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JP4648305B2 |
The invention relates to a process for cosmetic treatment, including the reduction of superficial and deep wrinkles, using ferutinine from Ferula spp extracts.
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JP4648631B2 |
The present invention relates to a method for the deracemisation or chiral inversion of chiral amines by enzymatic treatment. The method employs a stereoselective enzymatic conversion and either a non-selective or partially selective che...
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JP4647861B2 |
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JP4645986B2 |
The present invention provides processes for producing a (4E)-5-chloro-2-isopropyl-4-pentenoate and an optical isomer of the (4E)-5-chloro-2-isopropyl-4-pentenoate, namely a process for producing a (4E)-5-chloro-2-isopropyl-4-pentenoate ...
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JP4647413B2 |
To provide a method for producing a biodegradable polyester, which does not include a biodegradable polyester made of different materials or having an unreacted product, safely without lowering the recovery yield. According to the a depo...
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JP4645155B2 |
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JP4647521B2 |
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JP4644881B2 |
Provided is a method for producing a ruthenium complex comprises the step of reacting a ruthenium compound represented by general formula (1): [RuX(L)(PP)]X(1), wherein Ru represents a...
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JP4644805B2 |
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JP2011042690A |
To obtain a naproxen nitroxyalkyl ester having an enantiomeric excess of at least 97%, preferably 98% or higher.A halide of 2-(S)-(6-methoxy-2-naphthyl)-propionic acid of formula A-Hal (wherein A is an acyl residue of an acid) is reacted...
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JP4643474B2 |
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JP4643566B2 |
[PROBLEMS] To provide a novel method for the allylation of N-acylhydrazones by which enantioselectively allylated N-acylhydrazines can be efficiently obtained. [MEANS FOR SOLVING PROBLEMS] A method for the production of enantioselectivel...
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JP4644658B2 |
Disclosed is an industrially advantageous production method of optically active β-amino acid of formula (5a), which includes subjecting an enaminoester of formula (4a) to an asymmetric hydrogenation: wherein * shows an asymmetric carbon...
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JP4639368B2 |
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JP4639327B2 |
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JP4633731B2 |
A novel compound of the formula (I): wherein R1 is alkoxycarbonyl or the like, R2 is alkyl or the like; R3 is hydrogen or the like; R4 is alkylene or the like; R5 is optionally substituted heterocyclic group; R6, R7, and R8 are independe...
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JP4634369B2 |
1,2-bis(phenylaminocarbonyl)-pyrrolidine compounds (I) and their derivatives, salts, solvates and stereoisomers, including their mixtures in all proportions, are new. [Image] R : hydrogen, X, A, XCO- or ACO-; R 1>hydrogen, oxo, X, A, hyd...
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JP4632784B2 |
Process for the preparation of an ester of formula (1), wherein R<1> represents a leaving group, CN, OH or a COOR<5> group, R<3> and R<4> each independently represent a 1-3 C alkyl group, and R<2> and R<6> each independently represent an...
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JP4634932B2 |
A ligand represented by the formula (1): R1R2N-Q1-X-Q2-NR3R4 (1) wherein R1, R2, R3 and R4 are each the same or different and represent a group represented by the formula (2): wherein Q3 is an optionally substituted alkylene group, an op...
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JP4633047B2 |
Compounds of the formula (1), in which R1 is C1-C4alkyl, C6-C10aryi or C7-C11,aralkyl, R2 is an open-chain or cyclic secondary amino group, and R is a radical of the formula in which R3 is C1-C4alkyl or C1-C4alkoxy, and R4 is H, Cl-C4alk...
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JP4633934B2 |
The invention discloses a new method for producing enantiomer-enriched 1-amino-4-(hydroxymethyl)-cyclopent-2-ene derivatives of the general formulae (I) and (II) in which R1 is hydrogen or a possibly substituted C1-8 alkyl radical, aryl ...
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JP4631369B2 |
To produce a catalyst used for producing an optically active cyclopropane compound with good selectivity. A method for producing the optically active cyclopropane compound expressed by formula (4) comprises reacting a prochiral olefin ex...
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JP4632500B2 |
To provide a composition or a compound having sufficient chelating activity and extremely excellent biodegradability, the manufacturing process for the composition or compound, and a chelating agent using the composition or compound, and...
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JP2011026201A |
To provide a novel method of stereo-selectively producing an optically active pyrrolyl-succinimide derivative at a high yield, which derivative is useful as a chiral building block in producing a variety of pharmaceutical compounds and t...
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JP4627299B2 |
The present invention is concerned with a novel process for the preparation of compounds of formula I comprising catalytic asymmetric hydrogenation of a compound of formula (II) in the presence of a catalyst comprising ruthenium and a ch...
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JP4629973B2 |
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JP4628979B2 |
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JP4623745B2 |
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JP4621918B2 |
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JP2011503052A |
Provided is a method of preparing a (6R)-3-hexyl-4-hydroxy-6-undecyl-5,6-dihydropyran-2-one, and a (5R)-2-hexyl-5-hydroxy-3-iminohexadecanoate derivative used in said method as an intermediate.
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JP4620592B2 |
An asymmetric alkyl compound producing method of the present invention includes a synthesizing step of carrying out an asymmetric synthesis reaction by mixing (i) a reaction solution containing a glycine imine ester, an alkyl halide, and...
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JP4620346B2 |
The invention relates to 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production of these new intermediate products in the synthesis and the use for the product...
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JP4618297B2 |
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JP4618781B2 |
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JP4617114B2 |
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JP4614948B2 |
A method of the intramolecular and intermolecular cyclization of an N-acylhydrazone for obtaining a pyrazoline skeleton or pyrazolidine skeleton under ordinary conditions with high stereoselectivity and in high yield. An N-acylhydrazone ...
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JP4616833B2 |
Process for the synthesis of N-((S)-1-carboxy butyl)-(S)-alanine esters (I), by reaction of a morpholinone (III) either with allyl triflate or bromide to give (3S,5S) (IV) which is then hydrogenated, or with iodopropane, to give (V), and...
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JP4615861B2 |
Methods for production of chirally pure alpha -amino acids and N-sulfonyl alpha -amino acids are described. An aldehyde and a cyanide salt are reacted with an alpha -methylbenzylamine to afford a product. The product reacts with a strong...
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JP4610252B2 |
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JP4608922B2 |
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JP4610899B2 |
The invention concerns a process for preparing (S)-(+)-2-(substituted phenyl)-2-hydroxy-ethyl carbamates and to novel intermediates used in this process.
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JP2011500646A |
The invention relates to a compound of the formula (I) or the formula (II) in which: W is an oxygen atom or a radical of the formula NH; X is hydrogen or an alkaline cation or a C1-C8 alkyl or a —(CH2)n3—C(R4)(R5)(R6) radical; X and ...
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JP4607758B2 |
A method to stereospecifically prepare a steroidal sapogenin or a derivative thereof by reducing a 3-keto,5β-H steroidal sapogenin with a hindered organoborane or an organo-aluminium hydride. A 3β-hydroxy,5β-H steroidal sapogenin or d...
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JP4605606B2 |
The present invention provides a compound of the following formula (I) below. This compound (I) can be produced by reacting a 2,2'-dimethylene bromide-1,1'-binaphthyl derivative, which can be produced by a relatively small number of proc...
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JP4605321B2 |
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JP2010540433A |
The present invention provides a process for preparing an acid addition salt of a synthetic intermediate for carbapenem antibiotics and a novel acid addition salt of a synthetic intermediate for carbapenem antibiotics obtained from the p...
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JP2010285420A |
To provide a method for producing optically active aromatic hydroxycarboxylic acid condensates highly regulated in optical activity, and the optically active aromatic hydroxycarboxylic acid condensates produced by the production method.T...
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JP4601779B2 |
A novel process in which an optically active alcohol compound having a desired absolute configuration and a high optical purity can be obtained by asymmetrically hydrogenating a beta -keto acid compound through a simple operation. An opt...
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JP2010280712A |
To provide a low-cost and efficient industrial process for producing (S)-2-pentanol, (S)-2-hexanol, 1-methylalkylmalonic acid and 3-methylcarboxylic acid with high optical purity.There is provided (R)-1-methylalkylmalonic acid or (S)-1-m...
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JP2010539180A |
The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor.
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