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WO/2023/033515A1 |
The present application relates to a bone graft material composed of porous whitlockite including nanopores with a size of 100 nm to 1,000 nm, micropores with a size of 1 μm to 100 μm, and macropores with a size of 100 μm to 1,000 μm...
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WO/2023/025944A1 |
The present invention relates to an implant having a surface comprising a coating on at least a portion of the surface of the implant, wherein the coating comprises a first layer, the first layer comprising a polylactide and silver ions....
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WO/2023/027330A1 |
The present invention relates to a hyaluronic acid (HA) filler composition using polyethylene glycol (PEG) and glycolic acid (GA) as crosslinking agents and a method for preparing same. The present invention is characterized by preparati...
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WO/2023/027472A1 |
The present invention pertains to an intervertebral body fusion cage having a shell-type porous structure. More specifically, the present invention pertains to an intervertebral body fusion cage having a shell-type porous structure, wher...
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WO/2023/028030A1 |
Diversified grafts suitable for use in repair and reconstruction procedures are provided. Some diversified grafts (10) comprise two or more heterogenous features (118a, 118b) which form regions having different preferred properties. A di...
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WO/2023/024202A1 |
A photo-cured forming composite hydrogel matrix precursor and a preparation method therefor and a stent having the precursor. The photo-cured forming composite hydrogel matrix precursor comprises methacrylated gelatin, sodium alginate, s...
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WO/2023/024724A1 |
Provided in the present invention are a photothermal-curing resin composition, and a preparation method therefor and the use thereof. The resin composition comprises a combination of specific parts of a prepolymer, a monomer, a photoinit...
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WO/2023/027508A1 |
The present invention relates to a degradable ultrasound transducer which is naturally degraded in a use environment, wherein a degradable ultrasound transducer according to an embodiment of the present invention comprises: a piezoelectr...
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WO/2023/023772A1 |
The present invention is concerned with a manufactured article prepared from a biomaterial comprising isolated and purified type I collagen fibrils derived from abalone and a method of preparing such an article. The manufactured article ...
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WO/2023/028178A1 |
Methods, compositions of matter, and devices for delivering a therapeutic composition to a heart of a subject using a biopolymer scaffold material are described. In some embodiments, the biopolymer scaffold material including the therape...
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WO/2023/028584A1 |
The present disclosure relates to a hydrogel biomaterial comprising cell adhesive peptides to generate in vivo tumor models.
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WO/2023/027247A1 |
The present invention relates to a scaffold for bone regeneration and a construction method therefor. The scaffold for bone regeneration of the present invention has grooves and ridges formed on one surface thereof and is equipped with a...
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WO/2023/027663A1 |
The invention relates to a novel graft suitable for use in maxillary sinus lifting treatment, which enables the sinus membrane to be elevated with external or internal methods and inserted within the surgically created space and the prod...
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WO/2023/027094A1 |
It is desirable to provide a novel biomaterial and the like for tendon repair. Provided is a biomaterial for tendon repair containing a hydrogel formed by means of a cross-linking reaction between a reactive group A and a reactive group ...
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WO/2023/025856A1 |
Aortic valve stenosis (AS) also called also called Calcific aortic valve disease (CAVD), is the most frequent valvular heart disease in Europe and affects more than 1 in 4 people over 65 years old. AS progression from fibrotic thickening...
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WO/2023/022495A1 |
The present disclosure relates to a prognostic device, a prognostic method and a recording medium and, specifically, can provide a prognostic device, a prognostic method, and a recording medium, wherein the device and method can select d...
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WO/2023/022675A1 |
The present invention relates to a microfluidic injection device for creating microbubbles using multiple fluids containing bioactive materials, including but not limited to stem cells, biomaterials, and biocompatible gases for use in ca...
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WO/2023/020256A1 |
The present invention relates to a biological polysaccharide hydrogel, a preparation method therefor and an application thereof. The biological polysaccharide hydrogel of the present invention is formed by means of the mixing and reactio...
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WO/2023/021221A1 |
The present invention relates to a method for producing products with molecules or macromolecules attached thereto and apparatus for carrying out this method. The method comprises the steps of: (a) generating a plasma at a location separ...
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WO/2023/019360A1 |
Compositions and methods comprising medically-acceptable fucans suitable for medical and surgical applications, including treatment of capsular contracture and other foreign body reaction (FBR) conditions, and medical and surgical applic...
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WO/2023/022302A1 |
The present invention relates to a surface-treated implant structure. The implant structure according to an aspect includes a fixture acting as an artificial tooth root, and the nano-protrusions included in the outer peripheral surface o...
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WO/2023/016874A1 |
A mesenchymal stem/stromal (MSC) cell line, in particular a human mesenchymal stem cell (hMSC), capable of chondrogenic differentiation when cultured in a chondrogenic medium, comprising a first transgene comprising a first nucleic acid ...
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WO/2023/017157A1 |
The invention relates to implant devices, particularly the invention relates to scaffolds produced by electrospinning which can be used as implant device either combined with a hydrogel or by itself. The scaffolds have an aligned oriente...
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WO/2023/017508A1 |
The present invention provides an insertion tool for inserting an implant, said implant having an implant lower side and an implant upper side, said implant upper side comprising cells, said insertion tool comprising: an implant carrier ...
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WO/2023/018598A1 |
The patent application discloses a degradable polymers compounds. The polymer compounds comprises product of blends of polyglycolic acid and polylactic acid in a weight ratio of from about 99/1 to about 50/50 in mixture with a compatibil...
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WO/2023/017531A1 |
The present disclosure relates to an implant having an implant surface (104) of layered coatings and a method (300) of manufacturing an implant having an implant surface 1. The implant having an implant surface (104) comprises a micro-pa...
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WO/2023/015341A1 |
The invention relates to stabilized compositions comprising fibroblast growth factor 2. The present invention also relates to dosage forms and methods of treating wounds, including tympanic membrane perforations, by administering the com...
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WO/2023/017345A1 |
The present innovation relates to the field of biomaterials, drug delivery systems, load-bearing materials for bone regeneration and dental restauration. The method for fabrication of amorphous calcium phosphate ceramic-based drug delive...
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WO/2023/019143A1 |
Preparations capable of forming films are disclosed. The preparations include a biocompatible polymer and a purified amphiphilic peptide including a folding group having a plurality of charged amino acid residues and hydrophobic amino ac...
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WO/2023/015497A1 |
Biomedical tape, a preparation method therefor, and an application thereof. The biomedical tape comprises a dry state hydrogel carrier and a functional nanomaterial encapsulated within the dry state hydrogel carrier, and the dry state hy...
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WO/2023/013964A1 |
The present invention relates to a composition for preparing an organic-inorganic complex hydrogel and a kit for preparing an organic-inorganic complex hydrogel comprising same, and specifically, to a composition for preparing an organic...
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WO/2023/014587A1 |
A method of producing an osteoinductive composition for in vivo use, in which the method includes obtaining bone tissue; cleaning the bone tissue with a plurality of washes; milling, grinding, and/or cutting the cleaned bone tissue into ...
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WO/2023/012823A1 |
The present invention discloses a highly stretchable matrix, comprising mesh of lattice structures of microfibrillar filaments, having pore size enlargeable up to 8 times by moving the microfibrillar filaments perpendicular to the longit...
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WO/2023/012779A1 |
This invention provides optimized solid substrates for promoting cell or tissue growth or restored function and uses of same, which in some aspects address a need in populations at greater risk for osteochondral, bone or cartilage diseas...
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WO/2023/014586A1 |
A bone preparation system for enhancing cementless osseointegration of bone implants includes a gas delivery device, for cleaning the bone surface of the bone to receive the implant, and a supply of orthobiologic material or orthobiologi...
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WO/2023/012333A2 |
The present invention is directed to gels, cryogels and other polymer scaffolds, solid surfaces, aggregates, films and coatings comprising a soluble chemically modified cross-linked chitosan useful for 3D cell and organoid bioprinting an...
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WO/2023/010117A1 |
The present disclosure is directed to the identification and use of lipids involved in auto-immune reactions and foreign body responses. A. set of phospholipids was observed to preferentially deposit on immune-evasive implants, and these...
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WO/2023/007500A1 |
A three dimensional (3D) model of a glioblastoma tumor made of a synthetic material and a plurality of cell types, including malignant cells and non-malignant cells of the tumor. Methods of forming the 3D tumor model are also provided, a...
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WO/2023/007399A1 |
The present disclosure provides compositions, methods of preparing, and method of use of a composition comprising: (a) about 0.05 wt% to about 10.0 wt% ethylenediamaminetetraacetic acid, a salt thereof, a chelating agent, or a combinatio...
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WO/2023/007117A1 |
An implantable composition comprising a first particulate bioactive glass comprising SiO2, CaO, P2O5 and Na2O, and a second particulate bioactive glass comprising CaO, P2O5, Na2O and a metal oxide, wherein the composition of the first bi...
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WO/2023/009739A1 |
A medical device that is at least partially formed of a refractory metal alloy, and a method for inserting the medical device in a patient.
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WO/2023/009470A1 |
A poroelastic biomaterial including a polyaryletherketone (PAEK) matrix polymer and a plurality of tortuous channels extending from one surface to another surface of the biomaterial is disclosed. Advantageously, the poroelastic biomateri...
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WO/2023/009007A1 |
A method of preparing a cell-containing hydrogel for use in the production of cultured meat is provided, along with examples of device for performing the method. The method comprises steps of positioning a central body inside a circumfer...
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WO/2023/006537A1 |
The invention relates to a medical implant, more particularly stent, having a tubular lattice structure which can be transferred from a radially expanded compressed state to a radially compressed expanded state and has lattice elements t...
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WO/2023/007444A1 |
Disclosed herein are embodiments of a non-woven hybrid-scale fiber matrix sheet which can be used to improve wound healing. The non-woven hybrid-scale fiber matrix sheet may be both microporous, due to the hybrid-scale fiber matrix, as w...
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WO/2023/008686A1 |
An implant abutment including a connector reducing the diameter of a screw hole according to the present invention is characterized by comprising: a base through which a coupling hole having screw threads passes vertically; a connector w...
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WO/2023/006113A1 |
Disclosed in the present invention are a bioenergetic-active material and the use thereof. Specifically, disclosed is a bioenergetic-active material, which is a biodegradable polymer. A degradation product of the bioenergetic-active mate...
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WO/2023/009439A1 |
Skin graft methods are provided. Aspects of the methods include applying a skin graft to a wound in combination with a mechanotransduction blocker, such as a pharmacological mechanotransduction blocker, e.g., a focal adhesion kinase inhi...
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WO/2023/009315A1 |
The present application relates to a sunscreen composition comprising (i) about 0.01 wt.% to about 20 wt.% of avobenzone, (ii) about 0.01 wt.% to about 20 wt.% of benzyl o-toluate; and (iii) about 0.01 wt.% to about 95 wt.% of at least o...
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WO/2023/010113A1 |
The invention is directed to methods of improving the therapeutic efficacy of mesenchymal stromal cells (MSCs) for use in treating osteoarthritis (OA), and more specifically to methods of altering levels of certain proteins, phospho-prot...
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