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JP2011518771A |
A process for preparing the S or R enantiomer of a compound of formula A, the process comprising subjecting a compound of formula B to asymmetric hydrogenation in the presence of a chiral transition metal catalyst and a source of hydroge...
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JP4713134B2 |
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JP4714730B2 |
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JP4713480B2 |
The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of : a) contacting a pro-chiral sulphide of formula (II) wit...
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JP4705031B2 |
The present invention relates to a process for producing amino acid derivatives such as optically active ²-amino acid in short steps with good yield and high optical purity, which comprises reacting a keto acid of the formula (1): where...
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JP4704812B2 |
To provide an asymmetric ligand capable of highly selectively carrying out asymmetric addition reaction, asymmetric conjugated addition reaction, asymmetric hydroboration reaction, etc. and further readily and inexpensively being prepare...
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JP4709009B2 |
A guanidine compound having a biaryl skeleton represented by the following formula (1), which is useful as a catalyst for various asymmetric reactions. (wherein R1, R2 and R3 each independently represent a hydrogen atom, a hydrocarbon gr...
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JP4706241B2 |
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JP4708073B2 |
Disclosed is a novel enantiomeric synthesis of ceramide-like inhibitors of UDP-glucose: N -acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
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JP4706161B2 |
There is provided an industrial process for conveniently and efficiently producing a highly pure cinnamaldehyde derivative, for example, (2E)-(3-hydroxy-4-methoxy)cinnamaldehyde, which comprises reacting a benzaldehyde derivative, such a...
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JP2011116732A |
To provide a method for producing optically active alcohols by reducing corresponding unsymmetrical ketones.The method for producing the optically active alcohol represented by formula (III) [wherein R1 and R2 are substituents different ...
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JP2007531704T5 |
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JP4704422B2 |
The present invention relates to a process for preparing optically active aldehydes or ketones which have from 3 to 25 carbon atoms and at least one racemizable stereocenter by catalytic dehydrogenation of the corresponding optically act...
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JP4703925B2 |
A new class of chiral bidentate ligands to transition metals is disclosed which compounds have the following structure:wherein the substituents are as defined herein.
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JP4695095B2 |
The present invention relates to a new process for the preparation of optically pure(R)-5-(2-aminopropyl)-2-methoxybenzenesulphonamide, which is an intermediate in the synthesis of tamsulosin.
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JP4696077B2 |
The present invention relates to a process for the carbon-carbon double bond isomerisation of a 2-alkyl-cyclohex-3-enyl alkyl or alkenyl ketone into a mixture comprising the corresponding 2-alkyl-cyclohex-2-enyl ketones and the correspon...
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JP4696274B2 |
To provide a solid chiral zirconium catalyst which is capable of effecting long-term preservation and which is suitable for catalystic asymmetry aldol reaction and catalytic asymmetry hetero Diels-Alder reaction and to provide a syntheti...
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JP2011105608A |
To provide a method for producing optically active cyanohydrins, by which optically active cyanohydrins widely used as a raw material for medicines or agrochemicals can be obtained from an aliphatic aldehyde by an industrially simple met...
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JP4690814B2 |
The present invention provides a new method for manufacturing a prostaglandin analogue having one or more keto groups on the 5-membered ring and/or omega chain, which comprises the step of treating a corresponding hydroxyl group containi...
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JP2011516571T |
Thia ゾロピ lysine *2* yloxy * phenyl useful as a LTA4 hydrolase (LTA4H) regulation factor and a チアゾロ pyrazine *2* yloxy * phenylamine compound are indicated. Such a compound adjusts LTA4H, in the medicine constituent and meth...
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JP2011516438T |
The present invention is a ruthenium complex in which at least chiral 2 Lindner 配 has a child, the ルテニウム concerned has an oxidation state (+II) and at least the chiral 2 Lindner 配 concerned is related with the ruthenium com...
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JP4686466B2 |
The invention relates to a method for producing cyclic, N-substituted alpha-iminocarboxylic acids of formula (I). According to said method, biphenyl-4-yl-carbamic acid esters are converted into 4'-carbamic acid ester-biphenyl-4-sulphonic...
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JP4686701B2 |
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JP4688315B2 |
To provide a method for efficiently producing 4-demethoxydaunomycin from 4-demethyldaunomycin. This method for 4-demethoxydaunomycin production comprises introducing a trialkylsilyl group to a hydroxy group at the 7-position of 4- demeth...
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JP4685001B2 |
[PROBLEMS] To provide a method by which desired optically active carboxylic acids may be prepared from a carboxylic acid having a carbon-carbon double bond through asymmetric hydrogenation with a catalyst consisting of a transition metal...
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JP2011514887A |
The present invention relates to phosphorus compounds containing imidazole groups, to optically active ligands prepared using them, to transition metal complexes which comprise such ligands, and to catalysts which comprise such transitio...
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JP4681617B2 |
The present invention relates to an improved process for preparing imbacine analogs. The compounds are useful as thrombin receptor antagonists. The improved process may allow for at least one of easier purification by crystallization, ea...
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JP2011513469A |
A stereoselective and enrichment process for the preparation of ciclesonide is described.
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JP4677562B2 |
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JP4672397B2 |
There is provided a process for producing an alcohol or its silyl ether represented by the formula (4): wherein R 1 represents a hydrocarbon group, a heterocyclic group, or an alkoxycarbonyl group; R 2 represents a hydrogen atom or CO 2 ...
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JP4675065B2 |
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JP4673611B2 |
The present invention provides a process for producing a muscone represented by (1) by subjecting a citronellic acid derivative and an undecenoate to a Claisen condensation reaction to produce a keto ester compound represented by (2) dec...
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JP4674297B2 |
3R-carboxylate enantiomer derivative of formula (III) can be prepared easily and selectively by the method of the present invention, and a highly pure D-erythro-2,2-difluoro-2-deoxy-1-oxoribose derivative can be prepared efficiently from...
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JP4672720B2 |
A process for stereoselective synthesis of a compound of Formula (I) wherein R1, R2, R3, R4, and R5 are as described herein.
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JP4669040B2 |
The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, and a production method thereof, and a production method of an anti-HIV agent using the synthetic...
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JP4667691B2 |
4-nitroxybutyl ester of the 2-(S)-(6-methoxy-2-naphthyl)-propanoic acid having an enantiomeric excess of the (S) form higher than or equal to 97%.
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JP4668184B2 |
The invention provides a method for the preparation of enantiomerically pure mirtazapine, said method comprising a step of ring closure of a compound of formula (II) wherein X is a leaving group, said step comprising treatment with an ac...
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JP2011511020A |
The present application relates to novel substituted furan derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or...
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JP4665185B2 |
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JP4663629B2 |
An asymmetric reaction catalyst is obtained by mixing a pentavalent niobium compound and an optically active triol or tetraol having a binaphthol structure of R or S configuration, and the triol is represented by the following formula: (...
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JP4666454B2 |
The present invention relates to a novel process for producing a delta -lactone of the formula: using an acyl halide of the formula: wherein R<1>, R<2> R<3> and X are described herein, as well as novel intermediates. In particular, the p...
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JP4661272B2 |
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JP4659309B2 |
Processes by which 5-hydroxy-3-oxopentanoic acid derivatives useful as intermediates of drugs can be prepared from inexpensive and easily available raw materials under noncryogenic conditions. Specifically, a process for preparing 5-hydr...
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JP2011057601A |
To provide a method for dissolving a compound useful as an active pharmaceutical ingredient in water in sufficient solubility and at low decomposition rate and then crystallizing the compound for the purification thereof.The method for p...
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JP2011057665A |
To provide a new method for stereoselectively producing an optically active 1-amino-2-vinylcyclopropanecarboxylic acid ester.The method for producing an optically active 1-amino-2-vinylcyclopropanecarboxylic acid ester comprises the step...
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JP4658289B2 |
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JP4654444B2 |
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JP4651969B2 |
To provide a method for reducing extraction load at the after treatment of the reaction and for inhibiting the production of isomers of a target compound when synthesizing an epoxy triazole compound or a triazolyl alcohol compound by a r...
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JP4651155B2 |
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JP4649645B2 |
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