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WO/2003/042196A1 |
In accordance with the present invention, there are provided novel benzoxazine compounds and thermosetting resin compositions prepared therefrom. Invention compositions are particularly useful for increasing adhesion at interfaces within...
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WO/2003/042211A1 |
Phenyl substituted triazoles of formula (I) wherein R1 is naphthyl or phenyl optionally substituted with one or more substituents selected from halo, -O-C1-6alkyl, -S-C1-6alkyl, C1-6alkyl, C1-6haloalkyl, -O-(CH2)n-Ph, -S-(CH2)n-Ph, cyano...
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WO/2003/042195A2 |
The present invention provides photochromic oxazine compounds and methods for their manufacture, which compounds are useful as photochromic compounds. The compounds of the invention have aromatic substituents on the 2 position of the oxa...
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WO/2003/040096A2 |
Disclosed are compounds of the formula (I), wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of betasecretase and are therefore useful in treating a variety of discorder...
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WO/2003/037871A1 |
Provided herein is a compound having the formula (I) (R2 is typically a tertiary nitrogen atom, being either alkyl−substituted or member of q heterocyclic ring&semi R7 is typically a monocyclic or bicyclic aromatic ring or a heterocycl...
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WO/2003/037872A1 |
Provided herein is a compound having the formula (I), (R2 is typically a tertiary nitrogen atom, being either alkyl-substituted or member of a heterocyclic ring; R7 is typically a monocyclic or bicyclic aromatic ring or a heterocyclic ri...
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WO/2003/035735A1 |
The present invention relates to benzoxazinone compounds having a yellow index less than about 0, and a sodium concentration less than about 50 ppm. This invention also relates to a process for preparing these compounds comprising the st...
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WO/2003/033456A1 |
The present invention relates to novel propionic acid derivatives. More particularly, the present invention relates to beta-phenyl alpha-oxysubstituted propionic acids of the general formula (I). The present invention also relates to pro...
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WO/2003/032731A1 |
This invention pertains to methods for controlling invertebrate pests comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound of Formula (I) wherein B is O, S or NR?1¿; J is a ph...
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WO/2003/033481A1 |
The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I) their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharm...
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WO/2003/031431A1 |
The present formula application describes novel cyclic sulfone derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, X, U?a¿, X?a¿, Y?a¿, Z?a¿, R?1¿, R?2¿, R?b¿ and q are defined in ...
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WO/2003/031482A1 |
The invention relates to a method for gel post-crosslinking or surface post-crosslinking water-absorbing hydrogels with morpholine-2,3-diones, to the post-crosslinked hydrogels and to the use thereof.
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WO/2003/031458A1 |
The present invention relates to dihydrofolate reductase inhibitors having an aromatic group and a heteroaromatic group linked by a methylene group; methods of preparation of dihydrofolate reductase inhibitors that include metal mediated...
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WO/2003/028729A2 |
The present invention relates to prodrug compounds, comprising a 5- or 6- membered heterocyclic or aromatic ring substituted with a derivatized amidine, as well as compositions and methods useful for preventing and treating thrombotic co...
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WO/2003/029216A1 |
The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inh...
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WO/2003/029200A2 |
Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (Ia) and (Ib) where R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, R¿6?, R¿8?, R¿9? and X aredefined herein. The compoundsare useful for treating autoi...
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WO/2003/029224A1 |
The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhi...
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WO/2003/027084A1 |
The present invention relates to improved process for the preparation of antidiabetic compound having the formula (1). where R1 represents alkyl group such as methyl, ethyl, propyl, isopropyl and the like.
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WO/2003/024941A1 |
Naphthalene compounds represented by the general formula (1) or pharmaceutically acceptable salts, hydrates or solvates thereof, which exhibit anti−HIV activity and are useful in the treatment of AIDS: (1) wherein each symbol is as def...
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WO/2003/024448A2 |
The invention relates to the inhibition of histone deacetylase. The invention provides compounds e.g. (1) and methods for inhibiting deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell p...
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WO/2003/024949A1 |
The invention relates to the use of compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, in the preparation of a medicament for inhibiting the activity of DNA-PK, wherein R?1¿ and R?2Â...
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WO/2003/024401A2 |
The present application describes modulators of CCR3 of formula (I) or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
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WO/2003/020688A1 |
Compounds of formula (I) or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of disorders using the c...
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WO/2003/020709A1 |
The invention relates to novel oxazinones, methods of synthesizing the compounds, and the use of the compounds as antibacterial agents.
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WO/2003/018535A2 |
The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating patients comprising administering said compo...
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WO/2003/018565A1 |
The invention pertains, at least in part, to methods for synthesizing an oxazinone compound of formula (I). The method includes contacting an aminooxy compound of formula (II) with a cyclizing agent under appropriate conditions, such as ...
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WO/2003/018566A1 |
The invention provides compounds of formula (I), in which m, n, X, Y, R?1¿, R?2¿ and R?3¿ are as defined in the specification; processes for their preparation; pharmaceutical compositions containing them; and their use in therapy.
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WO/2003/016292A1 |
The present invention relates to novel ultraviolet light absorbers of the benzoxazinone, oxanilide, benzylidene malonate, quinazoline and benzotriazole classes. The invention also relates to polymer and photographic compositions stabiliz...
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WO/2003/011834A1 |
Novel compounds of the general formula (I), the use of these compounds as medicaments, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be...
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WO/2003/011931A1 |
A benzoxazine polymer having improved thermal properties. The properties are improved by inserting aromatic polyamines into the monomer, such as phenylenediamine, methylenedianiline, oxydianiline, diaminodiphenylsulfone, 2,2- bis(4-[amin...
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WO/2003/011298A1 |
The invention pertains, at least in part, to new intermediates and synthetic methods for the stereospecific synthesis of oxazinone compounds, which are useful, for example, as antibiotics. The invention also pertains to novel olefinic ox...
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WO/2003/008396A1 |
(−)−6−[3−(2−Indanyloxy)−4−methoxyphenyl]−6âˆ
’methyl−3,4,5,6−tetrahydro−2H−1,3−oxazin−2−one
, its hydrate or its solvate&semi and drugs containing the above compound as the active ingredient which are useful...
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WO/2003/008397A1 |
The present invention relates to an improved process for the preparation of antidiabetic compounds having the formula (1) where R?1¿ represents alkyl group such as methyl, ethyl, propyl, isopropyl, butyl, tert-butyl group and the like.
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WO/2003/006423A1 |
Disclosed are compounds of the formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the betasecretase enzyme that are useful in the treatment of Alzeheimer's disease and ot...
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WO/2003/002514A1 |
The present invention relates to novel antidiabetic compounds, their derivatives, their analogs and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel 3-aryl propanoic acid...
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WO/2003/000323A1 |
A medical injection device (10) is provided which includes a shield system (14) and a syringe (12) which may be coupled to the shield system. The shield system includes a syringe holder (26), a shield (28) telescopically received in the ...
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WO/2003/000322A1 |
A medical device (10) is provided which includes a shield system (14) and a syringe (12) which is coupled to the shield system. The shield system includes a syringe holder (26) and a shield (28) which is slidably coupled to the holder. A...
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WO/2003/000181A2 |
Compounds having Formula (I), including pharmaceutically acceptable salts and prodrugs thereof are inhibitors of the dipeptidyl peptidase-IV enzyme (DP-IV), and are useful in the treatment of DP-IV mediated diseases and conditions, such ...
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WO/2002/102782A2 |
Use of compound of formula (I), wherein (a) is (b) or (c) and wherein the symbols are as defined, or a pharmaceutically-acceptable and-cleavable ester, or acid addition salt thereof, for the preparation of a medicament for promoting the ...
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WO/2002/100843A1 |
The invention relates to the phenoxazine compounds of formulae I, and the pharmaceutical acceptable salts, esters, amides and prodrugs thereof, to the pharmaceutical compositions containing them, to the use of the preparation of the medi...
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WO/2002/096872A1 |
The invention relates to novel substituted imidates of formula (I) in which Z, n, X, R?1¿ and R?2¿ have the meanings given in the description, methods for the production and use thereof as pesticidal agents.
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WO/2002/096858A1 |
There is provided novel cinnamide derivatives of Formula I wherein R is C¿1-4? alkyl or trifluoromethyl, R?1¿ is selected from the group consisting of pyridinyl, quinolinyl, thienyl, furanyl, 1,4-benzodioxanyl, 1,3-benzodioxolyl, chrom...
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WO/2002/094797A1 |
The invention relates to oxazin(thi)one compounds of formula (1) in which the variables Z, R1, R2, R3 and n have the meaning cited in claim 1 and A represents a 5 or 6 membered carbocycle, fused with the oxazin(thi)one by means of two C ...
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WO/2002/092574A1 |
The invention relates to novel substituted benzoylcyclohexenones of formula (I), in which Q, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, Y and Z are defined as per the description. The invention also relates to a method for their production and t...
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WO2002028841B1 |
Novel fluorescent derivitization reagents are described that are suitable for coupling to biomolecules that contain aldehyde or ketone functional groups. The method of treating a sample with the derivativization reagents is described. Th...
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WO/2002/089800A2 |
This invention relates to N-aroyl cyclic amine derivatives of formula (I), wherein: Y represents a bond, oxygen, or a group (CH2)n, wherein n represents 1, 2 or 3; m represents 1, 2 or 3; p represents 0 or 1; X is O, S C=O, SO2, or -CH=C...
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WO/2002/090347A1 |
The present invention relates to compounds of the formula (I) wherein X?1¿ is wherein R?1¿, R?2¿ and R?10¿ are independently hydrogen or a suitable substituent; R?11¿ and R?12¿ are independently hydrogen or a suitable substituent; ...
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WO/2002/086138A2 |
The invention relates to a method for transforming amines of general formula (I), wherein A represents (i), into compounds of general formula (II) or (III), wherein B represents HO-CH¿2?-R?3¿- or R?4¿-. The method comprises the follow...
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WO/2002/085841A2 |
The invention relates to novel substituted catechol derivatives, derived from polybasic secondary amino acids and analogous structures of general formula (I). Said compounds are effective as siderophores in mycobacteria and gram-negative...
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WO/2002/085868A1 |
This invention relates to novel compounds of Formula (I) for use as vascular damaging agents: wherein: X is selected from: -O-, -S-, -S(O)-, -S(O¿2?)-, -N(R¿4?)- or -N(R¿4?)CH¿2?C(O)-; R¿1? is independently selected from: amino, hal...
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