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JP2017081931A |
To provide antibacterial agents which can prevent infections cause by gram-negative bacteria, other compounds for use in the preparation of medicines and combinations of such compounds.The present invention provides a compound represente...
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JP2017075155A |
To provide a (hetero)aryl cyclopropylamine compound, and a pharmaceutical composition comprising a pharmaceutically acceptable carrier, and their use in treating disease.The invention provides e.g. a compound represented by the formula, ...
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JP6118560B2 |
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JPWO2015163280A1 |
A parasite control or control agent that has an excellent control or control effect on parasites, especially endoparasites and can be used safely contains at least one selected from the compound represented by the formula (I) or a salt t...
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JP6104243B2 |
A urea reactor tray (4) having a base plate (10); and a number of first bottom cup-shaped members (11), which project vertically downwards from the base plate (10); and a number of second top cup-shaped members (11A) which project instea...
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JP6099149B2 |
The present invention provides a novel compound having an antiviral action, in particular, an HIV replication inhibiting action, as well as a pharmaceutical composition, in particular, an anti-HIV agent. wherein, a broken line means the ...
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JPWO2015056782A1 |
An object of the present invention is to provide a novel compound having ACC2 inhibitory activity. In addition, a pharmaceutical composition containing the above compound is provided. Equation (I):(In the formula, R1Is a substituted or u...
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JPWO2014174745A1 |
The water-soluble polycyclic compound of the present invention or a pharmacologically acceptable salt thereof has a large solubility in an aqueous solvent and has a large solubility in an aqueous solvent as compared with a conventional E...
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JPWO2014192823A1 |
Provided is a method for synthesizing urea having excellent reliability and productivity by minimizing the amount of oxygen used as a corrosion resistant agent without using a special duplex stainless steel. In a urea synthesizer having ...
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JP6080839B2 |
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JP6078429B2 |
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JP6067736B2 |
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JP2017501219A |
A compound having the following formula I, or a protonated product or salt thereof: [Chemical 1]In the formula, Y represents an optionally substituted aromatic group; n is 1 or 2; a is 0 to 4; R1And R2Are each independently H, optionally...
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JP6048406B2 |
The invention relates to new compounds of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
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JP6046154B2 |
The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula I as described and defined herein, and their use in therapy, including, e.g., in the treatment or prevention of cancer, a n...
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JP6040344B2 |
Alpha-helix mimetic structures and compounds represented by the formula (I) wherein the general formula and the definition of each symbol are as defined in the specification, a chemical library relating thereto, and methods relating ther...
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JP6030057B2 |
The disclosure is directed to: (a) phosphacycle ligands; (b) methods of using such phosphacycle ligands in bond forming reactions; and (c) methods of preparing phosphacycle ligands.
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JP6030724B2 |
Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structu...
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JP6005340B2 |
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JP2016169236A |
To provide a method for producing high-purity urea water, in which the biuret concentration of the urea water can be reduced by using the inexpensively-produced urea and by an inexpensive method.The method for producing high-purity urea ...
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JP2016528197A |
The present invention relates to compounds that regulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and proliferative disorders using the compounds, such ...
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JP5991766B2 |
Compounds and compositions comprising epoxyeicosatrienoic acid (EET) analogs that act as EET agonists and are useful as medications in the treatment of drug-induced nephrotoxicity, hypertension and other related conditions. Methods of ma...
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JP5991547B2 |
According to the present invention, a substituted aromatic compound represented by the following general formula (I) is provided. In general formula (I), A 1 , A 2 , and A 3 each independently represent an aryl group substituted by a hyd...
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JP2016164150A |
To provide a compound having high activity for pests, to provide a pest control agent using the compound and to provide a method for controlling pests by applying the compound.A benzamide compound represented by formula (I) or a salt the...
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JPWO2014065327A1 |
[Subject] Offer of acrylics which has a hydroxyl machine, or an methacrylic compound, and offer of these manufacturing methods. [Means for Solution] Acrylics which has a hydroxyl machine denoted by a following formula [1], or an methacry...
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JP5982001B2 |
The present invention relates to novel amide derivatives of N-urea substituted amino acids, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide ...
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JP5981719B2 |
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JP5970670B2 |
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JP5962323B2 |
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JP2016520515A |
In order to decrease a compound which adjusts a physiological function of pro protein conversion enzyme Subtilis ricin / Kexin 9 type (PCSK9), and LDL cholesterol concentration, And/or, a method of using these regulation substances for m...
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JP2016128417A |
To provide a method for connecting protein and drug to obtain a protein-drug conjugate.A drug is connected to protein through a specific branched linker, the branched linker contains a peptide chain, and is derived from o-hydroxy p-amino...
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JP2016128488A |
To provide inhibitors of cyclophilins having a selective inhibition activity for cyclophilin, for its use in the prevention and/or the treatment of viral pathologies or infections.The present invention relates to a compound represented b...
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JP5947724B2 |
The present invention relates to a compound of formula (I): wherein: n is 0, 1 or 2; A is in particular CH or N; X is in particular CO, SO2, CS, and R1 is in particular H, R2 is a group of formula NR3R4 or OR5, R3 and R4 being in particu...
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JP5941142B2 |
Disclosed are 1,3-Dioxoindene derivatives of Formula 1, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprisin...
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JP5936659B2 |
Compounds of Formula (Ia)wherein R is a C6-C12 substituted or unsubstituted aryl, a C6-C12 substituted or unsubstituted heteroaryl, a C1-C6 substituted or unsubstituted alkyl or -NR'R',Q is C(O), O, NR', S, S(O)2, C(O)2 (CH2)pY is C(O), ...
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JP5934184B2 |
Tranylcypromine derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of histone demethylases LSD1 and LSD2, such as the diseases characterized ...
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JP5934778B2 |
Disclosed herein are compounds of formula (I) or pharmaceutically acceptable salts, solvates, or combinations thereof, wherein X1, X2, X3, X4, J, K, L, X5, X6, Rb, G2, and m are defined in the specification. Compositions comprising such ...
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JP5934370B2 |
Disclosed is a method for urea finishing. A urea solution is subjected to crystallization and, other than in conventional processes, the urea crystals are shaped by exerting mechanical force onto them. Thus, the conventional prilling or ...
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JP2016094470A |
To reduce fuel consumption required for production of urea in order to reduce generation of greenhouse gases caused by burning fuel.The invention relates to a urea plant with a COand NHfeed, which comprises a purge line, characterized in...
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JP5921679B2 |
The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activi...
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JP5923496B2 |
The invention relates to a urea plant with a CO2 and a NH3 feed, which comprises a purge line, characterized in that the purge line is connected with a fuel gas input line of a utility plant or an NH3 plant.
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JP2016064991A |
To provide a method for producing high-purity urea aqueous solution preferable for reducer for SCR by using urea aqueous solution produced in an urea synthesis process in a urea production plant.There is provided a method for producing h...
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JP2016047846A |
To provide a neprilysin inhibitor.In one aspect, the invention relates to compounds having the formula (I), where R, R, R, a, R, Rand Rare as defined in the application or pharmaceutically acceptable salts thereof. These compounds have a...
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JP2016510320A |
Equation (I):Compounds or pharmaceutically acceptable salts thereof are described herein. In equation (I), N, R1, R4a, R4b, R5, R7And R8Is as defined herein. The compounds of the present disclosure have activity as SHIP1 modulators and c...
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JP5900920B2 |
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JP5893724B2 |
This invention relates to novel compounds which are inhibitors of acyl coenzymeA: diacylglycerol acyltransferase 1 (DGAT-1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy ...
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JP5875455B2 |
An electrophotographic photosensitive member that includes the outermost surface layer formed by curing a mixture of a charge transporting substance having a chain-polymerizable functional group and a urea compound represented by the fol...
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JP2016028062A |
To provide modulators of prostacyclin (PGI2) receptor useful for treatment of disorders related thereto.The present invention provides compounds represented by formula (XIIIa) or pharmacologically acceptable salts, solvates or hydrates t...
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JP5870114B2 |
The present invention relates to compounds 1, 1a (S-enantiomer) and 1b (R-enantiomer) of the following formula 1, and a method for preparing the same. [formula 1] The novel compound of the formula 1 is used as an important intermediate f...
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JP5863979B2 |
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