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Matches 1 - 50 out of 12,021

Document Document Title
WO/2018/160088A1
The present invention relates to a prodrug and the use thereof to treat patients suffering from viral and cancerous diseases. The present prodrug provides inhibition of NS5B HCV polymerase, HBV DNA polymerase and HIV-1 reverse transcript...  
WO/2018/160089A1
The present invention relates to a prodrug and to the use of same to treat the hepatitis C virus in patients. A prodrug of general formula 1, a stereoisomer thereof, an isotopically enriched analogue, a crystalline or polymorphic form.  
WO/2018/155451A1
The purpose of the present invention is to provide: a nucleic acid compound represented by formula (I) or formula (II), said nucleic acid compound hardly forming a non-Watson-Crick base pair; and an oligonucleotide which comprises the nu...  
WO/2018/152453A1
Provided herein are compounds useful for the treatment of cancer.  
WO/2018/152450A1
Provided herein are compounds useful for the treatment of cancer.  
WO/2018/149945A1
The present invention relates to a compound bearing at least two fucose moieties for its use as a drug in the prevention or treatment of infections caused by Aspergillus spp, said compound having a molecular weight comprised from 0.6 to ...  
WO/2018/143403A1
Provided is a novel compound or salt thereof that induces degradation by autophagy of an intracellular molecule. In this compound, a ligand having activity to bind to an intracellular molecule and a structure having activity to induce au...  
WO/2018/144778A1
The disclosure relates to synthetic thermostable polynucleotides, as well as methods of synthesizing and delivering the polynucleotides.  
WO/2018/144854A1
Methods and compositions are provided for oligonucleotides that bind targets of interest. The targets include cells and microvesicles, such as those derived from various diseases. The oligonucleotides can be used for diagnostic and thera...  
WO/2018/144088A1
Disclosed is a therapeutic regimen which includes S-adenosyl methionine, or a salt thereof; folic acid, or a metabolite thereof, or a salt thereof; and a compound of Formula (I), or salt thereof, useful in the treatment of a variety of c...  
WO/2018/138508A1
The invention relates to methods of synthesizing polymers, biopolymers, and nucleic acids, to immobilised dNTP/NTPs and kits comprising said immobilised dNTP/NTPs for use in said methods of nucleic acid synthesis.  
WO/2018/140734A1
Compounds for use in prevention and/or treatment of pain are disclosed. The compounds are derived by conjugation of N 6-(4-hydroxybenzyl)adenosine and analogous compounds with amino acids or peptides. In one embodiment of the invention, ...  
WO/2018/140270A1
Tunicamycin related compounds having an acyl chain double bond reduced and/or having an acyl chain double bond and an uracil ring double bond reduced are described as well as methods of making these tunicamycin related compounds. These t...  
WO/2018/132890A1
There is described herein, a method for inducing Tc22 lineage T cells from a population of CD8+ T cells, the method comprising: a) providing a population of CD8+ T cells; b) activating the population; and c) culturing or contacting the p...  
WO/2018/133854A1
Provided are a kind of nucleoside analogue compounds, and compositions comprising these compounds and pentostatin, their use for modulating circadian rhythm, preferably, for shifting circadian phase, and methods for modulating circadian ...  
WO/2018/134343A1
The present invention is directed to a compound of formula (III), its preparation and to its use for the preparation of a compound of formula (IV). The present invention hence is directed to a process for the preparation of compound of f...  
WO/2018/131950A1
The present invention relates to a carbocyclic nucleoside derivative represented by chemical formula A or a pharmaceutically acceptable salt thereof, and an antiviral agent comprising the same.  
WO/2018/122157A1
The present invention provides for stable nucleotide reagents used for nucleic acid amplification by PCR and RT-PCR (Reverse Transcriptase-PCR) that comprises modified nucleoside polyphosphates. The present invention also provides for me...  
WO/2018/121678A1
The present invention relates to a prodrug of antiviral nucleoside analogues, and a composition and use thereof, and specifically relates to a prodrug of anti-hepatitis C virus nucleoside analogues. The prodrug can be used as an inhibito...  
WO/2018/113710A1
Provided in the present invention is a method for preparing a β-nucleoside compound, comprising the steps of: 1) performing a silylation reaction of a nitrogenous base or an analogue thereof in the presence of TMSOTf to obtain the nitro...  
WO/2018/118664A1
Therapeutic combinations that comprise at least one antagonist of the Programmed Death 1 receptor (PD-1) and at least one cyclic dinucleotide compound that activates the Stimulator of Interferon Genes (STING) pathway are disclosed herein...  
WO/2018/115309A1
The present invention relates to methods for preparation of glyco-conjugated proteins and in particular to processes for preparation of sugar-nucleotides and modified sugar-nucleotides.  
WO/2018/119117A1
The present disclosure provides cyclic dinucleotides (CDNs), and methods of preparing and using the same. The subject methods can include contacting a CDN producing-enzyme with a precursor of a CDN under conditions sufficient to convert ...  
WO/2018/113592A1
The present invention relates to a solid form of a compound of formula (I), a method for preparing the solid form, a pharmaceutical composition comprising the solid form, and the use of the solid form in the treatment of a disease involv...  
WO/2018/113652A1
Provided in the present invention are a compound as shown in formula (I), a pharmaceutical composition comprising same, and a preparation method and use thereof as a NS5B polymerase inhibitor, a DNA polymerase inhibitor or a reverse tran...  
WO/2018/119284A1
The invention relates to novel heterocyclic compounds and pharmaceutical preparations thereof. The invention further relates to methods of treating or preventing cancer using the novel heterocyclic compounds of the invention.  
WO/2018/110643A1
[Problem] To provide a nucleoside derivative having antiviral activity against at least HBV and also having low toxicity for host cells. [Solution] A nucleoside derivative represented by general formula (1). In formula (1), R is an optio...  
WO/2018/110591A1
The present invention makes it clear that a nucleoside derivative which shows excellent antiviral activity against HBV and which has low cytotoxicity can be obtained by substituting specific functional groups at each of positions 2, 6, a...  
WO/2018/110678A1
[Problem] To provide a nucleoside that is more practical for RNA pharmaceuticals and other applications and a use therefor. [Solution] A nucleoside derivative indicated by formula (1) or (2) or a salt thereof. (In formula (1), R1 indicat...  
WO/2018/107377A1
A purification process of NADPH is used for purifying a crude NADPH product obtained by biocatalytic preparation. The present invention resolves the technical problems of existing ion exchange resin methods having low yields and low puri...  
WO/2018/109416A1
The invention relates to novel molecules pertaining to the family of nucleoside analogues, with an antiproliferative activity. The invention also relates to the method for the synthesis of said molecules and to the application thereof in...  
WO/2018/104856A1
A process of obtaining a purified geometric isomer of an unsaturated macrocyclic compound is disclosed herein. The process is effected by contacting an ion exchange medium comprising silver ions with a mixture comprising at least one geo...  
WO/2018/100137A1
The invention relates to nucleoside triphosphate and nucleoside triphosphate analogue prodrugs. It is an object of the present invention to provide improved nucleoside triphosphate or nucleoside triphosphate analogue prodrugs. To achieve...  
WO/2018/099946A1
The present invention relates to novel bicyclic nucleosides and oligomers prepared therefrom. In particular, the present invention relates to a compound of formula (I), wherein one of T1 and T2 is OR1 or OR2; and the other of T1 and T2 i...  
WO/2018/101431A1
The purpose of the present invention is to provide a 2-O-α-D-glycosyl-L-ascorbic acid composition which has excellent moisturizing properties and excellent skin wettability. The present invention relates to: a 2-O-α-D-maltosyl-L-ascorb...  
WO/2018/096831A1
Provided are a novel nucleoside derivative or salt thereof, polynucleotide synthesis reagent, polynucleotide production method, polynucleotide, and binding nucleic acid molecule production method. This nucleoside derivative or salt there...  
WO/2018/092107A1
Novel anti-Viral and anti-Cancer molecule containing nucleobase or its derivatives or its analogues attached to an Ascorbic Acid molecule or its derivatives or its analogues with or without an oxygen bond in-between.  
WO/2018/094148A1
Compounds that modulate the conversion of AMP to adenosine by 5'- nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions ...  
WO/2018/091542A1
The present invention relates to Compounds of Formula (I) or Formula (II) or a pharmaceutically acceptable salt, solvate or enantiomer thereof, wherein A, B, R1, R2, R3, R4, Q and V are as defined herein. The present invention also relat...  
WO/2018/093717A1
The present invention features compositions and methods for the treatment of HCV infection. In one embodiment, the compositions of the invention comprise (1) Compound 1 or a pharmaceutically acceptable salt thereof, and (2) Compound 2a o...  
WO/2018/089830A1
The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X", Z 1, Z2, n, R 1, R2, R3, R4, R5, R6,,R7, and R 8 are described herein, reduced analogs thereof, modified derivativ...  
WO/2018/085833A2
The disclosure is directed to compounds of Formula I, Formula II, and Formula III [Formulas should be inserted here]. Methods of their use and preparation are also described.  
WO/2018/085307A1
The present invention provides prodrugs of clofarabine. The compounds of the invention have formula (I), or a pharmaceutically acceptable salt thereof, wherein R1 is H or -C(=0)-X-R3 and R2 is H or -C(=0)-Y-R4, wherein X and Y are each i...  
WO/2018/081785A1
An antiviral compound of the following formula (I) is provided or a salt or a pharmaceutically acceptable salt thereof, where B is a naturally occurring or non-naturally occurring base; R1 is a C2-C14 alkyl group; X is O, S, CH=CH (cis) ...  
WO/2018/079503A1
Provided is a simple and practical method for removing iron ions, as a method for purifying P1,P4-di(uridine 5'-)tetraphosphate from a solution that contains iron ions. This method for purifying P1,P4-di(uridine 5'-)tetraphosphate by rem...  
WO/2018/071531A1
The disclosure provides linked purine pterin compounds of Formula I that are novel inhibitors of HPPK, a kinase responsible for an essential step in the biosynthesis of folic acid. (Formula I) The variables, e.g., A1-A3, R1-R4, B1-B2, an...  
WO/2018/070543A1
The purpose of the present invention is to provide a method for producing a phosphoramidite suitable for nucleic acid production (synthesis) with high efficiency and high purity. A phosphoramidite which allows for efficient nucleic acid ...  
WO/2018/067241A1
The present invention relates to macroheterocyclic nucleoside derivatives and their analogues, production and use thereof. These compounds are the prodrugs for treating viral and cancerous diseases and are inhibitors of HCV NS5B polymera...  
WO/2018/066690A1
The purpose of the present invention is to provide: crystals of cytidine diphosphate choline which contain no methanol and have improved powder properties; and a process for producing the crystals. The process according to the present in...  
WO/2018/064078A1
Apparatus and means by which a polysaccharide or other heterogeneous polymer is concatenated with a nucleic acid polymer that is captured by a primer on a polymerase tethered to a bead trapped by a nanopore. The translocation of the nano...  

Matches 1 - 50 out of 12,021