Heterocyclic Compounds

Matches 51 - 100 out of 440	< 1 2 3 4 5 6 7 8 9 >

Document	Document Title
WO/2001/014360A2	BENZOPYRANS AND BENZOTHIOPYRANS AS RAR SELECTIVE RETINOID AGONISTS This invention relates to new RAR selective retinoid agonists of formula (I) wherein the symbols are as defined in the specification to their pharmaceutically acceptable salts, individual isomers or to a racemic or non-racemic mixture; t...
WO/2000/075127A1	TRICYCLIC FUSED HETEROCYCLE COMPOUNDS, PROCESS FOR PREPARING THE SAME AND USE THEREOF Compounds represented by general formula (1) or pharmaceutically acceptable salts thereof. In said formula, X is CH, CH¿2?, CHR (wherein R is lower alkyl or substituted lower alkyl), or CRR' (wherein R and R' are each as defined above a...
WO/2000/069845A1	PROCESSES FOR THE PREPARATION OF 2,3-DIHYDROTHIEPINE DERIVATIVES A process for preparing simply and inexpensively 2,3-dihydrothiepine derivatives represented by general formula (I) [wherein R?1¿ is an electron-attracting group; R?2¿, R?3¿, R?4¿, R?5¿, R?6¿ and R?7¿ are each hydrogen, halogeno, ...
WO2000001687A9	BENZOTHIEPINES HAVING ACTIVITY AS INHIBITORS OF ILEAL BILE ACID TRANSPORT AND TAUROCHOLATE UPTAKE Novel benzothiepines, derivatives, and analogs thereof; methods of preparing such compounds; pharmaceutical compositions containing such compounds; and methods of using these compounds and compositions in the preparation of a medicament,...
WO/2000/039113A1	BENZOPYRANS AND BENZOXEPINES, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND PREPARATION PROCESS The present invention relates to benzopyrans and benzoxepines of formula (I), wherein X, A, R¿1?, R¿2? and (R)¿p? have the meanings as given in claim 1, which can be used in the treatment of dislipidaemias, atherosclerosis and diabete...
WO/2000/038728A1	COMBINATIONS OF ILEAL BILE ACID TRANSPORT INHIBITORS AND BILE ACID SEQUESTRING AGENTS FOR CARDIOVASCULAR INDICATIONS The present invention provides combinations of cardiovascular therapeutic compounds for the prophylaxis or treatment of cardiovascular disease including hypercholesterolemia, atherosclerosis, or hyperlipidemia. Combinations disclosed inc...
WO/2000/037455A1	BENZOTHIEPIN-ANILIDE DERIVATIVES, THEIR PRODUCTION AND THEIR USE FOR ANTAGONIZING CCR-5 This invention is to provide compound of formula (I) wherein R?1¿ is an optionally substituted 5- to 6-membered ring; the ring A is an optionally substituted 6- to 7-membered ring; the ring B is an optionally substituted benzene ring; n...
WO/2000/025767A2	USE OF TRIPHENYLBUTENE DERIVATIVES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS The use of a compound of Formula (VIII) in the manufacture of a medicament for the treatment of or the prevention of neurological disorders, in a warm-blooded mammal, wherein A and B are selected from: Formula (IX) or Formula (X) such th...
WO/2000/023417A1	NEW COMPOUNDS, THEIR PREPARATION AND USE The present invention relates to compounds of general formula (Ia). The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (P...
WO/2000/023416A1	NEW COMPOUNDS, THEIR PREPARATION AND USE The present invention relates to compounds of general formula (Ia). The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (P...
WO/2000/010965A2	QUATERNARY AMMONIUM SALTS AND THEIR USE AS ANTI-HIV AGENTS This invention is to provide a compound for antagonizing CCR5, said compound being represented by formula (I), wherein R?1¿ is an optionally substituted phenyl or an optionally substituted thienyl; Y is -CH¿2?-, -S- or -O-; and R?2¿, ...
WO/2000/001670A1	SUBSTITUTED NITROGEN AND SULFUR ALICYCLIC COMPOUNDS, INCLUDING METHODS FOR SYNTHESIS THEREOF The present invention provides new methods for preparation of various compounds that comprise alicyclic groups with nitrogen or sulfur as ring members, including 2,5-disubstituted tetrahydrothiophenes, 2,5-disubstituted pyrrolidines, 2,6...
WO/1999/064410A1	BENZO(b)THIEPINE-1,1-DIOXIDE DERIVATIVES, A METHOD FOR THE PRODUCTION THEREOF, MEDICAMENTS CONTAINING THESE COMPOUNDS, AND THEIR USE The invention relates to substituted benzo(b)thiepine-1,1-dioxide derivatives and to the acid addition salts thereof. The invention relates to compounds of formula (I), wherein R?1¿, R?2¿, R?3¿, R?4¿, R?5¿ and Z have the cited descr...
WO/1999/064409A2	BENZOTHIEPINE-1,1-DIOXIDE DERIVATIVES, METHOD FOR PRODUCING THEM, MEDICAMENTS CONTAINING THESE COMPOUNDS AND THEIR USE The invention relates to benzothiepine-1,1-dioxide derivatives and their acid addition salts, i.e. compounds of formula (I) wherein R?1¿, R?2¿, R?3¿, R?4¿, R?5¿ and Z have the meanings given in the description and their physiologica...
WO/1999/055690A1	GUANIDINE DERIVATIVES This invention relates to guanidine derivatives of formula (I) wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising...
WO/1999/039709A1	LIQUID PHARMACEUTICAL FORMULATION CONTAINING ZOTEPINE A liquid pharmaceutical formulation comprising a) 2 to 7% w/v of Zotepine; b) 0.5 to 35% w/v of an organic acid selected from the group consisting of ascorbic acid, citric acid, fumaric acid, glutaric acid, lactic acid, malic acid, sorbi...
WO/1999/037619A1	CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREFOR Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by s...
WO/1999/032478A1	METHOD OF PREPARING ENANTIOMERICALLY-ENRICHED TETRAHYDROBENZOTHIEPINE OXIDES A process for preparing enantiomerically-enriched tetrahydrobenzothiepine oxides comprises cyclizing an enantiomerically-enriched aryl-3-propanalsulfoxide wherein the sulfur atom of the aryl-3-propanalsulfoxide is a chiral center.
WO/1999/032100A2	PHARMACEUTICAL COMPOSITION FOR ANTAGONIZING CCR5 COMPRISING ANILIDE DERIVATIVE This invention is to provide a pharmaceutical composition for antagonizing CCR5 which comprises a compound of formula (I) wherein R?1¿ is an optionally substituted 5- to 6-membered ring; W is a divalent group of formula (a) or (b) where...
WO/1999/025687A1	AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR A treatment process is disclosed that comprises administering an effective amount of an aromatic sulfone hydroxamic acid that exhibits excellent inhibitory activity of one or more matrix metalloprotease (MMP) enzymes, such as MMP-2, MMP-...
WO/1999/003827A1	NOVEL PROCESS FOR PRODUCING DIBENZO[b,f]THIEPINE DERIVATIVES A process for producing diaryl sulfide derivatives useful as intermediates for medicinal compounds and a process for producing dibenzo[b,f]thiepine derivatives by using the intermediates. A halogen-substituted phenyl derivative represent...
WO/1998/055475A1	GUANIDINE DERIVIATIVES AS INHIBITORS OF NA+/H+ EXCHANGE IN CELLS This invention relatess to guanidine derivatives of formula (I), wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprisi...
WO/1998/046587A1	TRICYCLIC COMPOUNDS Tricyclic compounds of general formula (I) and pharmacologically acceptable salts thereof, which are useful for the treatment of pollakiuria and enuresis, wherein R?1� is hydrogen, substituted or unsubstituted lower alkyl or the like; ...
WO/1998/040375A2	COMBINATION OF ILEAL BILE ACID TRANSPORT INHIBITING BENZOTHIEPINES AND HMG Co-A REDUCTASE INHIBITORS Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperli...
WO/1998/035954A1	BICYCLIC HYDRAZONE HERBICIDES Compounds of Formula (I), and their $i(N)-oxides and agriculturally suitable salts, are disclosed which are useful for controlling undesired vegetation wherein Q is Q-1, Q-2, Q-3 or Q-4; and Q, Z, X, R?1� through R?20�, m, n, and r a...
WO/1998/007717A1	PROCESS FOR PREPARING 2-(10,11-DIHYDRO-10-OXODIBENZO[b,f]THIEPIN-2-YL)PROPIONIC ACID AND INTERMEDIATES THEREFOR A novel process for preparing zaltoprofen[2-(10,11-dihydro-10-oxodibenzo[b,f]thiepin-2-yl) propionic acid], which, as compared with the conventional processes, has better practicality from an overall viewpoint including availability and ...
WO/1998/001164A1	TRICYCLIC RADIOLABELED D4 RECEPTOR LIGANDS Herein described are radiolabeled compounds useful to image D4 receptors $i(in vivo), of formula (I), wherein X?1� is selected from NH, O and S; X?2� is selected from CH and N; Z is selected from iodide, cyano, nitro, tri(loweralkyl)...
WO/1997/033882A1	NOVEL BENZOTHIEPINES HAVING ACTIVITY AS INHIBITORS OF ILEAL BILE ACID TRANSPORT AND TAUROCHOLATE UPTAKE Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperli...
WO/1997/031904A1	2-AMINO-4-BICYCLOAMINO-1,3,5-TRIAZINES AS HERBICIDES AND PLANT GROWTH REGULATORS The invention concerns compounds of formula (I) and their salts which are suitable as herbicides and plant growth regulators, R1 to R6, Y1, Y2, Y3, m and n being defined as in claim 1. These compounds can be prepared in similar manner to...
WO/1997/028148A1	DIHYDROBENZOFURAN COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS A compound having structure (I) wherein (a) n is from 1 to about 3; (b) X is selected from the group consisting of O, S, SO, or SO2; (c) Y is independently hydrogen or straight, branched or cyclic alkyl having from about 1 to about 4 car...
WO/1997/028146A1	DIHYDROBENZOFURAN AND RELATED COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS A compound having structure (I) wherein (a) n is from about 1 to about 3; (b) X is selected from the group consisting of O, S, SO, or SO2; (c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 car...
WO/1997/028143A1	DIHYDROBENZOFURAN AND RELATED COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS A compound having structure (I) wherein (a) n is from 1 to about 3; (b) X is selected from the group consisting of O, S, SO, or SO2; (c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 carbon at...
WO/1997/025985A1	TRACHEAL SMOOTH MUSCLE RELAXANT A tracheal smooth muscle relaxant characterized by comprising as the active ingredient a compound represented by general formula (1) or a pharmacologically acceptable salt thereof; wherein when X and Y are bonded through a single bond, t...
WO/1997/023477A1	DIBENZOTHIEPIN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS A compound of formula (I) or a pharmaceutically acceptable salt thereof in which R1 and R2 are independently H or methyl (for example 2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethylethyl -amine) is used for preventing relapse in ...
WO/1997/014672A1	TRICICLIC COMPOUNDS Triciclic compounds represented by general formula (I) which are useful as a remedy for urinary incontinence, wherein R1 represents hydrogen, etc.; and -X1-X2-X3- represents -CR2=CR3-CR4=CR5- (wherein R2, R3, R4 and R5 represent each hyd...
WO/1997/003978A1	NOVEL HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF PAIN AND USE THEREOF Polycyclic alkaloids of formula (I), wherein R1 is H, C1-6 alkyl, or C6-12 aryl optionally substituted with polar groups; R2 and R3 are independently H, OH, C1-6 alkyl, -C(NH)-NH2, a positively charged group, or C7-13 aralkyl optionally ...
WO/1997/003979A1	POLYCYCLIC ALCALOID-DERIVATIVES AS NMDA-RECEPTOR ANTAGONISTS Polycyclic alkaloids of formula (I), wherein R1 is H, C1-6 alkyl, or C6-12 aryl optionally substituted with polar groups; R2 abd R3 are independently H, OH, C1-6 alkyl, -C(NH)-NH2, a positively charged group, or C7-13 aralkyl optionally ...
WO/1997/001550A1	HERBICIDAL KETALS AND SPIROCYCLES Compounds of Formula (I), and their agriculturally suitable salts, are disclosed which are useful for controlling undesired vegetation wherein Q is (Q-1) or (Q-2); R1 and R2 are each independently C1-C6 alkoxy, C2-C6 haloalkoxy, C1-C6 al...
WO/1997/000853A1	BICYCLIC AMINO DERIVATIVES AND PGD2 ANTAGONIST CONTAINING THE SAME Compounds of general formula (I), salts thereof or hydrates thereof wherein (a) represents (b) or (c), for example, the compounds (d) and (e), which are useful as a PGD2 antagonist and thus usable in, for example, a remedy for systemic m...
WO/1996/040660A1	CERTAIN SUBSTITUTED BENZYLAMINE DERIVATIVES: A NEW CLASS OF NEUROPEPTIDE Y1 SPECIFIC LIGANDS This invention encompasses compounds of formula (I) and the pharmaceutically acceptable salts thereof wherein Ar is an aryl group preferably selected from the group consisting of phenyl, 2-, 3-, or 4-pyridyl, 2- or 3-thienyl, 2-, 4- or 5...
WO/1996/022289A1	PROCESS FOR PRODUCING DIBENZOTHIEPIN DERIVATIVE A useful process for producing 2-(10,11-dihydro-10-oxodibenzo[b,f]thiepin-2-yl)propionic acid which comprises conducting the Friedel-Crafts reaction of 10,11-dihydrodibenzo[b,f]thiepin-10-one with 2-halogenopropionyl halide to yield a ke...
WO/1996/019471A1	POLYMERISABLE MONOMERS AND POLYMERS Compounds of formulae (1a) and (1b), wherein R1 to R4 may be the same or different and are selected from hydrogen, halogen, optionally substituted alkyl, optionally substituted aryl, nitrile, hydroxy, alkoxy acyloxy and ester; or R1 and ...
WO/1996/018622A1	N-METHYL PIPERAZINE COMPOUNDS HAVING DOPAMINE RECEPTOR AFFINITY Described herein are D4 receptor-selective compounds of general formula (I) wherein X1 is selected from CH2, NH, O and S; X2-- is selected from CH=, CH2-, and N=; R1 to R8 are each independently selected from H, C1-4alkyl, halo, cyano, n...
WO/1996/014314A2	THIEPANE COMPOUNDS INHIBITING AND DETECTING HIV PROTEASE Tri- and tetra substituted thiepane compositions having use as immunogens, therapeutics, diagnostics and for other industrial purposes are disclosed. The compositions inhibit proteolytic activity of viral enzymes and are useful for the i...
WO/1996/010021A1	NOVEL ANTIOXIDANT TRICYCLIC FUSED HETEROCYCLIC COMPOUND A novel antioxidant tricyclic fused heterocyclic compound represented by general formula (2) and a salt thereof (wherein X-Y represents CH2-C=O, CH2-CH2 or CH=CH; Z represents O, S or S=O; and R1 to R8 represent each hydrogen, hydroxy, h...
WO/1996/008484A1	NOVEL BENZOTHIEPINES HAVING ACTIVITY AS INHIBITORS OF ILEAL BILE ACID TRANSPORT AND TAUROCHOLATE UPTAKE This invention relates to novel benzothiepines, derivatives and analogs thereof, pharmaceutical compositions containing them and their use in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions, such as i...
WO/1996/005191A1	NATRIURETIC CYCLIC COMPOUNDS Compounds, methods and compositions are provided for inducing natriuresis in a mammal. Methods for isolating and synthesizing the natriuretic compounds are also provided. Therapeutic methods using the natriuretic compounds are also provi...
WO/1995/030641A1	NITRO COMPOUNDS AND THEIR COMPOSITIONS HAVING ANTI-INFLAMMATORY, ANALGESIC AND ANTI-THROMBOTIC ACITIVITIES New compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic activities, of the general formula: A-X1-NO2 or their salts, wherein: A is R(COXu)t, wherein t is zero or 1 and u is zero or 1; and X is O, NH o...
WO/1994/020062A2	BALANOIDS A novel class of therapeutic compounds, denominated Balanoids, is disclosed. Balanoids have protein kinase C inhibitory activity and selectivity among the isoforms of protein kinase C. Balanoids are useful for treatment of diseases relat...
WO/1994/001100A1	METHODS AND COMPOSITIONS FOR INHIBITING 5alpha-REDUCTASE ACTIVITY Disclosed is a novel class of antiandrogenic compounds including saturated and unsaturated fatty acids, their derivatives, and synthetic analogs, their method of synthesis, and their use in treating disorders associated with androgenic a...

Matches 51 - 100 out of 440	< 1 2 3 4 5 6 7 8 9 >