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WO/2016/202125A1 |
Disclosed are an intermediate, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-forma
midine]phenyl-2-propenamide (II), applicable in preparing AZD9291 (I) and a preparation method for the intermediate. Preparation steps comprise: ...
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WO/2016/201128A1 |
The present application provides, inter alia, chemical compounds useful as synthesis intermediates, said compounds comprising one or more guanidinium moieties and a hypervalent iodine atom. Methods for making these compounds are also pro...
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WO/2016/180840A1 |
The present invention relates to the use of a catalyst of the formula (I) for the crosslinking of a curable composition. The catalyst of the formula (I) contains at least one aliphatic guanidine group. It is substantially odourless and n...
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WO/2016/110822A1 |
The invention relates to a novel creatine derivative, the carboxylic biacyl creatine derivative of formula (I) and pharmaceutically acceptable salts thereof, methods of synthesis and the use thereof in the treatment of pathologies due to...
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WO/2016/070712A1 |
Disclosed are amino acid derivatives and applications thereof. The amino acid derivatives contain the oxalyl group, and thus can interfere with energy metabolism of cells and induce apoptosis. Therefore, the amino acid derivatives can be...
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WO/2016/059507A1 |
The present invention provided an improved process for the preparation of Metformin compound of formula I or its pharmaceutically acceptable salts 5 thereof, by employing an alcoholic solvent throughout the process
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WO/2016/015081A9 |
The invention relates to a method for producing polycondensation products of guanidine, aminoguanidine or diaminoguanidine G with one or more benzyl- or allyl-derivatives BA according to the following reaction scheme: wherein X represent...
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WO/2016/028016A1 |
The present invention relates to a method for preparing D-arginine, and more specifically, to a method for preparing D-arginine by light-splitting DL-arginine by using D-3-Bromocamphor-10-sulfonic acid as a light-splitting agent.
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WO/2015/168465A1 |
This invention relates to compounds that inhibit creatine transport and/or creatine kinase, pharmaceutical compositions including such compounds, and methods of utilizing such compounds and compositions for the treatment of cancer.
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WO/2015/146882A1 |
By adding carbobenzoxy chloride and a basic group in a water/organic solvent bilayer system to arginine or an arginine derivative (1) which are represented by belowmentioned formula (1), or a salt of said arginine derivative (1), the arg...
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WO/2015/077500A1 |
The invention relates to an integrated system for the preparation of purified terephthalic acid (PTA) and the use of the PTA for the production of poly(ethylene terephthalate) (PET). Advantageously, the integrated system design described...
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WO/2015/069699A1 |
The present invention provides novel creatine analogs useful for treating any creatine deficiency disorders and methods of treating and preventing creatine deficiencies utilizing the present compounds and the pharmaceutical compositions ...
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WO/2015/049239A1 |
A process for the preparation of the fluoroalkyl sulfonate salt of a nitrogen-based organic base said process comprising the step of reacting a fluoroalkyl sulfonyl halide with an organic base selected from the group consisting of tertia...
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WO/2014/204763A1 |
A process for preparing guanidino-functional, free radically polymerizable compounds comprises (a) combining (1) an amine compound comprising (i) at least one primary aliphatic amino group and (ii) at least one secondary aliphatic amino ...
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WO/2014/161412A1 |
Disclose in the invention are a tricyclic quinolone derivative having a novel structure with a peripheral group at position C10 being substituted by non-alkaline substituents or salts and hydrates thereof. Such compounds have been proven...
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WO/2014/124796A1 |
The present invention relates to a two‑ply, dielectric layer for a thin‑layer capacitor, characterized in that a) the bottom, first ply (4) comprises a self‑assembled monolayer containing phosphorus oxo compounds and b) the top, se...
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WO/2014/123364A1 |
The present invention provides an N1-cyclic amine-N5-substituted biguanide derivative compound represented by Formula 1, a method of preparing the same and a pharmaceutical composition including the biguanide derivative or the pharmaceut...
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WO/2014/121648A1 |
The present invention discloses a synthesis method for creatine. In a case of vacuum, carbamide and aqueous solution of sodium sarcosinate are mixed and heated. After drying, acid is added to adjust a pH value, and thermal reaction is pe...
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WO/2014/097335A1 |
A method of synthesizing (Boc)2-creatine derivatives of formula (III) which comprises a first step in which a sarcosine ester is reacted with a guanylating agent comprising two nitrogen atoms each protected with a t-butoxycarbonyl (t-Boc...
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WO/2014/082594A1 |
Provided are a compound shown in formula 1 or a purpose of a prodrug thereof in preparing medicines for treating and/or preventing infection of Tamiflu-resistant influenza virus strains. The Tamiflu-resistant influenza virus strains is p...
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WO/2014/019855A1 |
The present invention concerns a method for preparing a creatine fatty ester or derivative thereof comprising at least one step consisting in reacting a diprotected creatinine with a molecule bearing at least one alcohol functional group...
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WO/2014/011814A1 |
Provided herein are tri-salt compounds comprising a compound having two acidic functional groups and one basic functional groups (e.g., aspartate or glutamate), metformin, and polyunsaturated fatty acids, such as eicosapentaenoate or doc...
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WO/2014/007326A1 |
The purpose of the present invention is to provide a process for producing nafamostat mesylate without via nafamostat bicarbonate and while avoiding inclusion of sodium mesylate. The process for producing nafamostat mesylate comprises (1...
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WO/2013/188452A1 |
Presented herein inter alia are novel compounds and methods of using the same for the treatment of cancers.
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WO/2013/178065A1 |
Disclosed are an amino acid copper complex with the effects of preventing alopecia, growing hair and protecting skin, a preparation method and application. The amino acid copper complex is obtained by complexing divalent copper ions with...
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WO/2013/053766A1 |
The present invention relates to methods of inhibiting the formation or agglomeration of gas hydrates using amidines or guanidines. The invention further relates to compositions comprising amidines or guanidines that find use as gas hydr...
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WO/2013/022279A2 |
A N1-cyclic amine-N5-substituted biguanide derivative of Formula 1 or a pharmaceutically acceptable salt thereof, a method of manufacturing the same, and a pharmaceutical composition including the biguanide derivative or the pharmaceutic...
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WO/2013/022280A2 |
An N1-cyclic amine-N2-substituted biguanide derivative of Formula 1 or a pharmaceutically acceptable salt thereof, a method of manufacturing the same, and a pharmaceutical composition including the biguanide derivative or the pharmaceuti...
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WO/2013/022278A2 |
An N1-cyclic amine-N5-substituted phenyl biguanide derivative of Formula 1 or a pharmaceutically acceptable salt thereof, a method of manufacturing the same, and a pharmaceutical composition including the biguanide derivative or the phar...
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WO/2012/145932A1 |
The present invention relates to a novel process for preparing peramivir formula (I) or a pharmaceutically acceptable salt thereof, and to intermediates used therein.
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WO/2012/071766A1 |
A preparation method of L-arginine-α-ketoglutarate by direct crystallization from zymotic fluid is provided. The method includes: respectively pretreating L-arginine zymotic fluid and α-ketoglutaric acid zymotic fluid by flocculation, ...
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WO/2011/153402A1 |
An exhaust sensor comprises a sensing electrode and a reference electrode each in contact with an electrolyte. At least one of the sensing electrode and the reference electrode are formed by depositing an electrode precursor material on ...
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WO/2011/123742A1 |
Multi-modal tumor imaging of neuroblastoma is essential for tumor staging, response evaluation and detection of relapsed diseased. The present invention provides a norepinephine analogue with a near-infrared (near-IR) dye, W765-BG, that ...
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WO/2011/112594A1 |
The present invention is directed to a method for preparing a cyclic guanidine comprising reacting (i) a cyanamide, (ii) a polyamine, and (iii) a weak acid. The present invention is also directed to a coating composition comprising the c...
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WO/2011/095027A1 |
Compounds of formula (I) or pharmaceutically acceptable salts thereof, and use for treating cancer thereof are disclosed, wherein, the definitions of X, Y, R1, R2 and n are described in description.
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WO/2011/088918A1 |
The invention relates to a use of a guanidinium cation and a light-emitting component. According to the invention, for the first time matrix materials and emitters for uses in organic electrochemical light-emitting cells which contain a ...
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WO/2011/083998A2 |
The present invention provides a biguanide derivative or pharmaceutically allowable salt thereof represented by Formula 1 with N1-N5 substitution, a preparation method thereof and a pharmaceutical composition containing the biguanide der...
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WO/2011/083999A2 |
The present invention provides a biguanide derivative or pharmaceutically acceptable salt thereof represented by Formula 1 with N4-N5-substitutions, a preparation method thereof and a pharmaceutical composition containing the biguanide d...
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WO/2011/075472A1 |
A method of producing arginine bicarbonate is provided including reacting an arginine slurry with a source of carbon dioxide gas under elevated temperature and low pressure to form a solution of at least 50% arginine bicarbonate, and rec...
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WO/2011/075422A1 |
Methods of producing arginine bicarbonate solutions in very high concentrations including reacting an arginine slurry containing a first portion of arginine with a source of carbon dioxide gas at elevated pressure and temperature, adding...
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WO/2011/061272A2 |
The invention relates to a process for reducing the residual amount of p-chloroaniline in chlorhexidine. Also, the invention relates to a process for preparing chlorhexidine, or a pharmaceutically acceptable salt thereof, which is free o...
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WO/2011/056091A1 |
The invention relates to the field of pharmaceutical chemistry, specifically to processes for preparing biologically active substances (BAS), in particular creatine amides. What is proposed is a process for preparing creatine amides whic...
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WO/2011/008053A2 |
The present invention provides metformin propionate, a method of preparing the same, and pharmaceutical compositions and combinations containing the same. The metformin propionate according to the present invention has an excellent pharm...
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WO/2010/146249A1 |
The present invention relates to a method for coating a flexible medium made from fabric, paper, polyvinyl chloride, polyester, polypropylene, polyamide, polyethylene, polyurethane, non-woven fibreglass fabrics, or polyethylene terephtha...
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WO/2010/146250A1 |
The present invention relates to a method for coating a flexible medium made from fabric, paper, polyvinyl chloride, polyester, polypropylene or polyethylene terephtalate with a tin-free elastomer silicon composition which can be cross-l...
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WO/2010/146604A2 |
A process for reducing dimethylamine content in metformin hydrochloride is disclosed. The process comprises: (a) providing metformin hydrochloride having dimethylamine content more than 15 ppm; (b) pulverizing the metformin hydrochloride...
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WO/2010/094821A1 |
The invention relates to the use of vaginally-administered insulin-sensitizing agents for preventing and/or treating hyperandrogenism and/or polycystic ovarian syndrome and/or related disorders.
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WO/2010/074591A1 |
The invention relates to pharmaceutical chemistry, in particular to new biologically active substances (BAS) and to the properties thereof, namely, to creatine derivatives of general formula : NH=C(NH2)-N(CH3)- CH2-CO-NH-R٠X, wherein R ...
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WO/2010/074268A1 |
Provided are a novel arginine derivative and a cosmetic which is highly compatible with the skin and hair, has excellent effects of softening and conditioning the skin, shows little stickiness or skin-tautness, and has a good texture in ...
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WO/2010/060231A1 |
The present invention provides a kind of nitroguanidine compounds, its preparation method and uses. The structure of the compound is as follows of formular I, in which R1 is saturated or unsaturated C1-10 aliphatic alkyl, benzyl or subst...
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