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Matches 1 - 50 out of 12,557

Document Document Title
WO/2020/190073A1
The present invention relates to a pharmaceutical composition for the prophylaxis or treatment of cancer comprising a novel azolopyrimidine heterocyclic compound as an active ingredient, and the pharmaceutical composition for the prophyl...  
WO/2020/190703A1
The present application provides methods for treating wounds by administering a combination of nicotinamide riboside and pterostilbene. The compositions can be administered orally or as a topical formulation.  
WO/2020/188288A1
The present invention relates to compounds of Formula (I) for use in the treatment of nervous system disorders and pain, wherein Formula (I) is: formula(I) or a pharmaceutically acceptable salt or isomer thereof, wherein R is defined her...  
WO/2020/191252A1
Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and signi...  
WO/2020/186588A1
Disclosed is a crystal form A of a 2'-fluoro-4'-substituted nucleoside analog I, wherein same falls within the field of pharmaceutical chemistry. The crystal form A has the following structure: (I). The CuKα-XRPD pattern of the crystal ...  
WO/2020/184677A1
The present invention addresses the problem of providing an anti-hepatitis B virus agent and a prophylactic or therapeutic agent for hepatitis B virus-associated diseases, containing a nucleic acid analog as an active ingredient. The pro...  
WO/2020/186124A1
The present disclosure provides modified microRNA nucleic acid compositions that have one or more cytosine and/or uracil bases replaced with gemcitabine or a 5-halouracil, respectively. More specifically, the present disclosure reveals t...  
WO/2020/178162A1
The present application relates to exocyclic amine-substituted coumarin derivatives and their uses as fluorescent labels. These compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.  
WO/2020/178767A1
The invention relates to compounds of Formula (I), salts thereof, pharmaceutical compositions thereof, as well as methods of treating or preventing HIV in subjects.  
WO/2020/178768A1
The present disclosure relates to 3'3'-cyclic dinucleotides comprising a carbocyclic nucleotide and derivatives thereof, that can modulate the activity of the STING adaptor protein.  
WO/2020/177420A1
Disclosed is an ultrasonic composite acidic water extraction method for a Cordyceps polysaccharide and cordycepin in Cordyceps militaris, which falls within the technical field of food processing. The method comprises: picking, washing, ...  
WO/2020/178165A1
The present application relates to tertiary amine substituted coumarin derivatives of formula (I) and their uses as fluorescent labels. These compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applicat...  
WO/2020/176741A1
Provided are methods of treating multiple sclerosis, which comprises administering to a patient a therapeutically effective amount of DNA methylation blocker. Also provided are method of retarding development of multiple sclerosis by adm...  
WO/2020/169696A1
The invention relates to a compound of formula (II) wherein X, Y, R5, Rx, Ry and Nu are as defined in the description and in the claims. The compound of formula (II) can be used in the manufacture of medicaments.  
WO/2020/172629A1
Methods for stabilizing or encapsulating at least one compound selected from the group consisting of nicotinamide riboside (NR), nicotinic acid riboside (NAR), nicotinamide mononucleotide (NMN), nicotinic acid mononucleotide (NaMN), deri...  
WO/2020/168466A1
Disclosed herein are compounds, modified nucleosides, modified nucleotides, modified nucleic acids, and methods of synthesizing the same.  
WO/2020/131578A3
The disclosure provides nicotinamide riboside (NR), the reduced form of NR (NRH), nicotinic acid riboside (NAR), the reduced form of NAR (NARH), derivatives thereof, compositions thereof and uses thereof. The NR and NAR derivatives have ...  
WO/2020/168952A1
Disclosed are a modified cytidine compound, i.e. a new derivative cytidine generated by adding a guanidyl at position 4 of a cytidine, and a nucleic acid containing the modified compound, for example, RNA. The nucleic acid containing the...  
WO/2020/165334A1
The invention relates to a process for preparing a 3'-O-amino-ribonucleotide of formula (V) wherein (P) represents a phosphate group: (V). It also relates to a compound of formula (III), and its use as a precursor for the synthesis of a ...  
WO/2020/168125A1
The disclosure is directed to crystalline forms of the compound of Formula I, pharmaceutically acceptable salts of the compound of Formula I, and crystalline forms thereof. Pharmaceutical compositions comprising said crystalline forms an...  
WO/2020/136170A3
Embodiments of the present disclosure relate to nucleotide and nucleoside molecules with acetal or thiocarbamate 3ʹ-OH blocking groups. Also provided herein are methods to prepare such nucleotide and nucleoside molecules, and the uses o...  
WO/2020/163673A1
Provided herein are compounds of Formula (I) and pharmaceutically acceptable salts or tautomers thereof which may inhibit adenylate-forming enzymes. Also provided are pharmaceutical compositions, kits, uses, and methods involving the inv...  
WO/2019/152955A9
Disclosed are compounds having formula (I): or a pharmaceutically acceptable salt, ester, amide, solvate, or stereoisomer thereof, wherein L, Y1, Y2, Y3, Y4, Y5, Z1, Z2, Z3, Z4, Z5, Z6 are each as defined in the specification; compositio...  
WO/2020/163415A1
The invention generally relates to improved processes for the preparation of intermediates of a cyclic dinucleotide which is useful as a STING agonist.  
WO/2020/159447A1
There is provided a method of synthesizing a single-stranded nucleotide sequence, the method comprising adding a blocked nucleoside triphosphate to an initiator nucleotide sequence to incorporate a corresponding blocked nucleotide theret...  
WO/2019/145713A9
The present invention relates to methods for the high fidelity synthesis of oligonucleotides and polynucleotides on a solid surface. In particular, the invention relates to methods of synthesising oligonucleotides, polynucleotides, and d...  
WO/2020/154917A1
Phosphates and phosphonates compounds of 6-thio-2'-deoxyguanosine are provided. The uses and pharmaceutical compositions of these compounds are disclosed.  
WO/2020/158910A1
Disclosed are a 5'-modified nucleoside and a nucleotide using the same. The nucleoside according to the present invention is represented by formula (I). The 5'-modified nucleoside according to the present invention is usable as a substit...  
WO/2020/158687A1
In the present invention, a method for producing a compound of formula I comprises a step for causing a compound of formula III to undergo a Pechmann condensation reaction with respect to a compound of formula II in the presence of an or...  
WO/2020/154455A1
The present invention provides a new class of non-immunosupressive FK506 analogs which are FKBP-selective, small-molecule BMP agonists with modest potency therepeutics for tissue repair and regeneration. Also disclosed herein are methods...  
WO/2020/151295A1
Provided is a novel compound having a dinucleotide structure. Also provided are the method for preparing such compound having a dinucleotide structure, and the uses thereof in preparing a drug for treating virus infection, especially hep...  
WO/2020/154656A1
Disclosed is a method for preventing, delaying or reversing age-associated inflammation, by administering to a patient in need thereof a therapeutically effective amount of at least one reverse transcriptase inhibitor (RTI).  
WO/2020/154546A1
Compositions useful for the detection of single molecules in a sample are provided. In some aspects, the disclosure provides a nucleotide connected to a nucleic acid comprising a FRET label comprising at least three luminescent molecules...  
WO/2020/072931A3
The present disclosure provides inosine-5'-monophosphate dehydrogenase (IMPDH)-inhibiting nucleoside derivatives having anti-infective activities, and methods of their synthesis and use.  
WO/2020/154512A1
This disclosure relates to improved methods of identifying A-to-I RNA edits in a sample. In certain embodiments, this disclosure relates to methods of purifying RNA containing an inosine base comprising the steps of: exposing an RNA samp...  
WO/2019/152777A3
The present invention relates to polymers functionalized with non-migratory internal plasticizers.  
WO/2020/142825A1
It is provided an achiral, non-nucleosidic backbone for phosphoramidites that can be inserted with high yields in nucleic acid strands and sequence-controlled oligo(phosphodiester)s through solid phase synthesis (SPS) using a DNA synthes...  
WO/2020/143800A1
The present invention provides a liver-specific AMPK agonist, a preparation method therefor and the uses thereof. Specifically, the present invention provides a compound of formula (I) and the uses thereof for treating non-alcoholic fatt...  
WO/2020/146397A1
Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.  
WO/2020/143740A1
Disclosed are a cyclic dinucleotide prodrug molecule, a preparation method therefor and an application thereof relating to the field of pharmaceuticals. The cyclic dinucleotide prodrug molecule has a structure shown in formula I, II, or ...  
WO/2020/140559A1
Provided is a 5-deoxy-D-ribose derivative (III), when the derivative (III) is used for preparing capecitabine, the stereoselectivity is good and the yield is high. Further provided is a preparation method of the derivative, wherein the p...  
WO/2020/135715A1
Disclosed is a compound represented by Formula (I), optical isomers thereof, pharmaceutically acceptable salts thereof, and an application of the compound as a STING agonist. (I)  
WO/2020/136170A2
Embodiments of the present disclosure relate to nucleotide and nucleoside molecules with acetal or thiocarbamate 3ʹ-OH blocking groups. Also provided herein are methods to prepare such nucleotide and nucleoside molecules, and the uses o...  
WO/2020/139871A1
Methods, systems, compositions, and devices for the manufacturing of high-quality building blocks, such as polynucleotides, are described herein. Processes described herein provide for efficient washing of residual reagents, solvents, or...  
WO/2020/139962A1
Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin, galectin-3, or E-selectin and galectin-3 to ligands are disclosed. For examp...  
WO/2020/139960A1
Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of galectin-3 to ligands are disclosed. For example, inhibitors of galectin-3 are described an...  
WO/2020/131578A2
The disclosure provides nicotinamide riboside (NR), the reduced form of NR (NRH), nicotinic acid riboside (NAR), the reduced form of NAR (NARH), derivatives thereof, compositions thereof and uses thereof. The NR and NAR derivatives have ...  
WO/2020/131649A1
The present disclosure provides novel anhydrate crystalline Forms 1 and 4 of 4'- Ethynyl-2-fluoro-2'-deoxyadenosine and pharmaceutical compositions thereof, each of which may be useful for the inhibition of HIV reverse transcriptase, the...  
WO/2020/127461A1
The present invention relates to a stabilized amorphous form of a compound of formula (I) as well as compositions for oral administration comprising the compound of formula (I) in a therapeutically effective amount.  
WO/2020/128469A1
The present invention generally relates to a novel process for the preparation of 8-chloroadenosine derivatives, and particularly NUC-9701(8-chloroadenosine-5'-O- [naphthyl(benzyloxy-L-alaninyl)] phosphate) an anticancer ProTide of 8-chl...  

Matches 1 - 50 out of 12,557