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JP6450622B2 |
To prevent the precipitation of solidifying components and to suitably follow up to the change of driving conditions upon the cooling of an ammonium carbamate-containing fluid.Provided is a method for cooling the fluid, using a device in...
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JP6438658B2 |
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JP6417419B2 |
Disclosed are compounds of Formula (I): (I). Also disclosed are methods of using such compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowin...
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JP6407950B2 |
where R1, R2, R3, R4a, R4b, R5, R6 and R7 are defined herein, or stereoisomers or pharmaceutically acceptable salts thereof, are described herein. Such compounds have activity as SHIP1 modulators, and thus may be used to treat any of a v...
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JP6407951B2 |
R1, R2, R5 and R13 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds h...
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JP6397398B2 |
The present invention relates to tertiary amines of formula (I) for use in therapy, particularly for use in treating cardiovascular disorders. The compounds have been found to regulate phospholamban phosphorylation by interfering with th...
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JP2018525341A |
Growth of cancer, viral infections and / or inflammatory disorders, etc. using compounds that regulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds, and thi...
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JP6373297B2 |
Disclosed are 1,3-Dioxoindene derivatives of Formula 1, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprisin...
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JP6371851B2 |
There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, vi...
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JP6357248B2 |
The present invention provides a compound represented by general formula I or a pharmaceutical acceptable salt thereof, the preparation method therefor and the use thereof in preparing a medicine for treating a neurological disease, such...
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JP2018516238A |
Compounds of formula (I) that regulate or inhibit the enzymatic activity of indoleamine-2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds, and proliferative disorders using the compounds of the invention (eg, c...
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JPWO2017038871A1 |
An object of the present invention is to provide a compound having an inhibitory activity on discoidin domain receptor 1. The present invention provides a urea derivative represented by the following formula or a pharmacologically accept...
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JPWO2017038873A1 |
An object of the present invention is to provide a compound having an inhibitory activity on discoidin domain receptor 1. The present invention provides a urea derivative represented by the following formula or a pharmacologically accept...
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JP2018515438A |
Compounds that regulate or inhibit the enzymatic activity of indoleamine-2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds, and proliferative disorders (eg, cancer), viral infections and using the compounds of ...
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JP2018513183A |
Compounds of formula I-VI, including pharmaceutically acceptable salts thereof, as well as compositions and methods for treating human immunodeficiency virus (HIV) infections are described. Equation I is exemplified by the following equa...
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JP6329159B2 |
In a chemical plant 100 including a carbon dioxide recovery unit 10 and a urea plant 11, the carbon dioxide recovery unit 10 treats combustion exhaust gas from a boiler B to separate and recover carbon dioxide. Low-pressure steam 33 gene...
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JP2018077464A |
To provide a compound capable of suppressing the occurrence of alignment defects and lowering the phase transition temperature of a liquid crystal composition without impairing optical characteristics.The compound is represented by the f...
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JP6325139B2 |
The present invention relates to a safe and efficient process for the preparation of carmustine (1) and to useful intermediate compounds of such process and their preparation. Such process employs safe and readily available starting mate...
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JP6313415B2 |
There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, vi...
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JP6313416B2 |
There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, vi...
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JP6306571B2 |
Disclosed is a plant for the production of urea. The plant comprises conventional sections for synthesis and recovery, for evaporation and condensation, for urea finishing, and for dust scrubbing. According to the invention, an additiona...
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JP6306121B2 |
The disclosure is directed to: (a) phosphacycle ligands; (b) methods of using such phosphacycle ligands in bond forming reactions; and (c) methods of preparing phosphacycle ligands.
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JP6293266B2 |
The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of hypertension and/or fibrosis.
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JP2018035194A |
To provide modulators of the prostacyclin (PGI2) receptor useful for treatment of disorders related to the PGI2 receptor.Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in treatme...
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JP2018027960A |
To provide compounds that bind to and modulate a histone acetyltransferase protein, where the histone acetyltransferase protein is used for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide...
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JP2018020989A |
To provide a urea compound or thiourea compound with pharmacological action.One aspect of the present invention relates to a pharmaceutical component comprising a urea compound or thiourea compound represented by the general formula (I),...
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JP6275484B2 |
A dendrimer conjugate according to Formula (I), or its pharmaceutically acceptable salt, or solvate thereof: and complexes of Formula I conjugates with metals radionuclides of elements such as rhenium, technetium, yttrium, lutetium and o...
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JPWO2016159336A1 |
The present invention treats the first concentration step of concentrating the urea aqueous solution, the granulation step of producing solid urea from the concentrated urea solution produced in the first concentration step, and the exha...
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JP6247014B2 |
To provide a photosensitive resin composition excellent in storage stability and capable of maintaining good photolithographic characteristics while the composition includes a resin having an epoxy group, and to provide a resin film form...
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JP2017212174A |
To provide a secondary battery in which relatively inexpensive, environmental-friendly and relatively safe materials are used instead of a volatile organic solvent and an expensive active material on at least one side of positive and neg...
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JP6240063B2 |
The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R 2a , R 2b , R 2c , R 5 and t are as described herein. The present invention rel...
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JP6235048B2 |
The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, W, A and B are as described herein, compositions including the compounds and methods of using the compounds.
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JP6233812B2 |
Disclosed are selective histone deactylase inhibitors (HDACi) that having Formula (I). Methods of making and using these inhibitors for the treatment of cancer, in particular melanoma are also disclosed.
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JP2017530132A |
A novel solid drug form suitable for oral dosing, N- (2,6-bis (1-methylethyl) phenyl) -N'-((1- (4- (dimethylamino) phenyl) cyclopentyl) methyl) urea hydrochloride Salts (also called "ATR-101"), and related compositions, methods, and kits...
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JP2017178962A |
To provide a novel 4-dedimethylamino tetracycline compounds that can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms.The present invention pertains to substituted tetracycline...
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JP6203746B2 |
Provided are cajanine structure analogous compounds, synthesis method and pharmacological effects thereof, the compounds of the present invention having the structure as represented by general formulas I, II, III, IV and V. Also provided...
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JP6205406B2 |
New tranilast complexes and new tranilast cocrystals are disclosed. These include a 1:1 tranilast nicotinamide complex, a 1:1 tranilast nicotinamide cocrystal, a 1:1 tranilast saccharin complex, a 1:1 tranilast saccharin cocrystal, a 1:1...
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JP2017165091A |
To provide a thermosensitive recording material excellent in color development sensitivity and alcohol resistance.The thermosensitive recording material contains at least one compound represented by the general formula (1). [In the gener...
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JP2017160124A |
To provide: an aryloxy compound excellent in pest control activity, particularly, in acaricidal activity and/or insecticidal activity, excellent in safety and also industrially advantageously synthesizable; and a pest control agent conta...
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JPWO2016084870A1 |
Provided is an acylaminophenyl group-containing compound having a neuroprotective effect. Furthermore, a neuroprotective agent containing an acylaminophenyl group-containing compound is provided. The novel acylaminophenyl group-containin...
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JP6196749B1 |
A thematic invention indicates a useful compound more concretely especially as a color developer for thermal recording media. These compounds are p- (p-{3- [p- (p-hydroxy Phenoxy ) phenyl] Ureido } Phenoxy ) phenol, m- (p-{3- [p- (p-hydr...
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JP2017145219A |
To provide a novel eutectic mixture utilizable for various applications, which is a novel eutectic mixture utilizable for an absorber or the like of various gases, especially carbon dioxide or the like, as one application.In an eutectic ...
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JP6181060B2 |
The present invention relates to novel aryl urea derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) recep...
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JP2017136729A |
To provide a heat-sensitive recording material that has excellent water resistance and includes the texture having excellent heat resistance.A heat-sensitive recording material comprises at least one compound represented by the following...
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JP6169520B2 |
The present invention relates to method for connecting a protein and a drug to a protein drug conjugate, wherein the drug is linked to the protein through a specific branched linker, said branched linker comprises a peptide chain and is ...
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JPWO2016052592A1 |
A heat-sensitive recording material containing at least one compound represented by any of the following formulas (1) to (3) as a color-developing compound. [Chemical 1] [Chemical 2] [Chemical 3]
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JP6162887B2 |
The invention relates to novel carbodiimides having terminal urea and/or urethane groups, methods for the preparation thereof and use thereof as stabilizers in ester-based polyols, in polyethylene terephthalate (PET), in polybutylene ter...
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JP2017113988A |
To provide a heat-sensitive recording material which is excellent in color development, excellent in the water resistance and alcohol resistance of the printing part, and excellent in the heat resistance of the ground.A heat-sensitive re...
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JP2017113989A |
To provide a heat-sensitive recording material in which the color development part has excellent water resistance and the ground has excellent heat resistance at the time of heating.A heat-sensitive recording material has at least one co...
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JP2017088511A |
To provide a method for manufacturing 1-(2-aminophenyl)-3-phenylurea with high selectivity without using a specific organic solvent or a specific reaction device with a smaller solvent amount than conventional methods.There is provided h...
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