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WO/2002/052949A1 |
The present invention discloses the autoinducer compounds, such as acyl homoserine lactones, acyl homocysteine lactone, acyl thiolactones, furanones or signal peptides, and their use in animal feed additives and animal feeds to improve a...
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WO/2002/053724A2 |
Provided is a method of deprotecting a hydroxide or amine protected with a group of formula ArC?*¿(R)H-(CH¿2?)¿n?-O-C(&equals O)- where the substituents are as described below, the method comprising: contacting the protected hydroxide...
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WO/2002/050297A1 |
A process for producing an amide compound from a nitrile compound by using a microbial catalyst characterized in that microbial cells having a nitrile hydratase activity of at least 50 U/mg dry cells at a reaction temperature of 10°C, w...
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WO/2002/050298A1 |
The invention relates to a method for the continuous biotechnological production of compatible solutes. Said method is characterised in that organisms or cells are continuously multiplied on substrates which exhibit growth inhibition in ...
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WO/2002/050299A2 |
Known microbiological methods are based on the use of pigment-forming bacteria, especially Chromobacterium violaceum. Said methods are low-yielding and, therefore, large scale applications are not possible. However, the demand for natura...
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WO/2002/048383A1 |
A novel process for producing an optically active (4R)-1,3-thiazolidine-4-carboxylic acid which comprises treating a mixture of (4R)- and (4S)-1,3-thiazolidine-4-carboxylic acid amides with optionally treated microbial cells having an ac...
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WO/2002/047610A2 |
The invention is the discovery of an actinomycete genus, given the name Salinospora gen. no., that displays an obligate requirement of the seawater (NA?+¿) for growth and unique 16S rRNA signature nucleotides. The invention is also the ...
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WO/2002/046152A2 |
The invention relates to novel active agents (coniosetin and coniosetin derivatives) of formula I, which are produced by the micro-organism Coniochaeta ellipsoidea Udagawa (DSM 13856) during fermentation, R, R¿2?, R¿3?, R¿4?, R¿5?, X...
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WO/2002/045479A1 |
The shears comprise a support (5) that is associated with a power takeoff (42) from a motor (43) and a cutting mouth (44) consisting of two jaws (3a, 3b), at least one of which is an active cutting jaw (3a) that is rotationally mounted o...
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WO/2002/042311A2 |
The invention concerns biotin derivatives of general formula (I), wherein: R¿1? represents a specific compound; X¿1? represents a carbonaceous chain, preferably of 1 to 10 carbon atoms, substituted or not, optionally comprising one or ...
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WO/2002/040694A2 |
The present invention relates to a method of heterologous production of a taxane or a related compound by cloning a DNA sequence comprising a taxane synthesis pathway, making a DNA construct wherein said DNA sequence is under control of ...
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WO/2002/038598A1 |
The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypep...
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WO/2002/038772A1 |
The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70 % to a polynucleotide which codes for a polype...
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WO2001012827A9 |
The invention relates to a new type of expression cassettes which, under genetic control, contain regulating nucleic acid sequences a) nucleic acid sequence coding for 4-hydrophenylpyruvate dioxygenase (HPPD) or for one of its functional...
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WO/2002/034784A2 |
The nucleic acid and amino acid sequences of $g(a)1, $g(a)2, $g(b) and $g(e) subunits of acetyl-CoA carboxylase (ACCase) from $i(Streptomyces coelicolor) are provided. This subunit structure differs from that of known acyl carboxylases. ...
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WO/2002/032848A1 |
A method of isolating or purifying plavastatin or its pharmacologically acceptable salt characterized by involving, in the process of isolating or purifying plavastatin or its pharmacologically acceptable salt, the step of extracting pla...
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WO/2002/032906A1 |
Clavulanic acid, in which the median of the particles is from 8 $g(m)m to 35 $g(m)m and their use in pharmaceutical compositions.
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WO/2002/031174A2 |
This invention provides a process for the preparation of optically active 4-hydroxy-2-pyrrolidinone or N-substituted 4-hydroxy-2-pyrrolidinones, wherein an oxygen atom is inserted regio- and stereoselectively into the corresponding non-h...
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WO/2002/031173A2 |
The invention relates to improved methods for the biosynthesis of vitamin E. Said methods are characterized by the inhibition of the catabolization of homogentisate to maleylacetoacetate and fumarylacetoacetate and then to fumarate and a...
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WO/2002/029021A2 |
The invention relates to a novel enzyme that has 6-methyl nicotinic-2-dehydrogenase-activity, to a nucleotide sequence encoding said enzyme, and to novel methods for producing carboxylic acids with a hydroxy-nitrogen heterocycle of the g...
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WO/2002/026961A2 |
A process for producing Surfactin, comprising culturing a microorganism of the genus Bacillus in a liquid culture medium containing flour of beans such as soybean or an extract thereof as a nitrogen source and accumulating Surfactin in t...
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WO/2002/026744A1 |
MPC1001 derivatives represented by the general formula (I) or their pharmaceutically acceptable salts; medicines, particularly antimicrobial or antitumor agents, containing the derivatives or the salts; and Cladorrhinum sp. MPC1001 havin...
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WO/2002/027010A1 |
A novel xanthone compound having antitumor activity. The xanthone compound is represented by the formula (I).
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WO/2002/024642A1 |
2,5-bisaryl-$g(D)?1¿-pyrrolines of formula (I) can be produced by reacting amides of formula (II) with an N-deacetylation agent in the presence of a diluting agent. In said formulae, Ar?1¿, Ar?2¿ and R?9¿ have the meanings given in t...
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WO/2002/024865A2 |
Disclosed are methods for the modulation of secondary metabolite production by fungi through genetic manipulation of such fungi. Also disclosed are new commercial processes using ZBC proteins, or variants thereof, to significantly increa...
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WO/2002/022846A1 |
A novel process for the removal of impurities from clavulanic acid using a selective adsorption material, in particular a molecularly imprinted polymer. Novel selective adsorption materials suitable for the process, and a process for the...
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WO/2002/022845A1 |
A process for the preparation of N-substituted 4-hydroxypiperidine, wherein an oxygen atom is inserted regioselectively into the corresponding N-substituted piperidine, by using as a biocatalyst a bacterium degrading alkanes or alicyclic...
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WO/2002/020525A2 |
Use of a compound of formula (I), wherein each R, which are the same or different, is H or C¿1?-C¿6? alkyl, and X completes a ring which is a substituted triazine having one of the following formulae (II) to (IV), wherein R' is H or CÂ...
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WO/2002/018342A2 |
Novel bacterial quinolone signal molecules and, more particularly, pseudomonas quinolone signal ('PQS') molecules, e.g., 2-heptyl-3hydroxy-4-quinolone, and analogs and derivatives thereof are described, Therapeutic compositions containin...
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WO/2002/018587A1 |
Transformed cells having been transformed in the presence of at least one gene of an enzyme participating in the biosynthesis of tetrahydrobiopterin; and a process for producing biopterins by using these cells. Thus, biopterins can be in...
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WO/2002/017937A1 |
The present invention refers to extracts from the fungus Guignardia sp., and also a new isolate compound from the aforementioned extract, both having antimicrobial activities, and their use in pharmaceutical compositions. The new compoun...
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WO/2002/016583A2 |
The present invention relates generally to methods and techniques for the expression of metabolic pathways, novel gene fusion constructs encoding multi-functional enzymatic domains, and related hybrid proteins.
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WO/2002/016601A2 |
The present invention features methods for the identification of compounds and compositions useful as antibiotics and antibacterial agents. In particular, the invention features methods for the identification of modulators of a previousl...
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WO/2002/014529A1 |
Curvularol of formula (I), useful as an active ingredient of medicines such as anticancer agents.
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WO/2002/012263A1 |
The present invention is in the field of nucleic acid binding compounds comprising 7-substituted 7-deaza-8aza-2,6-diamino-purine bases, compounds useful for the preparation of such compounds, various uses thereof and methods for the dete...
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WO/2002/012534A2 |
The present invention relates to compounds made by a subset of modules from one or more polyketide synthase ('PKS') genes that are used as starting material in the chemical synthesis of novel molecules, particularly naturally occurring p...
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WO/2002/010425A2 |
Herein is disclosed a method of generating ascorbic acid from yeast. In one embodiment, the yeast is a $i(Zygosaccharomyces) or a $i(Kluyveromyces) spp. cultured in a medium comprising an ascorbic acid precursor. In a second embodiment t...
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WO/2002/010399A1 |
Novel polypeptides capable of forming (S)-N-benzyl-3-pyrrolidinol, DNA encoding the same and a method of using the same. A polypeptide having the following physicochemical properties (1) to (5): (1) function: asymmetrically reducing N-be...
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WO/2002/010426A1 |
The invention concerns a naturally occuring koji mold wich is incapable of producing a toxin and wich produces at least one compound wich is capable of lowering serum cholesterol concentration for use in a fermented food product. The inv...
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WO/2002/008269A2 |
An isolated nucleic acid fragment encoding a cytochrome P450 enzyme associated with the synthesis of plant D12-epoxy fatty acids is disclosed. The invention also relates to making a chimeric construct encoding all or a portion of the cyt...
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WO/2002/008440A2 |
Desoxyepothilone compounds are produced by fermentation of an epothilone microorganism in the presence of a P450 enzyme inhibitor.
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WO/2002/006268A1 |
Compounds of the general formula (I), or pharmacologically acceptable salts, esters, or other derivatives thereof, exhibiting excellent immunosuppressive activities wherein R?1¿ and R?2¿ are each hydrogen or an amino-protecting group; ...
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WO/2002/002753A2 |
The invention relates to a nucleotide sequence that encodes a benzaldehyde lyase and to the use thereof in a method for the stereoselective production of compounds that contain 2-hydroxyketone groups.
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WO/2002/000663A2 |
A novel class of antitumour compounds has been recognised based on the isolation from a new marine microbe, strain PO13-046, belonging to the genus $m(f)i$m(g)Actinomadura sp.$m(f)/i$m(g)), of a compound designated IB-00208. The class of...
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WO2001060976B1 |
A single colony of myxobacterium cells, a process for its production and its use. A process for the production of a myxobacterium Sorangium strain (Sorangium cellulosum) having an improved epothilone production rate. A process for the pr...
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WO/2001/098518A2 |
The invention relates to a method for producing biologically active ingredients. Active ingredients comprising additional functional groups, a modified spectrum of activity and modified application properties can be obtained from medicam...
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WO/2001/094337A1 |
A process for preparing optically active 2-[6-(hydroxy-methyl)-1,3-dioxan-4-yl]acetic acid derivatives which comprises reacting an enolate prepared by reacting an acetic acid ester derivative with a base or a zero-valent metal with (S)-$...
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WO/2001/092991A2 |
Methods for the computational analysis of polyketides and the computer-assisted design of PKS genes are facilitated by representing the structure of a polyketide and/or a PKS gene that encodes the PKS that produces the polyketide by alph...
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WO/2001/092553A1 |
Disclosed is a method for optically resolving a racemic alpha-substituted heterocyclic carboxylic acid (alpha-HCCA) by taking advantage of enantioselectivity of enzymes. alpha-HCCA is reacted with alcohol to give a racemic alpha-HCCA est...
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WO/2001/090110A1 |
The compounds of formula (I) wherein the substituents have various significances, whereby one of R¿2? to R¿4? is ethyl. They can be prepared by fermentation, or by replacement of hydroxy with chloro under simultaneous or concomittant e...
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