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JPH04502918A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPH04500687A |
An oligonucleotide conjugated to a steroid the oligonucleotide comprising: wherein A is selected from the group consisting of an aliphatic alkyl, branched aliphatic alkyl and an alkyl (branched) chain of 2 to 18 carbon atoms, R is select...
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JPH045226A |
PURPOSE: To obtain a liposome, composed of a long-chain active amide and a lipid capable of forming the liposome, useful as drug carriers, immulological analytical reagents, etc., and capable of modifying surfaces. CONSTITUTION: The obje...
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JPH0372628B2 |
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JPH03503527A |
This invention is a compound of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 is fluorine, chlorine or bromine; wherein R2 is hydrogen or (C1-C3) alkyl; wherein n is 1 or 2; wherein R3 is phenyl, 2-furyl, 3-furyl,...
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JPH03145446A |
NEW MATERIAL:A compound expressed by formula I [X is dimethylamino, piperidino, 1-pyrrolidinyl, etc.; Y is formula II (R1 is H or lower alkyl; l is 2-8), formula III (R2 is R1 or OH; m is 0-2; n is 2-5), etc.; Z is formula IV (R4 is H or...
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JPH03118325A |
NEW MATERIAL: This compound is represented by formula I [either one of broken lines in ring A is a double bond, R is α-H, α-hydroxy or α-acetoxy and/or formula II (W is a bond or a 1-12C alkylidene; R<2> is a 1-8C alkyl, etc.), =CH-W-...
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JPH0381288A |
NEW MATERIAL: A compd. of formula I, [where X is two Hs or one O; R is an amino alkyl residue of -(CH2)n-NR1R2, (where R1 and R2 are each 1-4C alkyl), or a sugar residue -W, (where W is aminodeoxy sugar of D- or L-series); a dotted line ...
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JPH0374399A |
NEW MATERIAL: A compound of formula I [R is H, 1-4C alkyl, phenyl, benzyl, benzhydryl or trityl; R1 is (di)deoxy sugar, amino(di)deoxy sugar, amino trideoxy sugar, etc.]. EXAMPLE: (20S, 21R)-3β-Dimethylaminopropoxy-14,21-epoxy-5β,14β-...
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JPH03500049A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPH0261480B2 |
Progesterone derivatives having a vinylidene or a 1-alkynyl substituent at the 18-position and further optionally hydroxylated at the 11-position and the 21-position are described herein. Compounds having both an ethynyl substituent and ...
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JPH0249320B2 |
This invention relates to novel mono- and bisquaternary ammonium derivatives of 5 alpha -androstanes having the formula: wherein: R1=H or alkyl (1-4 C); R2 and R3 each are alkyl (1-4 C) or form together with the N-atom a piperidino, pyrr...
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JPH0247479B2 |
The title compounds of formula I and their salts are, with certain exceptions, new: W is H or OH; X is ethyl, 1-hydroxyethyl, or acetyl; or W + X = ethylidene; R, is H or Me; R2 and R3 are each H, alkyl or hydroxyalkyl, R3 alternatively ...
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JPH0234958B2 |
Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula I' wherein R1 is an organic radical of 1 to 18 carbon atoms containing at least one atom selected from the group consisting of nitrogen, phosphorous and silicon with the ato...
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JPH02164898A |
NEW MATERIAL:A compound expressed by the formula (n is positive integer; X-1 is halogen ion). USE: A thermotropic liquid crystal substance and lyotropic liquid crystal forming substance. PREPARATION: ω-Halogenoaliphatic carboxylic acid ...
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JPH0214329B2 |
15-oxygenated sterols, having the ability to inhibit the biosynthesis of mevalonic acid, and produce other effects derived from their ability to inhibit the biosynthesis of mevalonic acid, are disclosed. The 15-oxygenated sterols corresp...
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JPH026359B2 |
Novel 17-oxazoline-steroids of the formula I wherein R1 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms optionally substituted with a member of the group consisting of halogen, oxygen function and nitrogen...
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JPH026360B2 |
The invention relates to novel bisquaternary ammonium derivatives of 2 beta ,16 beta -dipiperidino-5 alpha -androstanes having the formula: wherein R2=CH3, C2H5 or CH2CH=CH2; R3=CH3, C2H5 or CH2CH=CH2, with the proviso that R2 and R3 are...
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JPH01311098A |
NEW MATERIAL: Compd. of formula I {wherein R is formula II (wherein R1 is a 1-16C alkyl, an alkoxy, a halogen, etc., and R4 and R5 are each H, CH3, CN, etc.), formula III (wherein R2 is a 1-16C alkyl), formula IV [wherein B is a 1-16C al...
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JPH0129800B2 |
A novel process for the preparation of a conjugate of a 21-hydroxy steroid and a nucleoside-5'-monophosphate comprises reacting the 21-hydroxy steroid with a derivative of the nucleoside-5'-monophosphate (in which hydroxy groups on the c...
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JPH0121159B2 |
A novel process for the preparation of 3-oximes of the formula I wherein R is selected from the group consisting of methyl and ethyl and R' is selected from the group consisting of hydrogen and acyl of an organic carboxylic acid of 2 to ...
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JPH0116840B2 |
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JPH0112758B2 |
What is disclosed is corticoid 17-(alkyl carbonates) of the formula as defined in the specification, which compounds can be used in veterinary therapy and human therapy, in the form of suspensions, ointments, creams, sprays and the like,...
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JPS6411037B2 |
NEW MATERIAL:Compounds of formula I (R1 is 1-10C alkyl, monohydroxy- 2-10C-alkyl; R2 is 1-10C alkyl, 3-8C cycloalkyl; R3 is H, alpha-OH, d-methyl; R4 is H, F, Cl; R5 is H, F, Cl; X is O, S; Z is carbonyl, beta-hydroxymethylene; the dotte...
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JPS643880B2 |
24,25-Dihydroxycholestane derivatives of the formula wherein A is a steroid residue and R is an aryl group and a process for preparation of the same are disclosed. The derivatives are intermediates for synthesis of 24,25-dihydroxycholeca...
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JPS6360036B2 |
This invention relates to novel 3,20-dioxo-1,4-pregnadiene-17 alpha -ol 17-aromatic heterocyclic carboxylates, to pharmaceutical formulations thereof, and their use in the treatment and control of inflammatory conditions.
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JPS63280096A |
2 beta ,16 beta -diamino-3 alpha ,17 alpha -oxygenated androstanes having one quaternized group, process for the preparation of these compounds and pharmaceutical compositions comprising such compounds as the active ingredient. The afore...
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JPS63277694A |
NEW MATERIAL:A compound of the formula [W, X form >W-X such as carbonyl or β-hydroxyl; Y, Z form -Y-Z such as -PPSe)CH-CH2-(PP is phenyl, 2-pyridyl), -CH=CH-, -CBr=CH-, OR1, OR2 are acyloxy, sulfate ester or phosphate ester]. USE: A syn...
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JPS6356237B2 |
A new process for the preparation of 17 beta -hydroxy-3-oxo-17 alpha -pregn-4-ene-21-carboxylic acid gamma -lactone is described herein. The process makes use of androst-4-ene-3,17-dione as the starting material and 17 alpha -ethynyl-17 ...
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JPS6355520B2 |
A new process for the preparation of 17 beta -hydroxy-3-oxo-17 alpha -pregn-4-ene-21-carboxylic acid gamma -lactone is described herein. The process makes use of androst-4-ene-3,17-dione as the starting material and 17 alpha -ethynyl-17 ...
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JPS6350360B2 |
Fusidinic acid derivs. of formula (I) and their pharmaceutically acceptable salts and easily hydrolysable esters are new: (C24 and C25 are joined by a single or double bond, Q1 and Q2 are H HO or O. A=O, S or SO. R1 = opt. branched 1-8C ...
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JPS63233997A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS63201197A |
11 beta -substituted steroids of the formula wherein A and B together represent a second bond between the 6-position and 7-position carbon atoms, or, respectively, are each H; X is O, two H atoms or hydroximino; Z is the residue of a pen...
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JPS63196598A |
NEW MATERIAL:A compound expressed by formula I (R is formula IIWIV). EXAMPLE: (11β,17-Dihydroxy-3,20-dioxo-1,4-pregnadien-21-yl) 1-(4-chlorobenzoyl)-5- methoxy-2-methylindole-3-acetate. USE: An anti-inflammatory agent having powerful an...
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JPS6338360B2 |
A novel process for the preparation of a conjugate of a 21-hydroxy steroid and a nucleoside-5'-monophosphate comprises reacting the 21-hydroxy steroid with a derivative of the nucleoside-5'-monophosphate (in which hydroxy groups on the c...
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JPS6338040B2 |
Novel 17-[(hydroxymethyl)formamido methylene]-steroids of the formula I wherein R1 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms optionally substituted with halogen or an oxygen or nitrogen function and ...
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JPS6337796B2 |
Novel 19-nor-steroids of the formula I' wherein R1 and R2 taken together form a cycloalkyl of 3 to 8 carbon atoms or are individually selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of...
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JPS63501217A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS633879B2 |
Amino-3-cardenolide derivatives represented by the general formula (I) (I) wherein n and m, which may be the same or different, each represents an integer from 0 to 4; R1, R2, R4, R5 and R6, which may be the same or different, each repre...
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JPS6245879B2 |
New and pharmacologically useful pharmaceutically acceptable acid addition salts are disclosed for the 16 beta -mono-quaternary ammonium derivatives of either the 2 beta , 16 beta -bis-piperdino-3- alpha , 17 beta -dihydroxy-5 alpha -and...
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JPS6241239B2 |
A novel process for the preparation of 3-oximes of the formula I wherein R is selected from the group consisting of methyl and ethyl and R' is selected from the group consisting of hydrogen and acyl of an organic carboxylic acid of 2 to ...
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JPS6240359B2 |
A new process for the preparation of 17 beta -hydroxy-3-oxo-17 alpha -pregn-4-ene-21-carboxylic acid gamma -lactone is described herein. The process makes use of androst-4-ene-3,17-dione as the starting material and 17 alpha -ethynyl-17 ...
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JPS6238360B2 |
The present invention relates to a new series of fusidic acid derivatives, to salts and easily hydrolysable esters thereof, to the preparation of these compounds, and to pharmaceutical compositions containing the compounds, the new fusid...
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JPS6230200B2 |
Novel steroids of the formula I wherein R1 is selected from the group consisting of hydrogen and acyl of an organic carboxylic acid of 1 to 18 carbon atoms, R2 is selected from the group consisting of optionally substituted aryl of 6 to ...
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JPS6229438B2 |
Procedure for preparing new 2,2-dimethyl-19-nor-steroids of formula I: * (see formula I) * in which R1 represents a hydrogen atom, a hydroxyl group, an acyloxy group OCOR2, R2 representing a hydrocarbon radical containing from 1 to 17 ca...
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JPS6229439B2 |
A new process for the preparation of 17 beta -hydroxy-3-oxo-17 alpha -pregn-4-ene-21-carboxylic acid gamma -lactone is described herein. The process makes use of androst-4-ene-3,17-dione as the starting material and 17 alpha -ethynyl-17 ...
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JPS62501446A |
An immunoassay is provided for cholesterol epoxide. To prepare the antibodies used in the immunoassay, novel immunogens, are prepared which comprise a 3,5(6)-transdiaxial-dihydroxycholestane-6(5)-yl-hapten adduct linked to a covalently b...
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JPS6222998B2 |
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JPS6245597A |
NEW MATERIAL:1-0-[3-Hydroxy-1,3,5(10)-estratrien-17β-yl]-N-[4-[
ethyl(1,2,3,4- tetrahydro-1,4-dioxo-6-phthalazinyl)amino]butyl]-β-D-glucur
onamide shown by the formula I. USE: A luminescent labelled compound for determining an estrogen...
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JPS629119B2 |
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