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Matches 251 - 300 out of 506

Document Document Title
JP4755211B2
Aqueous solutions of hexasubstituted guanidinium chlorides are prepared from phosgene and secondary amines. The solutions may be employed as sources of hexasubstituted guanidinium salts useful as phase transfer catalysts and the reaction...  
JP4700880B2
The present invention relates to a novel process for the preparation of N-methyl-N'-nitroguanidine by reacting nitroguanidine with aqueous methylamine solution buffered by the addition of inorganic or organic acids.  
JP4690345B2
The present invention relates to a two-step process for the preparation of guanidinium salts of the formula (1), where the substituents R have a meaning indicated in Claim, and A- is a sulfonate, alkyl- or arylsulfate, hydrogensulfate, i...  
JP4658430B2
The present invention relates to compounds of the formula I, in which A, L, Y and k have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithro...  
JP4596793B2  
JP4597237B2
The invention relates to a process for preparing substituted cyclopentane derivatives represented by the formula (I)wherein R1, R2, R3, R4, X and Y are as described in the specification, and pharmaceutically acceptable salts thereof.The ...  
JP4588951B2
Method of producing compounds of formula (I), wherein R1 is hydrogen or C1-C4-alkyl; R2 is hydrogen, C1-C8-alkyl, C3-C6-cycloalkyl, or a radical -N(R3)R4; or R2 and R6 together are -CH2-CH2-S-; R3 and R4 are hydrogen, C1-C4-alkyl, C3-C6-...  
JP4573006B2  
JP4567889B2
The invention to a pharmaceutical composition comprising as active principle a compound of general formula (I), in which R1, R2, R3, and A are as defined in claim 1. These compositions can be used in the treatment of pathologies associat...  
JP4564786B2  
JP4545911B2  
JP4451058B2
This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, their use in treating human or animal disorders. The compounds of the invention are useful as modulators of th...  
JP2009533315A
What is provided herein is an aromatic compound substitution agent that is a tRNA synthetase inhibitor and thus can be used as an antibacterial agent. The compounds described herein are Gram-positive, Gram-negative, anaerobic or fungal m...  
JP4298098B2  
JP4262920B2
The invention relates to a process for preparing substituted cyclopentane derivatives represented by the formula (I)wherein R1, R2, R3, R4, X and Y are as described in the specification, and pharmaceutically acceptable salts thereof.The ...  
JP4242366B2
Disclosed herein is a method of forming a guanidine group on carbon nanotubes to improve the dispersibility of carbon nanotubes, a method of attaching carbon nanotubes having guanidine groups to a substrate, and carbon nanotubes and a su...  
JP4236578B2
A simple and economical process for the preparation of polyphosphates of organic bases consists of reacting a mixture of phosphorus pentoxide and at least one organic nitrogen base with at least one compound which releases water accompan...  
JP2008303216A
To provide a method for producing an intermediate for a bis-platinum (II) complex.The method for producing a polymethylene derivative of chemical formula (III) comprises a step of protecting the nitrogen atom of an -amino acid with a ter...  
JP2008273948A
To provide inhibition of viruses (especially influenza virus), especially, inhibition of glycolytic enzymes such as neuraminidase, and, especially, viral or bacterial neuraminidase inhibitors, to provide a method for synthesizing the inh...  
JP4177466B2
Substd. cinnamic acid guanidides of formula (I) and their salts are new: at least one of R1-R5 = XaYbLnU; X = CR16R17, O, S or NR18; a = 0-1; Y = 1-8C alkenyl, 1-8C alkenyl-T, 1-8C alkenyl-T2; T = NR20, O, S or phenyl (opt. substd. by 1-...  
JP4167301B2
PCT No. PCT/US97/12552 Sec. 371 Date Oct. 14, 1998 Sec. 102(e) Date Oct. 14, 1998 PCT Filed Jul. 22, 1997 PCT Pub. No. WO98/03518 PCT Pub. Date Jan. 29, 1998Bis-platinum(II) complexes with polymethylene derivatives, the method of making ...  
JP2008189587A
To provide a method for separating a carbon component, a nitrogen component in a cyanamide form, and a calcium component each contained in nitrolime and co-producing carbon, an aqueous cyanamide solution or dicyandiamide, and calcium car...  
JP2008523118A
The invention relates to a method for producing onium salts with tetrafluoroborate anion by reacting an onium halide with an oxonium tetrafluoroborate, sulfonium tetrafluoroborate, or triphenylcarbonium tetrafluoroborate.  
JP4105252B2
Aqueous solutions of hexasubstituted guanidinium chlorides are prepared from phosgene and secondary amines. The solutions may be employed as sources of hexasubstituted guanidinium salts useful as phase transfer catalysts and the reaction...  
JP4081159B2
Phenyl-substituted alkenyl-carboxylic acid guanidide compounds of formula (I) are new. T = a group (i); Ra = H, F, Cl, Br, I , CN, OH, OR6, 1-4C alkyl, Or-(CH2)aCbF2b+1, 3-8C cycloalkyl or NR7R8; r = 0 or 1; a = 0 - 4; b = 1 - 4; R6 = 1-...  
JP4067262B2  
JP2008507571A
Compounds of the formula (I): in which the radicals R and R1 to R10 are as defined in the description, processes for the preparation of them, use thereof for the treatment of cardiovascular diseases, and pharmaceutical compositions compr...  
JP2008502671A
The invention relates to compounds of formula I, or pharmaceutically acceptable salts thereof, wherein X1, X2 and X3 are each independently where Y is an alkylene, alkenylene or alkynylene group, each of which may be optionally substitut...  
JP4039588B2
2-Naphthoyl-guanidines (I) and their salts are new: R1 and R3-R8 = H; F; Cl; Br; I; CN; NO2; CF3; C2F5; VpQqU; XYaWZ; or X'YaWZ' (at least 1 is XYaWZ or X'YaWZ'); V = O; S; SO; SO2; NR60; OCO; CO; CONR60; COO; or CR66R67; Q = 1-8C alkyle...  
JP4010570B2
PCT No. PCT/EP98/01428 Sec. 371 Date Sep. 22, 1999 Sec. 102(e) Date Sep. 22, 1999 PCT Filed Mar. 12, 1998 PCT Pub. No. WO98/43951 PCT Pub. Date Oct. 8, 1998The invention relates to a novel process for the preparation of N-alkyl-N'-nitrog...  
JP2007532524A
A method for the fluoridation of an iodonium salt with a fluoride ion source which can be carried out in an aqueous reaction solvent.  
JP3927810B2
The invention relates to biocidal polymers based on guanidine salts characterized in that they are representatives of a number of polyoxyalkylene guanidines and their salts and are a product of a polycondensation of guanidine salts with ...  
JP3927274B2
To produce high-quality N-methyl-N'-nitroguanidine usable as an intermediate for a biologically active compound at a low reaction temperature without using an auxiliary in high yield. Nitroguanidine of formula I is reacted with an aqueou...  
JP3924018B2
To obtain the subject compound having an extremely good antiarrhythmic action, not having an undesired salt-excreting action and useful for treating arrhythmia, cardiac infarction, stenocardia, etc., by reacting a specific compound with ...  
JP3890543B2
To provide an industrially excellent method for producing guanidines by reacting dicyclohexylcarbodiimide with anilines when producing the guanidines. A Lewis acid is used as a catalyst when reacting dicyclocarbodiimide with anilines and...  
JP2007502883A
Disclosed is a method for producing a polyalkylene biguanidine salt, which can obtain various polyalkylene biguanidine salts without the need for a high-viscosity reactor and a toxic solvent. The production method involves polymerizing a...  
JP3854865B2
The invention concerns a method for making aminoguanidine bicarbonate from an aqueous solution of cyanamide and an aqueous solution of hydrazine in the presence of CO2. The invention is characterised in that it consists in proceeding wit...  
JP2006525247A
The invention relates to a process for the crystallization of the compounds of the formula (I) or acid-addition salts thereof, in which R1, R2 and R3 have the meaning indicated in Claim 1.  
JP3836425B2
A synthesis method which comprises reacting NH group-containing compounds with thiocyanates, cyanamides, nitriles or esters in the presence of a silylating agent to synthesize the corresponding nitrogen-containing addition or substitutio...  
JP3828597B2
To prepare the subject compound useful for the treatment or prophylaxis of cardiac infarct, angina pectoris, arrhythmia, ischemic conditions, apoplexy, shock states, atherosclerosis, late diabetic complications, carcinoses, fibrotic dise...  
JP3827712B2
PCT No. PCT/EP94/01008 Sec. 371 Date Dec. 27, 1995 Sec. 102(e) Date Dec. 27, 1995 PCT Filed Mar. 30, 1994 PCT Pub. No. WO94/22807 PCT Pub. Date Oct. 13, 1994A compound having the formula or a pharmaceutically acceptable salt thereof, whe...  
JP2006521373A
The invention relates to a process for the preparation of an alpha-amino carbonyl compound by reacting an imine starting material with a suitable electrophile in the presence of a base. This process has the advantage that the imine start...  
JP3806431B2
To provide a substituted benzoylguanidine compound useful for treating cardiovascular diseases, such as arrhythmia, and other diseases. The compound is a substituted benzoylguanidine represented by formula I [wherein, R(1) and R(2) are H...  
JP3802582B2
PURPOSE: To obtain the subject new compounds extremely suitable as an antiarrhythmic formulation having a cardioprotective component for prevention of infarction, treatment of infarction and treatment of angina pectoris. CONSTITUTION: Th...  
JP3796481B2
To provide a polymorphism of nafamostat mesilate useful as a drug. The polymorphism of nafamostat mesilate shows strong diffraction peaks at 17.0, 18.4, 19.3, 19.9, 20.9, 24.3, and 26.3°in the diffraction angle (2θ±0.1°) in the powde...  
JP3790557B2
PURPOSE: To obtain diacyl-substituted guanidine which inhibits Na+/H+ exchange in cells and therefore is used as a therapeutic agent for any acute or chronic lesion induced by ischemia or disease induced thereby. CONSTITUTION: A novel co...  
JP3775730B2
To provide an intermediate compound for producing a diacyl- substituted guanidine useful as a Na+/H+ exchange inhibitor. This intermediate compound is a compound of the formula III [wherein, X(2) is a group as shown in the formula (a)]. ...  
JP3732873B2
To obtain the subject novel compound having good heat protecting and antiarrhythmic actions, and useful for treatment and prevention of arrhythmia, angina pectoris and infarction. This compound is an alkylbenzoylguanidine compound shown ...  
JP3720709B2
A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.  
JP3718240B2
PURPOSE: To provide a novel compd. which is obtd. by the reaction of a benzoic acid deriv. activated matter and guanidine, has the action to suppress a cell Na+/H+ exchange function and is used as a cardiac disease therapeutic agent for ...  

Matches 251 - 300 out of 506