Heterocyclic Compounds

Matches 1,201 - 1,250 out of 4,419	< 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 >

Document	Document Title
WO/1999/042452A1	PHTHALAZINE DERIVATIVES AND REMEDIES FOR ERECTILE DYSFUNCTION Phthalazine derivatives represented by general formula (I) or pharmacologically acceptable salts thereof or hydrates of the same usable as remedies for erectile dysfunction, wherein R¿1? and R¿2? are the same or different and each repr...
WO/1999/038829A1	NOVEL TRICYCLIC COMPOUND A compound represented by formula (1) wherein each of ring A, ring B and ring C is independently a substituted or unsubstituted aromatic ring or a substituted or unsubstituted five or six-membered heterocycle which may be condensed with ...
WO/1999/038846A1	IMMUNOSUPPRESSIVE AGENTS Disclosed are methods of suppressing the immune system in a subject in need of immune system suppression. The method comprises administering to the subject an effective amount of a compound represented by Structural Formulas (I, II, III ...
WO/1999/038850A1	NOVEL ALKANOIC ACIDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM The present invention relates to novel hypolipidemic, antihyperglycemic, antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutical...
WO/1999/036407A1	NOVEL ALLYLTHIOPYRIDAZINE DERIVATIVES AND PROCESS FOR PREPARING THE SAME The present invention relates to a novel allylthiopyridazine derivative represented by formula (I) which exhibits a superior effect for prevention and treatment of hepatic diseases induced by toxic substances and for protection of human ...
WO/1999/032456A1	PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS Compounds of formula (I) wherein B is alkylene, amino, CONH or a bond; Cy is optionally substituted phenyl or heteroaryl; R is H, phenyl or (C¿1-4?)alkyl optionally substituted; R¿1? is (C¿1-6?)alkyl or polyfluoro(C¿1-6?)-alkyl; R¿2...
WO/1999/032081A1	TRANSMUCOSAL FORMULATIONS OF LEVOSIMENDAN Described is a method of administering transmucosally, particularly to oral or nasal mucosa, levosimendan or a pharmaceutically acceptable salt thereof to a patient. The method comprises contacting an intact mucous membrane with a source...
WO/1999/031090A1	DIHYDROBENZOFURANS Compounds of formula (I), wherein R1, R2, R3 and Het have the meanings as given in the description are novel effective bronchial-therapeutics.
WO/1999/031071A1	NEW PHTHALAZINONES Compounds of formula (I) wherein R1, R2, R3, R4 and R5 have the meanings as given in the description are novel effective bronchial-therapeutics.
WO/1999/031066A1	PYRIDONES AS SRC FAMILY SH2 DOMAIN INHIBITORS This invention relates to compounds of formula (I) wherein Ring a, A, B, C, D, E, R and Q are defined herein. These compounds possess the ability to disrupt the interaction between regulatory proteins possessing one or more SH2 domains a...
WO/1999/031065A1	N-BENZYL-3-INDENYLACETAMIDES DERIVATIVES FOR TREATING NEOPLASIA Substituted condensation products of N-benzyl-3-indenylacetamides of formula (I) with heterocyclic aldehydes are useful for inducing or promoting apoptosis and for arresting uncontrolled neoplastic cell proliferation, and are specificall...
WO/1999/025697A1	NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT Pyridazine derivatives represented by general formula (1) or salts thereof; and drugs containing the same as the active ingredient: wherein R?1¿ is (substituted) aryl; R?2¿ is phenyl substituted with lower alkoxy, lower alkylthio or th...
WO/1999/023063A1	SUBSTITUTED ANILIDES The invention is directed to physiologically active compounds of formula (I) wherein: R?1¿ is hydrogen, halogen, hydroxy, lower alkyl or lower alkoxy; X?1¿, X?2¿ and X?6¿ independently represent N or CR?10¿; and one of X?3¿, X?4¿ ...
WO/1999/021837A1	SUBSTITUTED BENZENE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND HERBICIDAL AND DEFOLIANT COMPOSITIONS CONTAINING THEM Novel herbicidal and defoliant substituted aniline derived compounds represented by general structure (I) are described. W, X, Y, Z, and Q are as defined in the disclosure. Also described are the processes for the manufacture of these co...
WO/1999/020272A1	AZAPEPTIDE ACIDS AS CELL ADHESION INHIBITORS Azapeptide acids of Formula (I) are antagonists of VLA-4 and/or $g(a)¿4?$g(b)¿7?, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into ph...
WO/1999/020624A1	BICYCLIC KINASE INHIBITORS The present invention relates to compounds of Formula (I) that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, their use, a process for preparing these compounds and intermediates useful in this process.
WO1999011624B1	OXO-SUBSTITUTED COMPOUNDS, PROCESS OF MAKING, AND COMPOSITIONS AND METHODS FOR INHIBITING PARP ACTIVITY Compound, compositions containing compounds, methods of using compounds, and processes of making compounds, of formula (I) containing at least one ring nitrogen, or a pharmaceutically acceptable base or acid addition salt, hydrate, ester...
WO/1999/017776A1	NOVEL CYCLOALKENYL SUBSTITUTED COMPOUNDS Novel pyridyl or pyrimidinyl substituted cycloalkenyl compounds and compositions for use in therapy.
WO/1999/018082A1	NOVEL SUBSTITUTED PYRIDAZINONES The invention relates to substituted pyridazinones of formula (I) and the salts thereof, whereby R?1¿-R?3¿ represent H, NO¿2?, OH, halogen, C¿1?-C¿6? alkoxyl, C¿1?-C¿6? haloalkoxyl, SH, C¿1?-C¿6? alkylthio, C¿1?-C¿6? haloalkyl...
WO/1999/014201A1	SUBSTITUTED 2-PHENYL-3(2H)-PYRIDAZINONES The invention concerns substituted 2-phenyl-3(2H)-pyridazinones of formula (I), and their salts. In said formula, n = 0, 1, 2; R?1¿ = alkyl C¿1?-C¿4?, alkyl halide C¿1?-C¿4?; R?2¿ = H, halogen; R?3¿ = halogen, CN; R?4¿ = H, NO¿2...
WO/1999/011649A2	PARP INHIBITORS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS OF USING SAME The present invention relates to PARP inhibitors, pharmaceutical compositions comprising the same, and methods of using the same to treat tissue damage resulting from cell damage or death due to necrosis or apoptosis, effect neuronal act...
WO/1999/011623A1	THIOALKYL COMPOUNDS, METHODS, AND COMPOSITIONS FOR INHIBITING PARP ACTIVITY A compound of formula (I) or a pharmaceutically acceptable salt, hydrate, ester, solvate, prodrug, metabolite, stereoisomer, or mixtures thereof, wherein: R?1¿ is lower alkyl, lower alkenyl or lower alkynyl; R?9¿, when present, is hydr...
WO/1999/011622A1	AMINO-SUBSTITUTED COMPOUNDS, METHODS, AND COMPOSITIONS FOR INHIBITING PARP ACTIVITY A compound of formula (I) or a pharmaceutically acceptable salt, hydrate, ester, solvate, prodrug, metabolite, stereoisomer, or mixtures thereof, wherein R?1¿, when present, is hydrogen or lower alkyl; X is -NR?4¿R?5¿, where R?4¿ and...
WO/1999/011628A1	ALKOXY-SUBSTITUTED COMPOUNDS, METHODS, AND COMPOSITIONS FOR INHI BITING PARP ACTIVITY A compound, compositions, methods of use, and processes of making formula (I) or a pharmaceutically acceptable salt, hydrate, ester, solvate, prodrug, metabolite, stereoisomer, or mixtures thereof, wherein: R?1¿, when present, is hydrog...
WO/1999/011645A1	POLY(ADP-RIBOSE) POLYMERASE ('PARP') INHIBITORS, METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING NEURAL OR CARDIOVASCULAR TISSUE DAMAGE This invention relates to compounds, pharmaceutical compositions, and methods of using compounds of formula (I), or a pharmaceutically acceptable salt, hydrate, prodrug, or mixtures thereof, wherein: Y is alkylhalo, alkyl-CO-G, COG, a di...
WO/1999/010331A1	ARYLPYRIDAZINONES AS PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE BIOSYNTHESIS INHIBITORS The present invention describes pyridazinone compounds which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX/2), COX-2 is the inducible isoform associated with inflammation, as op...
WO/1999/010332A1	PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE BIOSYNTHESIS INHIBITORS The present invention describes pyridazinone compounds which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform associated with inflammation, as op...
WO/1999/008299A1	NONAQUEOUS ELECTROLYTE FOR ELECTRICAL STORAGE DEVICES Improved nonaqueous electrolytes for application in electrical storage devices such as electrochemical capacitors or batteries are disclosed. The electrolytes of the invention contain salts consisting of alkyl substituted, cyclic delocal...
WO/1999/006406A1	4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-$i(b)]-INDOLE-1-ACETAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPY The invention concerns compounds of general formula (I) in which: X represents a hydrogen or halogen atom or a methyl, methoxy or phenylmethoxy group; Y represents a hydrogen atom, one or two halogen atoms or a methyl, hydroxy, methoxy o...
WO/1999/006404A1	1,2,4-TRIAZOLO[4,3-B]PYRIDO[3,2-D]PYRIDAZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Heterocyclic compounds of formula (I), wherein R?1¿ represents a hydrogen atom or a -(CH¿2?)¿m?-Y group, wherein m is an integer from 0 to 4 and Y represents an alkyl, haloalkyl, alkoxy, alkoxycarbonyl, C¿3?-C¿7? cycloalkyl, norborn...
WO/1999/006361A2	N-HYDROXYFORMAMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
WO/1999/005096A2	UROKINASE INHIBITORS Compounds having formula (I) are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions and a method of inhibiting urokinase in a mammal.
WO/1999/001436A1	3-(SUBSTITUTED PHENYL)-4-HALOPYRIDAZINE DERIVATIVES, PESTICIDES CONTAINING THE SAME AS THE ACTIVE INGREDIENT, AND INTERMEDIATES THEREOF New 3-(substituted phenyl)-4-halopyridazine derivatives useful as pesticides, particularly herbicides.
WO/1998/058905A1	NOVEL AMIDRAZONE DERIVATIVES HAVING ANTIFUNGAL ACTIVITY Amidrazone derivatives of formula (I) useful for prevention or treatment of lupus mycosis attributable to fungi, such as Candida, Aspergillus, and Cryptococcus, pharmaceutically acceptable salts thereof, and pharmaceutical compositions t...
WO/1998/058916A1	NEW $g(b)-AMINO AND $g(b)-AZIDOCARBOXYLIC ACID DERIVATIVES, THE PRODUCTION THEREOF AND THE USE THEREOF AS ENDOTHELIN RECEPTOR ANTAGONISTS, The invention relates to carboxylic acid derivatives of formula (I) wherein the constituents have the meaning given in the description. The invention also relates to the production of said derivatives, and to their use as endothelin rece...
WO/1998/054159A1	NON-STEROIDAL (HETERO) CYCLICALLY SUBSTITUTED ACYLANILIDES WITH MIXED GESTAGEN AND ANDROGEN ACTIVITY The invention relates to non-steroidal gestagens of general formula (I), wherein R?1� and R?2� are the same or different and stand for a hydrogen atom, a C�1?-C�5? alkyl group or a halogen atom, or together with the C atom of the...
WO/1998/052595A1	PEPTIDE NUCLEIC ACID MONOMERS AND OLIGOMERS Novel peptide nucleic acid (PNA) oligomers and their constituent monomers are disclosed. The PNA oligomers and linked PNAs form triple stranded structures with nucleic acids that show an increased specificity for thymidine in nucleic aci...
WO/1998/050031A1	INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES Compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R�1? is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L�2?-, and (i) heterocyclic -L�2?-;...
WO/1998/050029A1	INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES Compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R�1? is (a) hydrogen, (b) lower alkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl -L�2?-, and (i) heterocyclic -L�2?...
WO/1998/050030A1	INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES Compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R�1? is (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halo, (g) haloalkyl, (h) aryl-L�2?-, and (i) heterocyclic-L�2?-; ...
WO/1998/047969A1	ALKYL, ALKENYL AND ALKYNYL CHRYSAMINE G DERIVATIVES FOR THE ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND $i(IN VIVO) IMAGING AND PREVENTION OF AMYLOID DEPOSITION Amyloid binding compounds which are non-azo derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain $i(in vivo) and to diagnose other pathological conditions cha...
WO/1998/046574A1	PYRIDAZINE AND PHTHALAZINE DERIVATIVES, PROCESS OF THEIR PREPARATION AND THEIR USE AS ANTICONVULSANTS A method of treatment and/or prophylaxis of anxiety, mania, depression, panic disorders and/or aggression, disorders associated with a subarachnoid haemorrhage or neural shock, the effects associated with withdrawal from substances of ab...
WO/1998/046080A1	NUCLEOPHILE SUBSTITUTED ECTEINASCIDINS AND N-OXIDE ECTEINASCIDINS Five new nucleophile substituted ecteinascidin (Et) compounds have been isolated from extracts of $i(Ecteinascidia turbinata). These compounds have been purified by chromatographic techniques and their structures and bioactivities have b...
WO/1998/045292A1	THIAZOLIDINEDIONE AND OXAZOLIDINEDIONE DERIVATIVES HAVING ANTIDIABETIC, HYPOLIPIDAEMIC AND ANTIHYPERTENSIVE PROPERTIES The present invention relates to novel antidiabetic compounds, their tautomeric forms, their analogues, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable ...
WO/1998/041511A1	PYRIDAZINONES AS INHIBITORS OF CYCLOOXYGENASE-2 The invention encompasses the pyridazin-3-one compounds of formula (I) as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically eff...
WO/1998/038167A1	HETEROARYL-HEXANOIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1-ALPHA BINDING TO ITS CCR1 RECEPTOR Compounds of formula (I) wherein R?1� is optionally substituted (C�2?-C�9?)heteroaryl; R?2� is optionally substituted phenyl-(CH�2?)�m?-, naphthyl-(CH�2?)�m?-, (C�3?-C�10?)cycloalkyl-(CH�2?)�m?-, (C�1?-C�6?)al...
WO/1998/033788A1	MATRIX METALLOPROTEINASE INHIBITORS A compound of formula (I), wherein W is -NHOH or -OH, R�1? is either free or protected hydroxymethyl or mercaptomethyl or derivatives thereof, R�2? is free or protected hydroxy, R�3? and R�4? is an organic group, R�5? is hydrog...
WO/1998/031674A1	PHTHALAZINONES Compounds of formula (I) wherein R1, R2, R3, R4 and R5 have the meanings as given in the description are novel effective bronchial-therapeutics.
WO/1998/031681A1	3-HETEROCYCLYL-SUBSTITUTED BENZOYL DERIVATIVES, The invention concerns benzoyl derivatives of formula (I) in which the variables have the following meanings: R?1�, R?2�: hydrogen, nitro, halogen, cyano, alkyl, alkyl halide, alkoxy, alkoxy halide, alkylthio, alkylthio halide, alkyl...
WO/1998/028257A1	AROMATIC AMINE DERIVATIVES HAVING NOS INHIBITORY EFFECT Compounds represented by general formula (1) which have NOS inhibitory activities and are useful as drugs, for example, remedies for cerebrovascular disorders, wherein R�1? and R�2? represent each hydrogen, etc.; R�3? and R�4? re...

Matches 1,201 - 1,250 out of 4,419	< 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 >