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JP4700880B2 |
The present invention relates to a novel process for the preparation of N-methyl-N'-nitroguanidine by reacting nitroguanidine with aqueous methylamine solution buffered by the addition of inorganic or organic acids.
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JP4690345B2 |
The present invention relates to a two-step process for the preparation of guanidinium salts of the formula (1), where the substituents R have a meaning indicated in Claim, and A- is a sulfonate, alkyl- or arylsulfate, hydrogensulfate, i...
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JP4658430B2 |
The present invention relates to compounds of the formula I, in which A, L, Y and k have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithro...
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JP4596793B2 |
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JP4597237B2 |
The invention relates to a process for preparing substituted cyclopentane derivatives represented by the formula (I)wherein R1, R2, R3, R4, X and Y are as described in the specification, and pharmaceutically acceptable salts thereof.The ...
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JP4588951B2 |
Method of producing compounds of formula (I), wherein R1 is hydrogen or C1-C4-alkyl; R2 is hydrogen, C1-C8-alkyl, C3-C6-cycloalkyl, or a radical -N(R3)R4; or R2 and R6 together are -CH2-CH2-S-; R3 and R4 are hydrogen, C1-C4-alkyl, C3-C6-...
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JP4573006B2 |
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JP4567889B2 |
The invention to a pharmaceutical composition comprising as active principle a compound of general formula (I), in which R1, R2, R3, and A are as defined in claim 1. These compositions can be used in the treatment of pathologies associat...
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JP4564786B2 |
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JP4545911B2 |
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JP4451058B2 |
This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, their use in treating human or animal disorders. The compounds of the invention are useful as modulators of th...
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JP2009533315A |
What is provided herein is an aromatic compound substitution agent that is a tRNA synthetase inhibitor and thus can be used as an antibacterial agent. The compounds described herein are Gram-positive, Gram-negative, anaerobic or fungal m...
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JP4298098B2 |
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JP4262920B2 |
The invention relates to a process for preparing substituted cyclopentane derivatives represented by the formula (I)wherein R1, R2, R3, R4, X and Y are as described in the specification, and pharmaceutically acceptable salts thereof.The ...
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JP4242366B2 |
Disclosed herein is a method of forming a guanidine group on carbon nanotubes to improve the dispersibility of carbon nanotubes, a method of attaching carbon nanotubes having guanidine groups to a substrate, and carbon nanotubes and a su...
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JP4236578B2 |
A simple and economical process for the preparation of polyphosphates of organic bases consists of reacting a mixture of phosphorus pentoxide and at least one organic nitrogen base with at least one compound which releases water accompan...
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JP2008303216A |
To provide a method for producing an intermediate for a bis-platinum (II) complex.The method for producing a polymethylene derivative of chemical formula (III) comprises a step of protecting the nitrogen atom of an -amino acid with a ter...
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JP2008273948A |
To provide inhibition of viruses (especially influenza virus), especially, inhibition of glycolytic enzymes such as neuraminidase, and, especially, viral or bacterial neuraminidase inhibitors, to provide a method for synthesizing the inh...
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JP4177466B2 |
Substd. cinnamic acid guanidides of formula (I) and their salts are new: at least one of R1-R5 = XaYbLnU; X = CR16R17, O, S or NR18; a = 0-1; Y = 1-8C alkenyl, 1-8C alkenyl-T, 1-8C alkenyl-T2; T = NR20, O, S or phenyl (opt. substd. by 1-...
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JP4167301B2 |
PCT No. PCT/US97/12552 Sec. 371 Date Oct. 14, 1998 Sec. 102(e) Date Oct. 14, 1998 PCT Filed Jul. 22, 1997 PCT Pub. No. WO98/03518 PCT Pub. Date Jan. 29, 1998Bis-platinum(II) complexes with polymethylene derivatives, the method of making ...
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JP2008189587A |
To provide a method for separating a carbon component, a nitrogen component in a cyanamide form, and a calcium component each contained in nitrolime and co-producing carbon, an aqueous cyanamide solution or dicyandiamide, and calcium car...
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JP2008523118A |
The invention relates to a method for producing onium salts with tetrafluoroborate anion by reacting an onium halide with an oxonium tetrafluoroborate, sulfonium tetrafluoroborate, or triphenylcarbonium tetrafluoroborate.
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JP4105252B2 |
Aqueous solutions of hexasubstituted guanidinium chlorides are prepared from phosgene and secondary amines. The solutions may be employed as sources of hexasubstituted guanidinium salts useful as phase transfer catalysts and the reaction...
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JP4081159B2 |
Phenyl-substituted alkenyl-carboxylic acid guanidide compounds of formula (I) are new. T = a group (i); Ra = H, F, Cl, Br, I , CN, OH, OR6, 1-4C alkyl, Or-(CH2)aCbF2b+1, 3-8C cycloalkyl or NR7R8; r = 0 or 1; a = 0 - 4; b = 1 - 4; R6 = 1-...
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JP4067262B2 |
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JP2008507571A |
Compounds of the formula (I): in which the radicals R and R1 to R10 are as defined in the description, processes for the preparation of them, use thereof for the treatment of cardiovascular diseases, and pharmaceutical compositions compr...
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JP2008502671A |
The invention relates to compounds of formula I, or pharmaceutically acceptable salts thereof, wherein X1, X2 and X3 are each independently where Y is an alkylene, alkenylene or alkynylene group, each of which may be optionally substitut...
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JP4039588B2 |
2-Naphthoyl-guanidines (I) and their salts are new: R1 and R3-R8 = H; F; Cl; Br; I; CN; NO2; CF3; C2F5; VpQqU; XYaWZ; or X'YaWZ' (at least 1 is XYaWZ or X'YaWZ'); V = O; S; SO; SO2; NR60; OCO; CO; CONR60; COO; or CR66R67; Q = 1-8C alkyle...
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JP4010570B2 |
PCT No. PCT/EP98/01428 Sec. 371 Date Sep. 22, 1999 Sec. 102(e) Date Sep. 22, 1999 PCT Filed Mar. 12, 1998 PCT Pub. No. WO98/43951 PCT Pub. Date Oct. 8, 1998The invention relates to a novel process for the preparation of N-alkyl-N'-nitrog...
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JP2007532524A |
A method for the fluoridation of an iodonium salt with a fluoride ion source which can be carried out in an aqueous reaction solvent.
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JP3927810B2 |
The invention relates to biocidal polymers based on guanidine salts characterized in that they are representatives of a number of polyoxyalkylene guanidines and their salts and are a product of a polycondensation of guanidine salts with ...
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JP3927274B2 |
To produce high-quality N-methyl-N'-nitroguanidine usable as an intermediate for a biologically active compound at a low reaction temperature without using an auxiliary in high yield. Nitroguanidine of formula I is reacted with an aqueou...
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JP3924018B2 |
To obtain the subject compound having an extremely good antiarrhythmic action, not having an undesired salt-excreting action and useful for treating arrhythmia, cardiac infarction, stenocardia, etc., by reacting a specific compound with ...
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JP3890543B2 |
To provide an industrially excellent method for producing guanidines by reacting dicyclohexylcarbodiimide with anilines when producing the guanidines. A Lewis acid is used as a catalyst when reacting dicyclocarbodiimide with anilines and...
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JP2007502883A |
Disclosed is a method for producing a polyalkylene biguanidine salt, which can obtain various polyalkylene biguanidine salts without the need for a high-viscosity reactor and a toxic solvent. The production method involves polymerizing a...
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JP3854865B2 |
The invention concerns a method for making aminoguanidine bicarbonate from an aqueous solution of cyanamide and an aqueous solution of hydrazine in the presence of CO2. The invention is characterised in that it consists in proceeding wit...
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JP2006525247A |
The invention relates to a process for the crystallization of the compounds of the formula (I) or acid-addition salts thereof, in which R1, R2 and R3 have the meaning indicated in Claim 1.
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JP3836425B2 |
A synthesis method which comprises reacting NH group-containing compounds with thiocyanates, cyanamides, nitriles or esters in the presence of a silylating agent to synthesize the corresponding nitrogen-containing addition or substitutio...
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JP3828597B2 |
To prepare the subject compound useful for the treatment or prophylaxis of cardiac infarct, angina pectoris, arrhythmia, ischemic conditions, apoplexy, shock states, atherosclerosis, late diabetic complications, carcinoses, fibrotic dise...
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JP3827712B2 |
PCT No. PCT/EP94/01008 Sec. 371 Date Dec. 27, 1995 Sec. 102(e) Date Dec. 27, 1995 PCT Filed Mar. 30, 1994 PCT Pub. No. WO94/22807 PCT Pub. Date Oct. 13, 1994A compound having the formula or a pharmaceutically acceptable salt thereof, whe...
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JP2006521373A |
The invention relates to a process for the preparation of an alpha-amino carbonyl compound by reacting an imine starting material with a suitable electrophile in the presence of a base. This process has the advantage that the imine start...
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JP3806431B2 |
To provide a substituted benzoylguanidine compound useful for treating cardiovascular diseases, such as arrhythmia, and other diseases. The compound is a substituted benzoylguanidine represented by formula I [wherein, R(1) and R(2) are H...
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JP3802582B2 |
PURPOSE: To obtain the subject new compounds extremely suitable as an antiarrhythmic formulation having a cardioprotective component for prevention of infarction, treatment of infarction and treatment of angina pectoris. CONSTITUTION: Th...
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JP3796481B2 |
To provide a polymorphism of nafamostat mesilate useful as a drug. The polymorphism of nafamostat mesilate shows strong diffraction peaks at 17.0, 18.4, 19.3, 19.9, 20.9, 24.3, and 26.3°in the diffraction angle (2θ±0.1°) in the powde...
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JP3790557B2 |
PURPOSE: To obtain diacyl-substituted guanidine which inhibits Na+/H+ exchange in cells and therefore is used as a therapeutic agent for any acute or chronic lesion induced by ischemia or disease induced thereby. CONSTITUTION: A novel co...
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JP3775730B2 |
To provide an intermediate compound for producing a diacyl- substituted guanidine useful as a Na+/H+ exchange inhibitor. This intermediate compound is a compound of the formula III [wherein, X(2) is a group as shown in the formula (a)]. ...
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JP3732873B2 |
To obtain the subject novel compound having good heat protecting and antiarrhythmic actions, and useful for treatment and prevention of arrhythmia, angina pectoris and infarction. This compound is an alkylbenzoylguanidine compound shown ...
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JP3720709B2 |
A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.
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JP3718240B2 |
PURPOSE: To provide a novel compd. which is obtd. by the reaction of a benzoic acid deriv. activated matter and guanidine, has the action to suppress a cell Na+/H+ exchange function and is used as a cardiac disease therapeutic agent for ...
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JP3718250B2 |
PURPOSE: To provide a novel phenyl-substd. alkylcarboguanidide having a perfluoroalkyl group suppressing an Na+/H+ exchange mechanism of cells and effective against all of diseases developed by ischemia. CONSTITUTION: This compd. is repr...
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