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WO/1999/033435A1 |
The invention relates to the use of transitional metal (III) complexes of the formula (I), in which UM represents manganese, iron, cobalt, ruthenium, molybdenum or vanadium; R represents an alkylene-, alkenylene-, phenylene- or cycloalky...
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WO1998043678B1 |
The present invention provides for substituted metal chelating compounds in which at least two of the chelating atoms are nitrogen which are directly attached to aromatic rings and one or more of those nitrogen atoms has attached thereto...
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WO/1999/013920A2 |
The invention relates to a method for treating proliferative diseases by therapy, characterised in that an application catheter is first placed at the site of the lesion and a radioactive substance is applied locally. The catheter is the...
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WO/1999/012981A1 |
Catalyst systems useful for the polymerisation of 1-olefins are disclosed, which contain nitrogen-containing transition metal compounds comprising the skeletal unit depicted in Formula (B), wherein M is Fe[II], Fe[III], Ru[II], Ru[III] o...
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WO/1999/002632A1 |
The present invention relates to cleaning compositions, including laundry, dishwashing, hard surface cleaner, oral/dental cleaning compositions, comprising a proteinic substrate based oxygenase, which provide effective and efficient clea...
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WO/1998/058636A1 |
Synthetic low molecular weight catalysts for the dismutation of superoxide are potent analgesics that are effective in elevating the pain threshold in hyperalgesic conditions such as arthritis, and also operate to prevent or reserve tole...
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WO/1998/053858A1 |
The present invention provides novel radiopharmaceuticals useful for imaging the heart, brain, lungs, liver or kidneys, kits useful for preparing the radiopharmaceuticals, and methods of imaging the heart, brain, lungs, liver or kidneys ...
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WO/1998/048848A1 |
The invention relates to a method of preparing a compound of the general formula (I): $i(fac)-[M(CO)�3?(OH�2?)�3?]?+� wherein M is Mn, ?99m�Tc, ?186�Re or ?188�Re, by reacting a metal in the permetallate form with carbon mo...
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WO/1998/047907A1 |
The invention relates to a method for the production of organo-rhenium oxides from compounds containing rhenium, wherein a compound containing rhenium is reacted with a silylating agent and an organylating reagent and the compound contai...
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WO/1998/041242A1 |
A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises at least one functionalized hydroxyalkyl phosphine donor group and one or more sulfur or nitrogen donor and a metal combined with ...
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WO/1998/039335A1 |
Improved synthesis of a macropolycycle, more particularly, of a cross-bridged tetraazamacrocycle.
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WO/1998/039098A1 |
Catalytic systems and methods for oxidizing materials in the presence of metal catalysts (preferably manganese-containing catalysts) complexed with selected macropolycyclic rigid ligands, preferably cross-bridged macropolycyclic ligands....
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WO/1998/031399A2 |
A complex of a radiometal or paramagnetic metal ion with a metal chelating agent such as a diaminedioxime has attached thereto a substituent of formula -(Y)�m?-A-NHR, can function as a substrate for the fibrin-stabilising Factor XIIIa....
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WO/1998/027100A1 |
One of radioactive transition metal nitride hetero-complexes which can label physiologically active substances such as peptides or hormones without impairing the activities thereof. It is composed of a radioactive transition metal nitrid...
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WO/1998/005611A1 |
A novel catalyst comprising the formula: LRe(O)n wherein L is selected from the group consisting of: (a) (R�1?)(AL) wherein R�1? is an alkyl side chain containing at least one carbon-rhenium covalent bond, and AL is a molecule having...
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WO/1997/048787A1 |
A bleach and oxidation catalyst is provided comprising a catalytically active metal complex having a poly-dentate ligand containing at least 6 hetero atoms. Such metal complexes can activate hydrogen peroxide, peroxy acids or molecular o...
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WO/1997/044110A1 |
A 99Mo/99mTc generator system includes a sorbent column (11) loaded with a composition containing 99Mo. The sorbent column (11) has an effluent end (31) in fluid communication with an anion-exchange column (15) for concentrating 99mTc el...
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WO/1997/043293A1 |
Compounds of the formula (I): [M6Q8BnL6-n]x where M is Re or Rh; each Q is a bridging atom selected from O, S, Se and Te; B is a monovalent non-bridging atom or moiety; L is a PR3 group in which R is C1-6 alkyl or aryl, optionally substi...
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WO/1997/041856A1 |
Novel organometallic compounds for binding amyloid are described. Methods using such compounds for determining by imaging the localization or quantification of amyloid fibrils in a mammal, for diagnosing the degree of progression of Alzh...
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WO/1997/039006A1 |
The invention features the use of a compound of formula M2(CO)10 in which M represents Re or Tc, M being in radioactive or non-radioactive form, for preparing radiopharmaceutical products useful as diagnostic and therapeutic products. Th...
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WO/1997/036910A1 |
A method is provided for preparing organic hydroperoxides by oxidizing aryl alkyl hydrocarbons having a benzylic hydrogen with an oxygen containing gas using as a catalyst an oxo (hydroxo) bridged tetranuclear metal complex having a mixe...
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WO/1997/033877A1 |
Bioconjugates of low molecular weight mimics of superoxide dismutase (SOD) represented by formula (I) wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, R'9, X, Y, Z, M and n are as defined herein,...
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WO/1997/030144A2 |
Described are complexes of the transition metals manganese, iron, cobalt, ruthenium, molybdenum, titanium, vanadium and/or copper containing one or more ligands of general formula (I) ou (II) in which R is a direct bond or an optionally ...
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WO/1997/026017A2 |
The invention concerns new monomer perfluoroalkyl-substituted metal complexes, a process for their production, and their use in diagnostics and therapy. The compounds according to the invention to the invention are particularly suited fo...
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WO/1997/023489A1 |
The present invention provides a new tetradentate bis-amido bis-alkoxo, 1,2-(bis-2,20diphenyl-2-hydroxyethanamido)benzene (H4PHAB) and various derivatives thereof. This ligand is able to stabilize high valent metal oxo complexes by provi...
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WO/1997/019081A1 |
Metalated bacteriochlorophylls of the formula [M]-BChl, wherein M is a metal atom selected from divalent Pd, Co, Ni, Cu, Zn and Mn, trivalent Fe, Mn and Cr, and tetravalent Sn and Pt, and Bchl represents the residue of a demetalated natu...
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WO/1997/017092A1 |
The invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties of 1-amino-cycloalkyl-1-carboxylic acids, namely, their rapid uptake and prol...
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WO/1997/016210A1 |
Radiopharmaceutical compounds are disclosed. A tropane compound is linked through the N atom at the 8-position to a chelating ligand capable of complexing technetium or rhenium to produce a neutral labeled complex that selectively binds ...
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WO/1997/014445A1 |
This invention presents a series of novel tropane-based derivatives complexed with either technetium or rhenium that are specific for central nervous system receptors, in particular, dopamine or serotonin receptors. The compounds of the ...
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WO/1997/012850A2 |
New compounds have the general formula (I): M - L, in which M stands for a radio-isotope of Tc or Re and L stands for a ligand having the general formula (II): B-CR1R2-(CR3R4)n=1,2-S-CHR5-CHR6-SO2-NH-CR7R8-(CR9R10)m=1,2-
D, in which R1, ...
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WO/1997/012636A2 |
The invention concerns novel compounds of general formula (I), M-L, in which M stands for a radioisotope of Tc or Re and L stands for a ligand of general formula (II) R1S-CR2R3-(CR4R5)n=1,2-S-CHR6-CHR7-SO2-NH-(CR8R9)m=1,2-CO-B in which R...
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WO/1997/010852A2 |
The invention pertains to novel compounds of the general formula (I): M - L in which M stands for a radioisotope of Tc or Re, L stands for a ligand of the general formula (II): B-CO-(CR1R2)n=1,2-S-CHR3-CHR4-SO2-NH-CR5R6-(CR7R8)m=1,2-SR9 ...
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WO/1997/010853A2 |
The invention pertains to novel compounds of general formula (I) in which M stands for a radioisotope of Tc or Re, L stands for a ligand of general formula (II) in which R1, R2, R3, R4, R5 and R6 can have different meanings and stand for...
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WO/1997/006824A2 |
Bioconjugates of low molecular weight mimics of superoxide dismutase (SOD) represented by formula (I), wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, R'9, X, Y, Z and n are as defined herein, u...
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WO/1996/040149A1 |
The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form s...
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WO/1996/040148A1 |
The invention provides antioxidant salen-metal complexes, compositions of such antioxidant salen-metal complexes having superoxide activity, catalase activity, and/or peroxidase activity, compositions of salen-metal complexes in a form s...
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WO/1996/040658A1 |
A process for preparing a substituted polyazamacrocycle is provided which comprises contacting a diamine or triamine and a dicarboxylic acid or ester or anhydride thereof in the presence of a suitable base and a suitable solvent to produ...
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WO/1996/039396A1 |
Low molecular weight mimics of superoxide dismutase (SOD) represented by formula (I), wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, and R'9, M, X, Y, Z and n are as defined herein, useful as t...
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WO/1996/031243A1 |
This invention provides novel radiopharmaceuticals which are useful as imaging agents for the diagnosis of cardiovascular disorders, infectious diseases and cancer. The radiopharmaceuticals are comprised of phosphine or arsine ligated te...
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WO/1996/030054A1 |
The invention relates to a zero-charged 99mTc - labelled substance having a serotonin receptor binding activity, wherein the serotonin receptor binding compound is represented by the general formula (I): L - A - B - E, wherein L is a che...
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WO/1996/030056A1 |
A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises a functionalized hydroxyalkyl phosphine ligand and a metal combined with the ligand.
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WO/1996/015136A1 |
The present invention concerns novel maganese (II) carboxylate complexes having utility as disproportionation catalysts and processes for their preparation. The invention provides Mn(II) carboxylate complexes or their binuclear or polynu...
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WO/1996/013504A1 |
A 'beta','beta''-dihydroxy meso-substituted chlorin, bacteriochlorin or isobacteriochlorin compound having formula (I) or (II), wherein M is a metal. A novel method for synthesizing the compound of formula (I) or (II) comprises the steps...
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WO/1996/011907A1 |
Method of enhancing the water solubility of dry zinc and/or manganese methionine complex salts by reacting a water soluble zinc and/or manganese salt with methionine in the presence of ferric ion with the amount being between at least 15...
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WO/1996/008311A1 |
The present invention provides a novel synthesis for preparing D4-symmetric chiral porphyrins derived from 1R-(+)-nopinone. The simplicity and flexibility of this synthetic protocol provides an attractive route to this novel class of por...
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WO/1996/008497A1 |
Novel group 4, group 3 or lanthanide metal complexes wherein the metal is in the +3 formal oxidation state containing a cyclic or non-cyclic, non-aromatic, anionic, dienyl ligand group bound to M and having a bridged ligand structure, ca...
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WO/1996/007629A1 |
The invention relates to a compound of general formula (I) wherein: Y is a thio function or a group of formula (a), Z is a carboxy group, a (C1-C4)alkoxycarbonyl group, an aminocarbonyl group, an aminosulphonyl group or a carboxymethylam...
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WO/1996/006101A1 |
A palatable metal amino acid chelate for administration to humans and other warm-blooded animals is disclosed wherein there are sufficient ligands to provide ionic and coordinate covalent bonds equal to the coordination number of the cen...
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WO/1996/003410A1 |
The present invention concerns novel hydrophilic metal complexes and the use thereof as luminescent marker groups in immunoassays.
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WO/1996/003409A1 |
The present invention concerns novel metal complexes with charged linker and the use of such complexes as luminescent marker groups in immunoassays.
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