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WO/2023/072671A1 |
The present invention relates to the use of strobilurin type compounds of formula I and the N- oxides and the salts thereof for combating phytopathogenic fungi containing an amino acid substitution F129L in the mitochondrial cytochrome b...
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WO/2023/073115A1 |
The present invention relates to the use of the compound of the formula (I) and the composition thereof as control agent for plant diseases caused by fungi, oomycetes and bacteria. Plant pathogens produce self-aggregating proteins, like ...
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WO/2023/069721A2 |
Provided herein are USP28 inhibitors, pharmaceutical compositions, methods of their preparation, and methods of their use in treatment and/or diagnosis.
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WO/2023/064771A1 |
HDAC-7 inhibitors and uses thereof are provided, including their uses as therapeutic agents for treating brain cancer and/or solid tumors, for example, glioblastoma multiforme (GBM). In some embodiments, provided herein are HDAC-7 inhibi...
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WO/2023/062627A1 |
Provided herein are compounds that inhibit the protein-protein interaction of serine acetyltransferase (SAT) with O-acetyl serine sulfhydrylase (OASS), and can therefore be used as herbicides.
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WO/2023/061095A1 |
The present invention relates to the field of medicinal chemistry. Disclosed in the present invention are a 14-chloro-β-elemene nitric oxide donor type derivative, preparation and application thereof in preparing an antitumor drug. The ...
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WO/2023/043938A1 |
Provided herein are compounds and methods for the treatment of cancer. The methods include administering to a subject in need a therapeutically effective amount of a sulfamide RNR inhibitor disclosed herein.
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WO/2023/043803A1 |
Disclosed herein are FABP4 and FABP5 inhibitor compounds and their use in pharmaceutical compositions for treating diseases relating to fatty acid metabolism, including cancer. Also disclosed herein are methods for preparing the disclose...
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WO/2023/031775A1 |
The present invention relates to a pharmaceutical composition for preventing or treating Charcot-Marie-Tooth disease associated with a peripheral nervous system, comprising a compound represented by formula I, optical isomers thereof or ...
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WO/2023/034450A1 |
The present disclosure provides, in part, methods for site-specific labeling of proteins/peptides with radiohalogens and compositions resulting from said methods.
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WO/2023/285176A1 |
A process for producing alkyl trifluoroacetates The present invention relates to a process for producing alkyl trifluoroacetates by reacting trifluoroacetic acid with an alkyl alcohol R-OH in an aqueous solution, and wherein the alkyl tr...
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WO/2023/286855A1 |
The purpose of the present invention is to provide an excellent agricultural or horticultural plant disease control agent. Provided are: a formamide derivative represented by general formula [I] and the like (in the formula, X1, X2, X3...
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WO/2023/285977A1 |
The present invention relates to pharmaceutical compositions of ozanimod or a pharmaceutically acceptable salt thereof. In particular, the invention relates to pharmaceutical compositions of ozanimod or a pharmaceutically acceptable salt...
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WO/2023/280630A1 |
The present invention relates to a process for the preparation of substituted amidoximes of formula I, which can be obtained through reaction of nitrile compounds of formula II with free hydroxylamine in the presence of a solvent.
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WO/2023/280773A1 |
The invention relates to chiral 3-sulfinyl benzoic acids of the absolute configuration specified in formulae (I-R) and (I-S) as precursors for the production of herbicidal compounds. In formulae (I-R) and (I-S), X, Z and R' represent gro...
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WO/2023/283453A1 |
The disclosure herein provides phenyl acetamide based compounds of Formula (I), (I-a), (II), and pharmaceutical compositions thereof, for the modulation of IL-17A, useful in the treatment of inflammatory conditions such as psoriasis.
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WO/2023/280772A1 |
The invention relates to benzoic acid amides of general formula (I) as herbicides. In this formula (I), X, R and Z represent groups such as alkyl and halogen.
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WO/2022/269251A1 |
The invention relates to compounds of formula (I) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response: (I) wherein RA, RB, RC and RD are as defined herein.
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WO/2022/258040A1 |
Provided is a heterocyclic compound for a TEAD inhibitor. The heterocyclic compound has the structure shown in formula I, and the groups in formula I are defined as described herein. The heterocyclic compound is used for preventing and/o...
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WO/2022/253645A1 |
A compound of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, which can be used as fungicides.
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WO/2022/255900A1 |
The present invention relates to the field of organic chemistry and pharmaceutics, and more particularly to ligands of the cysteinyl leukotriene receptors CysLT1R and CysLT2R, having the given formulae, where R1, R2, R3 and R4 have the v...
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WO/2022/253033A1 |
The present invention relates to a chemical coupling linker and a use thereof, and a biologically active conjugate prepared by the chemical coupling linker. The present invention also relates to a use of the biologically active conjugate...
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WO/2022/249074A1 |
The present invention discloses a novel fungicidal composition comprising at least one compound of formula (I) or an agriculturally acceptable salt thereof as a component (1), Formula (I) wherein, R, A, L1, R1, and n are as defined in th...
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WO/2022/238247A1 |
The present invention related to compounds of Formula (I) or an agronomically acceptable salt thereof, wherein Q, R2, R3, R4 and R5 are as defined herein. The invention further relates to compositions comprising said compounds, to method...
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WO/2022/219546A1 |
The present application relates to Leukotriene A4 hydrolase (LTA4H) inhibitors of formula (I), for use in the treatment of various disorders.
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WO/2022/215020A1 |
The present invention relates to a novel 1,3,4-oxadiazole thiocarbonyl compound having a histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof, pharmaceutically acceptable salts thereof, a use thereof for preparing a m...
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WO/2022/216930A1 |
Disclosed herein are, inter cilia, compounds modulating activity and methods of use thereof for treating MDA-9/Syntenin associated conditions or disorders.
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WO/2022/212769A1 |
The present disclosure generally relates to compounds and compositions for use in imaging agents, methods of use for monitoring and/or treating conditions or diseases related to sphingosine-1-phosphate (S1P) signaling, and processes for ...
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WO/2022/207496A1 |
The present invention relates to 3-(hetero)aryl-5-chlorodifluoromethyl-1,2,4-oxadiazole compounds as well as the uses thereof for controlling harmful microorganisms, in particular phytopathogenic fungi, in crop protection.
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WO/2022/207494A1 |
The present invention relates to 3-(hetero)aryl-5-chlorodifluoromethyl-1,2,4-oxadiazole compounds as well as the uses thereof for controlling harmful microorganisms, in particular phytopathogenic fungi, in crop protection.
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WO/2022/212902A1 |
The present disclosure relates generally to therapeutic agents that may be useful as modulators of Integrated Stress Response (ISR) pathway.
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WO/2022/204288A1 |
The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. ...
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WO/2022/194278A1 |
A series of phenol compounds and the use thereof. Specifically disclosed are a compound as represented by formula (III) and a pharmaceutically acceptable salt thereof.
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WO/2022/192562A1 |
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of USP30, and the treatment of USP30-mediated disorders.
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WO/2022/189495A1 |
Disclosed are chiral N-(1,3,4-oxadioazole-2-yl)phenyl carboxylic acid amides of general formula (I) as well as their use as herbicides. In formula (I) X, Z, R and R' represent radicals such as alkyl, cycloalkyl and halogen.
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WO/2022/180080A1 |
The present invention relates to compounds of formula (I) and to salts, solvates, stereoisomers and tautomers thereof useful as anti-proliferative agents and/or as inhibitors of DEAD-box (DDX) RNA helicases. The present invention also pr...
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WO/2022/178228A1 |
The invention provides arylthioether acetamide and related compounds, pharmaceutical compositions, and their use in the treatment of medical conditions, such as bacterial infections, and in inhibiting LpxA activity.
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WO/2022/171176A1 |
Provided are a trifluoromethyloxadiazole compound, and a preparation method therefor and an application thereof, and a fungicide. The compound has a structure shown in formula (I). The trifluoromethyloxadiazole compound can have an excel...
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WO/2022/173795A1 |
Compounds that are selective inhibitors of Smad3 activation are disclosed. The compounds are (3-aryl-1,2,4-oxadiazol-5-yl)-3,4-dihydro-2H-pyrano[2,3-b]py
ridines of structure (I), in which Ar is aryl or heteroaryl. The compounds disclose...
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WO/2022/166764A1 |
The present invention relates to the field of organic chemistry, and in particular, relates to a use of a silicon compound in a cyclization reaction. On one hand, the present invention provides a method for preparing 2-chloro-5-chloromet...
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WO/2022/163446A1 |
The present invention addresses the problem of providing a new compound that binds specifically to intracellular and/or extracellular vesicles, a cellular vesicle stain, and a method for fluorescent staining of cellular vesicles. The p...
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WO/2022/149925A1 |
The present invention relates to a novel oxadiazole phenylalanine derivative and a medical use thereof. A novel tryptophan hydroxylase inhibitor and a pharmaceutical composition, which contain same, inhibit the synthesis of serotonin in ...
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WO/2022/129190A1 |
The present invention relates to the use of (hetero)aryl substituted 1,2,4-oxadiazole compounds for controlling harmful microorganisms, in particular phytopathogenic fungi, in crop protection (formula (I)). It also relates to novel (hete...
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WO/2022/023496A9 |
The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorop...
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WO/2022/122402A1 |
A dye encompassing a donor-acceptor-donor motif comprising a structure according to formulae (1), (2), (3), (4), (5), (6), (7) or (8). Further, a molecular probe, an analyte sensitive layer, a molecularly imprinted polymer, a sensor arra...
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WO/2022/111605A1 |
The present disclosure relates to an aryl or heteroaryl substituted 5-membered aromatic heterocyclic compound and the use thereof. In particular, provided is a compound as shown in formula I or a pharmaceutically acceptable salt thereof,...
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WO/2022/112139A1 |
The present invention provides novel compounds having the general formula (I) wherein R1 to R3 are as described herein, or a pharmaceutically acceptable salt thereof, compositions including the compounds and methods of using the compounds.
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WO/2022/064526A1 |
The present invention relates to solid state forms of Epacadostat of formula-1 which is chemically known as 4- ( { 2- [(amino sulfonyl) amino] ethyl} amino)-N-(3-bromo- 4 - fluoro phenyl) - N' - hydroxy- 1,2,5- oxa diazole- 3 - carboximi...
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WO/2022/055321A1 |
The present invention provides: a compound for a capping layer, represented by formula 1; and an organic light-emitting device including a first electrode, a second electrode, at least a single organic material layer interposed between t...
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WO/2022/050427A1 |
[Problem] To provide a novel method for producing a 1, 3, 4-oxadiazole-2-amine compound which is useful as a precursor of a heterocyclic amide compound that is useful as a herbicide. [Solution] A method for producing a 1, 3, 4-oxadiazole...
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