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JPS5647200B1 |
1365229 17 - Cyanosteroids ROUSSEL UCLAF 1 June 1972 [1 June 1971] 25576/72 Heading C2U The invention comprises compounds of Formula Ia, Ib, Ic, VI, VII, VIII and IX in the following reaction scheme wherein all conversions are effected i...
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JPS56142300A |
New steroid-spiro-oxathiazolidine derivatives pharmaceutical compositions containing the same, and to a process for the preparation thereof are disclosed. The new compounds have antimineral corticoide effects and have the following formu...
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JPS56124000A |
Compounds of the formula (I) having aldosterone-antagonizing activity are disclosed (I) wherein R3 and R4 are each C1 to C3 alkyl; and Z is one of the following groups (a) (b) (c) (d) (e) wherein R1 is hydrogen or methyl; R6 is hydrogen,...
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JPS5622797A |
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JPS55122800A |
NEW MATERIAL:A Δ4-3-ketosteroid of formula I [X is O or together form a thiazolidine ring, two X's cannot be O at the same time; R1 is H, 1W8C alkyl or halogen; R2 is H, OH, or -OOCR7 (R7 is H, 1W20C alkyl, etc.); R8 is H, Cl or F; R9 i...
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JPS5526158B2 |
New triamino-androstanes with curare-type properties and a process for the preparation thereof are disclosed.
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JPS5585521A |
PURPOSE: The title non-toxic remedy having improved prolonged pharmacological actions, comprising a specific progesterone prodrug as an active constituent. CONSTITUTION: A remedy comprising a progesterone compound of formula I [X is 0, f...
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JPS5517039B1 |
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JPS5517040B2 |
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JPS5549316A |
Compounds of formula: M-N=A in which M is a peptide substituent comprising z-gly-phe, gly-phe, z-arg-arg, or benzoyl-arg, and A or N=A is an active lysosome-inhibiting substance comprising a known therapeutic drug residue or an amino rad...
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JPS5519259A |
NEW MATERIAL:A compound of formula I: [R1 and R11 are H, F, or Cl; R2 is OH, -OCOR7 R7 is H, etc.); R3 and R4 are H or 1W8C alkyl groups; R5 is H or -COOR7 group; R6 is OH, F, etc.; R9 is H, 1W8C alkyl group, etc.; the compound may be a ...
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JPS5519266A |
Chemiluminescent-labeled conjugates of the formula: wherein R is hydrogen or straight chain alkyl containing 1-4 carbon atoms, n=2-6 and L(CO- is a specifically bindable ligand, such as an antigenic protein or polypeptide, a hapten or an...
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JPS5513273A |
NEW MATERIAL:A compound of formula I: [Z2 is oxo, β-hydroxyl group, etc.; R2 and R3 are H, alkyl, phenyl groups, etc., or may from -(CH2)n (n is an integer 5W7); R5 is -COOR11 (R11 is H, alkyl group, etc.); R10 is H, -COR11, etc.; R8 an...
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JPS54157553A |
NEW MATERIAL:A compound of formula I: {R1 and R2 are H or group of formula II [R6 and R7 are H, alkyl, -CH2OCOR8 (R8 is alkyl, alkenyl, phenyl group, etc., or may form a heterocyclic ring with the bonded N atom; Y is group -(CH2)n- (n is...
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JPS5439388B1 |
1306622 21 - (4 - Methyl - 1 - piperazinyl)- Steroid RICHTER GEDEON VEGYESZETI GYAR RT 30 April 1971 [13 May 1970] 12350/71 Heading C2U [Also in Division A5] In the preparation of 11#,17α-dihydroxy-21- (4 - methyl - 1 - piperazinyl) - p...
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JPS54132565A |
Diuretic pharmaceutically active steroid-spiro-oxazolidinone compounds of the formula (I), (I) wherein R1 is hydrogen or methyl, R2 is C1-4 alkyl, R3 is hydrogen, C1-4 alkyl or C2-4 alkenyl, Z1 and Z2 each are hydrogen or together form a...
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JPS546557B2 |
The invention relates to novel 2 beta ,16 beta -diamino-17-unsubstituted-androstanes, to acid addition salts and quaternary ammonium derivatives of these compounds and to processes for their preparation.
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JPS544957B1 |
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JPS53141259A |
Steroidal acids of the formula (I) are prepared from steroidal ketones of the formula (II) wherein R1 is hydrogen; hydroxy; lower alkyloxy; tetrahydropyranyloxy; aryloxy; alkyl; alkanoyloxy or aroyloxy; R2 is hydrogen; hydroxy; lower alk...
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JPS5344466B2 |
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JPS5339436B2 |
1505461 Esters of corticoids with a substituted acetic acid AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO ACRAF SpA 9 Jan 1976 [13 Feb 1975] 00873/76 Headings C2U and C2C Novel steroids of the formula (wherein R 2 is #-OH or O and there is...
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JPS53119873A |
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JPS53115814A |
The invention relates to a process for the determination of an immunologically active material in a sample. The process is characterised in that the sample is brought together with a receptor which is able to bind the immunologically act...
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JPS53101357A |
Novel and biologically active 11 beta -substituted steroids of the oestrane series are disclosed having the formula (I) wherein (a) R1 is O or ( alpha Y)( beta Z), wherein Y is selected from the group consisting of H, unsaturated aliphat...
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JPS5392753A |
PURPOSE: The title cpds. I [Z is oxo, β-OR1, etc.; R1 is II(R4 is H or alkyl; R2 and R3 are H, 1-8C alkyl, phenyl, etc.; R2 and R3 together form a ring); Q is oxo or III(R5 is H, -COOR4, etc.); the bond between C1 and C2 is single or do...
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JPS5363369A |
Pharmaceutical compsn. contains as active ingredient an azetidine deriv. of formula (I) or its acid addn. salts. In (I) R1 is H, 3-18C alkyl, 5-15C cycloalkyl, 1- or 2-adamantyl, benzylhydryl, benzyl (opt. substd. by 2, same, OH, alkoxy ...
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JPS5346956A |
PURPOSE: 12β-O-Cinnamoyl-20-O-nicotinoyltometogenin of formula.
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JPS539217B2 |
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JPS5334766A |
Iodinatable bile salt derivatives are obtained by providing bile salts and their glycine and taurine conjugates with iodinatable groups. The radioiodinated compounds are useful in the radioimmunoassay of bile salts and in physiological s...
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JPS52142056A |
A process for the preparation of steroids of the formula: *** in which R1 is a group -NraRb, in which Ra and Rb (which may be the same or different) are C1-6 alcoholic groups or C3 alkenyl- 6 (provided that Ra and Rb together contain 2-7...
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JPS52136158A |
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JPS52111552A |
4-Androsten-3-ones of the formula wherein R1 is hydrogen or the acyl radical of an organic or inorganic acid, R2 is hydrogen, alkyl, or the acyl radical of an organic or inorganic acid, R3 is methyl or ethyl, R4 is hydrogen or methyl, +t...
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JPS5231922B2 |
Title cpds. (I) their salts and quaternary ammonium salts. (where R is H, or 1-6C acyl, R1 is 1-6C alkyl, vinyl, allyl, or hydroxyethyl, R2 is H, 1-6C-alkyl, allyl or benzyl, X is H Y is OH or 1-6C acyloxy or X + Y is O and salt forming ...
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JPS5285159A |
Pregnanes and androstanes are described which essentially possess a 3.alpha.-hydroxy group, a S.alpha.-hydrogen atom or a 4,5- or 5,6-double bond, a 17.alpha.-hydrogen atom and an 11.beta.-aminoester group. Other optional substituents or...
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JPS5216112B1 |
1280569 6-Aminomethyl steroids UPJOHN CO 21 Oct 1970 [19 Nov 1969] 50030/70 Headings C2C and C2U Novel 6-aminomethyl steroids having in rings A and B the structure (wherein R1 and R2 are each C 1-12 alkyl, C 1-12 hydroxyalkyl, C 3-8 cycl...
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JPS5217401A |
The process for removing a secondary hydroxyl group from an organic compound having at least one secondary hydroxyl group and having any amino groups protected, comprises the reaction of a reactive ester of said secondary hydroxyl group ...
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JPS51125059A |
17 alpha ,21-Diesters of 17 alpha ,21-dihydroxysteroids of the pregnane series corresponding to the formula I in which the symbols X, Y, R<1> and R<2> have the meaning stated in Claim 1 are prepared by reacting a compound which has the g...
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JPS5138717B1 |
Compounds of the class of 20-pyrrolecarboxylic acid esters of 20-hydroxy- DELTA 16-pregnenes have cardiotonic activity; they are active ingredients of pharmaceutical compositions and have useful cardiotonic activity; a typical example is...
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JPS5141372A |
1484655 Preparing steroids electrolytically SIPHAR SA 29 July 1975 [8 Aug 1974] 31789/75 Heading C7B [Also in Division C2] Steroids of Formula: wherein R 1 and R 2 are each H, OH or aliphatic carboxylic acyloxy, R 3 is H or OH, R 4 is OH...
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JPS5136447A |
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JPS512460B1 |
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JPS50142556A |
The present invention relates to novel 11-substituted steroids of the estrane series having the general formula IN WHICH R1 = a free, esterified or etherified hydroxyl group or halogen; R2 = an alkyl group with 1-4 C-atoms; R3 = 0 or ( a...
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JPS50117766A |
1453583 Dipeptide CORNING GLASS WORKS 26 Feb 1975 [1 March 1974] 8007/75 Heading C3H [Also in Divisions C2 and G1] L-lysyl-L-tyrosine methyl ester is prepared by the reaction of L-tyrosine methyl ester with Nα - (tert - butoxycarbonyl) ...
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JPS5032157A |
Steroids bearing the substituent -X-NR1R2 wherein -NR1R2 is a tritium of carbon-14 labeled amino or amino-acid group and -X- is -R3-, -OCOR3-, =N-O-R3- or -NHCOR3- wherein R3 is -(CH2)nCO- in which n is 0-4, are useful as diagnostic agents.
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JPS5032161A |
1,3-Dihydroxy-8 alpha -estratrienes of the formula WHEREIN R is lower-alkyl and -A-B is WHEREIN R' is a saturated or unsaturated hydrocarbon group and R'' is lower-alkyl, aralkyl or phenyl, and the esters and ethers thereof, possess stro...
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JPS4932551B1 |
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JPS4976857A |
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JPS4961150A |
3 alpha -Hydroxy-5 alpha ,ss-pregnan- and -19-norpregnan-20-ones which have in position 21 a substituent selected from cyano, azido and cycloamino and which can additionally be substituted in position 11 by another oxo group and can have...
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JPS4949951A |
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JPS4949950A |
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