Heterocyclic Compounds

Matches 1,101 - 1,150 out of 5,014	< 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 >

Document	Document Title
WO/2003/090690A2	CELLULAR ACCUMULATION OF PHOSPHONATE ANALOGS OF HIV PROTEASE INHIBITOR COMPOUNDS AND THE COMPOUNDS AS SUCH Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for th...
WO/2003/090678A2	ANTILEISHMANIAL DINITROANILINE SULFONAMIDES WITH ACTIVITY AGAINST PARASITE TUBULIN Dinitroaniline compounds useful for the treatment of diseases caused by parasitic protozoa in subjects in need of such treatment. The compounds are particularly useful in the treatement of leishmaniasis. The compounds are preferably less...
WO/2003/091202A1	DIKETOHYDRAZINE DERIVATIVE COMPOUNDS AND DRUGS CONTAIING THE COMPOUNDS AS THE ACTIVE INGREDIENT Diketohydrazine derivatives represented by the following general formula (I) (wherein each symbol is as defined in the description) and pharmaceutically acceptable salts thereof: (I) Because of having a cysteine protease inhibitory activ...
WO/2003/090691A2	METHOD AND COMPOSITIONS FOR IDENTIFYING ANTI-HIV THERAPEUTIC COMPOUNDS Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Composit...
WO/2003/091264A2	NON NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS Phosphorus-substituted imidazole compounds with anti-HIV properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit reverse transcriptase activity and are useful therapeutically for th...
WO/2003/089429A1	PROCESS FOR 5-[[2(R)-[1(R)-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY]-3(S)-(4-FLUOROPHENYL)-4-M ORPHOLINYL]METHYL]-1,2-DIHYDRO-3H-1,2,4-TRIAZOL-3-ONE The present invention is concerned with a novel process for the preparation of the compound 5-[[2(R)-[1(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(S)- (4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4- triazol-3-one. This com...
WO/2003/087044A2	NOVEL CARBOXAMIDE COMPOUNDS FOR USE IN MCH RECEPTOR RELATED DISORDERS Novel compounds of formula (I) which modulate MCH activity are disclosed, in which A is a linker; B is a connecting moiety; Ar1 and Ar2 are aryl or heteroaryl groups; R1 and R2 are hydrogen, halogen atoms, CF3, OCF3, SCF3, SCH3, nitrile,...
WO/2003/084938A2	PYRIMIDONE DERIVATIVES USEFUL FOR THE TREATMENT OF INFLAMMATIN AND IMMUNOLOGICAL DISEASES AbstractThe present invention relates to novel pyrimidone derivatives of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their phar...
WO/2003/084936A2	AMINO SUBSTITUTED PYRIMIDINONE DERIVATIVES USEFUL IN THE TREATMENT OF INFLAMMATION AND IMMUNOLOGICAL The present invention relates to novel amino substituted pyrimidinone derivatives of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates...
WO/2003/084935A2	DIARYL PYRIMIDINONE DERIVATIVES USEFUL FOR THE TREATMENT OF INFLAMMATION AND IMMUNOGOLICAL DISEASES The present invention relates to novel diaryl pyrimidinedione derivatives of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their ...
WO/2003/084937A2	PYRIMIDINEDIONE DERIVATIVES USEFUL FOR THE TREATMENT OF INFLAMMATION AND IMMUNOLOGICAL DISEASES The present invention relates to novel pyrimidinedione derivatives of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmac...
WO/2003/084917A1	(2-((2-ALKOXY) -PHENYL) -CYCLOPENT-1-ENYL) AROMATIC CARBO AND HETEROCYCLIC ACID AND DERIVATIVES Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: (I) wherein A, R1 , R2 , Rx , R8 , R9 and n are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions c...
WO/2003/084927A1	HALOALKENES, PROCESS FOR PRODUCTION THEREOF, AND PEST CONTROLLERS CONTAINING THE SAME Haloalkenes represented by the general formula (I) which are useful as pest controllers: (I) wherein X1 and X2 are each halogeno; Y is hydrogen or halogeno; n is 0 to 5; and Q is (1) a heterocyclic group selected from among thienyl, fury...
WO/2003/082862A1	ANTI-INFLAMMATORY MORPHOLIN-ACETAMIDE DERIVATIVES Certain compounds of formula (I): wherein: R1 represents substituted or unsubstituted heteroaryl; Y represents -(CRnaRnb)n-; Rna and Rnb are each independently hydrogen or C1-6alkyl; n is an integer from 1 to 5;R2 represents unsubstitute...
WO/2003/082190A2	SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS Novel compounds of structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of ...
WO/2003/082836A1	NEW DIOXOMORPHOLINES FOR COMBATING ENDOPARASITES The present invention relates to new dioxomorpholines, to their use for combating endoparasites and to processes for their preparation.
WO/2003/082295A1	MORPHOLINE DERIVATIVES SUBSTITUTED AT THE 2-POSITION BY A HETEROCYCLYLALKYLUREA GROUP FOR USE AS CCR-3 ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY CONDITIONS Certain compounds of formula (I): wherein: R1 represents substituted or unsubstituted heterocyciyl; Y represents -(CRnaRnb)n-; Rna and Rnb are each independently hydrogen or C1-6 alkyl; n is an integer from 1 to 5; R2 represents unsubsti...
WO/2003/082835A1	PROCESS FOR THE PREPARATION OF MORPHOLINE DERIVATIVES AND INTERMEDIATES THEREFORE Processes for the preparation of a compound of formula (IIIA)(I), or a salt thereof; wherein; Z represents a bond, CO, SO2, CR10R7(CH2)n, (CH2)nCR10R7, CHR7(CH2)nO, CHR7(CH2)nS, CHR7(CH2)nOCO, CHR7(CH2)nCO, COCHR7(CH2)n or SO2CHR7(CH2)n;...
WO/2003/082837A1	HYDROXYMORPHOLINONE DERIVATIVE AND MEDICINAL USE THEREOF A compound represented by the following general formula (I): (I) (wherein R1 and R2 each represents optionally substituted lower alkyl) or a salt thereof. The compound or salt has calpain inhibitory activity.
WO/2003/082291A1	N-&lcub ´ (2S) -4- (3, 4-DIFLUOROBENZYL) MORPHOLIN-2YL!METHYL&rcub -2-&lcub 3-' (METHYLSULPHONYL) AMINO! PHENYL&rcub ACETAMIDE AS CCR3 ANTAGONIST FOR THE TREATMENT OF INFLAMMATORY CONDITIONS Compound of formula (I): HsC H H '(0) IIZZ V which is; 3-(f [(&lcub [(2S)-4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl&rcub amino)carbonyl]-amino&rcub methyl)=Nethlylbenzamide; and salts and solvates thereof, a process for its preparation...
WO/2003/082292A1	MORPHOLINE DERIVATIVES SUBSTITUTED AT THE 2-POSITION BY AN ARYLALKYLUREA GROUP FOR USE AS CCR-3 ANTAGONISTS IN THE TREATMENT OF INFLAMMATORY CONDITIONS Certain compounds of formula (I); wherein R1 represents unsubstituted or substituted aryl; Y represents -(CRnaRnb)n-; Rna and Rnb are each independently hydrogen or C1-6 alkyl; n is an integer from 1 to 5; R2 represents unsubstituted or ...
WO/2003/082294A1	MORPHOLINE DERIVATIVES WITH A SUBSTITUTED ACETAMIDE GROUP IN THE 2-POSITION FOR USE AS CCR-3 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES Certain compounds of formula (I); wherein R1 represents substituted or unsubstituted aryl; X represents -O- or a bond; Y represents -(CRna,Rnb) n-; Rna and Rnb are each independently hydrogen or C1-6alkyl; n is an integer from 1 to 5; R2...
WO/2003/082293A1	BENZENESULPHONATE SALT OF A MORPHOLINE UREA DERIVATIVE FOR USE AS A CCR-3 ANTAGONIST IN THE TREATMENT OF INFLAMMATORY CONDITIONS Compounds of formula (I), wherein A- represents the benzenesulphonate (besylate) anion; R represents H or C1-6 alkyl; and n is a number from 0.8 to 2.2 are CCR3 antagonists and are therefore indicated to be useful in therapy of inflammat...
WO/2003/082834A2	MORPHOLINE DERIVATIVES AND INTERMEDIATES THEREFOR Compound of formula (I); which is;3-(&lcub [(&lcub [(2S)-4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl&rcub amino)carbonyl]--amino&rcub methyl)-N-ethylbenzamide;and salts and solvates thereof, a process for its preparation, pharmaceutical ...
WO/2003/080736A1	USE OF OXAZINE DYES AS MARKING GROUPS FOR SINGLE MOLECULE ANALYSIS The invention relates to the use of oxazine dyes as marking groups for single molecule analysis, particularly for the single molecule sequencing of nucleic acids. The invention also relates to novel oxazine compounds.
WO/2003/078409A1	CARBOXYOIC ACID COMPOUNDS AND DRUGS CONTAINING THE COMPOUNDS AS THE ACTIVE INGREDIENT Carboxylic acid compounds represented by the following general formula (I) (wherein each symbol is as defined in the description) and drugs containing these compounds: (I) Because of binding to DP receptor and antagonizing the same, the ...
WO/2003/078376A1	NK1 ANTAGONISTS A NK1 antagonist having the formula (I), with the variables defined herein, which is useful for treating a number of disorders, including emesis, depression, anxiety and cough.
WO/2003/076639A1	OSTEOCLAST DIFFERENTIATION INHIBITORS Compounds represented by the following general formula (I); a process for producing a compound (substance F-1490) of the general formula (I), wherein X represents -O- and R represents hydroxy, by using a microorganism belonging to the ge...
WO/2003/075915A1	5-&rcub 2-HYDROXY-3-&grave 1-(3-TRIFLUOROMETHYLPHENYL)-CYCLOPROPYL!-PROPIONYLAMINO&rcub - PHTALIDE AND RELATED COMPOUNDS WITH PROGESTERONE RECEPTOR MODULATING ACTIVITY FOR USE IN FERTILITY CONTROL AND HORMONE REPLACEMENT THERAPY The present invention relates to non-steroidal progestins of the general formula (I) wherein R1 and R2 are independently of each other -H or -F, R3 is -CH3 or -CF3, and Ar is (a) or (b), or a pharmaceutically acceptable derivative or ana...
WO/2003/076374A1	PROCESS FOR PRODUCING trans-4-AMINO-1-CYCLOHEXANECARBOXYLIC ACID DERIVATIVE A process for producing a compound (I) which comprises the step of reacting a compound (II) with a base in an aprotic solvent as shown by the scheme: (II) (I) wherein R1 and R2 each independently represents lower alkyl.
WO/2003/074572A1	OPEN-CHAIN ALKOXYAMINES AND THEIR CORRESPONDING NITROXIDES FOR CONTROLLED LOW TEMPERATURE RADICAL POLYMERIZATION The present invention relates to open chain alkoxyamine compounds, a polymerizable composition comprising a) at least one ethylenically unsaturated monomer and b) at least one open chain alkoxyamine compound. Further aspects of the prese...
WO2002058695A9	(HALO-BENZO CARBONYL)HETEROCYCLO FUSED PHENYL P38 KINASE INHIBITING AGENTS Compounds described by the chemical formula (I) or a pharmaceutically acceptable salt thereof, are inhibitors of p38 useful in the treatment of inflammatory diseases such as arthritis.
WO/2003/072055A2	PROPARGYLAMINO INDAN DERIVATIVES AND PROPARGYLAMINO TETRALIN DERIVATIVES AS BRAIN-SELECTIVE MAO INHIBITORS The subject invention provides derivatives of propargylamino indan (PAI) and propargylamino tetralin that selectively inhibit monoamine oxidase (MAO) in the brain, having the structure:, wherein R1 is OC (O) R9 and R2 is H, wherein R9 i ...
WO/2003/072638A1	CURABLE COMPOSITIONS CONTAINING BENZOXAZINE Curable compositions comprise a benzoxazine compound or resin in combination with at least one additional curable compound or resin. Optionally, the composition will further comprise a curing agent and&sol or a filler. These compositions...
WO/2003/072537A2	SELECTIVE PROTEIN TYROSINE PHOSPHATATASE INHIBITORS Compounds of formula (I), or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of disorders using the ...
WO/2003/070709A1	NOVEL PHENYLALANINE DERIVATIVE The following phenylalanine derivative having an &agr 4 integrin inhibitory effect, its analogs and remedies for various diseases in which &agr 4 integrin participates.
WO/2003/068212A1	USE OF SODIUM/HYDROGEN EXCHANGE INHIBITORS FROM THE TREATMENT OF THROMBOTIC AND INFLAMMATORY DISEASES Inhibitors of cellular sodium/hydrogen exchangers display an inhibiting effect on the secretion of von-Willebrand factor and/or increased expression of P-selektin. Said inhibitors can thus be used for the treatment of thrombotic and infl...
WO/2003/066574A1	AROMATIC AMINO ACID DERIVATIVES AND MEDICINAL COMPOSITIONS Aromatic amino acid derivatives represented by the following general formula (I) or pharmacologically acceptable salts thereof: (I) wherein R1 represents hydrogen or an amino-protecting group; R2 represents hydrogen, alkylaralkyl or aryl...
WO/2003/062213A1	NILE RED TYPE COMPOUND EMITTING RED LIGHT, PROCESS FOR PRODUCING THE SAME, AND LUMINESCENT ELEMENT UTILIZING THE SAME A compound which emits a high-color-purity red light at a high luminance and has high fastness; and a luminescent element capable of emitting a light at a high luminance. The compound emitting a red light is a Nile Red type compound repr...
WO/2003/059899A1	GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL FORMULATIONS CONTAINING THEM AND USES THEREOF A compound of Formula (I), wherein R1, R2, R3, R4, R5, and R6 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid re...
WO/2003/057254A1	PREVENTIVES/REMEDIES FOR URINARY DISTURBANCE Preventives/remedies for urinary disturbance containing a compound having both of an acetylcholine esterase inhibitory effect and an &agr 1 antagonistic effect which exhibits an excellent effect of improving the urinary function of the b...
WO/2003/055851A1	HYDROXAMIC ACID DERIVATIVE AND MMP INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT A hydroxamic acid derivative represented by the following general formula (1), which has selective MMP inhibitory activity: (1) wherein R1 and R2 each represents hydrogen, lower alkyl, lower haloalkyl, etc.; X represents methylene or NR3...
WO/2003/053945A2	UREA DERIVATIVES AND THEIR USE AS VANILLOID RECEPTOR ANTAGONISTS Compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof: (I) wherein, R?1¿, R?2¿, P, p and n are as defined in the specification, a process for preparing such compounds, a pharmaceutical composition containing...
WO/2003/050154A2	CATALYTIC CARBONYLATION OF THREE AND FOUR MEMBERED HETEROCYCLES Epoxides, aziridines, thiiranes, oxetanes, lactones, lactams and analogous compounds are reacted with carbon monoxide in the presence of a catalytically effective amount of catalyst having the general formula [Lewis acid]z+&lcub [QM(CO)x...
WO/2003/049702A2	VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS Compounds having the general structure of the Formula (I) and compositions containing them, for treatment of various diseases.
WO/2003/048138A1	[1.2]-OXAZIN-3,5-DIONES The invention relates to novel [1.2] oxazin-3,5-dione derivatives of formula (I) in which W, X, Y, Z, G, D, A and B have the meanings given in the description, several methods for production and use thereof as microbicide, pesticide and ...
WO/2003/045956A1	PROCESS FOR THE PREPARATION OF 2-OR-9-OXA-3, 7-DIAZABICYCLO (3.3.1) NONANES FROM 2-AMINOMETHYL-2, 3-DIHYDROOXAZINES, INTERMEDIATES THEREFORE, AND PROCESSES FOR PREPARING SUCH INTERMEDIATES There is provided a process for the preparation of a compound of formula (I), which process comprises reaction of a compound of formula (II), with either: (a) a formaldehyde and a compound of formula (III), R?a¿-OH and/or (b) a protecte...
WO/2003/045315A2	CARBONYLBENZOXAZINE COMPOUNDS FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES This invention relates to the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for higher order behaviors. These brain networks are involved in co...
WO/2003/043618A2	AMINO DIOLS USEFUL IN THE TREATMENT OF ALZHEIMER'S DISEASE The present invention relates to the treatment of Alzheimer's disease and other similar diseases, and more specifically to the use of compounds that inhibit beta-secretase, an enzyme that cleaves amyloid precursor protein to produce A be...
WO/2003/043988A1	PIPERIDIN-2-ONE DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THESE COMPOUNDS AS THE ACTIVE INGREDIENT Piperidin-2-one derivative compounds represented by the following general formula (I) and salts thereof: wherein each symbol is as defined in the description. Because of inhibiting the activation of p38MAP kinase, the compounds represent...

Matches 1,101 - 1,150 out of 5,014	< 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 >