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JP2011525923A |
The instant invention involves the enantioselective hydrogenation of isomeric N—H imines (N-unsubstituted) using a transition metal based catalyst modified with a chiral phosphine derivative to produce enantiomerically enriched chiral ...
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JP2011190181A |
To provide a method for producing an optically active compound, making use of an ionic nucleophilic catalytic action of an optically active ammonium betaine based on the nucleophilicity of the anionic part thereof.The method for producin...
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JP2011190182A |
To provide a ligand comprising a quaternary onium salt bearing a functional group coordinatable to a metal in the molecule, and a manufacturing method of an allyl compound that promotes an allylation reaction of an α-nitro-ester efficie...
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JP4779109B2 |
To provide an advantageous method for producing an optically active compound useful as a synthetic intermediate of a medicine or the like by developing a new nonmetallic asymmetric catalyst capable of achieving high-yield and highly ster...
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JP4782329B2 |
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JP4780371B2 |
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JP4777332B2 |
Materials and methods for preparing (S)-(+)-3-aminomethyl-5-methyl-hexanoic acid and structurally related compounds via enzymatic kinetic resolution are disclosed.
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JP4778181B2 |
The present invention relates to a process for the preparation of acetyl-amidiniophenylalanyl-cyclohexylglycyl-pyridinioalanin
amides of the formula I, in which the anions X are physiologically acceptable anions, and their analogs, which...
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JP4773436B2 |
Processes for preparing cinacalcet are provided.
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JP4770174B2 |
Glutamic acid derivatives, in particular monatin, may be conveniently prepared by alkylating a 4-protected hydroxyl pyroglutamic acid derivative with an alkylating agent to prepare a 4-protected hydroxyl-4-alkylglutamic acid derivative, ...
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JP4771442B2 |
Methods for stereoselective substitution in which a (mono or un)-alpha-substituted unprotected beta-amino ester compound or salt thereof is reacted with an aliphatic electrophile in the presence of a base selected from alkyl lithium comp...
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JP2011524909A |
The present invention is directed to practical high-yielding synthetic processes to prepare compounds of general Formula III, IV, V, VII, VIII, IX, X, XII, XIV, and XV. Such compounds are useful as final products or can be used as interm...
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JP4769718B2 |
Compounds of formula (I): are useful in the treatment of diseases associated with deposition of beta-amyloid in the brain.
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JP4768638B2 |
The present invention relates a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic chiral catalyst...
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JP4764828B2 |
A process for the preparation of prostaglandin compounds having the formula (I); wherein A is selected from the group consisting Of C1-C6 alkyl; C7-C16 aralkyl wherein the aryl group is optionally substituted with one to three substituen...
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JP2011168519A |
To provide a means for efficiently manufacturing an optically active ketone.The manufacturing method of a ketone compound represented by the formula: (R1)(R2)>C=C(R3)-C*(R4)-CO-R5 (wherein R1 is an aryl group; R2 is a hydrogen atom or an...
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JP4763462B2 |
The present invention provides a method for producing (R)- or (S)-3-methyl carboxylic acid represented by the following formula (5): wherein R 1 represents an alkyl group containing 3 to 5 carbon atoms, and * represents an asymmetric car...
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JP4763771B2 |
The present invention relates to a method for preparing optically active 3-phenylpropionic acid derivatives, to optically active 1-chloro-3-phenylpropane derivatives obtainable therefrom and to optically active intermediates obtained the...
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JP4758907B2 |
The present invention relates to a titanium compound produced from a reaction mixture of a titanium tetraalkoxide compound with water and an optically active ligand represented by the following general formula (1), or a titanium oxoalkox...
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JP4754753B2 |
Ferrocene anchored chiral ligands and metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The metal complexes according to the present invention are useful as catalysts in asymmetric reactions, such...
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JP2011523631A |
The present invention relates to a process for obtaining cinatrins C 1 and C 3 and derivatives thereof which comprises the hydroxylation of a compound of formula (III). The invention also relates to the intermediates of said synthesis an...
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JP4752989B2 |
A process for the preparation of (2R)-2-propyloctanoic acid which is characterized by subjecting (2S)-2-(2-propynyl)octanoic acid or (2S)-2-(2-propenyl)octanoic acid to reduction using platinum on carbon. This process gives (2R)-2-propyl...
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JP4752759B2 |
The present invention provides a process for producing an optically active fluoro compound represented by formula (3) through reaction between a specific fluoroamine and an optically active diol; and a process for producing an optically ...
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JP4747298B2 |
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JP4752761B2 |
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JP4742423B2 |
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JP4744091B2 |
ÄProblemÜ The problem of the invention is to prepare nitro compounds and cyano compounds in high efficiency and high stereoselectivity by a simple and practical Michael reaction. ÄSolutionÜ A process for preparing optically activ...
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JP4742428B2 |
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JP4744507B2 |
The present invention relates to novel methods for the preparation of intermediates which are useful in the synthesis of cacipotriol. The present invention relates further to the use of intermediates produced with said methods for making...
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JP4742239B2 |
Processes for the preparation of certain [3.1.0]hexane derivatives which are useful as mGluR agonists, and intermediates prepared during such processes.
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JP4746749B2 |
3 process for the preparation of optically active beta -amino alcohols represented by the general formula (2): Ra-C*H(OH)-C*H(Rb)-Rc, Äwherein Ra and Rc are each independently hydrogen, optionally substituted alkyl, or the like; Rb is o...
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JP4741199B2 |
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JP4740248B2 |
A process for preparing optically active 2-methylalkan-1-ol of the general formula (III) comprising the following steps: (i) carbonyl-selective reduction of 2-methylalk-2-en-1-al of the general formula (I) to 2-methylalk-2-en-1-ol of the...
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JP4735263B2 |
There is provided a process for producing an optically active 2-alkylcysteine or a salt thereof, characterized by allowing cells of microorganism or treated products thereof having an activity of stereoselective hydrolysis of the amide b...
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JP4732180B2 |
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JP2011520794A |
A process for stereoselective synthesis of a compound of Formula (I) wherein R1, R2, R3, R4, and R5 are as described herein.
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JP2011140494A |
To provide a new method for preparing vinca-alkaloids, their addition salts with acids and their quaternary ammonium salts.The method includes obtaining an intermediate by reacting a product corresponding to general formula (II) with oth...
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JP4726491B2 |
The invention refers to a method for isolating entecavir or an entecavir intermediate from a diluted mixture, the diluted mixture comprising entecavir and water or a mixture comprising an entecavir intermediate and other process reagents...
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JP4730303B2 |
According to the present invention, crystals comprising (2R)-2-propyloctanoic acid and an amine, which can be used as bulk drugs for safely orally administrable solid preparations with keeping the pharmacological effect, are provided. Am...
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JP2011137014A |
To provide an antiulcer drug having a prolonged activity retention time, unlike proton pump inhibitors such as omeprazole or lansoprazole.An optically active material of tenatoprazole, (+) and (-)-5-methoxy-2-{[(4-methoxy-3,5-dimethyl-2-...
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JP2011519919A |
A process for preparing the S or R enantiomer of a compound of formula A, the process comprising subjecting a compound of formula B to asymmetric hydrogenation in the presence of a chiral catalyst and a source of hydrogen, wherein X is C...
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JP4725760B2 |
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JP4722037B2 |
A ruthenium complex RuCl[(S,S)-Tsdpen](p-cymene) represented by a formula below and a ketone compound are placed in a polar solvent, and the resulting mixture is mixed under pressurized hydrogen to hydrogenate the ketone compound and to ...
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JP4721541B2 |
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JP4723751B2 |
A method for safely and efficiently producing high purity 3- l -menthoxypropane-1,2-diol and intermediates to be used in the method. As shown in the following reaction formula, 3- l -menthoxypropane-1,2-diol represented by the chemical f...
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JP2011519340A |
The present invention is directed to a process for enantioselectively preparing substituted piperidine alkanoic acid integrin antagonist compounds.
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JP4716708B2 |
An object of the invention is to provide an industrially advantageous process capable of remarkably suppressing the generation of an undesirable by-product cepham compound to thereby efficiently produce a desired 2±-methyl-2²-[(1,2,3-t...
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JP4718452B2 |
The present invention provides a water-soluble transition metal-diamine complex which can be easily separated from reaction products through liquid separation, etc. and is recycleable; an optically active diamine compound constituting th...
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JP4719446B2 |
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JP2011518800A |
Embodiments of the invention relate to (5R)-1,5-diaryl-4,5-dihydro-1H-pyrazole-3-carboxamidine derivatives as cannabinoid-CB1 receptor antagonists, to methods for the preparation of these compounds, to novel intermediates useful for the ...
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