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WO/2004/007750A2 |
The invention provides polypeptides having a monooxygenase activity, polynucleotides encoding these enzymes, the use of such polynucleotides and polypeptides. In one aspect, the invention provides polypeptides having a monooxygenase acti...
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WO/2004/007709A2 |
The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and ...
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WO/2004/005311A1 |
The invention provides a compound of formula (I) and pharmaceutically acceptable salts thereof. Processes for the isolating of this bafilomycin metabolite from a novel Micromonospora species, pharmaceutical compositions containing this m...
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WO/2004/005275A1 |
The present invention provides a novel method for producing compound of formula (I), its acid form or any salt form, where R¿1? is H or CH¿3?, by solid state fermentation using fed-batch technique by culturing microorganisms capable of...
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WO/2004/005292A1 |
The invention relates to novel antibiotics against Vibrio anguillarum and the applications thereof in cultures of fish, crustaceans, molluscs and other aquaculture activities. Five diketopiperazines with activity against Vibrio anguillar...
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WO/2004/003213A1 |
A process for producing a lactone which comprises culturing Candida sorbophila in a culture medium containing at least one member selected from the group consisting of hydroxyfatty acids, hydroxyfatty acid derivatives, and hydrolyzates o...
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WO/2004/003210A2 |
Methods for preparative in vitro biocatalysis utilizing oxidoreductases. These methods are based on novel approaches to supply the oxidoreductases with reduction equivalents derived either from chemical or electrochemical sources. By uti...
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WO/2004/003214A1 |
The present invention provides a novel method for producing compound of Formula (I) or its any salt form, by solid state fermentation, optionally with fed-batch technique by culturing microorganisms capable of producing the compound of F...
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WO/2004/003001A1 |
The present invention relates to enzymatic' resolution of enantiomeric mixtures of 1,3-dioxolane-4-carboxylate esters of Formula I. More particularly, the present invention relates to a process for preparing R and S enantiomers of methyl...
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WO/2004/003212A1 |
The present invention provides a novel method for producing lipstatin, by solid substrate fermentation by culturing microorganisms.
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WO/2003/106690A1 |
The present invention provides a novel method for producing mycophenolic acid, by solid state fermentation using fed-batch technique by culturing microorganisms.
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WO2003048148A9 |
The present invention relates to compounds with structures resembling natural statins isolated from Penicillium sp. (Formula I); where R1 represents OH, C6H5COO, R6COO and R6 represents C1-C5 alkyl; R2-4 represents H, C1-C5 alkyl, C1-C5 ...
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WO/2003/105724A2 |
This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions related to elevated intraocular pressure in the eye of a patient. This invention also relat...
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WO/2003/106689A1 |
It is intended to provide a process for conveniently producing on an industrial scale an optically active &agr -methylcysteine derivative or its salt in the form of an L- or D-compound, which is useful as an intermediate of a drug, etc.,...
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WO/2003/104445A1 |
The present invention concerns a novel aldehyde dehydrogenase having the following physico-chemical properties: a molecular weight of 190,000 ± 15,000 Da which comprises a subunit structure of two &agr subunits and one β subunit, or a ...
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WO/2003/103667A1 |
Inhibitors against complex II of the electron transport system, containing as the active ingredient pyridinol derivatives of the general formula [I] or tautomers thereof, i.e., 2−pyridone derivatives of the general formula [II], or sal...
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WO/2003/102201A2 |
The present invention relates to biocatalysts that are cells, optimally of the Crabtree-negative phenotype, comprising expression vectors encoding genes heterologous to the cell that enable increased production of organic products. More ...
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WO/2003/102152A2 |
Recombinant yeast are provided having, in one aspect, multiple exogenous LDH genes integrated into genome, while leaving native PDC genes intact. In a second aspect, recombinant yeast are provided having an exogenous LDH gene integrated ...
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WO/2003/102200A2 |
Specific oxygen uptake (OUR) is used as a process control parameter in fermentation processes. OUR is determined during at least the production phase of fermentation process, and process parameters are adjusted to maintain the OUR within...
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WO/2003/099219A2 |
The present invention provides nucleic acid molecules that encode polypeptides that catalyze the synthesis of bioactive compounds, such as polyketides including bryopyran rings, such as bryostatins. Also provided is a composition includi...
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WO/2003/100050A1 |
The invention relates to isolated polypeptides with hydantoin recemase activity, that do not suffer from substrate inhibition. Such polypeptides are for instance isolated polypeptides with at least 87% identity with SEQ ID: NO. 2 or SEQ ...
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WO/2003/095458A1 |
The invention provides a process for the N-demethylation or the N- and O-demethylation of a thebaine derivative which process comprises fermenting the derivative with a biocatalyst selected from the filamentous fungi from Cunninghamella ...
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WO/2003/093456A1 |
The present invention relates to soya cell cultures and soya cell strains producing a high amount of isoflavones and to a process for preparing an isolating isoflavone compounds in high yields. The present invention also pertains to soya...
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WO/2003/093491A1 |
Enzymes which are capable of catalyzing esterifications and/or transesterifications such as selected lipases and esterases can, under specified conditions, convert certain lower linear oligomers of polyesters to their cyclic ester oligom...
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WO/2003/091210A1 |
The invention relates to a new inventive process sequence of steps (a) to (e) as claimed in Claim 1 for the preparation of porphobilinogen and intermediates per se as important precursors such as 3-[4-methoxycarbonylmethyl-5-(protected a...
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WO/2003/091396A2 |
Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(iridol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for produding...
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WO/2003/089634A1 |
The present invention concerns a novel aldehyde dehydrogenase having the following physico-chemical properties: a molecular weight of 100,000± 10,000 Da which comprises two homologous subunits or a molecular weight of 150,000± 15,000 D...
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WO/2003/087387A1 |
The present invention relates to a process for the synthesis of optically enriched dextro- and leavo-rotatory isomers of rose oxide from racemic citronellol.
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WO/2003/087376A1 |
By implanting at least a part of a DNA encoding caffeine synthase into a microorganism or a plant in the form of a sense or an antisense, it is intended to achieve the objects of: (1) efficiently producing caffeine synthase usable for in...
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WO/2003/082835A1 |
Processes for the preparation of a compound of formula (IIIA)(I), or a salt thereof; wherein; Z represents a bond, CO, SO2, CR10R7(CH2)n, (CH2)nCR10R7, CHR7(CH2)nO, CHR7(CH2)nS, CHR7(CH2)nOCO, CHR7(CH2)nCO, COCHR7(CH2)n or SO2CHR7(CH2)n;...
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WO/2003/080844A2 |
The invention relates to a method for the production of vitamin E by cultivating organisms, more particularly plants having an enhanced 2-methyl-6-phytyl hydroquinone-methyltransferase activity in relation to the wild type, to the use of...
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WO/2003/080819A1 |
The present invention provides an improved method of in situ extraction of betalaines from hairy roots of Beta vulgaris wherein hairy roots of beet root are cultured in nutrient liquid medium, aseptically and pigment is effluxed to the m...
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WO2002012533A9 |
Fermentation based methods for producing mycolactones allows one to produce large quantities of mycolactones, which can be purified by extraction and chromatography to yield pure preparations of mycolactones A, B, C, and D.
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WO/2003/080828A2 |
The present invention relates to the isolation and characterization of novel polyketide synthase and nonribosomal peptide synthetase genes from the myxobacterium Melittangium lichenicola Me I 46 that are necessary for the biosynthesis of...
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WO/2003/077868A2 |
The present invention is based on the discovery that 2-deoxyribose-5-phosphate aldolase (DERA, EC 4.1.2.4) and variants thereof can be used to catalyze sequential asymmetric aldol reactions between a wide variety of donor and acceptor al...
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WO/2003/078634A1 |
It is intended to provide a novel carbonyl reductase originating in a microorganism belonging to the genus Ogataea and a DNA encoding this enzyme. By reducing ketones with the use of carbonyl reductase, optically active alcohols, in part...
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WO/2003/077845A2 |
This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions related to elevated intraoccular pressure in the eye of a patient. This invention also rela...
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WO/2003/078418A1 |
A 3-hydroxy-3-(2-thienyl)propionamide compound represented by the following general formula (1), which is useful as an intermediate for medicines, etc.; and a process for industrially producing at low cost an optically active 3-amino-1-(...
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WO/2003/076581A2 |
Linking sequences which modulate cross-talk between modules of Type I polyketide synthases have been identified. Thus, arbitrarily chosen modules can be mixed and matched by supplying the appropriate linkers to obtain desired polyketide ...
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WO/2003/076639A1 |
Compounds represented by the following general formula (I); a process for producing a compound (substance F-1490) of the general formula (I), wherein X represents -O- and R represents hydroxy, by using a microorganism belonging to the ge...
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WO/2003/076638A1 |
Compounds represented by the following general formula (I); a process for producing these compound by culturing a microorganism, which belongs to the genus Aspergillus and is capable of producing the compounds, and collecting the compoun...
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WO2001083800A9 |
Recombinant Myxococcus host cells can be used to produce polyketides, including epothilone and epothilone analogs that can be purified from the fermentation broth and crystallized.
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WO/2003/072794A1 |
The present invention relates to a process of preparing geldanamycin by culturing Streptomyces hygroscopicus in an aqueous nutrient medium. The aqueous nutrient medium can comprise starch, a starch conversion enzyme, an assimilable sourc...
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WO/2003/072547A1 |
The present invention provides processes useful in the preparation of certain $g(b)¿3?-adrenergic receptor agonists of structural formula (I) the pharmaceutically acceptable salts thereof, and the hydrates of said pharmaceutically accep...
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WO/2003/072730A2 |
The present invention provides a generalized oxygen-limited cultivation method for myxobacterial strains engineered to heterologously express polyketides synthase (PKS) gene clusters under various oxygen tension conditions, modulating th...
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WO/2003/072785A2 |
A process for the preparation of a target fermentation product comprising cultivation of an aerobic microorganism to produce such product, wherein in the microorganism the efficiency of the respiratory chain is increased, transformed mic...
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WO/2003/068946A1 |
The invention relates to phenalenone derivatives, to the production of the same, whereby the micro-organism Penicillium herquei Bainer & Sartory, DSM 14142, is fermented and the phenalones formed during said fermentation are derivatized,...
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WO/2003/068955A2 |
The present invention relates to polynucleotide comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cult...
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WO/2003/066871A2 |
Isolated nucleic acid and amino acid sequences for phenylalanine aminomutase enzyme and methods for purifying this enzyme are provided. Methods for altering biosynthesis of compounds in plant cell cultures are also provided. In particula...
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WO2003008563A9 |
Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher organic-solvent resistance than the corresponding wild-...
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