Heterocyclic Compounds

Matches 1,301 - 1,350 out of 4,419	< 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 >

Document	Document Title
WO/1997/002023A1	USE OF Stat 6 SH2 DOMAIN SPECIFIC COMPOUNDS TO TREAT ALLERGIC REACTIONS Invented is a method of treating allergic reactions in a subject which comprises administering to the subject a therapectically effective amount of a compound which binds to a human Stat 6 SH2 domain with a binding affinity greater than ...
WO/1997/001537A1	SUBSTITUTED N-METHYLENETHIOUREAS AS PESTICIDES The invention pertains to new substituted N-methylenethioureas of general formula (I), wherein n, Het, R1 and R2 are as designated in the description, to a method for preparing them and to their use in pesticides, in particular as insect...
WO/1997/001530A1	O-BENZYL OXIME ETHER DERIVATIVES AND THEIR USE IN CROP PROTECTION COMPOSITIONS Oxime ethers of formula (I) in which a) X is an N atom and Y is an oxygen atom or NH, or b) X is CH and Y is an oxygen atom, in which furthermore R1 is C1-C4alkyl; R2 is hydrogen, C1-C4alkyl or cyclopropyl; and in which R3 and R4 are as ...
WO/1997/000863A1	AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM The invention relates to compounds of formula (I), wherein A is an optionally substituted ring system, provided that the -CH(R3)N(R2)B-R1 and -OR4 groups are positioned in a 1,2 relationship to one another on ring carbon atoms and the ri...
WO/1997/000864A1	AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM The invention relates to compounds of formula (I), wherein A is an optionally substituted, ring system provided that the -CH(R3)N(R2)B-R1 and -OD groups are positioned in a 1,2 relationship to one another on ring carbon atoms and the rin...
WO/1996/040165A1	METHODS OF REDUCING TOXICITY OF CHEMOTHERAPEUTIC AND ANTIVIRAL AGENTS WITH ACYLATED PYRIMIDINE NUCLEOSIDES The subject invention discloses compounds, compositions and methods for treatment and prevention of toxicity due to chemotherapeutic agents and antiviral agents. Disclosed are acylated derivatives of non-methylated pyrimidine nucleosides...
WO/1996/040646A1	DIHYDROPHTHALAZINE ANTAGONISTS OF EXCITATORY AMINO ACID RECEPTORS Substituted dihydrophthalazine compositions are provided which are active as non-NMDA ionotropic excitatory amino acid (EAA) receptor antagonists. The compositions are useful for treating disorders associated with excessive activation of...
WO/1996/040048A2	NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS This invention relates to the use of topically applied thyroid hormones and thyroid hormone-like compounds which are receptor binding ligands, either agonists or antagonists, to improve the appearance of the skin and underlying subcutane...
WO/1996/039392A1	PHENYLPYRIDAZINONES The invention concerns phenylpyridazinones of general formula (I), in which R1, R2, R3, R4, R5 and R6 have the meanings specified in the description. Also disclosed are methods of producing these compounds, their use as herbicides and no...
WO/1996/038439A1	NOVEL POLYMORPHS OF LESOPITRON DICHLOROHYDRATE AND ITS HYDRATED FORMS, PREPARATION METHODS AND COMPOSITIONS CONTAINING THEM The invention relates to the novel polymorphs (I and II) of dichlorohydrate of lesopitron, which are characterized by their X-ray diffractograms and infrared spectra. They are obtained by crystallization of lesopitron dichlorohydrate. It...
WO/1996/036611A1	3,4-DISUBSTITUTED-PHENYLSULPHONAMIDES AND THEIR THERAPEUTIC USE 3,4-Disubstituted-phenylsulphonamides formula (i) have therapeutic utility via TNF or phosphodiesterase inhibition.
WO/1996/036591A1	2-HYDROXYPHENYLALKYLAMINE DERIVATIVES AND MAILLARD REACTION INHIBITORS 2-Hydroxyphenylalkylamine derivatives having the activity of inhibiting Maillard reaction and represented by general formula (I) and pharmacologically acceptable salts thereof: wherein R1, R2, R3 and R4 may be the same or different and e...
WO/1996/034853A1	AZOCOMPOUNDS FOR THE ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION Amyloid binding compounds which are derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized b...
WO/1996/033168A1	BENZYLSULFIDE DERIVATIVE, PROCESS FOR ITS PRODUCTION AND PESTICIDE The present invention presents a benzylsulfide derivative of formula (I) or its salt: wherein R1 is a C1-6 alkyl group, a C1-6 haloalkyl group, a C2-4 alkenyl group, a cyano group, etc., and each of R2 and R3 is a hydrogen atom, a haloge...
WO/1996/033160A1	DIHALOPROPENE COMPOUNDS, INSECTICIDES CONTAINING THEM AS ACTIVE INGREDIENTS, AND INTERMEDIATES FOR THEIR PRODUCTION The present invention provides dihalopropene compounds of general formula (I), wherein R1 is C1-C10 alkyl or the like; L is C(=O)NH or the like; R2, R3 and R4 are independently halogen or the like; R5, R6 and R7 are independently hydroge...
WO/1996/030333A1	BICYCLIC AMINE DERIVATIVES AND THEIR USE AS ANTI-PSYCHOTIC AGENTS Compounds of formula (I), wherein X represents a single bond, O, S or CR9R10 where R9 and R10 each independently represent a hydrogen atom or a C1-4alkyl group; R1a, R1b and R1c each independently represent a substituent selected from: a...
WO/1996/025936A1	2,6-DIARYL PYRIDAZINONES WITH IMMUNOSUPPRESSANT ACTIVITY A class of 2,6-diarylpyridazinones of general structural formula (I) have been identified that exhibit immunosuppressant activity with human T-lymphocytes, and are useful as an immunosuppressant or a pharmaceutically acceptable salt, hyd...
WO/1996/024586A1	NEW DERIVATIVES OF PYRIDINE OR PYRIDAZINE, PROCESS FOR PRODUCTION THEREOF AND MEDICAMENTS CONTAINING THESE COMPOUNDS Compounds of formula (I), in which R1 stands for hydrogen, lower alkyl, lower alkenyl, cycloalkyl, cycloalkenyl, a possibly substituted mono- or bi-cyclic aryl, a possibly substituted hetaryl, a possibly substituted arylalkyl or one of t...
WO/1996/024581A2	NEW DERIVATIVES OF PYRIDIL PIPERAZINE OR PYRIDAZINYL PIPERAZYL, PROCESS FOR PRODUCTION THEREOF AND MEDICAMENTS CONTAINING THESE COMPOUNDS Compounds of formula (I), in which R1 stands for hydrogen, lower alkyl, lower alkenyl, cycloalkyl, cycloalkenyl, a possibly substituted mono-or bi-cyclic aryl, a possibly substituted hetaryl, a possibly substituted aryl alkyl or one of t...
WO/1996/022978A1	SUBSTITUTED PHENYL COMPOUNDS AS ENDOTHELIN ANTAGONISTS Compounds of formula (I) are described, wherein: R1 is CN, CH2CN, CH=CHCN, CHO, or CH=CHCO2H; R2 is aryl lower alkoxy, heteroaryl lower alkoxy, aryl lower alkylthio or heteroaryl lower alkylthio in which each of the aryl and heteroaryl m...
WO/1996/022290A1	COMPOUNDS HAVING EFFECTS ON SEROTONIN-RELATED SYSTEMS A series of hetero-oxy alkanamines are effective pharmaceuticals for the treatment of conditions related to or affected by the reuptake of serotonin and by the serotonin 1A receptor. The compounds are particularly useful for alleviating ...
WO/1996/021656A1	ESTROGEN AGONISTS/ANTAGONISTS Compounds of formula (I) are useful for treating or preventing obesity, breast cancer, osteoporosis, endometriosis, cardiovascular disease and prostatic disease.
WO/1996/016943A1	IMINOOXYBENZYLCROTONIC ACID ESTERS, PROCESS FOR THEIR PREPARATION AND USE THEREOF The invention concerns iminooxybenzylcrotonic acid esters of formula (I) in which the index and the substituents have the following meanings: n is 0, 1, 2, 3 or 4; R is nitro, cyano, halogen, optionally substituted alkyl, alkenyl, alkiny...
WO/1996/015117A1	OPTICALLY ACTIVE COMPOUND (R)-(-)-4,5-Dihydro-5-methyl-6-[4-[(2-propyl-3-oxo-1-cyclohe xenyl)amino]phenyl]-3(2H)-pyridazinone, its crystals, and a process for producing the same. The compound is reduced in the side effects and has such an excellent effect of cont...
WO/1996/015092A1	LIQUID CRYSTAL COMPOUNDS HAVING PERFLUOROETHER TERMINAL PORTIONS Fluorine-containing liquid crystal compounds comprise a fluorocarbon terminal portion having at least one catenary ether oxygen and a hydrocarbon terminal portion, the terminal portions being connected by a central core. The compounds ha...
WO/1996/014278A1	PURIFICATION OF STABLE ORGANIC COMPOUNDS Metal oxidizing agents (such as silver oxide or silver nitrate) are added to a solution of organic chemicals which comprise an unwanted level of organic reducing agents (either aqueous or organic solutions in which the metal oxidizing ag...
WO/1996/013485A1	PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS The invention relates to Pyridopyrimidones, Quinolines and fused N-heterocyclic compounds of formula (I) wherein Z is a group of the formula (a) or (b) in which X1 is N or C-R1, X2 is N or C-R9, X3 is N or C-R2, R1 is lower alkyl, R2 is ...
WO/1996/011902A1	PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS The present invention relates to compounds of formula (I), wherein: A, B and D are various ring systems as defined in the description, R1 is one of a variety of groups as defined in the description, R3 is hydrogen or C1-4 alkyl and Z is ...
WO/1996/006832A1	NOVEL 4-AMINOPYRIDAZINES, METHOD OF PREPARING THEM AND DRUGS CONTAINING THESE COMPOUNDS The invention concerns novel 4-aminopyridazines of general formula, (I), in which R1 means the group R2-SO2-O- or R2-SO2-NR3, wherein R2 means a cycloalkyl group, an unsubstituted or substituted aryl or heteroaryl group, R3 means a hydro...
WO/1996/005820A1	HYPERLIPEMIA REMEDY A hyperlipemia remedy containing an indan derivative represented by general formula (1) or a pharmaceutically acceptable salt thereof as the active ingredient; the use of the above compound for the preparation of a hyperlipemia remedy; a...
WO/1996/005176A1	FUSED PYRIDAZINE COMPOUND A fused pyridazine compound represented by general formula (I) and having the inhibitory effect against cyclic GMP-phosphodiesterase (cGMP-PDE), and a pharmacologically acceptable salt thereof. These compounds are useful as preventives a...
WO/1996/003374A1	THROMBIN INHIBITORS Compounds of the invention have structure (I) for example formula (II). These compounds inhibit thrombin and associated thrombosis.
WO/1996/003380A1	AROMATIC AMINO ETHERS AS PAIN RELIEVING AGENTS The present invention relates to compounds of formula (I), wherein A is an optionally substituted phenyl, naphthyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidyl, thienyl, thiazolyl, oxazolyl, thiadiazolyl having at least two adjacent ring ...
WO/1996/000720A1	ARYL AND HETEROARYL ALKOXYNAPHTHALENE DERIVATIVES Compounds of formula (I) wherein R1, R2, R4, R23, R24, R25 and R26 are defined as in the specification. These compounds are useful psychotherapeutics and are potent serotonin (5-HT1) agonists and antagonists.
WO/1995/033731A1	HYDROXAMIC ACID DERIVATIVES The invention provides hydroxamic acid derivatives of general formula (I) wherein R1 represents 1-7C alkyl; R2 represents a saturated 5-, 6- or 7-membered monocyclic or bridged N-heterocyclic ring which is attached via the N atom and whi...
WO/1995/031439A1	THERAPEUTIC PHENOXYALKYLPYRIDAZINES AND INTERMEDIATES THEREFOR Compounds of formula (A), Z is (B) or (C) wherein: R1 and R2 are each independently chosen from hydrogen, halo, alkyl, alkenyl, alkoxy, hydroxy, hydroxyalkyl, hydroxyhaloalkyl, alkoxyalkyl, alkylthioalkynyl, hydroxyalcoxy, alkylthioalkyl...
WO/1995/031448A1	N-(5-ISOTHIAZOLYL)AMIDE PESTICIDES This invention relates to novel N-(5-isothiazolyl)amide compounds of formula (1, 2, or 3), and compositions useful as nematicides, insecticides, miticides, and plant fungicides. The present invention also provides nematicidal, insecticid...
WO/1995/029892A1	HYDROXAMIC ACID AND AMINO ACID DERIVATIVES AND THEIR USE AS ANTI-ARTHRITIC AGENTS The present invention relates to a class of novel hydroxamic acids and carbocyclic acids and derivatives thereof that inhibit stromelysin, and are therefore useful for the treatment of arthritis. The class of compounds useful in this met...
WO/1995/026957A1	N-HETEROCYCLYL SULPHONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS The invention concerns pharmaceutically useful compounds of formula (I), wherein Q is a naphthyl or biphenyl group; W, X, Y and Z are independently selected from nitrogen and CR2 such that two or three of W, X, Y and Z are nitrogen and t...
WO/1995/026339A1	SALTS OF SUBSTITUTED HETEROAROMATIC NITROGEN COMPOUNDS, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOUNDS CONTAINING SAME Compounds of formula (I), wherein AmO is a substituted 1-pyridylium radical, a substituted 3-thiazolylium radical, a substituted 1-pyridazinylium radical or a substituted 3-imidazolylium radical, and their optically pure or racemic salts...
WO/1995/026357A1	THIONATION PROCESS USING ELEMENTAL PHOSPHORUS AND SULFUR There is disclosed a novel process for preparing products of the reaction of elemental phosphorus and elemental sulfur under reaction conditions wherein the phosphorus and sulfur are combined in a pre-mix at temperatures below the reacti...
WO/1995/025710A1	ELECTROPHILIC SUBSTITUTION OF TRIPHENYLENE-BASED DISCOTIC LIQUID CRYSTALS A triphenylene such as hexa-'beta'-substituted hexyloxytriphenylene is 'alpha'-substituted by an electrophile in mixed polar cosolvents according to the reaction scheme (a).
WO/1995/024403A1	(4,4-DIFLUOROBUT-3-ENYLTHIO)-SUBSTITUTED HETEROCYCLIC OR CARBOCYCLIC RING COMPOUNDS HAVING PESTICIDAL ACTIVITY A compound of formula (I), or a salt thereof, wherein n is 0, 1 or 2; and R is a group of formulae (II) to (XXI), wherein: the S(O)nCH2CH2CH=CF2 group is at least one of R1 (when attached to a carbon atom), R2, R3, R4, R5 or R6; R1 (when...
WO/1995/024393A1	NAPHTHALENE DERIVATIVES AS PROSTAGLANDIN I2 AGONISTS A compound of formula (I) wherein, R1 is carboxy or protected carboxy; R2 is hydrogen, hydroxy or protected hydroxy; R3 is hydrogen, hydroxy, protected hydroxy, etc.; R4 is hydrogen or halogen; A1 is lower alkylene; A2 is bond or lower a...
WO/1995/022520A1	SUBSTITUTED BIPHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS A compound of structure (I), wherein, when R8 = H: R1 = alkyl, cycloalkyl, arylalkyl, aryl; R2 = cycloalkyl, aryl, C3-C10 alkyl; X, Y = O, S(O)n, NH; Z = CH2OH, NHSO2R3, CHO, CO2R3, CONHR4R5, CN, COR6, H, halo, NHCN, NHCONR4R5, CONR4OR5,...
WO/1995/021828A1	PROCESS FOR PRODUCING HEXAHYDROPYRIDAZINE AND HEXAHYDROPYRIDAZINE-1,2-DICARBOXYLATE DERIVATIVE A process for producing a hexahydropyridazine-1,2-dicarboxylate derivative represented by general formula (3) (wherein R1 and R2 represent each independently alkyl) by reacting a hydrazinedicarboxylate derivative represented by the gener...
WO/1995/021153A1	PHENYL ACETIC ACID DERIVATIVES, PROCESS AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION AND AGENTS CONTAINING THEM Phenyl acetic acid derivatives of formula (I) in which the components and index have the following meanings: X is NOCH3, CHOCH3 CHCH3 and CHCH2CH3; R1 is hydrogen and alkyl; R2 is cyano, nitro, trifluoro methyl, halogen, alkyl and alkoxy...
WO/1995/021154A2	PHENYL ACETIC ACID DERIVATIVES, PROCESS AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION AND AGENTS CONTAINING THEM Phenyl acetic acid derivatives of formula (I) in which the substituents and index have the following meanings: X is oxygen or sulphur; R is hydrogen and alkyl; R1 is hydrogen and alkyl; R2 is cyano, nitro, trifluoromethyl, halogen, alkyl...
WO/1995/021174A1	PHENYLIMINO-THIADIAZABICYCLOALKANE DERIVATIVES, PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES Compounds of formula (I): wherein R is C1-C6alkyl, C1-C6haloalkyl, C3-C6alkenyl, C3-C6alkynyl, C1-C4alkoxy or C3-C6cycloalkyl; R1 is halogen; R2 and R3 are each independently of the other C1-C4alkyl; R4 is halogen or a group of the formu...
WO/1995/019969A1	PYRIDAZINONE DERIVATIVE A pyridazinone derivative represented by general formula (I) and an antithrombocytic agent containing the same, wherein R represents hydrogen or C1-C4 alkyl; X represents hydrogen, chlorine or bromine; An represents pyridyl or phenyl sub...

Matches 1,301 - 1,350 out of 4,419	< 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 >