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JPH07502749A |
Compositions and methods for modulating the activity of RNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. The reactive portions preferably compris...
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JPH0717673B2 |
The invention relates to 17-(isocyano-sulfonylmethylene)-steroids and a process for the preparation of these compounds from 17-oxo-steroids. Furthermore the invention relates to 17-formamido-sulfonylmethylene)-steroids, which compounds a...
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JPH0741496A |
PURPOSE: To provide a steroid derivative for preventing and treating diseases such as prostatic hypertrophy, prostatic cancer, etc., caused by excessive 5α- dihydrotestosterone, having excellent inhibitory action on testosterone 5α-red...
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JPH0733795A |
PURPOSE: To obtain the above-mentioned novel compound advantageous for treating cardiovascular disorders, such as heart failure, hypertension, or the like. CONSTITUTION: 14-Deoxy-14a-cardenolide 3β-thioderivative is represented by formu...
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JPH0733719A |
PURPOSE: To provide a novel compound which, when administered to warm- blooded animals, induces a bio-affecting response characteristic of the original acid from which the compound is derived and is less irritating and more excellent in ...
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JPH0699470B2 |
The invention relates to a new process for the preparation of 21-hydroxy-20-keto-steroids from 17-(isocyano-sulfonylmethylene)-steroids whereby simultaneously an unsaturated bond is introduced between C16 and C17. Furthermore the inventi...
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JPH0696636B2 |
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JPH0659239B2 |
A cholesterol esterase substrate of the general formula I in which A is an alkylene or alkenylene group with 1 to 20 C atoms, Chol is the 3-cholesterol radical, X is the radical of an aromatic hydroxy or thiol compound and Y is -S- or -O...
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JPH06219951A |
PURPOSE: To provide a drug for cardiovascular diseases such as cardiac insufficiency and hypertension which contains 17-(3-furyl)-and 17β-(4-pyridazinyl)-5β,14β- androstane derivs. which effect the cardiovascular system. CONSTITUTION:...
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JPH06506937A |
The sensitizing amines of the present invention, illustrated by the steroidal amines (I) ), bicyclic ethers (IV), tricyclic compounds (V), indoles (VI) and various species are useful in treating individuals who have cancer has become res...
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JPH06211893A |
PURPOSE: To provide the novel derivative exhibiting low toxicity and useful for remedy for diseases such as hear failure, hypertension or the like containing the derivative active on cardiovascular system. CONSTITUTION: By condensing a 1...
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JPH06192287A |
PURPOSE: To obtain new safe compounds having low toxicities and useful for treating cardiac and vascular diseases such as heart failure and hypertension. CONSTITUTION: There compounds of formula I [a wave line means that 17- positioned s...
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JPH06192286A |
PURPOSE: To obtain a new compound having an activity against the cardiovascular system and extremely low in toxicity and useful for treating cardiac and vascular diseases such as heart failure and hypertension. CONSTITUTION: This compoun...
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JPH06505958A |
Method, compositions, and compounds for modulating brain excitability to alleviate stress, anxiety, and seizure activity using certain steroid derivatives that act at a newly identified site on the gamma-ammobutyric acid/benzodiazepine r...
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JPH06184187A |
PURPOSE: To provide a new compd. useful as a therapeutic agents for cardiovascular diseases such as heart failure and hypertension. CONSTITUTION: A compd. of formula I {Y is, when the double line of a solid line and a broken line is a si...
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JPH06184189A |
PURPOSE: To provide a new compd. having fast-acting and useful as highly effective intravenous an a esthetic. CONSTITUTION: The new compd. is (2β,3α,5α)-21-chloro-3-hydroxy-2(4-morphorinyl) pregnane-20-one of the formula. The compd. i...
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JPH0649717B2 |
The intermediate products of formula (II): R' = especially H or optionally substituted alkyl, alkenyl, alkynyl, aryl or aralkyl, hydroxyl, tetrahydropyranyl, tert-butoxy, optionally esterified carboxyl, amino, mono- or dialkylamino, trit...
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JPH0637513B2 |
Digoxigenin derivatives of the formula (I) in which n is an integer from 1 to 4 and Z is a carboxyl group or a functional derivative thereof, and digoxigenin conjugates of the formula (II) in which the carrier is an immunogenic carrier m...
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JPH0633315B2 |
Hapten derivatives of the general formula (I) …… in which Hap is the radical formed by elimination of an oxo group from a hapten with keto or aldehyde groups, and R<1> and R<2> are identical or different and are a lower alkyl group w...
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JPH0665285A |
PURPOSE: To obtain a new compd. which is useful as a therapeutic drug for cardiovascular diseases such as heart failure and hypertension, is low toxic and which acts as a partial agonist for enzymic activity of Na+, K+-ATPase. CONSTITUTI...
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JPH0665284A |
PURPOSE: To obtain the subject low-toxic new compd. useful as a therapeutic drug for cardiovascular diseases such as heart failure and hypertension. CONSTITUTION: This invention provides a compd. expressed by formula I or its salts, and ...
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JPH0656670A |
PURPOSE: To obtain a new derivative useful for treatment of hyperlipemia, having ability to regulate directly or indirectly, synthesis of LDL receptor at chromosome level. CONSTITUTION: The compound of formula I R<1> is 1-4C alkyl or 1-4...
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JPH0656839A |
PURPOSE: To prepare a new compd. useful as a pharmaceutic for the photodynamic chemotherapy of tumors. CONSTITUTION: This compd. is expressed by formula I, for example, bis(diphenylcholesteryloxysiloxy)germanium-phthalocyanine. In the fo...
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JPH0610187B2 |
This invention relates to hydroxylated derivatives of vitamin D2, to processes for preparing such compounds, to intermediates utilized in such processes and to certain isotopically labelled vitamin D2 compounds. The vitamin D2 derivative...
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JPH061797A |
PURPOSE: To obtain an ethylenically unsatd. bile acid deriv. having an ethylenically unsatd. group bonded to a bile acid deriv. through a bridge group and used as starting material for the preparation of a polymeric bile acid deriv. whic...
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JPH05507518A |
Fluorescent dyes which are free of aggregation and serum binding are provided. These dyes are suitable for applications such as fluorescence immunoassays, in vivo imaging and in vivo tumor therapy.
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JPH0578320B2 |
1. Derivatised nucleic acid sequence with one or more structural elements of the general formula : X-A-M in which X signifies the group see diagramm : EP0173251,P7,F2 or see diagramm : EP0173251,P7,F3 whereby the N-atom represents the am...
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JPH05255089A |
PURPOSE: To provide a new antiviral agent having broad antiviral spectrum and exhibiting strong antiviral action and, accordingly, useful for the prevention and treatment of viral infectious diseases and effective in treating even viruse...
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JPH0559918B2 |
11 beta -Arylestradienes of general Formula I are disclosed (I) wherein R2 is a hydrogen atom, a methyl group, or an ethyl group, R3 is a hydrogen atom or an acyl group, R1 and A-B have various meanings, which possess antigestagen and an...
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JPH05194582A |
PURPOSE: To prepare a new compd. inhibiting testosterone 5α-reductase and useful for the treatment of benign prostatic hypertrophy or the like. CONSTITUTION: This is a new compd. of formula I [R is 1-6C alkyl, 1-4C alkoxy, (substituted)...
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JPH05504561A |
A process for preparing oxazoline corticosteroid intermediates of formula (V) wherein R<1> represents hydrogene (H), loweralkyl, phenyl or phenylalkyl; R<4> represents H or loweralkyl, preferably methyl having either the alpha or beta st...
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JPH05503705A |
The present invention discloses 5-oxygenated amino substituted pyrimidines (X), where R1 is (1) steroid substituent of formula (Steroid), (2) trolox substituent of formula (trolox), (3) an alkyl substituent selected from the group consis...
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JPH0535158B2 |
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JPH0533238B2 |
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JPH0586090A |
PURPOSE: To obtain a new intermediate which is important to synthesize the compd. of the title as a testosterone 5α-reductase inhibitor useful for treatment for acne, seborrhea, female hirsutisum and prostatomegaly. CONSTITUTION: This c...
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JPH0518840B2 |
This invention relates to hydroxylated derivatives of vitamin D2, to processes for preparing such compounds, to intermediates utilized in such processes and to certain isotopically labelled vitamin D2 compounds. The vitamin D2 derivative...
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JPH0518839B2 |
This invention relates to hydroxylated derivatives of vitamin D2, to processes for preparing such compounds, to intermediates utilized in such processes and to certain isotopically labelled vitamin D2 compounds. The vitamin D2 derivative...
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JPH0518837B2 |
11 beta -Arylspirolactones in the steroid series of the general formula I in which R1 is with R and R meaning in each case alkyl with 1 to 4 carbon atoms or R and R, with the inclusion of N, meaning a 5- or 6-membered saturated heterocyc...
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JPH053479B2 |
The invention relates to a new process for the preparation of 21-hydroxy-20-keto-steroids from 17-(isocyano-sulfonylmethylene)-steroids whereby simultaneously an unsaturated bond is introduced between C16 and C17. Furthermore the inventi...
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JPH053478B2 |
The invention relates to 17-(isocyano-sulfonylmethylene)-steroids and a process for the preparation of these compounds from 17-oxo-steroids. Furthermore the invention relates to 17-formamido-sulfonylmethylene)-steroids, which compounds a...
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JPH0475919B2 |
Using cyanohydrin intermediates, 17-keto steroids are transformed to corticoids and 17 alpha -acyl progesterones.
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JPH0469638B2 |
The invention discloses 4-substituted androstendione derivatives of the following formula (I) (I) wherein R is amino or substituted amino or azido, one of R1 and R2 is hydrogen and the other is hydrogen, alkyl, alkenyl or alkynyl, and (x...
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JPH0466879B2 |
Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula I' wherein R1 is an organic radical of 1 to 18 carbon atoms containing at least one atom selected from the group consisting of nitrogen, phosphorous and silicon with the ato...
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JPH04506066A |
The invention is a method of treating angiogenesis in a warm blooded mammal who is in need of such treatment which comprises administration of an angiogenic inhibiting amount of a combination of a suramin-type compound and an angiostatic...
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JPH04295493A |
PURPOSE: To provide a medicinal compsn. that is prepd. by compounding 2β,16β- diamino-3α,17-dihyroxy androstane deriv. or its salt with an assistant, etc., has no undesirable side effects and is used for treating an arrhythmic disorde...
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JPH04504572A |
A method of inhibiting hair growth in mammals which comprises the topical administration of a composition comprising an anti-angiogenic effective amount of an angiostatic compound of formula (I). The formula (I) compound is present in an...
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JPH0443916B2 |
This invention relates to hydroxylated derivatives of vitamin D2, to processes for preparing such compounds, to intermediates utilized in such processes and to certain isotopically labelled vitamin D2 compounds. The vitamin D2 derivative...
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JPH0443077B2 |
Novel 19-nor-steroids of the formula I wherein R1 is an organic group of 1 to 18 carbon atoms optionally containing at least one heteroatom with the atom immediately adjacent the 11-carbon atom being carbon, R2 is a hydrocarbon of 1 to 8...
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JPH0435458B2 |
This invention relates to hydroxylated derivatives of vitamin D2, to processes for preparing such compounds, to intermediates utilized in such processes and to certain isotopically labelled vitamin D2 compounds. The vitamin D2 derivative...
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JPH0434540B2 |
This invention relates to hydroxylated derivatives of vitamin D2, to processes for preparing such compounds, to intermediates utilized in such processes and to certain isotopically labelled vitamin D2 compounds. The vitamin D2 derivative...
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