Heterocyclic Compounds

Matches 1,351 - 1,400 out of 4,419	< 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 >

Document	Document Title
WO/1995/017402A1	NEW PYRIDAZINO[4',5':3,4]PYRROLO-[2,1-A]ISOQUINOLINES AND THEIR USE FOR PREPARING PHARMACEUTICAL COMPOSITIONS New pyridazino[4',5':3,4]pyrrolo-[2,1-a]isoquinolines have formula (I), in which X stands for O, S or NHO. These new compounds have precious therapeutic properties. They are useful as heart and brain protective agents, as therapeutic age...
WO/1995/012584A1	NOVEL BENZOYL GUANIDINES, THEIR PRODUCTION AND THEIR USE IN MEDICAMENTS The novel compounds of formula (I), which is explained in the description, can be conventionally produced and used as medical substances.
WO/1995/011244A1	PYRIDAZINO QUINOLINE COMPOUNDS The present invention relates to compounds, pharmaceutical compositions and methods of using compounds of formula (I) in the treatment and/or prevention of certain diseases or conditions. In formula (I), A is chosen from ortho substitute...
WO/1995/011242A1	PHENYL OR HETEROARYL AND TETRAHYDRONAPHTHYL SUBSTITUTED DIENE COMPOUNDS HAVING RETINOID LIKE BIOLOGICAL ACTIVITY Compounds of formula (I), wherein m is 1-4; R1-R4 independently are hydrogen, lower alkyl of 1 to 6 carbons, Cl, Br, or I; R5 is hydrogen, lower alkyl of 1 to 6 carbons, Cl, Br, I, lower alkoxy or lower thioalkoxy of 1-6 carbons; R6 is h...
WO/1995/009842A1	ISOQUINOLINONE-, PHTHALAZINONE-, QUINAZOLINONE- AND BENZOTRIAZOLINONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTI-THROMBOTICS The invention relates to heterocyclic carbamates of formula (I) in which X denotes a nitrogen atom or the group CR4 and Y denotes a nitrogen atom or the group CR5, where R2 and R3 independently of one another stand for radicals of the fo...
WO/1995/007269A1	POLAR-SUBSTITUTED HYDROCARBONS The invention relates to retroviral protease inhibitors of the general formula (I): W-(A)n-B-(A)m-V where W, A, B, A, V, n and m are as defined herein, including related prodrugs of general formula (I) comprising a solubilising group w...
WO/1995/007264A1	PYRIDAZINONE DERIVATIVES OR THEIR SALTS, PROCESSES FOR THEIR PRODUCTION, AND ANTI-SHOCK AGENTS CONTAINING THEM A pyridazinone derivative of formula (I) or a pharmaceutically acceptable salt thereof, wherein Q is -CH2- or -CO-, A is a furanyl group which may be substituted, a thienyl group which may be substituted, a pyridyl group which may be sub...
WO/1995/006034A1	COMPOUNDS AND METHODS FOR INHIBITION OF HIV AND RELATED VIRUSES The present invention is directed to compounds, compositions and methods of inhibiting and treating HIV and related viruses, and methods for cocrystallizing reverse transcriptase in vitro, inhibition of the replication of HIV and related...
WO/1995/005366A1	VASOCONSTRICTIVE SUBSTITUTED ARYLOXYALKYL DIAMINES The present invention is concerned with compounds having formula (I), the pharmaceutically acceptable acid addition salts thereof, and the stereochemically isomeric forms thereof, wherein R1 is hydrogen or C1-6alkyl; R2 is hydrogen or C1...
WO/1995/004045A1	COMPOUNDS AS PDE IV AND TNF INHIBITORS This invention is directed to a [di(ether or thioether)heteroaryl or fluoro substituted aryl] compound or an N-oxide thereof or a pharmaceutically acceptable salt thereof, which is useful for inhibiting the production of physiological ef...
WO/1995/003053A1	OXOPHTHALAZINES FOR TREATING CACHEXIA This invention relates to a new use of the oxophthalazine compounds or pharmaceutically acceptable salts thereof as the prophylactic and/or therapeutic treatment of cachexia and the like, wherein oxophthalazine compounds can be represent...
WO/1995/003280A1	HYDRAZINO-TYPE RADIONUCLIDE CHELATORS HAVING AN N3S CONFIGURATION Radionuclide chelating compounds are provided for conjugation to targeting molecules such as proteins, peptides or antibodies. The resulting labelled targeting molecules may be used in diagnosis and therapy.
WO/1995/001343A1	PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY A 3(2H)-pyridazinone derivative of formula (I), its salt, a process for its production and a pharmaceutical composition containing it, wherein each of R1, R2 and R3 which are independent of one another, is a hydrogen atom or a C1-4 alkyl...
WO/1994/026720A1	NOVEL COMPOUNDS FOR USE IN LIQUID-CRYSTAL COMPOSITIONS The present invention provides compounds of formula (I) and liquid-crystal compositions containing the compounds, in which R1 is, for example, a straight-chain or branched alkyl radical having 1 to 22 carbon atoms, in which one -CH2- gro...
WO/1994/026709A1	GUANIDINE DERIVATIVES AS INHIBITORS OF Na+/H+ EXCHANGE IN CELLS Guanidine derivatives of formula (I), wherein Y is N or C-R1 (in which R1 is hydrogen, lower alkyl, hydroxy, protected hydroxy, etc.), R2 is hydrogen, aryl which may have one suitable substituent, aryloxy, etc., R3 is hydrogen, lower alk...
WO/1994/025440A1	ARTHROPODICIDAL AND NEMATOCIDAL HETEROCYCLIC SULPHONATES Compounds of the formula (I): R1-SO2-O-Q, their isomeric forms and salts thereof, wherein Q is the group (a), G is selected from the group S, S(=O), S(=O)2, C=S and C=O; R1 is selected from the group C1-C3 alkyl and C1-C3 haloalkyl; R2, ...
WO/1994/025467A1	THIADIAZABICYCLONONANE DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES Compounds of formula (I) in which M is hydrogen, an alkali metal or alkaline earth metal cation or an ammonium cation, A is C2-C6alkylene, R1 is chlorine or bromine, and R2 is hydrogen or fluorine, the preparation of these compounds and ...
WO/1994/022812A1	IMINO-SUBSTITUTED PHENYLACETIC ACID AMIDES, THEIR PREPARATION AND FUNGICIDES CONTAINING THEM Described are compounds of the formula (I) in which Y is oxygen or an NR6 group; Z1 and Z2 are hydrogen, halogen, alkyl, alkenyl, alkinyl, alkoxy, alkenyloxy, haloalkyl, haloalkoxy, haloalkenyloxy, cyano or nitro; R1 is hydrogen, alkyl, ...
WO/1994/021613A1	CONDENSED NITROGEN HETEROCYCLES, METHODS OF PREPARING THEM AND THEIR USE AS PEST-CONTROL AGENTS, FUNGICIDES AND ANTIMYCOTICS The invention concerns compounds of formula (I) in which two of the symbols A, B, D and E stand each for CR1 and each of the other two symbols stands for CH or nitrogen, or one of the other two symbols stands for CH while the other stand...
WO/1994/020455A1	STYRYL DERIVATIVES, THEIR PREPARATION AND USE AS PDE-IV INHIBITORS Compounds of general formula (1) are described wherein Y is a halogen atom or a group -OR1, wherein R1 is an optionally substituted alkyl group; X is -O-, -S-, or -N(R6), wherein R6 is a hydrogen atom or an optionally substituted alkyl g...
WO/1994/020446A1	TRISUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS AND PROCESSES FOR THEIR PREPARATION Compounds of general formula (1) are described wherein Y is a halogen atom or a group -OR1, where R1 is an optionally substituted alkyl group; X is -O-, -S- or -N(R7)-, where R7 is a hydrogen atom or an alkyl group; R2 is an optionally s...
WO/1994/018174A1	SUBSTITUTED TETRAHYDROPYRIDAZINE CARBOXAMIDES The present invention pertains to new substituted tetrahydropyridazine carboxamides of general formula (I), in which R1 stands for hydrogen or alkyl, R2 stands for alkyl carbonyl or alkoxy carbonyl or R1 and R2 together with the nitrogen...
WO/1994/017096A1	PEPTIDES HAVING ANTI-HIV ACTIVITY Compounds of formula (I), wherein Ar, W, Z, Q, R1, U, and L are as set forth herein, are described. These compounds are active as agents against HIV and inhibit renin and therefore are also active against hypertension. Similar retrovirus...
WO/1994/015927A1	CATALYTIC OXIDATION PROCESS Catalytic oxidation of thiols or thiol salts or dithiocarbamic acids or their salts using oxygen, optionally in the presence of a primary or secondary amine, is accomplished with a carbon catalyst which contains no metal complex of porph...
WO/1994/014979A1	ENZYME-CATALYZED CHEMILUMINESCENT DETECTION OF PROTEINS AND NUCLEIC ACIDS USING HYDROXYARYL CYCLIC DIACYLHYDRAZIDE COMPOUNDS A method and test kit using a hydroxyaryl cyclic diacylhydrazide, a peroxide and a peroxidase enzyme on a blotting membrane for detecting DNA, RNA or proteins (polypeptides) is described. The method and kit provide enhanced chemiluminesc...
WO/1994/014800A1	STYRIL DERIVATIVES AND PROCESSES FOR THEIR PREPARATION Compounds of general formula (1) are described, wherein Y is a halogen atom or a group -OR1, wherein R1 is an optionally substituted alkyl group; X is -O-, -S- or -N(R6)-, where R6 is a hydrogen atom or an alkyl group; R2 is an optionall...
WO/1994/014742A1	TRI-SUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS Compounds of general formula (1) are described wherein Y is a halogen atom or a group -OR1, where R1 is an optionally substituted alkyl group; X is -O-, -S- or -N(R8)-, where R8 is a hydrogen atom or an alkyl group; R2 is an optionally s...
WO/1994/013652A1	HERBICIDES A compound of formula (I), where E is oxygen or sulphur; A is CR3 or N where R3 is hydrogen or hydrocarbyl; D completes a 5 or 6-membered non-aromatic heterocyclic ring which optionally contains additional heteroatoms selected from oxyge...
WO/1994/012461A1	CATECHOL DIETHERS AS SELECTIVE PDEIV INHIBITORS This invention relates to 4-substituted catechol diether compounds which are selective inhibitors of phosphodiesterase (PDE) type IV. The compounds of the present invention are useful in inhibiting PDEIV and in the treatment of AIDS, ast...
WO/1994/012479A1	PYRIDAZINONE DERIVATIVE AND INSECTICIDAL AND MITICIDAL AGENT A pyridazinone derivative represented by general formula (1) and having (1) potent insecticidal and miticidal effects on agricultural insect pests; wherein R represents hydrogen, alkyl, alkoxyalkyl, or phenyl which may be substituted by ...
WO/1994/011353A1	PROCESS FOR THE PREPARATION OF (3R)- AND (3S)-PIPERAZIC ACID DERIVATIVES A process of preparing a piperazic acid derivative of formula (1) wherein R represents an amino, hydroxyl or thiol group or an organic group as defined below and each of A and B represents a hydrogen atom or a non-interfering substituent...
WO/1994/010151A1	SUBSTITUTED PHTHALAZINONES AS NEROTENSIN ANTAGONISTS Novel substituted phthalazinones of formula (I) are useful as neurotensin antagonists.
WO/1994/010116A1	ACETYLENE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, LIQUID CRYSTAL COMPOSITION CONTAINING THE SAME AS ACTIVE INGREDIENT, AND LIQUID CRYSTAL ELEMENT MADE THEREFROM An acetylene derivative represented by general formula (I), wherein R1 represents C3-C20 saturated or unsaturated alkyl; R2 represents optionally halogenated C1-C20 saturated or unsaturated alkyl or C2-C20 alkoxyalkyl; A and B represent ...
WO/1994/009784A1	PLATELET AGGREGATION INHIBITOR A platelet aggregation inhibitor containing a compound represented by general formula (I) or a pharmaceutically acceptable complex thereof as the active ingredient, wherein Y represents -CH2-CH2- or -CH2-CH2-CH2-; R represents hydrogen o...
WO/1994/010118A1	TRI-SUBSTITUTED PHENYL DERIVATIVES AND PROCESSES FOR THEIR PREPARATION Compounds are described in formula (1), wherein Y is a halogen atom or a group -OR1, where R1 is an optionally substituted alkyl group; R2 is an optionally substituted cycloalkyl or cycloalkenyl group; R3 is a monocyclic or bicyclic aryl...
WO/1994/009785A2	METHODS AND COMPOSITIONS OF (+) DOXAZOSIN FOR THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA AND ATHEROSCLEROSIS Methods and compositions are disclosed utilizing the optically pure (+) isomer of doxazosin. This compound is a potent drug for the treatment of benign prostatic hyperplasia while avoiding the concomitant liability of hypotensive effects...
WO/1994/010151A2	SUBSTITUTED PHTHALAZINONES AS NEROTENSIN ANTAGONISTS Novel substituted phthalazinones of formula (I) are useful as neurotensin antagonists.
WO/1994/008943A1	2-AMINO-1,3-PROPANEDIOL COMPOUND AND IMMUNOSUPPRESSANT A 2-amino-1,3-propanediol compound represented by general formula (I) or a pharmaceutically acceptable salt thereof, and an immunosuppressant containing the same as the active ingredient. In said formula R represents optionally substitut...
WO/1994/006280A1	INHIBITORS OF METAZOAN PARASITE PROTEASES Compositions and methods for treating a patient infected with a metazoan parasite by inhibiting the enzymatic action of the metazoan parasite protease. These compositions and methods have particular utility in the treatment of schistosom...
WO/1994/005276A1	CYTOTOXIC COMPOUNDS Compounds are disclosed which display cytotoxic effects against estrogen-independent tumors. These compounds may be represented by the formula X-R1 wherein X is a phenyl ring which may be substituted with one or more nitro, methyl or tri...
WO/1994/004510A1	PYRIDAZINE DERIVATIVE A compound represented by general formula [I], which is useful as a remedy for hypertension, congestive failure and chronic renal diseases, wherein R1, R2 and R3 represent each independently hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, pheny...
WO/1994/001412A1	1-ARYLSULPHONYL, ARYLCARBONYL AND 1-ARYLPHOSPHONYL-3-PHENYL-1,4,5,6-TETRAHYDROPYRIDAZINES 1-phenylsulphonyl, 1-phenylcarbonyl, 1-phenylthiocarbonyl and 1-phenylphosphenyl-3-aryl-1,4,5,6-tetrahydropyridazines are disclosed to promote bone cell growth to be progestin antagonists and agonists and to bind to the GABAA receptor.
WO/1993/025537A1	3-PYRIDAZINE DERIVATIVES AND THEIR USE IN RUBBER Thiols, disulfides and sulfenamides of certain pyridazines are effective accelerators in the sulfur vulcanization of rubber. These compounds, based on 3-pyridazine show improved rates of vulcanization and states of cure compared with kno...
WO/1993/025541A1	2-PYRAZINE DERIVATIVES AND THEIR USE IN RUBBER Thiols, or thiolate salts, disulfides and sulfenamides or certain pyrazines are effective accelerators in the sulfur vulcanization of rubber. These compounds, based on 2-pyrazine, show improved rates of vulcanization compared with known ...
WO/1993/021921A1	ANTI-ISCHEMIC MEDICAMENT [[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl] hydrazono]propanedinitrile which has been previously suggested for the treatment of congestive heart failure is useful in the treatment of myocardial ischemia.
WO/1993/022396A1	LIQUID CRYSTAL COMPOUNDS HAVING PERFLUOROETHER TERMINAL PORTIONS Fluorine-containing liquid crystal compounds are provided. The compounds comprise a fluorocarbon terminal portion having at least one catenary ether oxygen and a hydrocarbon terminal portion, the terminal portion being connected by a cen...
WO/1993/022303A1	1-PIPERAZINEACETIC DERIVATIVES AS FIBRINOGEN RECEPTOR ANTAGONISTS The invention thus provides the compounds of general formula (I) and salts, solvates and pharmaceutically acceptable derivatives thereof, in which X1 and X2 represent CH or are different and represent CH or N; Y1, Y2, Y3 and Y4 represent...
WO/1993/022290A1	NOVEL SUBSTITUTED TERTIARY AMINO COMPOUND OR SALT THEREOF A substituted tertiary amino compound represented by general formula (I) or a pharmaceutically acceptable salt thererof. They have an aromatase inhibiting activity and are useful as a prophylactic and/or therapeutic agent for breast canc...
WO/1993/021772A2	SYNERGISTIC COMPOSITION AND PROCESS FOR SELECTIVE WEED CONTROL Herbicidal composition comprising N-[2-(3,3,3-trifluoropropyl)-phenylsulfonyl]-N'-(4-methoxy-6 -methyl-1,3,5-triazin-2-yl)-urea of formula (I) or agrochemically tolerated salts thereof, and a synergistic amount of one or more further her...
WO/1993/019046A1	NOVEL SULFONAMIDE FIBRINOGEN RECEPTOR ANTAGONISTS A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet anti-aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation.

Matches 1,351 - 1,400 out of 4,419	< 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 >