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WO/1990/014881A2 |
A new series of bifunctional chelating agents useful for attaching metal ions to proteins, polypeptides and other polymers and methods for their preparation are described. These reagents are unique in their ability to bind a variety of m...
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WO/1990/014106A2 |
A myocardial imaging agent for humans is a technetium(III) complex ligated in the planar positions by a tetradentate ligand such as (acac)2en and in the axial positions by an ether containing phosphine ligand such as tris(3-methoxy-1-pro...
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WO/1990/013530A1 |
The process of the present invention includes preparing a first aqueous solution of rhenium in the form of radioactive perrhenate, wherein the concentration of rhenium in said solution is within the range of about 5 x 10-6 M to about 2 x...
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WO/1990/010633A1 |
The present invention involves a novel tripyrroledimethine-derived "expanded porphyrin" (texaphyrin), the synthesis of such compounds, their analogs or derivatives and their uses. These expanded porphyrin-like macrocycles are efficient c...
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WO/1990/009987A1 |
Polynitrogenous derivatives comprising four or five coordinating functions capable of bonding with a metal atom, especially with cobalt. The invention concerns, more particularly, the use of metal complexes comprising said derivatives fo...
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WO/1990/008138A1 |
There are provided heterocyclic chelating agents particularly useful for the preparation of diagnostic and therapeutic agents for magnetic resonance imaging, scintigraphy, ultrasound imaging, radiotherapy and heavy metal detoxification, ...
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WO/1990/007342A1 |
The present invention is directed to a novel process for preparing isothiocyanate functionalized chelates by reacting amino functionalized chelates with thiophosgene.
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WO/1990/006137A1 |
The invention concerns a radiopharmaceutical product having, in particular, a cardiac tropism, comprising a nitruro complex of a transition metal, and process for preparation thereof. The complex has the formula (M=N)L1L2 in which M is a...
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WO/1990/005733A1 |
The present invention relates to a technetium-99m complex of general formula (I), wherein Z is a sulphur atom or an amino group of the general formula R17-N-(R18)k, in which k is 0 or 1 and R17 and R18 have the same meanings as the symbo...
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WO/1990/003975A1 |
A process is provided for the preparation of Mn(II) chelates for use as contrast agents in magnetic resonance imaging, said process comprising reacting insoluble manganese (II) oxide with an aqueous suspension comprising a molar equivale...
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WO/1990/001024A1 |
Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with alkoxyalkylamide derivatives of diethylenetriaminepentaacetic acid (''DTPA'') or ethylenediaminetetyraacetic acid (''EDTA''). These novel imaging agents...
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WO/1990/000854A1 |
Complexes useful as radiopharmaceutical imaging agents comprise technetium bonded to a ligand which generally can be described by formula (I), wherein Z is N, C, B or P; the three Y groups can be the same or different, each characterized...
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WO/1989/012640A1 |
A ligated technetium (III/II) complex is useful as a brain perfusion imaging agent. The complex has a technetium (III/II) center surrounded by six ligating moieties. The complex preferably has a reduction potential Tc(III) to Tc(II) whic...
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WO/1989/011875A1 |
A method is provided utilizing contrast agents which provide increased diagnostic information in the magnetic resonance image of the hepatobiliary system and alimentary tract, especially the small intestine. Novel contrast agents which a...
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WO/1989/011877A2 |
The present invention provides conjugates formed from calcified tissues targeting agents and radiolabeled compounds. One such conjugate comprises a chelate and a targeting agent that is capable of associating with calcified tissue, where...
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WO/1989/012058A2 |
The present invention constitutes a class of organometallic complexes which reversibly react with hydrogen to form dihydrides and processes by which these compounds can be utilized. The class includes bimetallic complexes in which two cy...
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WO/1989/012049A1 |
The new derivatives of metalloporphyrines in accordance with the invention are described in formula (I), in which A and B each represent (alpha) or (beta) and Z+ represents N+-R1 or C-N+R1R2R3, R1 being a straight aliphatic group of bran...
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WO/1989/011475A1 |
The invention is a chelate having general formula (I), wherein R1-4 is -CH2COOH; n is 1 to 5; X is a member selected from the group consisting of -NO2, -NH2, -NCS, -NHCOCH2-Z with Z being a member selected from the group consisting of Br...
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WO/1989/010759A1 |
The invention relates to a method of preparing a diaminedithiol chelating agent by reacting a cyclic diamine disulfide with a thiol compound as a reducing agent, said thiol compound being selected from the group consisting of dithiothrei...
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WO/1989/008657A2 |
Preparation of 99m technetium or 186 rhenium or 188 rhenium compounds usable as radiopharmaceutical products. To obtain said preparation an oxygenated compound of 99mTc, 186Re or 188Re, for example an ammonium or alcaline metal pertechne...
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WO/1989/004302A1 |
Electrochemiluminescent moieties having the formula [Re(P)m(L1)n(L2)o(L3)p(L4)q(L5)r(L6)s]t(B)u, wherein P is a polydentate ligand of Re; L1, L2, L3, L4, L5 and L6 are ligands of Re, each of which may be the same as or different from eac...
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WO/1989/003388A1 |
The invention concerns cationic complexes of Technetium-99m with bidentate ligands (L), including complexes having the formulae [Tc(NO) X L2]+ and [Tc L3]+, which are of interest as heart imaging agents. The ligands are characterized by ...
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WO/1989/002433A1 |
Tris(isonitrile)copper(I) complex salts with anions selected from BF4, PF6, Cl04, I, Br, Cl and CF3COO are useful in preparing radionuclide complexes rapidly at room temperature. Preferred isonitrile ligands are ether isonitriles. The tr...
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WO/1989/001331A1 |
Tertiary butyl esters of anticancer drugs are provided which have formula (I), wherein R1 and R2 are the same or different and are selected from the group consisting of H, F, Cl, Br, and I and R2 can also be NH2; R3, R4, and R5 are the s...
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WO/1988/008720A1 |
Complexes useful as radiopharmaceuticals contain the 99mTc-NO moiety and a ligand which confers biological target-seeking properties on the complex. Preferred are mono-cationic complexes, particularly having the formula: [99mTc(NO)L2X]+,...
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WO/1988/006154A1 |
Molecular systems formed from ordered heterometallic chains containing A and B ions with different spins, connected by bis-bidentate ligands which, due to their substituent (s), are capable of creating a strong steric hindrance around th...
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WO/1988/005439A1 |
Complex comprised of a bioreagent alkilated-complexed by an organo-metallic compound. Said organo-metallic compound comprises a cluster of alcyne-carbonyle metal. Application of complexes of bioreagents as tracers for dosings of biologic...
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WO/1987/007608A1 |
Perfluoroalkylcyclopentadienylthallium compounds of general formula (I), wherein n = 1-5 which are useful to modify the properties of transition metal complexes by the introduction of an electron-withdrawing perfluoroalkylcyclopentadieny...
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WO/1987/007608A2 |
Perfluoroalkylcyclopentadienylthallium compounds of general formula (I), wherein n = 1-5 which are useful to modify the properties of transition metal complexes by the introduction of an electron-withdrawing perfluoroalkylcyclopentadieny...
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WO/1987/003605A1 |
Oligomers are produced from unsaturated monomers. They contain terminal unsaturation and have a degree of polymerization of from 2 to 200. These oligomers are produced by the free radical polymerization of unsaturated monomers using as a...
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WO/1987/001721A1 |
Metal complexes of hydroxyl and/or thiol containing Mannichs are prepared by reacting a transition metal containing agent with an aromatic Mannich. The Mannich is prepared from a substituted hydroxyl and/or thiol containing aromatic, an ...
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WO/1987/001290A1 |
A coordination complex comprising a radionuclide selected from the class consisting of radioactive isotopes of Tc, Ru, Co, Pt and Re and an isonitrile ligand of the formula: (CNX)R, where X is a lower alkyl group having 1 to 4 carbon ato...
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WO/1986/002841A1 |
Homologs of Diamide-DTPA-Paramagnetic compounds (such as diamido acetyl diethylene triamine triacetic acid) provide excellent contrast agents for magnetic resonance (MR) imaging. The magnetic dipole generated by the unpaired electron wit...
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WO/1986/003010A1 |
Method for labelling amine-containing compounds like proteins with a metal, particularly technetium-99m comprising reacting metal ions in an acidic medium with a compound represented by formulae (I) or (II), wherein R1, R2 and R3 are ind...
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WO/1986/002005A1 |
Homologs of Diester-DTPA-Paramagnetic compounds (such as dimethyl acetyl diethylene triamine triacetic acid) provide excellent contrast agents for magnetic resonance imaging (MRI). The magnetic dipole generated by the unpaired electron w...
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WO/1986/000897A1 |
A dihydropyridine$(1,7)$pyridinium salt type of redox, or chemical, delivery system for the site-specific and/or site-enhanced delivery of a radio-nuclide to the brain. A chelating agent capable of chelating with a radionuclide and havin...
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WO/1985/005617A1 |
New N- AD2-(4-fluoro-phenyl)-1-methyl BD-ethyl-N-methyl-N-propynyl amine of the general formula (I), and isomers and salts thereof. The compound of the formula (I) is useful as medicine. The compound of the formula (I), may be prepared b...
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WO/1985/004406A1 |
Novel vicinal dioxyalkylene organometalates comprising a cation having hydrocarbyl-containing substituent. The vicinal dioxyalkylene organometalates can be reacted with water to yield alkylene glycols.
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WO/1985/003871A1 |
A method of prophylaxis or treatment of atheromatosis in susceptible vertebrates comprising administration of manganese-containing pharmaceutical preparations in appropriate ratios of tryptophan to manganese to prevent development and pr...
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WO/1985/003873A1 |
Method of treatment of hypertension and toxemia of pregnancy in vertebrates. It comprises the administration of manganese-containing pharmaceutical preparations in appropriate ratios with tryptophan to lower the blood pressure. These are...
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WO/1985/003872A1 |
Method of lowering blood glucose in vertebrates comprising administration of manganese-containing pharmaceutical preparations in appropriate ratios with arginine, leucine, ornithine, tryptophan and valine and in appropriate ratios as bet...
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WO/1985/003869A1 |
Method of treatment for memory disorders of the elderly comprising administering manganese-containing pharmaceutical preparations in appropriate ratios with isoleucine, methionine, phenylalanine, tyrosine and valine and in appropriate ra...
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WO/1985/003870A1 |
Method of raising blood glucose in vertebrates comprising administration of manganese-containing pharmaceutical preparations in appropriate ratios with isoleucine, methionine, phenylalanine, tyrosine and valine and in appropriate ratios ...
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WO/1985/003874A1 |
Method of treatment for depression in vertebrates and other organisms comprising administration of manganese-containing pharmaceutical preparations in appropriate ratios with phenylalanine and tyrosine to return the emotional state of th...
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WO/1985/000955A1 |
A biocidal composition, particularly a fungicidal and/or bactericidal composition, comprising a thiosemicarbazone having the general formula (I), and their complexes formed by reaction with compounds of the metals Cu, Zn, Mn, Fe, Ca, Mg,...
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WO/1983/003761A1 |
A coordination complex of an isonitrile ligand and radionuclide such as Tc, Ru, Co, Pt, Fe, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb and Ta, is useful as a diagnostic agent for labelling liposomes or vesicles, and selected living cells ...
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WO/1983/002615A1 |
A composition useful for preparing cationic lipophilic technetium complexes for radiodiagnostic imaging. The composition comprising an admixture of (a) an accelerator compound selected from the group of water-soluble organic bidentate li...
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WO/1983/001450A1 |
A normally solid, hydrophilic compound capable of binding with Tc-99m to form a cationic complex. The compound has a formula selected from:$(30,)$wherein: R, R', R'', R''', R1, R2, R3, R4, R5. R6. R21, R22 and R23 are each independently ...
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WO/1981/003494A1 |
Manganese compounds of the formula MnIILX2(Q)n (I) wherein L is a monodentate ligand of the formula PR1R2R3 (II) wherein R1, R2, and R3 are identical or different and are substituted or unsubstituted alkyl, cycloalkyl, alkenyl, alkynyl, ...
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WO/1980/001690A1 |
Compositions of matter which are highly useful in hydroformylation processes. The compositions are non-charged, non-chelated bis- and tris-(alkyl diaryl phosphine) rhodium carbonyl hydrides. The substituents of the alkyl group include he...
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