Steroids

Matches 751 - 800 out of 1,879	< 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 >

Document	Document Title
JP7248819B2	3α5β-neuroactive steroids for the treatment of epilepsy and seizure disorders 3α5β-steroid compounds of general formula I is disclosed. These compounds are useful in the treatment of epilepsy or comorbidities associated with epilepsy or conditions associated with convulsions, such as seizures associated with hyp...
JP2023040180A	NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF To provide new and improved neuroactive steroids that modulate brain excitability for the prevention and treatment of CNS-related conditions.The invention provides compounds represented by formula (I) and pharmaceutically acceptable salt...
JP7241792B2	Neuroactive 19-alkoxy-17-substituted steroids, prodrugs thereof and methods of treatment using same The present disclosure is generally directed to neuroactive 19-alkoxy-17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorde...
JP2023022187A	COMPOSITIONS AND METHODS FOR TREATING CNS DISORDERS To provide compositions and methods for treating CNS disorders.Described herein are neuroactive steroids of the formula (II) in the figure or pharmaceutically acceptable salts thereof. Such compounds are supposed, in certain embodiments,...
JP2022543242A	Human aminosterol ENT-03 compounds, related compositions containing same, and methods of using same The present invention relates generally to novel aminosterol compounds, compositions containing the same, and methods of making and using the novel aminosterol compounds and compositions. [Selection drawing] Fig. 1C
JP2022543244A	Human squalamine derivatives, related compositions containing same, and methods of using same This application relates generally to novel aminosterol compounds, compositions containing them, and methods of making and using the novel aminosterol compounds and compositions. [Selection drawing] Fig. 1
JP7136802B2	Process for the preparation of sulfonyl carbamate bile acid derivatives The present invention relates to processes for preparing compounds of Formula (I) and compounds of Formula (II) or a pharmaceutically acceptable salt or solvate thereof. These compounds and pharmaceutical compositions are useful as FXR o...
JP2022116318A	COMPOSITIONS AND METHODS FOR TREATING CNS DISORDERS To provide compositions and methods for treating CNS disorders.The invention provides a compound of a formula (I) or a pharmaceutically acceptable salt thereof. In the formula (I), A is aryl, heterocyclyl or heteroaryl; R1 and R2a are C1...
JP2022533069A	Small molecule modulator of gut bacterial bile acid metabolism Described herein are methods and compositions for the inhibition of bile salt hydrolases (BSH), as well as their use. Provided herein are metabolic disorders (eg, diabetes, obesity), gastrointestinal disorders (eg, gastrointestinal infec...
JP2022105088A	C7, C12 AND C16 SUBSTITUTED NEUROACTIVE STEROIDS AND THEIR METHODS OF USE To provide C7, C12 and C16 substituted neuroactive steroids which have GABA receptor modulation action and are useful in preventing and/or treating CNS-related conditions, and their methods of use.The invention employs neuroactive steroi...
JP7083394B2	Panaxadiol saponin derivative, its preparation method and use The invention discloses a panaxadiol glycoside derivative and a preparation method and application thereof. Such compounds show strong anti-inflammatory effects in vitro and in animal model experiments, and thus can be used to prepare an...
JP2022075974A	C17, C20 AND C21 SUBSTITUTED NEUROACTIVE STEROIDS AND THEIR METHODS OF USE To provide C17, C20 and C21 substituted neuroactive steroids and their methods of use.Described herein are neuroactive steroids or pharmaceutically acceptable salts thereof. Such compounds are expected, in certain embodiments, to behave ...
JP7065825B2	C7, C12, and C16 replacement neurostimulatory steroids and how to use them Described herein are neuroactive steroids of Formula (I), Formula (V), or Formula (IX) or a pharmaceutically acceptable salt thereof; wherein each instance of R2, R3, R4, R5, R6, R7, R11a, R11b, R12, R16, R17, R19, and are as defined her...
JP7064515B2	15β- [3-Propanamide] -Substituted Estra-1,3,5 (10) -triene-17-one compounds and their 17-oxime for use in the inhibition of 17β-hydroxysteroid dehydrogenase The invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereofwherein R1 to R4 are as defined in the claims. The invention further relates to their use as inhibitors of 17β-HSD1 and in treatment or preve...
JP7057783B2	Method for preparing sulfonylurea bile acid derivative or a pharmaceutically acceptable salt or solvate thereof, and intermediates of use in said processes.
JP7050008B2	How to prepare deoxycholic acid and intermediates useful for preparing deoxycholic acid The present invention relates to new and improved processes for the preparation of deoxycholic acid (DCA) and pharmaceutically acceptable salts thereof, as well as to novel intermediates useful for the preparation of DCA and pharmaceutic...
JP7049313B2	C17, C20, and C21 replacement neurostimulatory steroids and how to use them Described herein are neuroactive steroids or a pharmaceutically acceptable salt thereof. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. Also provided are pharmaceutical compositions comprising a comp...
JP7034094B2	Methods and intermediates for 6,7-α-epoxidation of the steroid 4,6-diene The invention relates to a process for preparing a compound of general formula (Ia): wherein R2, Y, R4 and R5 are as defined herein, wherein the epoxidation is conducted using an oxidant and methyltrioxorhenium as a catalyst (MeReO3). Th...
JP7034093B2	Intermediates for the synthesis of bile acid derivatives, especially obeticholic acid The invention relates to compounds of general formula (I):wherein: , R1, R2, R3, R4, R5, R6 and Y are as defined herein.The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditi...
JP7034092B2	Steroids as chemical intermediates 6.7.β-epoxides wherein R2, Y, R4 and R5 are as defined herein. The invention also relates to certain compounds per se. The compounds are intermediates in the synthesis of synthetic bile acids.
JP6995757B2	Inhibitor of glucocorticoid receptor The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The s...
JP2021533206A	Fluorinated bile acid derivative Compound of general formula (I): [Chemical 1](In the formula, R2a, R2b, R3a, R3b, R5, Y and R7Is a selective agonist of FXR receptors, non-alcoholic steatohepatitis (NASH); primary biliary cirrhosis; primary sclerosing cholangitis; bilia...
JP6974388B2	Neuroactive steroids, compositions, and their use Described herein are neuroactive steroids of the Formula (I):or a pharmaceutically acceptable salt thereof; wherein R1a and R1b are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. T...
JP6948680B2	Compounds for the treatment of metabolic diseases, methods for producing them, and applications Provided are a compound for treating metabolic diseases having the structure as shown in formula (I) or formula (II), or a racemate, stereoisomer, geometric isomer, tautomer, solvate, hydrate, metabolite, pharmaceutically acceptable salt...
JP2021120396A	METHODS OF MAKING ONAPRISTONE INTERMEDIATES To provide methods and systems for making intermediates in the synthesis of onapristone.A method comprises irradiation with narrow band frequency light from a lamp selected from the group consisting of an excimer DBD light source and an ...
JP2021518842A	Solid forms and formulations containing glucocorticoid receptor antagonists, and their use The present invention generally relates to formulations and methods for treating cancer. Formulations comprising substituted steroid derivatives are provided herein. The subject formulation is useful in the treatment of cancer. [Selectio...
JP6893173B2	Compositions and Methods for Treating CNS Disorders Described herein are neuroactive steroids of the Formula (II):or a pharmaceutically acceptable salt thereof; wherein A, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6and------are as defined herein. Such compounds are envisioned, in certain emb...
JP2021512909A	Steroidal derivative modulator, its manufacturing method and application The present invention relates to a steroidal derivative modulator, a method for producing the same, and an application thereof. The present invention particularly relates to a compound represented by the general formula (I), a method for...
JP2021073200A	BIOORTHOGONAL COMPOSITIONS To provide novel carrier compositions for efficiently delivering a therapeutic agent, diagnostic agent, or targeting agent to a therapeutic site, in the treatment of diseases such as cancer, or in vivo diagnosis.Provided is a carrier com...
JP2021073250A	AMINOSTEROID COMPOUNDS FOR TREATMENT OF PTP1B ASSOCIATED DISEASE To provide aminosteroid compounds for selective inhibition of the enzyme PTP1B in a mammal, and compositions comprising the aminosteroid compounds.The invention provides various aminosteroid compounds which inhibit protein phosphatase IB...
JP6867577B2	Panaxidiol-type ginsenoside derivative, its production method and its use Provided are panaxdiol-type ginsenoside derivatives having structures as shown in formula I or formula II. Also provided are the uses thereof in the preparation of drugs for preventing and treating atherosclerosis. The panaxdiol-type gin...
JP6861703B2	TGR5 modifiers and how to use them The application relates to compounds of formula (A): or a salt, solvate, ester, tautomer, amino acide conjugate, or metabolite thereof. The compounds of formula A are TGR5 modulators useful for the treatment of various diseases, includin...
JP6853833B2	Combination of estrogen receptor regulators Described herein, inter alia, are compositions and methods for treating or preventing hyperproliferative disorders, including cancer.
JP6852118B2	Neuroactive 19-alkoxy-17-substitute steroids, their prodrugs and treatments using them The present disclosure is generally directed to neuroactive 19-alkoxy-17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorde...
JP2021046409A	INHIBITORS OF GLUCOCORTICOID RECEPTOR To provide novel compounds for treating or preventing cancer.Provided herein are substituted steroidal derivative compounds having the structure in the figure, and pharmaceutical compositions comprising the compounds. The subject compoun...
JP6849233B2	Polyethylene Glycol-Binding Glucocorticoid Prodrug and Compositions and Methods of It Polyethylene glycol (PEG)-conjugated glucocorticoid prodrugs, methods of preparation, and use for the treatment of diseases and disorders are disclosed. In particular, PEG-conjugated dexamethasone compounds and methods of using them for ...
JP2021504480A	Compounds for treating myopia Cataracts and presbyopia affect billions of people worldwide. Described herein are new compounds and methods for treating and preventing these diseases. The present disclosure provides new compounds, salts, compositions and their use in ...
JP2021008504A	NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF To provide compounds and pharmaceutical compositions useful for prevention and treatment of CNS-related conditions.Compounds of a formula (I) in the figure are provided, where Z is selected from, e.g., a substituted or unsubstituted C1-C...
JP6802862B2	Inhibition of hepatitis B virus and hepatitis D virus and NTCP transport by polymerized bile acid derivatives The invention provides for treating HBV or HDV infection or inhibiting human sodium taurocholate co-transporting polypeptide (hNTCP) with a polymeric bile acid or salt thereof, and pharmaceutical compositions comprising a polymeric bile ...
JP2020536566A	Bile acid hydrolase probe and its manufacturing method and usage method Probe embodiments for targeting, identifying, and isolating enzymes exhibiting BSH activity, as well as devices and kits that use the probes, are described herein. It also describes how to make and use probes, devices, and kits. In some ...
JP6801093B2	Inhibitor of glucocorticoid receptor The present invention relates generally to compositions and methods for treating cancer and hypercortisolism. Provided herein are substituted steroidal derivative compounds and pharmaceutical compositions comprising said compounds. The s...
JP6800748B2	Lipid-based platinum compounds and nanoparticles The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to platinum based compounds comprising platinum moiety, linker moiety and lipid moiety and corres...
JP6796366B2	Industrial process for the synthesis of uripristal acetate and its 4'-acetyl analogs The present invention relates to a new process for the synthesis of compounds of formula (I) (wherein the meaning of R is dimethylamino or acetyl group) using the compound of formula (II) (wherein the meaning of R is dimethylamino or 2-m...
JP6785788B2	Bile acid derivatives as FXR / TGR5 agonists and how to use them The present invention provides compounds represented by Formula I, or pharmaceutically acceptable salts, stereoisomers, solvates, hydrates or combination thereof,The invention also provides pharmaceutical compositions comprising these co...
JP6781148B2	Hydroxysteroid compounds, their intermediates, their preparation methods, compositions and uses The present invention relates to novel steroidal compounds of formula (I), process for preparation of the same and composition comprising these compounds.
JP2020528892A	Isotope-labeled bile acid derivatives The present application relates to isotope-labeled compounds of formula I, as well as methods of their preparation and use.
JP6735665B2	Hydrophilic high quantum yield acridinium ester with improved stability and rapid emission Hydrophilic, high quantum yield, chemiluminescent acridinium compounds with increased light output, improved stability, fast light emission and decreased non specific binding are disclosed. The chemiluminescent acridinium esters possess ...
JP6712599B2	3α-ethynyl, 3β-hydroxy, 5α-pregnane-20-oxime for use in the treatment of CNS diseases The invention relates to 3α-ethynyl, 3β-hydroxy, 5α-pregnan-20-oxime or a pharmaceutically acceptable salt thereof, which compounds and/or salts are useful as modulators of the mammal brain excitability via the gamma-5 aminobutyric ac...
JP6704535B2	Lanosterol prodrug compound, its production method and application Disclosed are a lanosterol prodrug compound, a pharmaceutically acceptable salt and an isomer thereof, and a pharmaceutical composition comprising the lanosterol prodrug compound and the use thereof in the preparation of a drug for treat...
JP2020073868A	COMPOSITION FOR MAKING BIOLOGICAL TISSUE TRANSPARENT AND METHOD FOR MAKING BIOLOGICAL TISSUE TRANSPARENT USING THE SAME To provide a composition for making biological tissue transparent and a method for making biological tissue transparent using the composition.A transparentizing method for transparentizing a biological tissue using a biological tissue tr...

Matches 751 - 800 out of 1,879	< 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 >