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Patent Searching and Data


Matches 501 - 550 out of 1,795

Document Document Title
WO/1995/002418A1
Chelating compounds of specified structure are useful for radiolabeling targeting proteins such as antibodies as well as proteinaceous and non-proteinaceous ligands and anti-ligands. The radiolabeled antibodies, ligands or anti-ligands, ...  
WO/1995/002423A1
Protein, ligand and anti-ligand conjugated chelated metal radionuclides are provided for use in vivo. Intermediates are provided for preparing the compositions efficiently.  
WO/1995/001124A1
The present invention provides new and structually diverse compositions for diagnostic imaging comprising compounds of general formula (I), wherein A is N or CR1; D, E, and F are independently O, -O(CH2)2O-, O(CH2)3O-, or NR5; X is CO2H,...  
WO1994026263A3  
WO/1994/027977A1
The invention concerns the use, as temperature probes, of macrocyclic metal complexes consisting of a complexing agent of the formula I, in which n, R1, R2, R3 and A are defined differently, plus at least one metal ion with an atomic num...  
WO/1994/027978A1
The invention concerns fluorine-containing macrocyclic metal complexes consisting of a complexing agent of formula (I), in which n, m, R1, R2, R3 and A are defined differently, plus at least one metal ion with an atomic number of 21 to 2...  
WO/1994/026754A1
Bicyclopolyazamacrocyclophosphonic acid compounds are disclosed which may form inert complexes with Gd, Mn or Fe ions. The overall charge of the complex can be varied to alter the in vivo biolocalization. Such complexes can be covalently...  
WO/1994/026275A1
2-Pyridylmethylenepolyazamacrocyclophosphonic acid compounds and their derivatives are disclosed which may form inert complexes with Gd, Mn or Fe ions. The overall charge of the complex can be varied to alter the in vivo biolocalization....  
WO/1994/026263A2
The use of transition metal complexes in the treatment of septic shock, in particular the hypotension associated therewith and pharmaceutical formulations comprising such complexes are disclosed. The use of such transition metal complexe...  
WO/1994/022816A1
Ligands for radiopharmaceutical use are capable of chelating radiometal species and of being bound to biological targeting molecules. The ligands have formula (a) and (b), where A, A' = -SZ or Y, B = O or S, Y = (c), Z = H or a thiol pro...  
WO/1994/022491A1
New technetium and rhenium chelate compounds are disclosed, as well as a process for preparing the same, radiopharmaceuticals containing these compounds, conjugates of these compounds with substances which selectively accumulate in disea...  
WO/1994/022492A1
New bifunctional chalcogen-atom interrupted chelators, pharmaceutical containing these compounds, their use in radiodiagnosis and radiotherapy as well as a process for producing these compounds are disclosed. In the compound having gener...  
WO/1994/022493A1
New bifunctional chalcogen-atom interrupted chelators, pharmaceuticals containing these compounds, their use in radiodiagnosis and radiotherapy as well as a process for producing these compounds are disclosed. In the compound having the ...  
WO/1994/022497A1
Novel bifunctional chalcogenic-atom-discontinuous chelating agents, pharmaceutical preparations containing them, their use in radio diagnosis and radio therapy, and methods of preparing them. The invention concerns compounds of the gener...  
WO/1994/021304A1
The present invention relates particularly to novel heterocycle based nitrogen-sulfur ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes.  
WO/1994/020148A1
The present invention relates particularly to novel imidazole based nitrogen-sulfur ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes.  
WO/1994/017083A1
A compound which is, or which contains at least two repeating units, represented by formula (1): (LnMn1)n2An3 or by formula (2): (LnMn1)n2L'n4An3 wherein L and L' are the same or different bis-lactam ligand represented by formula (3) or ...  
WO/1994/015925A1
The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by formula (I), wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, R'9, R10 and R'10, X, Y...  
WO/1994/013300A1
The invention provides antioxidant salen-metal complexes in a form suitable for pharmaceutical administration to treat or prevent a disease associated with cell or tissue damage produced by free radicals such as superoxide.  
WO1994008949A3  
WO/1994/010182A1
The present invention relates to novel compounds for use as imaging agents. In particular, the present invention relates to paramagnetic metal clusters having oxygen and/or nitrogen containing ligands useful as contrast agents for magnet...  
WO/1994/008949A2
The invention concerns novel metal chelating compounds, and radiometal, e.g. technetium-99m complexes thereof. The compounds can be used to radiolabel small biologically active species with minimal effect on their biodistribution and act...  
WO/1994/009128A1
A composition suitable for administration to a warm-blooded animal comprising antisense MCP-1 peptide or oligonucleotide or a molecule capable of interacting with MCP-1 peptide or information for its synthesis which may or may not be lab...  
WO1994000489A3  
WO/1994/005422A1
A process for preparing a manganese complex catalyst having the formula: [LMn(OR)3] Y, wherein Mn is manganese in the +4 oxidation state; R is a C1-C20 radical selected from the group consisting of alkyl, cycloalkyl, aryl, benzyl and rad...  
WO1993010747A3  
WO/1994/004141A1
Vitamin and mineral absorption in warm-blooded animals is promoted by means of a class of vitamin chelates where at least one of the bonds between the metal ion and the vitamin ligand is formed between the ion and an electron rich pi-clo...  
WO/1994/003271A1
A compound of formula (I), in which M is a transition metal ion; A is a counter-ion if required; r, s and t are independently 0 to 3 such that r+s+t is in the range of 1 to 3; Ra, Rb, Rc are each independently hydrogen or CH2OR\' where R...  
WO/1994/002456A1
Hydroxyphenylthioalkyl amines represented by formula (I), wherein R1 is H or C1-C8 alkyl; R2 is H or C1-C8 alkyl; R3 is H, C1-C8 alkyl or C1-C8 alkanoyl; R4 is H or C1-C8 alkanoyl; Ra is a radioactive material useful in radioimaging and/...  
WO/1994/001406A1
Complexing agents of general formula (I) in which R1, R2, R3 and R4 are the same or different and stand for H, COOH, C(O)NHR5, where R5 is H and C1-C4 alkyl, PO3H2, SO3H and a radical of general formula (IIa) or (IIb) in which R6 and R7 ...  
WO/1994/001426A1
The present invention relates particularly to novel preorganized hexadentate ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes.  
WO/1994/000489A2
This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to peptide derivatives and analogs of somat...  
WO/1993/025562A1
A process is described for the preparation of a manganese complex catalyst having formula (1) wherein Mn is manganese in a III or IV oxidation state; each X is independently a coordinating or bridging species; L is an organic ligand cont...  
WO/1993/021962A1
This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a ...  
WO/1993/020088A1
Mixed ligand metal complexes of nitric oxide-nucleophile adducts, useful as cardiovascular agents of the formula KA, wherein A is [(M)x'x(L)y(R1R2N-N2O2)z], and M is a pharmaceutilcally acceptable metal, or where x is at least two, M may...  
WO/1993/019788A1
Methods and diagnostic compositions are disclosed for enhancing magnetic resonance imaging which utilize a parmagnetic metal cluster. Magnetic resonance contrast media containing Z+[Mn12X12(OYR)16(L)4]-, where OYR is an oxyacid such as b...  
WO/1993/017026A1
A process for preparing compounds of formula (B) wherein: one of A1' or A2' represents hydrogen and the other represents a group CF3-Y- wherein Y represents -CF2-, > C=O, or -CH(OH)-, or A1' and A2' are groups convertible to A1 and A2 re...  
WO/1993/015770A1
The present invention relates to novel ligands and labelling techniques. The present invention further relates to a diagnostic composition suitable for administration to a warm-blooded animal comprising somatostatin or hirudin or a molec...  
WO/1993/015771A1
Amide-thiolate ligands having improved metal chelate formation kinetics are disclosed. The ligands include an amine to facilitate rapid formation of an amine-amide-thiolate intermediate complex, followed by transfer of the metal to or co...  
WO/1993/013800A1
The composition of a new radiopharmaceutical for use as a tumor imaging agent comprising methyl glyoxal Bis (guanyl hydrazone), SnCl2.2H2O, and 99mTc in the form of 99mTcO-4, obtained from a generator and formulated in a mixture for use ...  
WO/1993/014031A1
Manganese bromide solution used in forming organo-manganous compounds, for application in synthesizing of organic products, particularly ketones.  
WO/1993/011801A1
Complexes of bicyclopolyazamacrocyclophosphonic acid compounds with a metal ion, e.g. 153Sm, 177Lu, 159Gd, 149Pm, 140La, 175Yb, 166Ho, 90Y, 47Sc, 186Re, 188Re, 142Pr, 99mTc, 67Ga, 68Ga, 105Rh, 97Ru, 111In, 113mIn or 115mIn ion, are discl...  
WO/1993/012256A1
This invention relates to a new electrochemiluminescent (ECL) label for oligonucleotides using phosphoramidite chemistry.  
WO/1993/011800A1
Complexes of bicyclopolyazamacrocyclocarboxylic acid with Gd, Mn or Fe ions are disclosed. The complexes can be covalently attached to a biologically active molecule, e.g. an antibody or antibody fragment, to form conjugates. The complex...  
WO/1993/010747A2
The invention relates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99m for such imaging. The invention provides peptides which bind Tc-99m and which can be targete...  
WO/1993/010822A1
Disclosed are cationic complexes of Tc-99m and ligands having structure (A), wherein: R1 is hydrogen or is selected from the group consisting of C1 to C20 alkyl; C3 to C12 cycloalkyl; C7 to C24 aralkyl; C2 to C16 alkyl ethers, thioethers...  
WO/1993/010823A1
The present invention relates particularly to novel aminothiol ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes.  
WO/1993/008839A1
A class of diagnostic and therapeutic compounds derived from phosphinimines that include ligands containing either a single phosphinimine functionality or both a phosphinimine group and a phosphine or arsine group, or an aminato group, o...  
WO/1993/003838A1
Chiral catalysts for enantioselectively epoxidizing a prochiral olefin and for enantioselectively oxidizing a prochiral sulfide are disclosed, together with methods of using such catalysts. In accordance with one aspect of the invention,...  
WO/1993/003351A1
The present invention relates to the preparation of amino acid containing compounds which also have multiple carboxylic acid functional groups. Paramagnetic metal (II) or (III) ion chelate complexes are formed using these compounds for u...  

Matches 501 - 550 out of 1,795