Heterocyclic Compounds

Matches 1,551 - 1,600 out of 4,425	< 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 >

Document	Document Title
JP2023552793A	4-(2-fluoro-4-methoxy-5-3-(((1-methylcyclobutyl)methyl)carbamoyl)bicyclo[2.2.1]h eptan-2-yl as an RXFP1 modulator for the treatment of heart failure )carbamoyl)phenoxy)-1-methylcyclohexane-1-carboxylic acid derivatives and similar compounds The present invention provides RXFP1 modulators for the treatment of heart failure, heart failure with preserved ejection fraction, heart failure with mildly reduced ejection fraction, heart failure with reduced ejection fraction, chroni...
JP2023179445A	INHIBITORS OF DIHYDROCERAMIDE DESATURASE FOR TREATING DISEASE To provide new dihydroceramide desaturase (Des) inhibitor compounds and compositions, and their application as pharmaceuticals for the treatment of disease.For example, the following compound is illustrated.SELECTED DRAWING: None
JP2023179389A	PHARMACEUTICAL COMPOSITION To provide a compound for treating and preventing diseases and conditions including heart failure, heart failure with a maintained ejection fraction, heart failure with a mildly reduced ejection fraction, heart failure with a reduced eje...
JP2023550751A	Novel compounds and organic light-emitting devices containing them [summary] The present invention provides a novel compound and an organic light emitting device containing the same.
JP2023550831A	Phthalazine derivatives as P2X3 inhibitors The present invention relates to compounds of formula I that inhibit P2X purinergic receptor 3; in particular the present invention relates to compounds that are phthalazine derivatives, processes for the preparation of such compounds, p...
JP2023550830A	(Aza)quinoline 4-amine derivatives as P2X3 inhibitors The present invention relates to compounds of formula I that inhibit P2X purinergic receptor 3; in particular the invention relates to compounds that are (aza)quinoline 4-amine derivatives, processes for the preparation of such compounds...
JP7389786B2	Modulators of the integrative stress pathway Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
JP7387818B2	Molecules with pesticidal action, intermediates, compositions and methods related thereto This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions con...
JP2023548947A	Benzylamine or benzyl alcohol derivatives and their uses The present invention discloses compounds and their uses as sodium channel modulators, and compounds of this type have pronounced inhibitory and blocking effects on the activity of voltage-gated sodium ion channel subtype Nav1.8 ion chan...
JP2023547770A	Compounds and compositions as modulators of TLR signaling The present disclosure provides compounds, pharmaceutical compositions comprising such compounds, and methods or treatments for the treatment of inflammatory diseases and certain neurological disorders associated with inflammatory signal...
JP7379374B2	heterocyclic compound The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity.A compound represented by the formula (I):wherein each symbol is as described in the description, or a salt thereof has an orexin ty...
JP2023547381A	Process for preparing 6-(4-nitro-phenoxy)-2H-pyridazin-3-one and 6-(4-amino-phenoxy)-2H-pyridazin-3-one derivatives as intermediates for thyroid hormone analogs The present disclosure describes a method for preparing pyridazinone derivatives, the method comprising contacting a compound of formula (I) or a salt thereof: (I) with a compound of formula (II) or a salt thereof: (II). , a compound of ...
JP7375019B2	Novel hydrazone derivatives whose terminal amine groups are substituted with aryl or heteroaryl groups and their uses The present invention relates to novel hydrazone derivatives in which a terminal amine group is substituted with an aryl group or a heteroaryl group, and uses thereof.
JP7369139B2	Trisubstituted aryl and heteroaryl derivatives as regulators of PI3 kinase and autophagy pathway The present disclosure relates to tri-substituted aryl and heteroaryl derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for modulating autophagy or preventing, reversing, slowing or in...
JP7368365B2	P300/CBP HAT inhibitors and methods of their use Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with histone acetyltransferase (HAT).
JP2023542843A	Compounds and organic light-emitting devices containing them The present specification relates to a compound represented by Chemical Formula 1 and an organic light-emitting device containing the same.
JP2023145722A	MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS AND PROCESSES RELATED THERETO To provide molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and pr...
JP7357135B2	Pyridazinone compounds and their uses Substituted pyridazinone compounds, conjugates, and pharmaceutical compositions for use in the treatment of neuromuscular diseases, such as Duchenne Muscular Dystrophy (DMD), are disclosed herein. The disclosed compounds are useful, amon...
JP2023542231A	new compound The present invention relates to novel compounds for use as inhibitors of NLRP3 inflammasome production, such compounds being as defined by compounds of formula (I), with the integer R1,R2and R3is defined herein and the compounds may be ...
JP7352565B2	Small molecule modulators of pantothenate kinase The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associ...
JP2023134482A	METHODS AND REAGENTS FOR ANALYZING PROTEIN-PROTEIN INTERFACES To provide methods and reagents useful for analyzing interfaces between target proteins.The present disclosure provides methods and reagents useful for analyzing protein-protein interfaces, such as interfaces between a presenter protein ...
JP2023539526A	Agonist of interferon gene stimulator STING Disclosed herein are compounds represented by formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. The compounds are useful as agonists of stimulator of interferon genes (STING), eg, in methods...
JP2023539451A	Preparation process of pyridazinone derivatives The invention inter alia provides a process for producing compounds of formula (I), wherein the substituents are as defined in claim 1. The invention further provides intermediate compounds used in the process and methods of producing th...
JP2023538304A	Compounds, compositions and methods This disclosure generally describes small molecule modulators of the NLR family pyrin domain containing 3 (NLRP3) or pharmaceutically acceptable salts, isotopically enriched analogs, stereoisomers, mixtures of stereoisomers or prodrugs t...
JP2023538022A	Preparation Process of Quaternized Pyridazine Derivatives The present invention relates inter alia to compounds of formula (I) wherein the substituents are as defined in claim 1. The invention further provides intermediate compounds utilized in said process and methods for producing said interm...
JP7337790B2	Modulators of integrated stress pathways Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
JP7335241B2	Modulators of integrated stress pathways Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
JP7331067B2	Crystal form of 5-amino-2,3-dihydrophthalazine-1,4-dione A new crystalline form of 5-amino-2,3-dihydro-1,4-phthalazinedione (luminol) is provided. Advantageous uses for this crystalline form as a detecting agent or as an agent for forensic purposes are disclosed, as well a pharmaceutical compo...
JP2023535957A	substituted haloalkylsulfonanilide herbicides Disclosed are compounds of Formula 1, stereoisomers, N-oxides, and salts thereof, [Chemical 1] where G is CONR5R.6or [Chemical 2] is selected from R.1~R18, Rfand G are as defined in this disclosure. Also disclosed is a composition contai...
JP2023116627A	SELECTIVE INHIBITORS OF NLRP3 INFLAMMASOME To provide compounds, pharmaceutical compositions and methods of use that are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes, and useful in treatment of disorders in which inflammasome ac...
JP2023533496A	Use of N-phenylacetamide with P2X4 receptor antagonist activity to treat certain eye diseases [Chemical 1] P2X4 antagonists for the treatment of dry eye syndrome, more particularly for use in the treatment or prevention of dry eye syndrome, particularly dry eye, ocular neuropathic pain, ocular trauma and post-operative eye pain, ...
JP2023533388A	Inhibitor of YAP/TAZ-TEAD oncoprotein, its synthesis and use Disclosed herein are for the treatment of cancers such as glioblastoma, gastric cancer, colorectal cancer, pancreatic ductal adenocarcinoma (PDAC), and malignant pleural mesothelioma (MPM) Synthesis and use of covalent inhibitors that ar...
JP2023532298A	Compounds, compositions and methods The present disclosure generally provides small molecule modulators of NLR family pyrin domain-containing 3 (NLRP3) or pharmaceutically acceptable salts, isotopically enriched analogs, stereoisomers, mixtures of stereoisomers or prodrugs...
JP7313492B2	Quinoline and cinnoline derivatives as DNA-PK inhibitors Disclosed in the present invention are a compound as represented by formula (I), and an isomer or pharmaceutically acceptable salt thereof, and disclosed is an application thereof in preparing drugs for treating DNA-PK inhibitor-related ...
JP2023531283A	Substituted N-phenylacetamides with P2X4 receptor antagonism Substituted N-phenylacetamide compounds of general formula (I), processes for preparing said compounds, intermediate compounds useful in preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, an...
JP2023100613A	COMPOUND LIBRARY To provide a compound library having structural diversity, and a method of producing the same and a screening method.A library includes a compound of 1×102-1×108. The compound includes a structure of (first CB)-(first L)-(second CB), i...
JP2023530761A	Process for producing 1,4-disubstituted pyridazine compounds The present invention provides 1,4-disubstituted pyridazine compounds such as 5-(1H-pyrazol-4-yl)-2-(6-((2,2,6,6-tetramethylpiperidin-4-yl ) New processes, new process steps, and new intermediates useful for the preparation of oxy)pyrida...
JP2023530708A	thyroid mimetic The compounds provided herein function as thyroid mimetic agents and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, a...
JP2023530343A	Carbonohydrazonoyl dicyanide compound containing at least two aryl or heteroaryl linked by novel linker and use thereof The present invention relates to carbonohydrazonoyl dicyanide compounds containing at least two aryl or heteroaryl linked via a novel linker and uses thereof.
JP2023530231A	Transcriptional enhancing associated domain (TEAD) inhibitor and use thereof Provided herein are compounds of Formula (I''), Formula (I'), Formula (I), Formula (II'), and Formula (II), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labele...
JP2023530314A	Novel oxopyridazinyl-phenyl-carbonohydrazonoyl dicyanide compound and use thereof The present invention relates to novel oxopyridazinyl-phenyl-carbonohydrazonoyl dicyanide compounds and uses thereof.
JP2023529475A	Azabicyclyl-substituted heterocycles as novel fungicides The present disclosure provides formula (I): [Chemical 1] (In the formula, A1, A2, m, R3, R4, R5, L, R6, T, ring Y, p, R7, and Q have the meanings defined herein), compositions comprising such compounds, processes and intermediates for t...
JP2023529294A	Azabicyclic (thio)amides as fungicidal compounds The present invention relates to azabicyclic (thio)amide compounds and their use for controlling phytopathogenic microorganisms such as phytopathogenic fungi. It also relates to processes and intermediates for preparing these compounds.
JP2023529022A	Compounds for the treatment of coronavirus infections This application relates to the use of phthalazinediones in the prevention or treatment of coronavirus infections. Pharmaceutical compositions, combinations and advantageous formulation techniques are disclosed.
JP7301758B2	Fused bicyclic compounds, compositions and applications thereof Fused bicyclic compounds are inhibitors of GPR91. The compounds, their stereoisomers, tautomers, prodrugs, polymorphs, solvates, pharmaceutically acceptable salts, and pharmaceutical compositions containing them are useful in the treatme...
JP7301861B2	Inhibitor of TRPC6 The present invention relates to polycyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 to R4, R7 to R10, Y and A are as defined herein. The invention also relates to pharmaceutical compositions com...
JP2023527498A	STAT inhibiting compounds and compositions Provided herein are compounds useful for inhibiting signaling and activators of transcription 5a and 5b (STAT5), and pharmaceutical compositions comprising the compounds. Additionally, the compounds and compositions are useful for treati...
JP2023527379A	Substituted benzamides as modulators of TREX1 Provided are compounds of formula (I): (I), and pharmaceutically acceptable salts and compositions thereof, that are useful for the treatment of various conditions associated with TREX1.
JP2023527010A	Compound The present invention relates to novel compounds for use as inhibitors of NLRP3 inflammasome production, such compounds as defined by the compounds of formula (I) [Chemical 1] and the integer R1, R2and R3is defined herein and the compoun...
JP2023526247A	Pyridazinone compounds for the treatment of neuromuscular diseases Disclosed herein are substituted pyridazinone compounds, conjugates, and pharmaceutical compositions for use in treating neuromuscular diseases such as Duchenne muscular dystrophy (DMD). The disclosed compounds are useful, inter alia, fo...

Matches 1,551 - 1,600 out of 4,425	< 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 >