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JP6484220B2 |
A tri-carbobenzoxy-arginine represented by the following formula (2): is produced by carbobenzoxylating the arginine or arginine derivative (1) represented by the following formula (1), or a salt thereof: by adding carbobenzoxy chloride ...
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JP6483332B2 |
This invention relates to a method of preparing D-arginine, and more particularly to a method of preparing D-arginine by optically resolving DL-arginine using D-3-bromocamphor-8-sulfonic acid or a salt thereof as an optical resolving agent.
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JP6469053B2 |
To provide a composition comprising a solid crystal with a predetermined crystalline structure that is easy to handle and excellent in semiconductor characteristics.Provided is a composition comprising a solid crystal containing 2 kinds ...
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JP6403671B2 |
The present invention concerns a method for preparing a creatine fatty ester or derivative thereof comprising at least one step consisting in reacting a diprotected creatinine with a molecule bearing at least one alcohol functional group...
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JP6374320B2 |
Provided herein are phenyl-guanidine derivatives for the inhibition of Rac1 which blocks its interaction with guanosine exchange factors (GEFs) belonging to the DBL family as agents for the treatment of aggressive and/or resistant tumors...
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JP6364025B2 |
The present invention relates to compounds of the formula (I) and in particular to medicaments comprising at least one compound of the formula I for use in the treatment and/or prophylaxis of physiological and/or pathophysiological condi...
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JP6360074B2 |
The present invention relates to the mannose-receptor selective lysinylated cationic amphiphile and a process for preparation thereof. The compounds of the present invention can target DNA vaccines to antigen presenting cells (APCs) such...
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JP2018513122A |
Provided herein are processes and intermediates for the preparation of compounds of formula (I) or pharmaceutically acceptable salts thereof using cyanamide in the reaction. Where Y is CH2CO2H, CH2CONR1R2Or CH2CO2R1And R1, R2Are independ...
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JP6280175B2 |
Methods for incorporating chlorhexidine salts into solvent based adhesives are described. The methods involve freeze drying an aqueous solution of the chlorhexidine salt and obtaining the chlorhexidine salt in a particulate form. The dry...
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JP6252991B2 |
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JP6216421B2 |
The present invention generally relates to novel synthetic methods, systems, kits, salts, and precursors useful in medical imaging. In some embodiments, the present invention provides compositions comprising an imaging agent precursor, w...
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JP6198741B2 |
The invention relates to oseltamivir derivatives as influenza neuraminidase inhibitors for treating influenza infections and to a method for producing said compounds.
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JP6186236B2 |
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JP2017512762A |
The techniques of the invention provide peptides, methods of producing peptides, and pharmaceutically acceptable salts of peptides. In some embodiments, the peptide is 2'6'-Dmt-D-Arg-Phe-Lys-NH.2Or Phe-D-Arg-Phe-Lys-NH2Is.
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JP2017061430A |
To provide a prodrug which can be applied to many useful compounds, has higher solubility in an aqueous solvent than a useful compound and can rapidly generate a useful compound under neutral to weakly basic conditions.There is provided ...
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JP6073929B2 |
The invention relates to complex compounds of germanium with amino acids and carboxylic acids of the general formula Ge[OH] a [AA] b [CA] c (I), where AA is an amino acid, CA is a carboxylic acid, a = 0-3, b = 1-3, c = 0-3, and 1
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JP2016204283A |
To provide a compound and a photo-base generator, being photosensitive materials, serving as an initiator for polymerization reaction and chemical reaction when used in photoresist and the like, as well as suitable as a photo-base genera...
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JP6026400B2 |
The present invention relates to (1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-guanidi
no-2-hydroxy-cyclopentyl-1-carboxylic acid hydrates compounds, preparing methods thereof, pharmaceutical compositions containing said compounds...
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JP6021860B2 |
Novel compounds that find use as imaging agents within nuclear medicine applications (PET imaging) for imaging of cardiac innervation are disclosed. These PET based radiotracers may exhibit increased stability, decreased NE release (ther...
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JP5992399B2 |
The present invention generally relates to novel synthetic methods, systems, kits, salts, and precursors useful in medical imaging. In some embodiments, the present invention provides compositions comprising an imaging agent precursor, w...
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JP2016160225A |
To provide a method for forming a basic compound by efficiently separating a basic compound blocked by a blocking group, and the basic compound obtained by the method.A method for forming a basic compound is characterized by separating a...
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JP5809304B2 |
The present invention relates to an automatic system for synthesizing iodine-123 meta-iodobenzylguanidine (123I-MIBG), which comprises a first reactor for subjecting radioactive iodine-containing sodium iodide and meta-iodobenzylguanidin...
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JP5805742B2 |
To provide a slowly available liquid fertilizer including guanylurea and capable of reducing additional fertilization workload by reducing a number of addition of fertilizer.The slowly available liquid fertilizer comprises guanylurea obt...
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JP2015172034A |
To coupledly and batch-simultaneously produce 18 kinds of liquid amino acids other than either one kind of glutamine or glutamic acid and either one kind of asparagine or asparaginic acid among 20 kinds of amino acids.Dust obtained in su...
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JP5701832B2 |
The present invention provides a method represented by Scheme 1: wherein X represents I, Br, Cl, alkylsulfonate, or arylsulfonate; Z represents optionally substituted aryl, heteroaryl or alkenyl; L represents hydrogen or a negative charg...
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JP2015038096A |
To provide an efficient method of producing arginine bicarbonate at low pressure.A method of producing arginine bicarbonate comprises bringing carbon dioxide of a pressure of 6,895 Pa(1 psi) to 6,8947 Pa(10 psi) into contact with an inci...
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JP5649909B2 |
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JP5625914B2 |
An object of the invention is to provide a novel arginine derivative and a cosmetic satisfactory in compatibility with the skin and hair, excellent in skin softening effect and skin-conditioning effect, and satisfactory in use feeling wi...
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JP5619867B2 |
The present invention provides an enantioselective composite membrane useful for separation of optical isomers and the process for the preparation thereof. The invention further provides a membrane based pressure driven separation proces...
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JP5603328B2 |
The invention provides a novel apparatus and method for preparing a solution of a shear sensitive material.
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JP5551691B2 |
The present invention relates to metformin glycinate salt and pharmaceutical compositions thereof for the treatment of diabetes mellitus. The method includes administration of the metformin glycinate salt by various routes selected from ...
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JP5520235B2 |
The present invention provides methods to produce arginine bicarbonate more rapidly and efficiently than conventional methods.
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JP2014510038A |
Methods for incorporating chlorhexidine salts into solvent based adhesives are described. The methods involve freeze drying an aqueous solution of the chlorhexidine salt and obtaining the chlorhexidine salt in a particulate form. The dry...
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JP2013542059A |
A method is described for separating CO2 and/or H2S from a mixed gas stream by contacting the gas stream with a non-aqueous, liquid absorbent medium of a primary and/or secondary aliphatic amine, preferably in a non-aqueous, polar, aprot...
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JP5345518B2 |
A process for producing creatine, creatine monohydrate or guanidinoacetic acid is proposed, wherein firstly N-methylethanolamine or ethanolamine is catalytically dehydrogenated in each case in alkaline solution and the sarcosinate or gly...
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JP5292404B2 |
Disclosed herein are a novel dicarboxylic acid salt of N,N-dimethylimidodicarbonimidic diamide, a preparation method thereof and a pharmaceutical composition comprising the same. More specifically, disclosed herein are a novel dicarboxyl...
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JP5291854B2 |
The present invention provides a method represented by Scheme 1: wherein X represents I, Br, Cl, alkylsulfonate, or arylsulfonate; Z represents optionally substituted aryl, heteroaryl or alkenyl; L represents hydrogen or a negative charg...
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JP5268982B2 |
To provide a disinfectant which includes olanexidine in such a concentration as to show an effective bactericidal activity, is used for stable disinfection without depositing olanexidine, and is reduced in side effects such as skin irrit...
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JP5266499B2 |
The present invention provides a method represented by Scheme 1: wherein X represents I, Br, Cl, alkylsulfonate, or arylsulfonate; Z represents optionally substituted aryl, heteroaryl or alkenyl; L represents hydrogen or a negative charg...
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JP2013514357A |
Methods of producing arginine bicarbonate solutions in very high concentrations including reacting an arginine slurry containing a first portion of arginine with a source of carbon dioxide gas at elevated pressure and temperature, adding...
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JP2013514362A |
A method of producing arginine bicarbonate is provided including reacting an arginine slurry with a source of carbon dioxide gas under elevated temperature and low pressure to form a solution of at least 50% arginine bicarbonate, and rec...
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JP2013010735A |
To provide a 1, 2, 4-triazole compound capable of introducing a guanidine skeleton to an ordinary amine and even to a bulky secondary amine, in which a steric hindrance is supposed, such as diisopropylamine, and to provide a method for s...
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JP5078993B2 |
The present invention provides a process for producing 1-(3,4-dichlorobenzyl)-5-octylbiguanide or a salt thereof, the process comprising reacting 1-cyano-3-octylguanidine or a salt thereof, with 3,4-dichlorobenzylamine or a salt thereof,...
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JP5057782B2 |
The present invention relates to a method for synthesis of an acrylamide derivative, starting with dissolving a salt of a nucleophilic amine in water to form an aqueous solution and desalting said solution with a base, comprising the fol...
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JP5038725B2 |
The invention relates to biocidal polymers based on guanidine salts characterized in that they are representatives of a number of polyoxyalkylene guanidines and their salts and are a product of a polycondensation of guanidine salts with ...
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JP5010713B2 |
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JP2012148997A |
To provide a guanidine thiocyanate compact sufficiently preventing solidification without using any anticaking agent over long-term storage.A specific surface area of a molded product of guanidine thiocyanate included in the guanidine th...
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JP4955659B2 |
The inventive molecular transporter compound shows significantly high permeability through a biological membrane such as a plasma membrane, nuclear membrane and blood-brain barrier, and accordingly, can be effectively used in delivering ...
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JP4846238B2 |
One aspect of the present invention relates to a method of purifying radiolabelled compounds comprising a) loading onto a fluorous polymer a radiolabelled compound precursor comprising a fluoroalkyl tin moiety; b) reacting the radiolabel...
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JP4758584B2 |
The invention relates to a method for producing 1-methyl-3-nitroguanidine. According to said method, nitroguanidine is reacted with methylamine and/or a methylammonium salt in an aqueous solution, at temperatures of 30 to 60° C. and at ...
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