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JP2023524980A |
Formula (II): or a pharmaceutically acceptable salt thereof, wherein R1, n, and Y1is as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of formula (II), or a pharmaceutically acceptable sa...
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JP2023076525A |
To provide a method for eliminating denatured protein aggregates by activating p62 being, a key regulator of selective autophagy, without lowering an activity of mTOR being, a regulator of the non-selective autophagy.The present inventio...
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JP2023521294A |
The present invention relates to pharmaceutical compositions for preventing or treating muscle weakness-related diseases, comprising alverine, 4-hydroxyalverine, derivatives thereof, or pharmaceutically acceptable salts thereof. Treatmen...
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JP2023071752A |
To provide compounds for imaging of mammalian tissue overexpressing PSMA, intermediates thereof, compositions thereof, medicaments thereof, and methods.A compound disclosed herein is a compound of formula (IV) or a pharmaceutically accep...
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JP7279020B2 |
[Solution] In a urea manufacturing plant, a method for manufacturing urea from manufacturing raw materials including NH3 and CO2, wherein the urea manufacturing plant includes a plurality of processing units including a reactor, a stripp...
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JP7277672B2 |
Disclosed is a method for the removal of ammonia from the off-gas of a finishing section of a urea production plant. Also disclosed is a corresponding urea plant, and a method of accordingly modifying a pre-existing urea plant. In a scru...
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JP7268116B2 |
The present invention provides compounds of Formula (I):or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This inven...
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JP7267273B2 |
An apparatus for treatment of process vapours coming from a vacuum concentration section of a urea plant, comprising a vacuum system having a plurality of successive condensation stages, connected in series by respective line portions an...
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JP2023517519A |
Compounds (including corresponding sulfonamides) that inhibit ferroptosis activity or modulate or inhibit diseases associated with ferroptosis dysregulation such as neuropathy, ischemia-reperfusion injury, acute renal failure and cancer,...
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JP2023517722A |
The present invention provides a co-crystal of (1R,3S)-3-(5-cyano-4-phenyl-1,3-thiazol-2-ylcarbamoyl)cyclop
entanecarboxylic acid, a method for obtaining said co-crystal, said Combination products and pharmaceutical compositions containi...
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JP2023515192A |
In the present invention, methanol and ammonia are co-produced, the ammonia is reacted with carbon dioxide recovered from the exhaust gas of the primary reformer, and at least part of the ammonia is produced together with the carbon diox...
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JP2023048820A |
To provide an extractant for selectively extracting lithium salt, a method for recovering lithium salt, and a method for producing lithium salt.A lithium salt extractant comprises at least one selected from a group consisting of a compou...
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JP7252365B2 |
In a urea synthesis process, temperature distribution in a submerged condenser is reduced. The process includes: synthesizing urea from NH3 and CO2 to generate a urea synthesis solution; by heating the solution, decomposing ammonium carb...
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JP2023513354A |
Compounds of formula (I) or (X) are provided, including for the treatment of disorders such as disorders or conditions associated with neuronal cell death. In one aspect, compounds are provided that are selective inhibitors of calpain-2....
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JP2023512786A |
Provided are compounds of formula (II): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, and p are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of formu...
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JP2023041047A |
To provide a novel urea (meth)acrylate, a binder composition which includes at least one repeating unit derived from the urea (meth)acrylate, production of them, and use of them in adhesive and coating applications.The urea (meth)acrylat...
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JP2023041046A |
To provide the one-pot synthesis of polymerizable and acyclic urea (meth)acrylates, preferably mono(meth)acrylates, via in-situ synthesis of urea alcohols or amines followed by direct reaction with a (meth)acrylate reactive diluent.The u...
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JP7239497B2 |
The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein inhibit the matura...
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JP7231413B2 |
The present technology is directed to compounds, intermediates thereof, compositions thereof, medicaments thereof, and methods related to the imaging of mammalian tissue overexpressing PSMA. The compounds are of Formula IVor a pharmaceut...
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JP7229482B2 |
An object of the invention is to develop a group of new compounds with inhibitory activity against the function of Pin1 as candidate compounds for drugs.The present invention provides compounds represented by the following Formula (I) or...
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JP7228897B2 |
The present invention provides a pharmaceutical composition for treating or preventing a cognitive disease or disorder, comprising a compound represented by Formula (I), an enantiomer thereof, a diastereomer thereof, or a pharmaceuticall...
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JP2023026190A |
To provide a catalyst for efficiently advancing oxidative carbonylation reaction which is easy to separate without using expensive noble metal, and which is usable repeatedly.A catalyst for oxidative carbonylation reaction includes Bi2Se...
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JP2023507133A |
The present disclosure relates to co-crystals of pterostilbene and coformers capable of forming hydrogen bonding interactions, processes for their preparation, and their use as pharmaceuticals or dietary supplements. The present disclosu...
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JP2023025110A |
To provide novel compounds used for treating autoimmune disease and the like, their pharmaceutically acceptable salts, pharmaceutical compositions, use methods, and methods for their preparation.The present disclosure relates to compound...
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JP7225944B2 |
To provide an inexpensive production method of aluminum nitride with a uniform particle diameter in a short process.There are provided: a production method of aluminum nitride comprising a step of forming an aluminum chloride-organic ami...
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JP7224685B2 |
The present invention relates to a novel AUTOTAC chimeric compound in which a new p62 ligand and a target-binding ligand are connected by a linker, a stereoisomer, hydrate, solvate or prodrug thereof, and a pharmaceutical or food composi...
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JP7222935B2 |
The use of carbamides as extractants for fully or partially separating uranium(VI) from plutonium(IV) in an aqueous solution obtained by dissolving a spent nuclear fuel in nitric acid, by method of liquid-liquid extraction, without carry...
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JP2023021468A |
To provide novel lipids for intracellular delivery of therapeutic agents and compositions involving the same.Nanoparticle compositions in the present disclosure include a novel lipid as well as additional lipids such as phospholipids, st...
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JP2023013730A |
To provide a method for degrading a polycarbonate resin which enables urea and/or bisphenol to be efficiently obtained, and a method for producing urea using the degradation method and a method for producing bisphenol using the degradati...
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JP7209874B2 |
A method is disclosed for stripping in a stripper a urea synthesis solution received from a urea forming process wherein ammonia and CO2 are reacted under urea forming conditions. The shell space of the stripper comprises a continuous ve...
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JP7202354B2 |
A urea production process comprises a step of synthesis of urea by reaction of ammonia and carbon dioxide, where at least part of the carbon dioxide for the urea reaction synthesis is produced in an oxy-combustion process; the oxy-combus...
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JP2022554266A |
The present invention relates to a method for producing urea granules. In that method of manufacture, an exhaust gas stream (11) from a urea granulator (10) is subjected to a dust scrubbing process in a granulator exhaust gas scrubber (1...
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JP7197732B2 |
Disclosed is a urea finishing method including an off-gas treatment, the method comprising urea finishing and supplying the off-gas to a quenching zone and to a scrub column comprising a sump and a venturi stage, wherein the sump has a s...
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JP2022553143A |
The present invention is a method for the effective removal of residual monomeric aliphatic isocyanates from reaction mixtures containing aliphatic polyisocyanates, comprising (i) SiO2, and optionally X, where X is a trivalent element2O3...
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JP2022184467A |
To provide a novel mixture that is liquid at room temperature.A mixture is provided, including a lithium salt and a compound represented by the following general formula (1). [In the formula (1), R1 and R2 each independently represent a ...
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JP2022551066A |
The present disclosure relates to carmabinoid derivatives of Formula (I), wherein R4 or R7 is a carboxamide group, pharmaceutical compositions comprising these compounds, and methods of using the carmabinoid derivatives. These compounds ...
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JP2022549227A |
The present invention provides substituted saturated and unsaturated N-heterocyclic carboxamides and related compounds, compositions containing such compounds, medical kits, and medical disorders such as cancer, lysosomal accumulation in...
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JP7173350B2 |
The present invention provides a compound represented by formula [I] having an LPA1 receptor-antagonizing action, or a pharmaceutically acceptable salt thereof.
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JP7173766B2 |
To provide a compound capable of suppressing the occurrence of alignment defects and lowering the phase transition temperature of a liquid crystal composition without impairing optical characteristics.The compound is represented by the f...
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JP7167502B2 |
To provide a catalyst for producing a polyurethane foam resin that causes little amine emission and realizes production of a polyurethane foam product with good productivity and formability, and a method of producing a polyurethane foam ...
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JP2022546208A |
Compounds, compositions and methods for treating diseases, disorders or conditions affected by modulation of DHODH are disclosed. Such compounds have the following formula (I): [Chemical 1] [In the formula, R1, R2, R3, and R6is defined h...
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JP7157684B2 |
Provided is a novel process and a novel apparatus for urea production capable of performing heat recovery from a relatively low-temperature fluid. A process for urea production includes a synthesis step, a high-pressure decomposition ste...
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JP2022544275A |
1. A process for recycling polyethylene terephthalate (PET) to produce bis(2-hydroxyethyl) terephthalate (BHET) comprising: (a) preferably in two depolymerization reactors in series, ethylene glycol and depolymerizing PET in the presence...
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JP2022539597A |
The present application provides, in one aspect, a method of producing urea in a urea plant comprising a high pressure synthesis section with a reactor, the method comprising NH3feed and CO2reacting the feeds in a reactor under urea-form...
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JP7128968B2 |
A fluidized bed granulator for granulation with urea or urea-containing liquids is described, wherein the granulation liquid is supplied via a supply manifold comprising a header and risers. The risers are at least in part provided insid...
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JP2022535927A |
The present invention provides the synthesis of citrulline from transition metal complexes of ornithine using a cyanate to derivatize the terminal amino group of ornithine. The present invention also provides purification of citrulline p...
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JP2022115835A |
To provide stable crystalline forms in use environment of a urea compound which antagonizes an LPA1 receptor as a medicine, and a production method thereof.The problem is solved by a crystal of a N-methyl-D-glucamine salt hydrate of tran...
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JP7105863B2 |
The invention pertains to a finishing process for urea-comprising material, a plant for finishing urea-comprising material, a method of modifying an existing plant, and a use. Methods are disclosed for preventing the clogging of the cond...
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JP2022533267A |
This disclosure is based on Equation I. [Chemical 1] With respect to arylamidine and its use as a fungicide. One embodiment of the present disclosure comprises applying a compound of formula I or a composition comprising a compound to a ...
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JP7096160B2 |
An object of the present invention is to find a novel pharmaceutical that has an excellent tryptophanase inhibitory effect, and suppresses worsening of renal function to preserve the kidney by reducing production of indoxyl sulfate in th...
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