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WO/2005/014834A1 |
The invention relates to transgenic plant cells expressing nucleic acid molecules which encode polypeptides with expoxygenase activity wherein said cells naturally contain high levels of linoleic acid; plants comprising said cells and me...
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WO/2005/014844A1 |
The present invention relates to L-gulose dependent vitamin C synthesis. More specifically, the present invention relates to a synthesis pathway of vitamin C, comprising the formation of GDP-L-gulose by GDP-mannose 3',5'-epimerase, and...
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WO/2005/014839A2 |
The present invention relates to novel sweetener compositions comprising monatin and methods for making such compositions. The present invention also relates to sweetener compositions comprising specific monatin stereoisomers, specific b...
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WO/2005/012498A2 |
Methods and materials for producing porphyrins are described. In particular, microorganisms that contain one or more exogenous nucleic acids are described that produce porphyrins in high yield.
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WO/2005/009391A2 |
Fermentation of a nutrient medium with a eubacterium Streptomyces sp. yields a novel antibacterial compound of structure (I).
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WO/2005/005618A1 |
The present invention related to the microorganism for producing pravastatin and the process for producing pravastatin using the microorganism. The Micropolyspora roseoalba CGMCC 0624 of the present invention has a stronger tolerance to ...
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WO/2005/003137A1 |
The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains CNB392 and CNB476 are effective inhibitors of hyperproliferative mammalian cells. The CNB392 and CNB476 strains lie wit...
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WO/2005/000042A1 |
It is intended to provide a composition containing a lactic acid-bacterium producing equol characterized by containing a lactic acid bacterium belonging to the genus Lactococcus that is capable of metabolizing at least one daidzein compo...
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WO/2005/001105A1 |
A method for producing monatin, characterized in that it comprises treating a liquid to be treated containing monatin and impurities with a non-polar resin containing an aromatic ring to thereby separate monatin from the liquid to be tre...
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WO/2004/111230A1 |
To obtain nemadictin as C-13 hydroxylnemadictin to which a saccharide can add, a strain capable of producing C-13 hydroxylnemadictin is constructed by modifying nemadictin aglycon biosynthesis genes. Further, a C-13 glycosylnemadictin-pr...
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WO/2004/111205A1 |
Provided is a Streptomyces sp. CJPV 975652 (KCCM-10497) capable of converting compactin to pravastatin and a method for producing pravastatin using a strain of Streptomyces sp. CJPV 975652 (KCCM-10497), which includes: culturing the stra...
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WO/2004/111255A1 |
The invention encompasses a process for purifying a fermentation broth by providing a fermentation broth; adjusting the pH of the fermentation broth; isolating a filtrate from the fermentation broth; and passing the filtrate through a ca...
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WO/2004/110439A1 |
This invention relates to novel biologically active polyene oxazoles of Formula (I), their pharmaceutically acceptable salts and derivatives, and to methods of obtaining them. One method for obtaining the compounds is by cultivation of S...
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WO/2004/108944A1 |
A method for producing an optically active chroman-carboxylate, which comprises esterifying one antipode of a racemic chroman-carboxylic acid in the presence of a biocatalyst in a solvent containing an alcohol, separating the unreacted o...
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WO/2004/106557A2 |
The present invention provides a method for producing thiamin products using a microorganism containing a mutation that causes it to overproduce and release thiamin products into the medium. Biologically pure cultures of the microorganis...
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WO/2004/104008A1 |
The invention relates to an enzymatic process for the production of an intermediate, bicyclic-heteroaryl-2-carboxylic acid, of the formula (I) wherein X and Y are defined in the specification and which are useful in the preparation of be...
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WO/2004/104206A1 |
The invention provides a compound of the formula (I). Furthermore, the invention provides a process for the production of a compound of formula (I). The present invention also provides a process for the production of natamycin by a Strep...
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WO/2004/104205A2 |
The present invention relates to a process for preparing a chiral indole ester by enzymatic resolution using a lipase from Pseudomonas fluorescens as the catalyst for the enantioselective hydrolysis of an ester.
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WO/2004/101803A2 |
The disclosure describes the production of anticancer agent LL-D45042, having the structure (I) by fermentation, to methods for the recovery and concentration of this anticancer agent from crude solutions, and to processes for the purifi...
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WO/2004/099174A2 |
A continuous process for the process for the enzyme-catalyzed preparation of cyclic ester oligomers from linear ester oligomers. The process may use a linear or recirculating reactor.
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WO/2004/096188A1 |
A structure containing polyhydroxyalkanoate and a magnetic substance includes an external phase part containing polyhydroxyalkanoate and an internal phase part contained in the external phase part, at least one of the external phase part...
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WO/2004/094645A1 |
Staurosporine of the formula (I) is recovered from a fermentation broth in a process comprising an ultrafiltration and a diafiltration step.
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WO/2004/092389A2 |
New processes for improving the manufacture of clavams e.g. clavulanic acid. Novel DNA sequences and new microorganisms capable of producing increased amounts of clavulanic acid are also disclosed.
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WO/2004/090094A2 |
The invention relates to proteins that have an enzymatic activity for reducing substituted alkanones, such as 3-methylamino-1-(2-thienyl)-propane-1-on. The invention also relates to nucleic acids that encode these proteins, to nucleic ac...
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WO/2004/090147A1 |
A method of purifying an aqueous amide compound solution, which comprises filtering an aqueous solution containing an amide compound obtained with a biocatalyst through an ultrafiltration membrane having a fractional molecular weight of ...
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WO/2004/087935A2 |
The invention relates to a fermentation process for the preparation of substantially pure pravastatin. The process provides a method of producing pravastatin by microbial hydroxylation of compactin (ML-236B) by maintaining a concentratio...
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WO/2004/087909A1 |
2-Hydroxyisoflavanone dehydratase substantially having the amino acid sequence represented by SEQ ID NO:1 is isolated from licorice. Further, a polynucleotide encoding 2-hydroxyisoflavanone dehydratase of the SEQ ID NO:2 is obtained. Fur...
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WO/2004/087938A1 |
Novel substances PF1270A, PF1270B and PF1270C represented by the following formula (1) or pharmacologically acceptable salts thereof; a process for producing the same; and a pharmaceutical composition comprising at least one thereof as a...
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WO/2004/087932A2 |
The present invention relates to a method for preparing (2S,3R) alkyl trans-3-phenylglycidate or (2R,3S) methyl trans-3-phenylglycidate comprising:- enzymatic resolution by trans-esterification of ± methyl trans-3-phenylglycidate with e...
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WO/2004/087940A2 |
Process for producing enantiopure β-amino acid derivatives corresponding to general formula (I) R1-NZ-CHR2-CH2-COOR3 (I) in which R1 and R2 independently denote organic residues optionally forming a cyclic substituent, R3 denotes H or a...
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WO/2004/081176A2 |
A method for biotransformation of organic compounds using non-prokaryotic microalgae is disclosed. The method is useful to biotransform a chemical precusor compound, preferably a heterocyclic compound, to a chemically distinct final prod...
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WO/2004/081219A1 |
The present invention relates to a novel and efficient chemoenzymatic process of preparation of optically active trans alkyl phenylglycidates. The invention particularly discloses a novel process for the chemoenzymatic synthesis of two e...
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WO/2004/078951A1 |
It has been required to economically produce a large amount of an optically active &gammad -lactone derivative (for example, pantolactone) which is useful as an intermediate in synthesizing a useful substance such as a drug. To achieve t...
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WO/2004/078978A1 |
Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vec...
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WO/2004/077944A1 |
It is intended to provide a nematocide which is extracted and purified form a culture liquid of a fungus belonging to the genus Aspergillus sp. Namely, a nematocide characterized by containing, as the active ingredient, an organic acidic...
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WO/2004/076676A1 |
A method for the production of partially esterified (meth)acrylic acid esters of polyalcohols and the use thereof.
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WO2004040955B1 |
There is provided a microbiological one-step method for the manufacture of ascorbic acid. The method comprises use of the operon expressing 2-ketogluconate dehydrogenase in naturally occurring microorganisms and microorganisms transforme...
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WO/2004/071382A2 |
The present invention relates to substituted heterocycles, processes for their preparation, and their use in medicaments, especially for the treatment of inflammatory disease, i.e. asthma, or cancer.
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WO/2004/069845A1 |
The present invention provides a novel method for producing compound of formula (I) or any of its salt form, by solid state fermentation, optionally using fed-batch technique by culturing microorganisms capable of producing the compound ...
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WO/2004/070045A1 |
A process for producing an optically active 6-formyl-1,4-benzodioxin-2-carboxylic acid derivative represented by the general formula (3): (wherein R3 is C1-6 alkyl), which comprises reacting a compound represented by the general formula ...
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WO/2004/065607A1 |
By culturing Pleurotaceae Panus rudis K-3574 strain (FERM BP-8265), a compound RS-K3574 represented by the following formula (I) is produced as a physiologically active substance showing an activity of inhibiting ubiquitin activating enz...
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WO/2004/065591A1 |
This invention relates to a novel farnesylated dibenzodiazepinone, named ECO-04601, its pharmaceutically acceptable salts and derivatives, and to methods for obtaining such compounds. One method of obtaining the ECO-04601 compound is by ...
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WO/2004/064745A2 |
Processes for preparing racemic and optically pure 3,6-dihydro-2H-pyrans of formulae H, I, N and O are described. These compounds may be further transformed into compounds of formulae J, K, L, M, P, Q, S, T, U, V, Y and Z with potential ...
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WO/2004/062558A2 |
The present invention describes a process for the preparation of β-lactam antibiotics, cephalexin and ampicillin, wherein the β-lactam nucleus is acylated with an acylating agent, D-phenylglycine, by means of a reaction biocatalyzed by...
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WO/2004/063383A1 |
This invention relates to ionic liquids and their use as solvents in biocatalysis. According to a first aspect of the invention there is provided a method of carrying out an enzyme-catalysed reaction comprising providing a liquid reactio...
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WO2003089452B1 |
Disclosed herein are zinc finger proteins that bind to targt sites in a plant gammatocopherol methyl transferase (GMT) gene; compositions comprising these GMT-targeted zinc finger proteins and methods of making and using such zinc finger...
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WO/2004/061116A2 |
Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vec...
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WO/2004/058976A2 |
The present invention relates to the biosynthesis of polyketides and derives from the cloning of nucleic acids encoding a polyketide synthase and other associated proteins involved in the synthesis of the polyketide borrelidin. Materials...
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WO/2004/057011A1 |
Antibiotics caprazamycin D and caprazamycin G represented by the following general formula (I) are obtained by culturing Streptomyces sp. MK730−62F2 (Accession No. FERM BP−7218). Caprazamycins D and G show excellent antimicrobial act...
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WO/2004/056998A1 |
A gene cluster has open reading frames which encode polypeptides sufficient to direct the synthesis of a safracin molecule.
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