Steroids

Matches 851 - 900 out of 1,879	< 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 >

Document	Document Title
JP5147814B2	Steroid-derived antibiotics To provide a new compound for treating patients having a bacterial infectious disease, and to provide pharmaceutical preparations containing an effective amount of the compound. An antibiotic derived from a steroid is, for example, a com...
JP5139609B2	Steroid-derived antibiotics A series of novel steroid derivatives are described. The steroid derivatives are antibacterial agents. The steroid derivatives also act to sensitize bacteria to other antibiotics including erythromycin and novobiocin.
JP5133937B2	7-Procedures and intermediates for the production of substituted antiestrogens A process for preparing an intermediate compound of formula (II) where X is as defined in the specification, R 1 is haloalkyl, alkyl, alkenyl, cycloalkyl, carboxyalkyl, alkoxycarbonylalkyl, aryl or arylalkyl; R 2 , R 3 , R 4 and R 5 are ...
JP2012532833A	Non-polar and polar leaving groups The present invention provides novel and advantageous processes for preparing and purifying pharmaceuticals The processes comprise a nucleophilic reaction wherein a modified leaving group LM, which has increased lipophilicity, of a vecto...
JP5095413B2	Production method of vitamin D derivative using photoreaction There are provided a novel process for producing [{(5Z,7E)-(1S,3R,20S)-1,3-dihydroxy-9,10-secopregna-5,7,10(1 9),16-tetraen-20-yl}oxy]-N-(2,2,3,3,3-pentafluoropropyl)acet amide, which process is characterized by irradiating a compound re...
JP5097724B2	Stereoselective synthesis of 24-hydroxylated compounds useful for the production of aminosterols, vitamin D analogs and other compounds A method is described for stereoselectively reducing an unsaturated alkyl ketone substituent attached to a fused ring base. In this method, the unsaturated alkyl ketone reacts with a chiral oxazaborolidine reagent. This reaction stereose...
JP5094400B2	Hypertension treatment The present invention provides a novel hypertension therapeutic agent. The hypertension therapeutic agent of the present invention contains, as an active ingredient, a compound represented by formula (1): [F1] or a pharmaceutically accep...
JP5074655B2	17-aryl-linker derivatized estrogen 3-sulfatase as an inhibitor of steroid sulfatase There is provided a compound of Formula I wherein X is a ring system; R 1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; R 2 is any one of a sulphamate group, a...
JP5052726B2	Bile acid complex with metal ion chelate and its use Compounds able to chelate paramagnetic metal ions and the use thereof as contrast agents in the technique known as "Magnetic Resonance Imaging" (M.R.I.).
JP5052730B2	Steroid-derived antibiotics A series of novel steroid derivatives are described. The steroid derivatives are antibacterial agents. The steroid derivatives also act to sensitize bacteria to other antibiotics including erythromycin and novobiocin.
JP5031942B2	Fatty acid derivatives of bile acids and bile acid derivatives The present invention relates to bile acid or bile salt fatty acid conjugates (hereinafter called "BAFAC), to their use in dissolving cholesterol gallstones in bile, preventing their occurrence or recurrence, to their use in reducing or ...
JP4999784B2	Lipopolyamine as a transfection agent and its pharmaceutical use Lipopolyamines useful for the transfection of nucleic acid and methods of preparation thereof are disclosed. The lipopolyamines are of general formula I, in which R4 comprises at least one C10-C22 aliphatic radical.
JP5000294B2	Compound There is provided a compound of Formula I wherein (I) R 1 is a selected from (i) an alkyloxyalkyl group (ii) a nitrile group, and wherein R 2 is capable of forming a hydrogen bond (iii) alkylaryl group, wherein the aryl group is substitu...
JP2012517463A	How to make coryl-L-lysine A process for the preparation of cholyl-L-lysine comprising the steps of: —(a) reacting N-ε-CBZ-cholyl-L-lysine with a hydrogen source in the presence of a catalyst in a solvent comprising one or more alkanols; (b) removing the cataly...
JP4959276B2	New anti-estrogen steroids, as well as related pharmaceutical compositions and uses Novel and anti-estrogenic compounds are provided which are useful to treat a variety of disorders, particularly estrogen-dependant disorders. Preferred compounds have 1,3,5-estratiene nucleus, and are substituted at the C-17 or C-11 posi...
JP4958377B2	Estrogen as an inhibitor of steroid sulfatase-17-sulfatase There is provided a compound of Formula I wherein X is a ring system; R 1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; R 2 is any one of a sulphamate group, a...
JP2012511027A	Highly permeable composition and its uses The invention provides compositions or pharmaceutical compositions of novel high penetration compositions (HPC) of a parent compound, which are capable of crossing biological barriers with high penetration efficiency. The HPCs are capabl...
JP4933250B2	Antitumor activity 2-Replaced estra-1,3,5 (10) -trien-3-yl sulfamate The invention relates to the use of 2-substituted estra-1,3,5(10)-triene-3-yl sulfamates of general formula I, in addition to their pharmaceutically acceptable salts for producing a medicament. Said compounds have an anti-tumour action.
JP4931312B2	Halogenated sulfamate-, phosphonate-, thiophosphonate-, sulfonate-, and sulfonamide-compounds as inhibitors of steroid sulfatase A compound is described. The compound has the formula (Ia) as presented in the FIG. 1; wherein: X is a ring having at least 4 atoms in the ring; K is hydrocarbyl group; Rh1 is an optional halo group; Rh2 is an optional halo group; at lea...
JP4928729B2	Photoactive material Diamine compounds, which in particular are useful as precursors for the production of liquid crystal alignment layers, represented by the general formula I: wherein A<1> represents an organic group of 1 to 40 carbon atoms; A<2> repre...
JP2012051935A	17-α-SUBSTITUTED-11-β-SUBSTITUTED-4-ARYL AND 21-SUBSTITUTED 19-NORPREGNADIENEDIONE AS ANTIPROGESTATIONAL AGENT To provide new steroids which possess antiprogestational activity with minimal antiglucocorticoid activity.In addition to providing compounds of formula I, the present invention relates to methods where the compounds of Formula I are adv...
JP4866740B2	Herix 12-oriented steroid drug Compounds having the structure or their salts: are used to treat or reduce le likelihood of acquiring androgen-dependent diseases, such as prostate cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, acne, hirsutism, sebor...
JP4860880B2	8β-hydrocarbyl-substituted estrogen as a selective active estrogen The invention relates to novel 8ß-substituted estratrienes of the general formula (I), wherein R2, R3, R6, R6', R7, R7', R9, R11, R11', R12, R14, R15, R15', R16, R16', R17 and R17' are defined as in the description and R8 represents a s...
JP4842475B2	Method for producing bile acid derivative A process for the preparation of the compounds of general formula (I)in whichR1 is H or OH;R2 is H, alpha-OH, or beta-OH; andR3 is a straight or branched C1-C4 alkyl group or a benzyl group,comprising the reduction of compounds of formul...
JP4837858B2	17β-acyl-17α-propynyl-11β- (cyclic amino) aryl steroids and derivatives thereof with antagonistic hormone properties The invention is directed to a novel class of 17beta-acyl-17alpha-propynyl steroids which exhibit potent antiprogestational activity.
JP4833471B2	4-Benzylaminoquinoline conjugates with bile acids and their heteroanalogs, their methods of manufacture, drugs containing their compounds and their use The invention relates to substituted 4-benzylaminoquinolines and their hetero analogs, and to the pharmaceutically acceptable salts and physiologically functional derivatives thereof. Compounds of formula Iin which the radicals are defin...
JP4778438B2	New 17β-Hydroxysteroid Dehydrogenase Type I Inhibitor The present invention relates to novel 3, 15 substituted estrone derivatives which represent inhibitory compounds of the 17beta-hydroxysteroid dehydrogenase type I (17beta-HSD1), to their salts, to pharmaceutical preparations containing ...
JP4768941B2	Bile Acid Substituted Phenyl Alkenoyl Guanidines, Methods of Their Production, Their Use as Pharmaceuticals or Diagnostics, and Pharmaceuticals Containing them Substituted acylguanidines and their pharmaceutically tolerable salts and physiologically functional derivatives.Compounds of the formula Iin which the radicals have the meanings indicated, and their physiologically tolerable salts, phys...
JP4750281B2	New 11β-substituted steroid derivatives, methods of their production and intermediates of this method, their use as drugs and pharmaceutical compositions containing them. The invention concerns compounds of formula (I) wherein: X, Y, R1, R2, Z, G are as defined in the description, the methods for preparing them and the intermediates in said method, their use as medicine and the pharmaceutical compositions...
JP2011148821A	REDUCED CORTISOL CONJUGATE To provide a novel method for preparing a cortisol conjugate.The method for preparing the cortisol conjugate includes reacting 3-cortisolcarboxymethyl oxime conjugated to bovine serum albumin (3-CMO-BSA) with sodium borohydride.
JP4727923B2	SYN3 composition and its method Disclosed are aqueous and nonaqueous solution formulations containing agents that are useful for treating cancer.
JP4719144B2	Estrogen derivative as an inhibitor of steroid sulfatase The present invention provides a compound comprising a steroidal ring system and an optional group R1 selected from any one of —OH, a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide ...
JP4718512B2	New anti-estrogen steroids, as well as related pharmaceutical compositions and uses Novel and anti-estrogenic compounds are provided which are useful to treat a variety of disorders, particularly estrogen-dependant disorders. Preferred compounds have 1,3,5-estratiene nucleus, and are substituted at the C-17 or C-11 posi...
JP4718439B2	Antitumor activity 2-substituted D-homoestra-1,3,5 (10) -trien-3-yl sulfamate This invention relates to 2-substituted D-homo-estra-1,3,5(10)-trien-3-yl sulfamates of general formula I (I), in which R3 means a C1-C5-alkyl or C1-C5-alkyloxy group as well as their use for the production of a pharmaceutical agent for ...
JP2011121966A	TRANSFECTION REAGENT To provide cationic lipids and compositions of the cationic lipids having utility in lipid aggregates for delivery of macromolecules and other materials into cells.There are provided compounds expressed by general structural formula. The...
JP4709751B2	Specific glucocorticosteroid compounds with anti-inflammatory activity A process for preparing a compound of formula (I): wherein X represents O or S; R 1 represents C 1-6 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkylmethyl or C 3-8 cycloalkenyl any of which optionally may be substituted by one or more methyl g...
JP4709752B2	Specific glucocorticosteroid compounds with anti-inflammatory activity A process for preparing a compound of formula (I): wherein X represents O or S; R 1 represents C 1-6 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkylmethyl or C 3-8 cycloalkenyl any of which optionally may be substituted by one or more methyl g...
JP4648891B2	Enzyme inhibition immunoassay The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, ...
JP4629333B2	Aminoglycoside lipid derivative The invention concerns novel transfecting compounds consisting of an aminoglycoside bound to a lipid via a spacer, and their polyguanidyl derivatives. Said compounds are useful for in vitro, ex vivo or in vivo transfection of nucleic aci...
JP4629030B2	17-Halogenated 19-New method for producing norsteroid compounds and intermediates The invention relates to a process for preparing compounds of formula (I): in which R1, R2, R3, n and X are as defined in the description, and to the intermediate compounds for implementing this process.
JP4616479B2	Phenyl alkenoylguanidines substituted with bile acids, their production methods, their use as drugs or diagnostics, and drugs containing them Substituted phenylalkenoylguanidines, processes for their preparation, uses as medicaments or diagnostics, and medicaments containing them are described. The invention relates to substituted phenylalkenoylguanidines and their pharmaceuti...
JP4615998B2	9-α-substituted estratriene as a selective active estrogen The invention relates to novel 9 alpha -substituted estratrienes of general formula (I) - wherein R3, R7, R7', R13, R16, R17 and R17' have the designations cited in the description, and R9 represents a linear-chain or branched-chain, opt...
JP4611019B2	A novel glucocorticoid receptor conjugate for the treatment of metabolic disorders This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in the regulation of metabolism, especially lowering ...
JP4601297B2	Aminoalkylsterol compounds with antitumor and neuroprotective activity Sterol derivatives (I) are new. Sterol derivatives of formula (I) are new. T1, T2 = H or Me, Me being in alpha- or beta-configuration; T4 = H, Me or Et; T3 = H or beta-Me; dotted line = optional additional 5(6) or 6(7) bond; Z = H or OH ...
JP2010538072A	How to treat diabetes This application is directed to the use of steroid compounds for the selective inhibition of the enzyme PTP1B in a mammal for the treatment of diabetes.
JP4586190B2	Azobenzene compounds and gelling agents made of them and their production methods To provide a compound having photoresponsive gelatinizing effect, and to provide a method for easily producing the gelatinizer. The azobenzene compound is provided, being represented by the formula (wherein, m is an integer of 1-7; n is ...
JP4545929B2	17β-amino and hydroxylamino-11β-allyl steroids with agonist or antagonist hormonal properties and their derivatives The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.
JP4545930B2	17β-nitro-11β-allyl steroids with agonist or antagonist hormonal properties and their derivatives The invention is directed to 17 beta -nitro-11 beta -arylsteroids of formula I: wherein R1, R6, R7, R12 and X are as defined by the specification. The compounds exhibit potent antiprogestational activity and are useful in the treatment o...
JP4541166B2	Methods and compositions for inducing sleep Methods and compositions for interacting with the GABAA receptor complex to induce sleep in humans using certain 5 3 alpha -hydroxy-5-reduced steroid derivatives.
JP2010529152A	17β-cyano-18a-homo-19-nor-androsto-4-ene derivative, its use and pharmaceuticals containing the derivative The 17beta-cyano-18a-homo-19-nor-androst-4-ene derivatives of the present invention possess gestagenic activity. They have the general chemical formula 1, in which Z is selected from the group comprising O, two hydrogen atoms, NOR and NN...

Matches 851 - 900 out of 1,879	< 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 >