess potent antivira...
JP4102923B2	Positive radiation-sensitive resin composition for semiconductor device manufacturing
JP2008516989A	Composition and its use as an antitumor agent The present invention provides novel compounds and pharmaceutical compositions thereof, as well as methods for using the compounds and pharmaceutical compositions for treating tumors. Examples of specific tumor types that the compounds m...
JP2008514547A	Ceramutane Modulator This invention relates to agents that are inhibitors or activators of variant forms of endogenous proteins and novel methods of identifying such variants. Of particular interest are inhibitors and activators of endogenous protein variant...
JP4081167B2	Vitronectin receptor antagonist, its production and its use Guanidine and cycloguanidine derivatives of formula A-B-D-E-F-G (I) and their salts are new. A = R<2>R<3>N-C(=NR<2>)NR<2>Z- or a group of formula (a) or (b); Z = C(Q) or S(O)n; Q = O or S; n = 1 or 2; R = 5-10 membered mono- or polycycli...
JP4070244B2	Surface-modified carbonized material Battery has an electrolyte comprising a solvent and a salt (I) comprising a hydroxonium, nitrosonium, ammonium, metal, organic or organometallic cation and a 5-membered (hetero)cyclic anion. Battery has an electrolyte comprising a solven...
JP4049742B2	Pyrimidine, triazine and pyrazine derivatives as glutamate receptors The present invention is a pyrimidine, triazine or pyrazine derivative of the formula or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, R4, X, Y and Z are as defined in the specification. The invention is a pharmaceutical...
JP4051230B2	Treatment of hair loss using silomimetic compounds The present invention provides methods and compositions for treating hair loss, including arresting and/or reversing hair loss and/or promoting hair growth, in mammals, such as humans, companion animals and livestock, using certain thyro...
JP2008504360A	5- [4- (2-Hydroxy-propyl) -3,5-dioxo-4,5-dihydro-3H-1,2,4-triazine-2-yl by deprotecting hydroxyl-protected precursors ] -Method for producing benzamide derivative The present invention relates to the methods for preparing compounds of the formula I: or the pharmaceutically acceptable salts thereof, wherein R1, R2, R4, R10, and R11 have any of the values defined in the specification. The compounds ...
JP2008504362A	A 5- [4- (2-hydroxy-ethyl) -3,5-dioxo-4,5-dihydro-3H- [1,2,4] triazine-2-yl] -benzamide derivative having P2X7 inhibitory activity, A method for producing by reacting an oxylane with a derivative not substituted at the 4-position of triazine in the presence of a Lewis acid. The present invention relates to methods of preparing compounds of formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R4, and R7 have any of the values as defined in the specification. The compounds are useful as ag...
JP4039684B2	Substituted aromatic thiocarboxylic acid amides and their use as herbicides There is disclosed substituted thiocarboxamides of the general formula (I)useful as herbicides.
JP2008007781A	SURFACE MODIFIED CARBONATED MATERIAL To graft a polymer at the surface of a carbonated material containing carboxyl, amine and/or hydroxyl functions at its surface.The carbonated material is suspended in a solution comprising the polymer to be grafted, which includes the ca...
JP2008001635A	GLYCINE DERIVATIVE AND ITS USE To provide a medicine having excellent therapeutic or prophylactic action for allergic dermatitis and excellent in absorbing property in oral administration and in stability in organisms, namely the agent enabling oral administration and...
JP2007538107A	Substituted cyclic urea derivative Certain novel phenyl substituted cyclic urea derivatives have unexpected insecticidal activity. These compounds are represented by formula I: where A, B a, D, b, E, G, c, d, J, X and R through R10, inclusively, are fully described herein...
JP4001542B2	N-alkyl-adamantane tilt riazinyl benzamide derivative The present invention relates to novel to N-adamantylalkyl benzylamide derivatives of formmula I and to process for their preparation, intermediates useful in their preparation, pharmaceutical compositions containing them, and their use ...
JP2007528420A	New M3 muscarinic acetylcholine receptor antagonist Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.
JP3981892B2	How to make nicotine aldehyde water A process for the preparation of an aqueous medium of nicotinaldehyde by the catalytic reduction of 3-cyanopyridine under hydrogen in the presence of Raney-nickel.
JP3964478B2	HETEROGENEOUS RING-CONTAINING CARBOXYLIC ACID DERIVATIVE AND MEDICINE CONTAINING THE SAME To obtain the subject compound having a retinoid receptor agonist action, and useful for preventing and treating autoimmune diseases and malignant neoplasm and for immunosuppression on the transplantation of an organ. A heterogeneous rin...
JP3954127B2	CYCLIC AMIDE DERIVATIVE AND HERBICIDE PURPOSE: To obtain a new cyclic amide derivative exhibiting excellent weeding activity to injurious weed generating in paddy field or upland field in soil treatment or stem and leaf-treatment and exhibiting high safety to crop and useful...
JP2007519734A	Amino Cyclopentyl Pyridopyrazineone Chemokine Receptor Activity Modulator Compounds of Formula I and Formula II (wherein A, E, j, k, m, n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, R17, R18, R19, R24, R25, R26, R27, R28, R29, R30, R31, R32, R33, R34, X, Y and Z are as defined herein) which are modulat...
JP2007182456A	CYCLIC AMIDE DERIVATIVE AND HERBICIDE To provide a herbicide having a selective action for killing only weeds without damaging crops, even when simultaneously applied to both the crops and the weeds.A cyclic amide derivative represented by the general formula [I] [-A-B- is -...
JP2007145723A	UREIDO TROPOLONE DERIVATIVE To provide a novel compound exhibiting cytokinin activities.An agrochemical or the cytokinin-active agent comprises a compound represented by general formula (I) or a salt thereof. In the formula, R1 is a hydroxy group, an optionally sub...
JP2007511612A	Quinazolinone compounds with reduced bioaccumulation A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the formula IA a...
JP3913983B2	Cyclic hydrazine derivative as a TNF-α inhibitor Hydrazine derivatives and their pharmaceutically acceptable salts useful for the treatment of inflammatory and autoimmune diseases, osteoarthritis, respiratory diseases, tumors, cachexia, cardiovascular disease, fever, hemorrhage, and se...
JP2007508349A	A novel alanylaminopeptidase inhibitor for functionally affecting different types of cells to treat immune, inflammatory, neurological, and other disorders The invention relates to substances which specifically inhibit peptidases splitting ala-p-nitroanilide for use in medicine. The invention further relates to the use of at least one such substance or of a pharmaceutical or cosmetic compos...
JP2007504176A	Guanidine derivative The invention relates to the guanine derivatives of general formula (I), and to hydrates or solvents thereof, for use as neuropeptide FF receptor antagonists in the treatment of pains and hyperalgesia, of withdrawal symptoms of addiction...
JP3884232B2	Glucokinase activator The present invention relates to compounds of formula (I) wherein R<1>, R<2>, R<3> and R<4> are as defined in claim 1 and pharmaceutically acceptable salts thereof. The compounds are glucokinase activators which increase insulin secretio...
JP2007501861A	Guanidino-substituted quinazolinone compounds as MC4-R agonists A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structures V...
JP3857722B2	Has insecticidal activity (4,4-difluorobut-3-enylthio) -substituted heterocycle or carbocyclic compound A compound having the formula R-S(O)nCH2CH2CH=CF2, wherein R is a phenyl group or a heterocyclic group selected from furyl, thienyl, isoxazolyl, isothiazolyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, 1,2,4-oxadiazolyl, 1,2,4-thiadiazo...
JP2006526619A	Sulfonamide compounds that regulate chemokine receptor activity (CCR4) The invention provides pyrimidine, pyridazine and triazine compounds for use in therapy.
JP2006524694A	Use of alkyl metal reagents for orientation metallization of aza aromatic compounds Substituted alkylmetal reagents such as (trimethylsilylmethyl)lithium are reacted with pyridinic compounds to produce functionalized pyridinic compounds.
JP3824638B2	N-heterocyclyl sulfonamide derivatives and their use as endoterin antagonists Pyrimidine sulphonamide compounds of the following formula, wherein Q is a naphthyl or biphenyl group either unsubstituted or substituted with A1, and where A1, R1 and R2 are a variety of alkyl, aryl and cyclic moieties, as described in ...

Matches 651 - 700 out of 1,290	< 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 >