Heterocyclic Compounds

Matches 1,251 - 1,300 out of 4,419	< 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 >

Document	Document Title
WO/1998/027066A1	ISOQUINOLINAMINE AND PHTHALAZINAMINE DERIVATIVES WHICH INTERACT WITH CRF RECEPTORS Disclosed are compounds that are highly selective partial agonists or antagonists at human CRF�1? receptors that are useful in the diagnosis and treatment of treating stress related disorders such as post traumatic stress disorder (PTS...
WO/1998/027098A1	SUBSTITUTED NITROGEN CONTAINING HETEROCYCLES AS INHIBITORS OF p38 PROTEIN KINASE The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The inven...
WO/1998/027070A1	HETEROCYCLIC CARBOXYLIC ACID DERIVATIVES, THE PRODUCTION AND USE THEREOF AS ENDOTHELIN RECEPTOR ANTAGONISTS, The present invention relates to carboxylic acid derivatives of formula (I), wherein the substituents have the meaning cited in the description, as well as to the production and use of said substances as endothelin receptor antagonists.
WO/1998/025597A2	METHOD FOR TREATING AND PREVENTING HEART FAILURE AND VENTRICULAR DILATATION Matrix metalloproteinase inhibitors are useful for preventing and treating heart failure, and ventricular dilatation in mammals.
WO/1998/023565A2	AMINOGUANIDINES AND ALKOXYGUANIDINES AS PROTEASE INHIBITORS Aminoguanidine and alkoxyguanidine compounds, including compounds of formula $i((I)) wherein X is O or NR?9� and R?1�-R?4�, R?6�-R?9�, R?11�, R?12�, R?a�, R?b�, R?c�, Y, Z, n and m are set forth in the specification, ...
WO/1998/021188A1	HETEROCYCLE DERIVATIVES WHICH INHIBIT FACTOR Xa The invention relates to heterocyclic derivatives of the formula (I): A-B-X?1�-T?1�(R?2�)-L?1�-T?2�(R?3�)-X?2�-Q or pharmaceutically acceptable salts thereof, which possess antithrombotic and anticoagulant properties due to...
WO/1998/020008A1	1-(3-AMINOINDAZOL-5-YL)-3-PHENYLMETHYL-CYCLIC UREAS USEFUL AS HIV PROTEASE INHIBITORS The present invention relates to compounds of formulae (I) and (II), or pharmaceutically acceptable salt forms or prodrugs thereof, which are useful as inhibitors of HIV protease, and to pharmaceutical compositions and diagnostic kits co...
WO/1998/019672A1	NITROSATED AND NITROSYLATED PHOSPHODIESTERASE INHIBITOR COMPOUNDS, COMPOSITIONS AND THEIR USES Disclosed are nitrosated and/or nitrosylated phosphodiesterase inhibitors having the formula NO�n?-PDE inhibitor wherein n is 1 or 2. The phosphodiesterase inhibitor can be nitrosylated or nitrosated through sites such as oxygen (hydro...
WO/1998/018476A1	METHODS OF TREATING OR PREVENTING CARDIAC ARRHYTHMIA A method of treating or preventing supraventricular tachyarrhythmias is disclosed which comprises the use of a compound which selectively blocks the ultra-rapidly-activating delayed rectifier K+ current (I�Kur?) of the human atrium.
WO/1998/018475A1	METHODS OF TREATING OR PREVENTING CARDIAC ARRHYTHMIA This application discloses a method of treating or preventing atrial arrhythmias which utilizes compounds which are blockers of the ultra-rapidly-activating delayed rectifier K?+� current (I�Kur?) of the human atrium in a use-depende...
WO/1998/017632A1	PRODUCTION OF PYRIDAZINE HERBICIDES Carboxylic acids of formula (1) wherein R?2� and R?3� are independently hydrogen or C�1?-C�3? alkyl, and Q is optionally substituted phenyl, can be easily converted by ring closing into pyridazin-3-one derivatives of formula (7)....
WO/1998/017633A1	PRODUCTION OF PYRIDAZINE HERBICIDES Carboxylic acid ester derivatives of formula (1), wherein R is C�1?-C�6? alkyl, R?2� and R?3� are independently hydrogen or C�1?-C�3? alkyl, and Q is optionally substituted phenyl, can be easily converted by ring closing into...
WO/1998/016508A2	SYNTHESIS OF AROMATIC COMPOUNDS BY DIELS-ALDER REACTION ON SOLID SUPPORT Methods for synthesizing compounds, e.g., aromatic heterocycles, by Diels-Alder reaction on solid support, are disclosed. Also disclosed are compounds immobilized on solid supports and libraries of compounds.
WO/1998/014431A1	NITROGENOUS HETEROCYCLIC COMPOUNDS Nitrogenous heterocyclic compounds of general formula (I) and pharmacologically acceptable salts thereof, which hinder the phosphorylation of PDGF acceptors and the abnormal proliferation or migration of cells and so are effective in pre...
WO/1998/009969A1	NOVEL ARYL-PYRIDAZINES Use of a compound of formula (I) wherein, A, A?1�, A?2� and A?3� are all CH or CR?4� or one of A, A?1�, A?2� or A?3� is nitrogen and the others are all CH or CR?4�; Ar?1� and Ar?2� are independently phenyl, pyridyl, b...
WO/1998/008807A1	SYNTHESIS OF A HYDRAZONE $g(b)-KETO ESTER BY THE REACTION WITH A DIAZO ESTER The present invention relates to the synthesis of a hydrazone $g(b)-keto ester by the reaction of an alkyl diazo ester with a hydrazone aldehyde in the presence of a Lewis acid. In a preferred embodiment, the hydrazone $g(b)-keto ester i...
WO/1998/007430A1	REMEDY FOR ERECTION FAILURE COMPRISING FUSED PYRIDAZINE COMPOUND A remedy for erection failure containing as the active ingredient a fused pyridazine compound represented by general formula (I) or a pharmacologically acceptable salts thereof, wherein ring C represents an aromatic five- or six-membered...
WO/1998/007706A1	NEW POLYCYCLIC PHTHALAZIN DERIVATIVES AND THEIR USE New polycyclic phthalazins, in particular 2-substituted maduraphthalazins (10,12,15,16-tetrahydroxy-8-methoxy-11-methyl-1,9,14-trioxo- 1,2,6,7,9,14-hexahydronaphtaceno-1,2-g-phthalazins), of formula (I) and their use are disclosed. The d...
WO/1998/006704A1	ARYLALKANOYL PYRIDAZINES Arylalkanoyl pyridazine derivatives of formula (I) as well as their physiologically harmless salts, wherein R?1�, R?2�, Q and B have the meanings indicated in claim 1, present a phosphodiesterase IV inhibition and can be employed to ...
WO/1998/005635A1	HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY The invention concerns hydroxamic acid and carboxylic acid derivatives of formulae (I): B-X-(CH�2?)�n?-CHR?1�-(CH�2?)�m?-CONHOH and (Ia): B-S(O)�1-2?-(CH�2?)�n?-CHR?1�-(CH�2?)�m?-COOR?2� ��, in which X is O, NR�3?...
WO/1998/004247A1	CELL ADHESION INHIBITORS The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds...
WO/1998/004247A2	CELL ADHESION INHIBITORS The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds...
WO/1998/004913A1	MOLECULAR MODEL FOR VLA-4 INHIBITORS Pharmacophore models of VLA-4 inhibitors, methods of identifying novel inhibitors and novel inhibitors identified by these methods.
WO/1998/004556A1	PYRIDAZINO [4,5-B]-QUINOLINE 5-OXIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS GLYCINE ANTAGONISTS Pyridyl-phtalazin diones having formula (I), wherein R1 and R2 are selected from the group consisting of hydrogen, halogen, and methoxy or wherein R1 and R2 together form methylenedioxy, and pharmaceutically acceptable salts thereof, and...
WO/1998/003494A1	CERTAIN AMIDO- AND AMINO-SUBSTITUTED BENZYLAMINE DERIVATIVES; A NEW CLASS OF NEUROPEPTITE Y1 SPECIFIC LIGANDS This invention encompasses compounds of the formula (I) where X�1?, X�2?, and X�3?, independently represents substituents of formula (A) and the pharmaceutically acceptable salts thereof wherein C = N or O; D = nothing when C = O, ...
WO/1998/003487A1	COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING INFLUENZA Substituted pyridazine derivatives are useful in prophylaxis and treatment of influenza virus infection.
WO/1997/047604A1	5-PHENYL-3-PYRIDAZINONE DERIVATIVES AND DRUG COMPOSITIONS CONTAINING THE SAME 5-Phenyl-3-pyridazinone derivatives represented by general formula (I) wherein R1 is optionally substituted C1-C8 alkyl, C3-C7 cycloalkyl, or indanyl; R2 is C1-C4 alkyl; R3 is hydrogen, optionally substituted C1-C5 alkyl, C3-C7 cycloalky...
WO/1997/047601A1	FUSED HETEROCYCLIC COMPOUNDS AND MEDICINAL USES THEREOF Fused heterocyclic compounds represented by general formula (I), optical isomers or pharmaceutically acceptable salts thereof, medicinal compositions comprising these compounds and pharmaceutically acceptable additives, and drugs compris...
WO/1997/045403A1	ARYL SUBSTITUTED CYCLIC AMINES AS SELECTIVE DOPAMINE D3 LIGANDS Compounds and their pharmaceutically acceptable salts suitable for treating central nervous system disorders associated with the dopamine D3 receptor activity of structural Formula (I) where X and Y are at the 5, 6, or 7 position wherein...
WO/1997/043237A1	SUBSITUTE 4-ARYLBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have generalized formula (I) wherein R1 repr...
WO/1997/043239A1	INHIBITION OF MATRIX METALLOPROTEASES BY SUBSTITUTED BIARYL OXOBUTYRIC ACIDS Matrix metalloprotease inhibiting compounds, pharmaceutical compositions thereof and a method of disease treatment using such compounds are presented. The compounds of the invention have generalized formula (1) wherein r is 0-2, T is sel...
WO/1997/041896A2	INCLUSION COMPLEXES OF ARYL-HETEROCYCLIC SALTS Compositions of matter comprising a pharmaceutically acceptable salt of an aryl-heterocyclic compound, such as ziprasidone, in a cyclodextrin. Preferred cyclodextrins are SBECD and HPBCD. The composition can comprise a dry mixture, a dry...
WO/1997/040020A1	PHTHALAZINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DRUGS Described are compounds of formula (I), their preparation and their use as drugs.
WO/1997/039001A1	ISOXAZOLIDINE DERIVATIVES This invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is zero to 6; p is zero to 3; q is zero to 3; r is zero to...
WO/1997/035841A2	METHOD FOR OBTAINING PURE ENANTIOMERS OF A PYRIDAZINONE DERIVATIVE A method for preparing optically substantially pure (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phe nyl]hydrazono]propanedinitrile from racemic 6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone intermediate is descri...
WO/1997/034876A1	CINNOLINE DERIVATIVES AND USE AS MEDICINE The invention relates to the use of cinnoline derivatives of formula (I), wherein Z represents -O-, -NH-, -S- or -CH2-; m is an integer from 1 to 5; R1 represents hydrogen, hydroxy, halogeno, nitro, cyano, trifluoromethyl, C1-3alkyl, C1-...
WO/1997/031907A1	SUBSTITUTED 4-HYDROXY-PHENYLALCANOIC ACID DERIVATIVES WITH AGONIST ACTIVITY TO PPAR-GAMMA A compound having formula (I), wherein A is selected from the group consisting of: (i) phenyl, wherein said phenyl is optionally substituted by one or more halogen atoms, C1-6alkyl, C1-3alkoxy, C1-3fluoroalkoxy, nitrile, or -NR7R8 where ...
WO/1997/031901A1	HYDROXYHEXAHYDROPYRIDAZINES The present invention relates to hydroxyhexahydropyridazines of general formula (I). These compounds are found to be inhibitors of glycoside cleaving enzymes and it is therefore envisaged that such compound may be used for treatment of o...
WO/1997/030971A1	M-AMIDINO PHENYL ANALOGS AS FACTOR Xa INHIBITORS The present application describes m-amidino phenyl analogs of formula (I), wherein D can be amidino and E can be phenyl, which are useful as inhibitors of factor Xa.
WO/1997/028129A1	AMINOHETEROCYCLIC DERIVATIVES AS ANTITHROMBOTIC OR ANTICOAGULANT AGENTS Compounds of formula (I), wherein G1 is CH or N; G2 is CH or N; R1 is a variety of optional substituents; L1 is (1-4C)alkylene; T1 is CH or N; R2 and R3 are independently hydrogen or (1-4C)alkyl or are joined to form a ring; X1 and X2 re...
WO/1997/026247A1	1-ARYLPHTHALAZINE ANTAGONISTS OF EXCITATORY AMINO ACID RECEPTORS Substituted 1-arylphthalazine compositions such as formula (1) are provided which are active as non-NMDA ionotropic excitatory amino acid (EAA) receptor antagonists. The compositions are useful for treating disorders associated with exce...
WO/1997/024120A1	THIENO(2,3-b)PYRAZOLO(3,4-d)PYRIDIN-3-ONES TO ENHANCE ERYTHROPOIESIS Invented are substituted thieno(2,3-b)pyrazolo(3,4-d)pyridin-3-ones, pharmaceutical compositions containing these compounds, and methods of using these compounds to enhance erythropoiesis. Also invented are intermediates and processes us...
WO/1997/022594A1	COMBINATORIAL LIBRARIES The invention provides a method for the production of a combinatorial library of compound of general formula (I) using solid phase methodologies. The cleavage of the array of immobilised compounds of the phthalimido type from the solid s...
WO/1997/021432A1	USE OF BICYCLIC MONO- OR DIKETONE DERIVATIVES, RESULTING COMPOUNDS, AND USE THEREOF AS A DRUG FOR TREATING INFLAMMATION, MIGRAINE AND SHOCK The therapeutical use of bicyclic derivatives and pharmaceutically acceptable salts thereof having general formula (I), wherein each of X1, X2, X3 and X4 is independently a carbon atom or a nitrogen atom, with n being 0 or 1; A is select...
WO/1997/017332A1	1-ARYLSULPHONYL, ARYL(THIO)CARBONYL PYRIDAZINO DERIVATIVES AND METHODS OF PREPARATION 1-Arylsulphonyl, arylcarbonyl and aryl(thio)carbonyl pyridazino derivatives and processes for making said derivatives are described. The novel derivatives are non-steroidal heterocyclic compounds which act as selective progestins and/or ...
WO/1997/014681A1	HETEROCYCLIC COMPOUNDS AS H+-ATPASES This invention relates to a compound of formula (I), wherein R1 is a heterocyclic group or aryl, each of which may be substituted with suitable substituent(s), A is -CONH- or -NHCO-, n is an integer of 0 or 1, and (II) is a group of form...
WO/1997/013758A1	PYRIDAZINONES AS ENDOTHELIN-RECEPTOR ANTAGONISTS Novel compounds of formula (I), wherein R1, R2, R3 and Y have the meanings indicated in claim 1, and their salts, have endothelin-receptor antagonistic properties.
WO/1997/012883A1	INTERMEDIATES AND PROCESS FOR THE PREPARATION OF SUBSTITUTED SALICYLIC ACID DERIVATIVES AS PLANT PROTECTIVE AGENTS The invention relates to organic tin compounds of formula (I), wherein the rests have the following meaning: R1 is optionally substituted benzyl, alkyl, dihydropyranyl, trialkyl silyl, alkoxy alkyl and dialkoxy alkyl; and R2 is alkyl, cy...
WO/1997/012616A1	DRUG FOR TREATING GLAUCOMA The use of 6-[4-[2-[3-(5-chloro-2-cyanophenoxy)-2-hydroxy-propylamino]- 2-methylpropylamino]phenyl]-4,5-dihydro-5-methyl-3(2H)-pyrid azinone or its salt in treating glaucoma.
WO/1997/007104A1	PYRIDAZIN-3-ONE DERIVATIVES, THEIR USE, AND INTERMEDIATES FOR THEIR PRODUCTION Novel pyridazin-3-one derivatives of formula (1) are provided, which are useful as active ingredients of herbicides, wherein R1 is haloalkyl; R2 and R3 are the same or different and are hydrogen, alkyl, haloalkyl, or alkoxyalkyl; and Q i...

Matches 1,251 - 1,300 out of 4,419	< 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 >