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JP4851020B2 |
The invention provides a multistep synthesis for the preparation of 4,5-diamino shikimic acid derivatives of formula starting from an isophtalic acid derivative of formula 4,5-Diamino shikimic acid derivatives are potent inhibitors of vi...
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JP4853757B2 |
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JP4852230B2 |
The invention concerns compounds of formula (I), wherein A is a group of formula (a) or (b), wherein: R represents a hydrogen or halogen atom, a -S(O)z(C1-C4)Alk wherein z is 0, 1 or 2, a -NHSO2(C1-C4)Alk, -SO2NH(C1-C4)Alk, -NHSO2-(C1-C4...
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JP2012500251A |
The present invention relates to the compound of formula (I) and to the use thereof as an intermediate for the synthesis of the compound of formula (A) or pharmaceutically acceptable salts thereof: formulae (II).
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JP4845470B2 |
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JP4847662B2 |
The compounds are of the class thienoisoxazolyl- and thienylpyrrazolyl-phenoxy substituted propyl derivatives, useful as D4 antagonists. Said compounds are useful for the treatment of medical conditions mediated by inhibition of D4 recep...
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JP4844969B2 |
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JP4846552B2 |
3-Phenyl-N,N-dimethyl-propylamine derivs. of formula (I) and their isomers and acid-addn. salts are new; X = H, OH, F, Cl or 2-4C alkanoyloxy; R1 = 1-4C alkyl; R2 = H or 1-4C alkyl; R3 = H or 1-4C n-alkyl; or CR2R3 = 4-7C cycloalkylidene...
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JP4841799B2 |
Compounds of formula (I), wherein R1 and R2 are, independently of one another, H,C1-C6alkyl, C1-C6halogenalkyl, C1-C6alkoxyl, C1-C6alkoxy-C1-C6alkyl, or C1-C6alkoxy-C1-C6alkyloxy, and R3 is C1-C6alkyl, are obtainable in high yiedls by st...
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JP4842842B2 |
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JP4842123B2 |
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JP4839528B2 |
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JP4839724B2 |
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JP2011529955A |
A compound of Formula (I): is useful in the treatment or prevention of a disease or medical condition mediated through glucokinase (GLK or GK), leading to a decreased glucose threshold for insulin secretion.
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JP2011529895A |
Processes for preparing oxazoline compounds are disclosed. These oxazoline compounds are useful intermediates in the preparation of Florfenicol and related compounds.
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JP4837857B2 |
Chiral ligands and transition metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The chiral ligands include phospholanes, P,N ligands, N,N ligands, biphenols, and chelating phosphines. The ferrocen...
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JP4834545B2 |
There is provided a method for industrially producing optically active epoxy compounds by asymmetrically epoxidizing prochiral unsaturated compounds with an oxidant using as a catalyst a single substance or a di-µ-oxo dimer derived ther...
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JP4829121B2 |
The present invention relates to a process for asymmetric synthesis in the presence of a chiral catalyst comprising at least one complex of a metal of transition group VIII with ligands capable of dimerization via noncovalent bonds, such...
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JP4829418B2 |
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JP4829152B2 |
To provide a production method of a new synthetic method of febrifugine (3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4(3H)-quinazoli
none) and isofebrifugine having very strong activity against tropical malaria parasite by total synthesi...
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JP2011241191A |
To provide a method for producing an optically active alcohol in high yield with high enantio-selectivity from a ketone compound.The method for producing an optically active alcohol includes a step of allowing a ketone compound to react ...
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JP4828773B2 |
Certain chiral monophosphites and their monothio derivatives are suitable as ligands in the asymmetrical transition-metal-catalyzed hydrogenation, hydroborination and hydrocyanation of prochiral olefins, ketones and imines.
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JP4827189B2 |
Process of oxidizing an alcohol in an amide solvent with use of a mixed reagent containing hydrogen peroxide and a tungsten catalyst.
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JP4824874B2 |
Preparation of 3-hydroxy-gamma -butyrolactone involves hydrogenating optically active 4-substituted oxy-3-hydroxybutyrate, in the presence of a heterogeneous hydrogenation catalyst and an acidic substance, followed by deprotection and si...
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JP4825825B2 |
The invention provides a novel, crystalline polymorphic form of (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phe
nyl]hydrazono]propanedinitrile and a method for making the polymorph. The compound is useful as a cardiotonic ag...
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JP4827531B2 |
An asymmetric synthesis of amino acid compound that is useful as a starting material or synthetic intermediate for production of medicinal products, agrichemicals, perfumes, functional polymers, etc. There is provided a method of enanthi...
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JP4822844B2 |
A method of an enantioselective nucleophilic addition reaction to carbonyl, which enables an asymmetric synthesis of an optically active ±-hydroxy-³-keto acid ester, an optically active ±-hydroxy-³-amino acid ester, hydroxydiketone c...
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JP2011231017A |
To provide: a process for producing an optically active epoxy compound and an optically active sulfoxide compound; a ligand and a complex for use in the process; and a process for producing the complex.Disclosed are: an optically active ...
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JP4818124B2 |
The present invention relates to a process for the preparation of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate as well as intermediates for use in sai...
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JP4814427B2 |
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural an...
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JP4811547B2 |
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JP4806763B2 |
An efficient cost-effective process for preparation of 1-erythro-2-amino-1-phenyl-1-propanol from 1-1-phenyl-1-hydroxy-2-propanone, which comprises converting 1-1-phenyl-1-hydroxy-2-propanone to 1-1-phenyl-1-hydroxy-2-propanone oxime and...
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JP4807549B2 |
To provide a new method for asymmetrically synthesizing an optically active organosilicon compound, used in producing the compound, especially an optically active siloxane, an optically active silanol, and an optically active silane, and...
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JP4807751B2 |
To provide a new asymmetric organic catalyst and provide a method for producing an optically active carboxylic acid compound by using the asymmetric organic catalyst. The invention provides a chiral sulfonamide derivative expressed by fo...
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JP4805577B2 |
The invention relates to certain chiral transition metal catalysts, to the metal of which at least two structurally different monophosphorus ligands are bonded, at least one of said monophosphorus ligands being chiral. Said chiral transi...
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JP4802191B2 |
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JP4800213B2 |
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JP2011205986A |
To provide a method for producing an optically active mandelic acid derivative useful as a raw material for pharmaceuticals and agrochemicals, liquid crystal material and optical resolution agent in improved productivity and yield.The me...
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JP4795559B2 |
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JP4798924B2 |
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JP4798426B2 |
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JP4795348B2 |
An enantioselective route to compounds of formula I is disclosed: The compounds of formula I are key intermediates in the synthesis of compounds useful in treatment of Alzheimer's disease.
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JP4796303B2 |
The present invention relates to processes for preparing peptides and to intermediates involved in such processes, e.g. a process for preparing a compound of formula VIII wherein R12 and R13 are as defined herein.
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JP4789934B2 |
The present invention relates to compounds with the formula (I), (II), (III) or (IV): wherein R1, R2, R3, R4, R5, R6, R7, X and Z are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as methods...
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JP4793930B2 |
The present invention relates to a process for the preparation of an optically active 5-substituted cyclohexenone (II) by treating an achiral macrocyclic 3-substituted-1,5-diketone (I) in the presence of an optically active sodium, potas...
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JP4793976B2 |
The present invention relates to a production method of optically active hydrazine compound (IV), which includes reacting azo compound (II) with compound (III) in the presence of optically active compound (I). The present invention also ...
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JP4787495B2 |
The present invention relates to compounds of formula 1 or pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is methyl, ethyl or isopropyl, and the other is H; R3 and R4 are each independently H, branched or unbranched ...
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JP4786040B2 |
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JP4787021B2 |
A guanidine compound having a biaryl skeleton represented by the following formula (1), which is useful as a catalyst for various asymmetric reactions. (wherein R1, R2 and R3 each independently represent a hydrogen atom, a hydrocarbon gr...
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JP4786551B2 |
The present invention relates to a process for preparing optically active hydroxy-, alkoxy-, amino-, alkyl-, aryl- or chlorine-substituted alcohols or hydroxy carboxylic acids having from 3 to 25 carbon atoms or their acid derivatives or...
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