Acyclic or Carbocyclic Compounds

Matches 351 - 400 out of 1,376	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >

Document	Document Title
WO/1998/000427A1	PROCESS FOR THE PRODUCTION OF 8-CHLORO-6-(2-FLUOROPHENYL)-1-METHYL-4H-IMIDAZO[1,5-A]BENZODIAZEPINE The present invention discloses new processes in the preparation of midazolam (VII), a commercially important pharmaceutical, as well as new intermediates in those processes from a known benzophenone (I) starting material.
WO/1997/049673A1	SELECTIVE THROMBIN INHIBITORS The present invention relates to a novel selective thrombin inhibitor having formula (I), which is also effective by oral administration, in which R1 represents acetyl substituted with aryl or aryloxy, or represents sulfonyl substituted ...
WO/1997/047589A1	AMINOPHTHALIC ACID DERIVATIVES The present application concerns the use of aminophthalic acid derivatives as fungicides, and novel aminophthalic acid derivatives and several processes for their production.
WO/1997/046515A1	SUBSTITUTED BENZENES HAVING NOS INHIBITORY EFFECTS Compounds represented by general formula (1), possible tautomers, stereoisomers and optical isomers thereof, and pharmaceutically acceptable salts thereof which have potent inhibitory effects on nitrogen monoxide synthetases and are usef...
WO/1997/046511A1	COUMPOUNDS ACTIVE AT A NOVEL SITE ON RECEPTOR-OPERATED CALCIUM CHANNELS USEFUL FOR TREATMENT OF NEUROLOGICAL DISORDERS AND DISEASES Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hypoxia-induced nerve cell damage, epilepsy, anxiety, neuropsyc...
WO/1997/042167A1	PROCESS TO PREPARE TAXOL The present invention includes processes to prepare commercially important taxols (X) from substituted amino-3-phenyl (2R, 3S) isoserinates (II). In addition processes to prepare the substituted amino-3-phenyl (2R, 3S) insoserinates (II)...
WO/1997/042166A1	AMIDINE DERIVATIVES AND DRUG CARRIERS COMPRISING THEM Novel amidine derivatives of general formula (1); and drug carriers (such as liposomes or emulsions) comprising the derivatives, which can enclose genetic materials or drugs and transfer them to cells or affected sites efficiently and sa...
WO/1997/037969A1	TRYPTASE INHIBITOR AND NOVEL GUANIDINO DERIVATIVES A tryptase inhibitor comprising as the active ingredient at least one member selected from among guanidinoaliphatic acid derivatives of general formula (I), guanidinobenzoic acid derivatives of general formula (II), guanidinophenol deriv...
WO/1997/036862A1	META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS The present invention relates to a class of compounds represented by Formula (I), or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula (I), and methods of selectively inhibiting o...
WO/1997/036859A1	PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS The present invention relates to a class of compounds represented by Formula (I) or a phramaceutically acceptable salt thereof, pharmaceutical composition comprising compounds of Formula (I), and methods of selectively inhibiting or anta...
WO/1997/032844A1	HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.
WO/1997/030971A1	M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS The present application describes m-amidino phenyl analogs of formula (I), wherein D can be amidino and E can be phenyl, which are useful as inhibitors of factor Xa.
WO/1997/029067A1	BENZAMIDINE DERIVATIVES SUBSTITUTED BY AMINO ACID AND HYDROXY ACID DERIVATIVES AND THEIR USE AS ANTI-COAGULANTS This invention is directed to benzamidine derivatives substituted by amino acid and hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of ...
WO/1997/025983A1	INDANE DERIVATIVES FOR ANTIPSYCHOTIC COMPOSITIONS The present invention provides novel indane-like compounds which can be useful for treating psychosis and other conditions associated with the modulation of a muscarinic receptor. The invention provides formulations and methods for using...
WO/1997/026300A1	COMBINATORIAL PROCESS FOR PREPARING SUBSTITUTED INDANE LIBRARIES This invention relates to a novel solid phase process for the preparation of indane combinatorial librairies (1). These libraries have use for drug discovery and are used to form wellplate components (3) of novel assay kits, as illustrat...
WO/1997/024118A1	SUBSTITUTED N-[(AMINOIMINOMETHYL OR AMINOMETHYL)PHENYL]PROPYL AMIDES The compounds according to the invention are substituted N-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides of formula (I) herein which exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical co...
WO/1997/021670A1	NEW PHENYLAMIDINE DERIVATIVES, A PROCESS FOR PREPARING THE SAME AND THEIR USE AS MEDICAMENTS New phenylamidine derivatives, a process for preparing the same and their use as medicaments are disclosed. The disclosed phenylamidines correspond to the general formula (I).
WO/1997/021437A1	NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS Novel naphthyl-substituted benzimidazole compounds and their pharmaceutically acceptable salts are described herein. This invention is also directed to an anticoagulant composition comprising a naphthyl-substituted benzimidazole compound...
WO/1997/019953A2	NEW LH-RH ANTAGONISTS WITH IMPROVED EFFECTIVENESS New LH-RH antagonists are disclosed, in particular peptidomimetics and peptides modified in a side chain, their salts with pharmaceutically acceptable acids and a process for preparing these LH-RH antagonists and their salts. The disclos...
WO/1997/019911A1	AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND PROCESSES FOR PREPARING THEM The invention relates to new amino acid derivatives of general formula (I), wherein B, T, Z, Y, V and n are defined as in claim 1, the tautomers, diastereomers and enantiomers thereof, the mixtures thereof and the salts thereof, particul...
WO/1997/017949A1	BENZAMIDOXIME PRODRUGS AS ANTIPNEUMOCYSTIC AGENTS A method of treating Pneumocystis carinii pneumonia in a subject in need of such treatment is disclosed. The method comprises orally administering to the subject a bis-benzamidoxime, or a pharmaceutically acceptable salt thereof, that is...
WO/1997/016415A1	PHENYLCARBAMATES, PROCESSES AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND THEIR USE AS PESTICIDES AND FUNGICIDES The invention concerns phenylcarbamates of formula (I) in which the substituents and the index have the following meanings: R = cyano, nitro, trifluoromethyl, halogen, alkyl or alkoxy; m = 0, 1 or 2; R1 = alkyl, alkenyl, alkinyl, cycloal...
WO/1997/010204A1	L-N6-(1-IMINOETHYL)LYSINE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS There are disclosed derivatives of L-N6-(1-iminoethyl)lysine of general formula (I), pharmaceutical compositions containing these compounds, and to their use in therapy, in particular their use as nitric oxide synthase inhibitors. Y is a...
WO/1997/009053A1	2-DEOXYSTREPTAMINE AS A MOLECULAR SCAFFOLD FOR PREPARING FUNCTIONALLY AND SPACIALLY DIVERSE MOLECULES AND PHARMACEUTICAL COMPOSITIONS THEREOF 2-Deoxystreptamine is an aminocyclitol whose structural stability and abundant functionality make it an attractive scaffold for the combinatorial generation of small molecules. The ability to selectively functonalize the various position...
WO/1997/003678A1	CYCLO-OXYGENASE INHIBITOR AND AMIDINE DERIVATIVE SALTS, PREPARATION METHOD THEREFOR, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID SALTS Cyclo-oxygenase inhibitor and amidine derivative salts, preparation methods therefor, pharmaceutical compositions containing said salts and the use thereof particularly as NO synthase and cyclo-oxygenase inhibitors, are disclosed.
WO/1997/003947A1	PROCESS FOR THE PREPARATION OF ETHYL 3S-[[4-[[4-(AMINOIMINOMETHYL)PHENYL]AMINO]-1,4-DIOXOBUTYL]AMINO]-4-PENTYNOATE The present invention relates to a novel process for the preparation of ethyl 3S-[[4-[[4-(aminoiminomethyl)-phenyl]amino]-1,4-dioxobutyl]a mino]-4-pentynoate and pharmaceutically acceptable acid addition salt thereof which comprises trea...
WO/1997/001530A1	O-BENZYL OXIME ETHER DERIVATIVES AND THEIR USE IN CROP PROTECTION COMPOSITIONS Oxime ethers of formula (I) in which a) X is an N atom and Y is an oxygen atom or NH, or b) X is CH and Y is an oxygen atom, in which furthermore R1 is C1-C4alkyl; R2 is hydrogen, C1-C4alkyl or cyclopropyl; and in which R3 and R4 are as ...
WO/1997/000856A1	CARBOXYLIC ACID AMIDE DERIVATIVES AND THEIR USE AS PESTICIDES Carboxylic acid amide derivatives having formula (I) are disclosed, as well as several processes for preparing the same and their use as fungicides. In formula (I), Ar stands for optionally substituted arylene or heteroarylene; E stands ...
WO/1997/000866A1	PESTICIDAL TRIS-OXIMINO HETEROCYCLIC COMPOUNDS Compounds of formula (I) and their possible isomers and isomer mixtures, in which (Z) is a group (a), (b), (c) or (d) and in which the other substituents are as defined herein. They can be used for pest control, in particular as microbic...
WO/1996/037464A1	SUBSTITUTED 'beta'-AMINO ACID DERIVATIVES USEFUL AS PLATELET AGGREGATION INHIBITORS Novel substituted amino acid derivatives are provided which inhibit platelet aggregation and which are useful in pharmaceutical compositions and methods of inhibiting platelet aggregation.
WO/1996/036325A1	AGENTS FOR REDUCING WEIGHT Use of amine and amidine containing compounds of formula (I) such as galegine and related substituted amine and amidine containing compounds as agents for reducing weight in mammals, pharmaceutical formulations containing compound of for...
WO/1996/033970A1	SUBSTITUTED PHENYL AMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND PROCESS FOR PRODUCING THEM The present invention relates to phenyl amidines of general formula (I), in which R1 to R5 are as defined in claim 1, their tautomers, their stereoisomers and their mixtures and their salts, especially their physiologically acceptable sa...
WO/1996/030329A1	SUBSTITUTED BENZENE DERIVATIVES USEFUL AS NEURAMINIDASE INHIBITORS The invention relates to substituted benzenes and derivatives thereof, useful as neuraminidase inhibitors, to pharmaceutical compositions comprising such compounds, and to methods of using these compounds for treating viral and other inf...
WO/1996/028427A1	BENZAMIDINE DERIVATIVES THEIR PREPARATION AND THEIR USE AS ANTI-COAGULANTS This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to tr...
WO/1996/022288A1	GLYCOPROTEIN IIb/IIIa ANTAGONISTS This invention relates to certain bicyclic compounds having a nucleus formed of two fused six membered rings, for example, benzopyran, isoquinoline, isoquinolone, tetrahydronaphthalene, dihydronaphthalene, or tetralone, substituted with ...
WO/1996/020917A1	SUBSTITUTED AMIDINONAPHTHYL ESTER DERIVATIVES A novel substituted amidinonaphthyl ester derivative which is efficacious against thrombosis and represented by the general formula (I) or an acid-addition salt thereof usable as a medicine, wherein R1 and R2 are each as defined in the s...
WO/1996/019440A1	ACETAMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS FOR THE NITRIC OXIDE SYNTHASE A class of acetamidine derivatives of general formula (I), methods for the manufacture thereof in therapy, particularly as inhibitors of nitric oxide synthase, is disclosed or a salt thereof, wherein R1 is hydrogen, a C1-6 hydrocarbyl gr...
WO/1996/018602A1	BICYCLIC FIBRINOGEN ANTAGONISTS This invention relates to compound of formula (I) which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, and a method for inhibiting platelet aggregation.
WO/1996/018644A1	AROMATIC HETEROCYCLIC DERIVATIVES AS ENZYME INHIBITORS The present invention discloses peptide aldehydes of formula (I) which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them a...
WO/1996/017884A1	WATER-ABSORBENT RESIN, PROCESS FOR PRODUCTION THEREOF, AND WATER-ABSORBENT RESIN COMPOSITION A water-absorbent resin is produced by dispersing a solid blowing agent with an average particle diameter in the range of 1 to 100 'mu'm in an aqueous solution containing an unsaturated monomer and a cross-linking agent and polymerizing ...
WO/1996/016026A1	O-BENZYL OXIME ETHER DERIVATIVES AND THEIR USE AS PESTICIDES Compounds of formula (I), wherein Y is hydrogen, C1-C4alkyl, C1-C4alkoxy, OH, CN, NO2, Si(CH3)3, CF3 or halogen, and T is a group (a) or (b), and wherein the remaining substituents have the following definitions: X is O, S or NR13; A is ...
WO/1996/015104A2	METHODS AND COMPOSITIONS FOR TREATING PHYTOPATHOGENIC FUNGI INFECTIONS The invention provides fungicidal compounds having the general formula (I): X1-A1-B1-C-B2-A2-X2 wherein X1 is an amidine, a guanidine, or an imidazole group. A1 is either a five-numbered aromatic ring, a six-membered aromatic ring, a fus...
WO/1996/015120A1	AMINOTETRAZOLE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS Compounds having formula (I) and pharmaceutically acceptable salts thereof, wherein B is NR5R11, wherein R5 is selected from the group consisting of hydrogen, lower alkyl, lower alkenyl, lower alkynyl and aryl, and R11 is selected from a...
WO/1996/011902A1	PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS The present invention relates to compounds of formula (I), wherein: A, B and D are various ring systems as defined in the description, R1 is one of a variety of groups as defined in the description, R3 is hydrogen or C1-4 alkyl and Z is ...
WO/1996/011180A1	'gamma'-DIKETONE COMPOUND HAVING PLATELET AGGREGATION INHIBITING EFFECT A 'gamma'-diketone compound represented by general formula (I) and having a platelet aggregation inhibiting effect, a pharmacologically acceptable salt thereof, and a solvate thereof, wherein B represents -Z(CH2)q-COOR7; and A represents...
WO/1996/009297A1	COMPOSITIONS AND METHODS FOR TREATING MAST-CELL INFLAMMATORY CONDITION Novel compounds, compositions and methods effective for the prevention and treatment of mast-cell mediated inflammatory disorders are described. The compounds, compositions and methods are effective for the prevention and treatment of in...
WO/1996/007636A1	IMIDIC ACID DERIVATIVES AND THEIR USE AS PESTICIDES The invention pertains to new imidic acid derivatives of formula (I), methods for preparing them and their use as pesticides.
WO/1996/004239A1	N-ALKOXY-AMIDINE DERIVATIVES AND THEIR USE AS PESTICIDES New N-alkoxy-amidine derivatives having the formula (I) are disclosed, as well as a process for preparing the same and their use as pesticides. Also disclosed are new intermediate products and a process for preparing the same.
WO/1996/002497A1	SUBSTITUTED BENZAMIDINES, THEIR PRODUCTION AND THEIR USE AS MEDICAMENTS The novel compounds of formula (I) (the meanings of A and R1 to R4 are given in the description) may be produced by conventional methods and therapeutically used as, for example, LTB4 antagonists.
WO/1996/002496A1	NOVEL CHEMICAL COMPOUND, ITS PREPARATION AND USE AS A DRUG The novel compound of formula (I) can be prepared according to conventional methods and used therapeutically as an LTB4-receptor antagonist.

Matches 351 - 400 out of 1,376	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >